Title:Casein Kinase 2 Affects Epilepsy by Regulating Ion Channels: A Potential
Mechanism
Volume: 23
Issue: 7
Author(s): Yan Liu, Di Xia, Lianmei Zhong, Ling Chen*, Linming Zhang, Mingda Ai, Rong Mei and Ruijing Pang
Affiliation:
- Department of Neurology, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032,
China
- Yunnan Provincial Clinical Research Center for Neurological Disease, Kunming, Yunnan, 650032, China
Keywords:
Casein kinase 2, ion channels, epilepsy, calmodulin, ankyrin G, neuronal excitability.
Abstract: Epilepsy, characterized by recurrent seizures and abnormal brain discharges, is the third
most common chronic disorder of the Central Nervous System (CNS). Although significant progress
has been made in the research on antiepileptic drugs (AEDs), approximately one-third of patients with
epilepsy are refractory to these drugs. Thus, research on the pathogenesis of epilepsy is ongoing to
find more effective treatments. Many pathological mechanisms are involved in epilepsy, including
neuronal apoptosis, mossy fiber sprouting, neuroinflammation, and dysfunction of neuronal ion channels,
leading to abnormal neuronal excitatory networks in the brain. CK2 (Casein kinase 2), which
plays a critical role in modulating neuronal excitability and synaptic transmission, has been shown to
be associated with epilepsy. However, there is limited research on the mechanisms involved. Recent
studies have suggested that CK2 is involved in regulating the function of neuronal ion channels by directly
phosphorylating them or their binding partners. Therefore, in this review, we will summarize recent
research advances regarding the potential role of CK2 regulating ion channels in epilepsy, aiming
to provide more evidence for future studies.
