Casein Kinase 2 Affects Epilepsy by Regulating Ion Channels: A Potential Mechanism

Title:Casein Kinase 2 Affects Epilepsy by Regulating Ion Channels: A Potential Mechanism

Volume: 23 Issue: 7

Author(s): Yan Liu, Di Xia, Lianmei Zhong, Ling Chen*, Linming Zhang, Mingda Ai, Rong Mei and Ruijing Pang

Affiliation:

• Department of Neurology, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, China
• Yunnan Provincial Clinical Research Center for Neurological Disease, Kunming, Yunnan, 650032, China

Keywords: Casein kinase 2, ion channels, epilepsy, calmodulin, ankyrin G, neuronal excitability.

Abstract: Epilepsy, characterized by recurrent seizures and abnormal brain discharges, is the third most common chronic disorder of the Central Nervous System (CNS). Although significant progress has been made in the research on antiepileptic drugs (AEDs), approximately one-third of patients with epilepsy are refractory to these drugs. Thus, research on the pathogenesis of epilepsy is ongoing to find more effective treatments. Many pathological mechanisms are involved in epilepsy, including neuronal apoptosis, mossy fiber sprouting, neuroinflammation, and dysfunction of neuronal ion channels, leading to abnormal neuronal excitatory networks in the brain. CK2 (Casein kinase 2), which plays a critical role in modulating neuronal excitability and synaptic transmission, has been shown to be associated with epilepsy. However, there is limited research on the mechanisms involved. Recent studies have suggested that CK2 is involved in regulating the function of neuronal ion channels by directly phosphorylating them or their binding partners. Therefore, in this review, we will summarize recent research advances regarding the potential role of CK2 regulating ion channels in epilepsy, aiming to provide more evidence for future studies.

Cite this article as:

Liu Yan, Xia Di, Zhong Lianmei, Chen Ling*, Zhang Linming, Ai Mingda, Mei Rong and Pang Ruijing, Casein Kinase 2 Affects Epilepsy by Regulating Ion Channels: A Potential Mechanism, CNS & Neurological Disorders - Drug Targets 2024; 23 (7) . https://dx.doi.org/10.2174/1871527322666230622124618