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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Cardiospecific Troponins as Laboratory Biomarkers of Myocardial Cell Injury in Hypertension: A Mini-Review

Author(s): Aleksey Michailovich Chaulin*

Volume 31, Issue 10, 2024

Published on: 28 April, 2023

Page: [1235 - 1250] Pages: 16

DOI: 10.2174/0929867330666230220100323

Price: $65


To date, it is well known that a significant number of diseases of cardiovascular genesis (coronary heart disease, myocardial infarction, cardiomyopathy, Takotsubo syndrome, heart failure, etc.) and extra-cardiac genesis (renal failure, chronic obstructive pulmonary disease, sepsis, diabetes mellitus, etc.) cause injury to contractile cells of the heart muscle (myocardial cells). The most sensitive and specific criteria for proving myocardial cell injury are cardiospecific troponins (CSTns) - CSTnI and CSTnT. According to the current clinical recommendations of the European, American, and Russian Cardiological Communities, CSTnI and CSTnT are the main biomarkers for early diagnosis of myocardial infarction. Hypertension is one of the most dangerous and common risk factors for the development of cardiovascular pathologies and is associated with a high risk of dangerous cardiovascular complications. Therefore, there is an urgent need to search for new biomarkers for the timely assessment of the prognosis of patients with hypertension.

This mini-review aims to substantiate the possibilities of using the cardiomarkers (CSTnI and CSTnT) to assess the prognosis of patients suffering from hypertension and to discuss potential mechanisms that cause injury to myocardial cells and increase serum levels of CSTnI and CSTnT.

This is a narrative mini-review, which was prepared using the following databases: Pubmed/Medline, PubMed Central, Embase, Scopus, and Web of Science. The following keywords were used in the literature search: “myocardial cells”, “injury”, “damage”, and “hypertension” in combination with the terms “mechanisms of injury” “predictive significance”, “cardiac troponins”, or “cardiospecific troponins”.

Keywords: Myocardial cells, injury, mechanisms of injury, cardiovascular diseases, hypertension, blood pressure, cardiospecific troponins, high-sensitive, predictive significance.

Hasić, S.; Kiseljaković, E.; Jadrić, R.; Radovanović, J.; Winterhalter-Jadrić, M. Cardiac troponin I: The gold standard in acute myocardial infarction diagnosis. Bosn. J. Basic Med. Sci., 2003, 3(3), 41-44.
[] [PMID: 16232149]
Chaulin, A.; Duplyakov, D. Analytical review of modern information on the physiological and pathochemical mechanisms of the release of cardiospecific proteins from muscle tissue, methodology and technologies of their research, interpretation of the results. East. Eur., 2022, 11, 78-97.
Santaló, M.; Martin, A.; Velilla, J.; Povar, J.; Temboury, F.; Balaguer, J.; Muñoz, M.; Calmarza, P.; Ortiz, C.; Carratalá, A.; Gich, I.; Mercé, J.; Jaffe, A.S.; Ordoñez-Llanos, J. Using high-sensitivity troponin T: The importance of the proper gold standard. Am. J. Med., 2013, 126(8), 709-717.
[] [PMID: 23764266]
Collet, J.P.; Thiele, H.; Barbato, E.; Barthélémy, O.; Bauersachs, J.; Bhatt, D.L.; Dendale, P.; Dorobantu, M.; Edvardsen, T.; Folliguet, T.; Gale, C.P.; Gilard, M.; Jobs, A.; Jüni, P.; Lambrinou, E.; Lewis, B.S.; Mehilli, J.; Meliga, E.; Merkely, B.; Mueller, C.; Roffi, M.; Rutten, F.H.; Sibbing, D.; Siontis, G.C.M.; Kastrati, A.; Mamas, M.A.; Aboyans, V.; Angiolillo, D.J.; Bueno, H.; Bugiardini, R.; Byrne, R.A.; Castelletti, S.; Chieffo, A.; Cornelissen, V.; Crea, F.; Delgado, V.; Drexel, H.; Gierlotka, M.; Halvorsen, S.; Haugaa, K.H.; Jankowska, E.A.; Katus, H.A.; Kinnaird, T.; Kluin, J.; Kunadian, V.; Landmesser, U.; Leclercq, C.; Lettino, M.; Meinila, L.; Mylotte, D.; Ndrepepa, G.; Omerovic, E.; Pedretti, R.F.E.; Petersen, S.E.; Petronio, A.S.; Pontone, G.; Popescu, B.A.; Potpara, T.; Ray, K.K.; Luciano, F.; Richter, D.J.; Shlyakhto, E.; Simpson, I.A.; Sousa-Uva, M.; Storey, R.F.; Touyz, R.M.; Valgimigli, M.; Vranckx, P.; Yeh, R.W.; Barbato, E.; Barthélémy, O.; Bauersachs, J.; Bhatt, D.L.; Dendale, P.; Dorobantu, M.; Edvardsen, T.; Folliguet, T.; Gale, C.P.; Gilard, M.; Jobs, A.; Jüni, P.; Lambrinou, E.; Lewis, B.S.; Mehilli, J.; Meliga, E.; Merkely, B.; Mueller, C.; Roffi, M.; Rutten, F.H.; Sibbing, D.; Siontis, G.C.M. 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur. Heart J., 2021, 42(14), 1289-1367.
[] [PMID: 32860058]
Chaulin, A. Cardiac troponins: Contemporary biological data and new methods of determination. Vasc. Health Risk Manag., 2021, 17, 299-316.
[] [PMID: 34113117]
Marston, S.; Zamora, J.E. Troponin structure and function: A view of recent progress. J. Muscle Res. Cell Motil., 2020, 41(1), 71-89.
[] [PMID: 31030382]
Chaulin, A.M. Some common causes of false positive increases in serum levels of cardiac troponins (mini-review). Curr. Cardiol. Rev., 2022, 18(6), e130422203527.
[] [PMID: 35422225]
Parvatiyar, M.S.; Pinto, J.R.; Dweck, D.; Potter, J.D. Cardiac troponin mutations and restrictive cardiomyopathy. J. Biomed. Biotechnol., 2010, 2010, 1-9.
[] [PMID: 20617149]
Mogensen, J.; Hey, T.; Lambrecht, S. A systematic review of phenotypic features associated with cardiac Troponin I Mutations in hereditary cardiomyopathies. Can. J. Cardiol., 2015, 31(11), 1377-1385.
[] [PMID: 26440512]
Cheng, Y.; Regnier, M. Cardiac troponin structure-function and the influence of hypertrophic cardiomyopathy associated mutations on modulation of contractility. Arch. Biochem. Biophys., 2016, 601, 11-21.
[] [PMID: 26851561]
Tobacman, L.S.; Cammarato, A. Cardiomyopathic troponin mutations predominantly occur at its interface with actin and tropomyosin. J. Gen. Physiol., 2021, 153(3), e202012815.
[] [PMID: 33492345]
Thygesen, K.; Alpert, J.S.; Jaffe, A.S.; Chaitman, B.R.; Bax, J.J.; Morrow, D.A.; White, H.D. Fourth universal definition of myocardial infarction. Glob. Heart, 2018, 13(4), 305-338.
[] [PMID: 30154043]
Russian Society of Cardiology. 2020 Clinical practice guidelines for Acute ST-segment elevation myocardial infarction. Russ. J. Cardiol., 2020, 25(11), 4103.
Barbarash, O.L.; Duplyakov, D.V.; Zateischikov, D.A.; Panchenko, E.P.; Shakhnovich, R.M.; Yavelov, I.S.; Yakovlev, A.N.; Abugov, S.A.; Alekyan, B.G.; Arkhipov, M.V.; Vasilieva, E.Y.; Galyavich, A.S.; Ganyukov, V.I.; Gilyarevskyi, S.R.; Golubev, E.P.; Golukhova, E.Z.; Gratsiansky, N.A.; Karpov, Y.A.; Kosmacheva, E.D.; Lopatin, Y.M.; Markov, V.A.; Nikulina, N.N.; Pevzner, D.V.; Pogosova, N.V.; Protopopov, A.V.; Skrypnik, D.V.; Tereshchenko, S.N.; Ustyugov, S.A.; Khripun, A.V.; Shalaev, S.V.; Shpektor, V.A.; Yakushin, S.S. 2020 Clinical practice guidelines for Acute coronary syndrome without ST segment elevation. Russian Journal of Cardiology, 2021, 26(4), 4449.
Dubin, R.F.; Li, Y.; He, J.; Jaar, B.G.; Kallem, R.; Lash, J.P.; Makos, G.; Rosas, S.E.; Soliman, E.Z.; Townsend, R.R.; Yang, W.; Go, A.S.; Keane, M.; deFilippi, C.; Mishra, R.; Wolf, M.; Shlipak, M.G. Predictors of high sensitivity cardiac troponin T in chronic kidney disease patients: a cross-sectional study in the chronic renal insufficiency cohort (CRIC). BMC Nephrol., 2013, 14(1), 229.
[] [PMID: 24148285]
Chaulin, A.M.; Duplyakov, D.V. Comorbidity in chronic obstructive pulmonary disease and cardiovascular disease. Cardiovasc. Ther. Prev., 2021, 20(3), 2539.
Nolte, C.H.; Scheitz, J.F.; Endres, M. Troponinerhöhung nach ischämischem Schlaganfall. Med. Klin. Intensivmed. Notf. Med., 2017, 112(3), 222-226.
[] [PMID: 26564181]
Ananthan, K.; Lyon, A.R. The role of biomarkers in cardio-oncology. J. Cardiovasc. Transl. Res., 2020, 13(3), 431-450.
[] [PMID: 32642841]
Chaulin, A.M.; Duplyakov, D.V. Arrhythmogenic effects of doxorubicin. Complex Issues Cardiovasc. Dis., 2020, 9(3), 69-80.
Chaulin, A.M.; Duplyakov, D.V. Cardioprotective strategies for doxorubicin-induced cardiotoxicity: Present and future. Ration. Pharmacother. Cardiol., 2022, 18(1), 103-112.
Rezende, P.C.; Everett, B.M.; Brooks, M.M.; Vlachos, H.; Orchard, T.J.; Frye, R.L.; Bhatt, D.L.; Hlatky, M.A. Hypoglycemia and elevated troponin in patients with diabetes and coronary artery disease. J. Am. Coll. Cardiol., 2018, 72(15), 1778-1786.
[] [PMID: 30286920]
Chaulin, A.M. Elevation mechanisms and diagnostic consideration of cardiac troponins under conditions not associated with myocardial infarction. Part 2. Life, 2021, 11(11), 1175.
[] [PMID: 34833051]
Eggers, K.M.; Lindahl, B. Application of cardiac troponin in cardiovascular diseases other than acute coronary syndrome. Clin. Chem., 2017, 63(1), 223-235.
[] [PMID: 28062620]
Chaulin, A.M. Cardiac troponins metabolism: From biochemical mechanisms to clinical practice (literature review). Int. J. Mol. Sci., 2021, 22(20), 10928.
[] [PMID: 34681585]
Stavroulakis, G.A.; George, K.P. Exercise-induced release of troponin. Clin. Cardiol., 2020, 43(8), 872-881.
[] [PMID: 31975465]
Chaulin, A. Elevation mechanisms and diagnostic consideration of cardiac troponins under conditions not associated with myocardial infarction. Part 1. Life, 2021, 11(9), 914.
[] [PMID: 34575063]
Lindner, G.; Pfortmueller, C.A.; Braun, C.T.; Exadaktylos, A.K. Non-acute myocardial infarction-related causes of elevated high-sensitive troponin T in the emergency room: A cross-sectional analysis. Intern. Emerg. Med., 2014, 9(3), 335-339.
[] [PMID: 24326466]
Chaulin, A.M.; Dupliakov, D.V. Physical activity and cardiac markers: Part 1. Human. Sport. Medicine, 2022, 22(2), 15-28.
Lazzarino, A.I.; Hamer, M.; Gaze, D.; Collinson, P.; Steptoe, A. The association between cortisol response to mental stress and high-sensitivity cardiac troponin T plasma concentration in healthy adults. J. Am. Coll. Cardiol., 2013, 62(18), 1694-1701.
[] [PMID: 23810896]
Chaulin, A.M. Cardiac troponins: current information on the main analytical characteristics of determination methods and new diagnostic possibilities. Medwave, 2021, 21(11), e002132.
[] [PMID: 34890387]
Rocco, E.; La Rosa, G.; Liuzzo, G.; Biasucci, L.M. High-sensitivity cardiac troponin assays and acute coronary syndrome. J. Cardiovasc. Med., 2019, 20(8), 504-509.
[] [PMID: 31259857]
Chaulin, A.M.; Duplyakova, P.D.; Duplyakov, D.V. Circadian rhythms of cardiac troponins: Mechanisms and clinical significance. Russ. J. Cardiol., 2020, 25(3S), 4061.
van der Linden, N.; Cornelis, T.; Klinkenberg, L.J.J.; Kimenai, D.M.; Hilderink, J.M.; Litjens, E.J.R.; Kooman, J.P.; Bekers, O.; van Dieijen-Visser, M.P.; Meex, S.J.R. Strong diurnal rhythm of troponin T, but not troponin I, in a patient with renal dysfunction. Int. J. Cardiol., 2016, 221, 287-288.
[] [PMID: 27404692]
Zaninotto, M.; Padoan, A.; Mion, M.M.; Marinova, M.; Plebani, M. Short-term biological variation and diurnal rhythm of cardiac troponin I (Access hs-TnI) in healthy subjects. Clin. Chim. Acta, 2020, 504, 163-167.
[] [PMID: 32035091]
Chaulin, A.M.; Duplyakov, D.V. High-sensitivity cardiac troponins: Circadian rhythms. Cardiovasc. Ther. Prev. (Fidenza), 2021, 20(1), 2639.
Chaulin, A.M. Main analytical characteristics of laboratory methods for the determination of cardiac troponins: A review from the historical and modern points of view. Orv. Hetil., 2022, 163(1), 12-20.
[] [PMID: 34974429]
Lyngbakken, M.N.; Vigen, T.; Ihle-Hansen, H.; Brynildsen, J.; Berge, T.; Rønning, O.M.; Tveit, A.; Røsjø, H.; Omland, T. Cardiac troponin I measured with a very high sensitivity assay predicts subclinical carotid atherosclerosis: The Akershus Cardiac Examination 1950 Study. Clin. Biochem., 2021, 93, 59-65.
[] [PMID: 33861986]
Witkowski, M.; Wu, Y.; Hazen, S.L.; Tang, W.H.W. Prognostic value of subclinical myocardial necrosis using high-sensitivity cardiac troponin T in patients with prediabetes. Cardiovasc. Diabetol., 2021, 20(1), 171.
[] [PMID: 34419046]
Laufer, E.M.; Hofstra, L. Subclinical thrombotic events as a mechanism for troponin release? J. Am. Coll. Cardiol., 2018, 71(9), 1056.
[] [PMID: 29495991]
Hayama, H.; Ide, S.; Moroi, M.; Kitami, Y.; Bekki, N.; Kubota, S.; Uemura, Y.; Hara, H.; Kutsuna, S.; Ohmagari, N.; Hiroi, Y. Elevated high-sensitivity troponin is associated with subclinical cardiac dysfunction in patients recovered from coronavirus disease 2019. Global Health & Medicine, 2021, 3(2), 95-101.
[] [PMID: 33937572]
Aydin, S.; Aydin, S.; Kobat, M.A.; Kalayci, M.; Eren, M.N.; Yilmaz, M.; Kuloglu, T.; Gul, E.; Secen, O.; Alatas, O.D.; Baydas, A. Decreased saliva/serum irisin concentrations in the acute myocardial infarction promising for being a new candidate biomarker for diagnosis of this pathology. Peptides, 2014, 56, 141-145.
[] [PMID: 24747283]
Mirzaii-Dizgah, I.; Riahi, E. Salivary troponin I as an indicator of myocardial infarction. Indian J. Med. Res., 2013, 138(6), 861-865.
[PMID: 24521627]
Chaulin, A.M.; Karslyan, L.S.; Bazyuk, E.V.; Nurbaltaeva, D.A.; Duplyakov, D.V. Clinical and diagnostic value of cardiac markers in human biological fluids. Kardiologiia, 2019, 59(11), 66-75.
[] [PMID: 31849301]
Chen, J.Y.; Lee, S.Y.; Li, Y.H.; Lin, C.Y.; Shieh, M.D.; Ciou, D.S. Urine high-sensitivity Troponin I predict incident cardiovascular events in patients with diabetes mellitus. J. Clin. Med., 2020, 9(12), 3917.
[] [PMID: 33276667]
Klichowska-Palonka, M.; Załęska-Chromińska, K.; Bachanek, T. Possibility of using saliva as a diagnostic test material in cardiovascular diseases. Wiad. Lek., 2015, 68(3 pt 2), 354-357.
[PMID: 28501835]
Chaulin, A.M.; Duplyakova, P.D.; Bikbaeva, G.R.; Tukhbatova, A.A.; Grigorieva, E.V.; Duplyakov, D.V. Concentration of high-sensitivity cardiac troponin I in the oral fluid in patients with acute myocardial infarction: A pilot study. Russ. J. Cardiol., 2020, 25(12), 3814.
Williams, B.; Mancia, G.; Spiering, W.; Agabiti Rosei, E.; Azizi, M.; Burnier, M.; Clement, D.L.; Coca, A.; de Simone, G.; Dominiczak, A.; Kahan, T.; Mahfoud, F.; Redon, J.; Ruilope, L.; Zanchetti, A.; Kerins, M.; Kjeldsen, S.E.; Kreutz, R.; Laurent, S.; Lip, G.Y.H.; McManus, R.; Narkiewicz, K.; Ruschitzka, F.; Schmieder, R.E.; Shlyakhto, E.; Tsioufis, C.; Aboyans, V.; Desormais, I.; De Backer, G.; Heagerty, A.M.; Agewall, S.; Bochud, M.; Borghi, C.; Boutouyrie, P.; Brguljan, J.; Bueno, H.; Caiani, E.G.; Carlberg, B.; Chapman, N.; Cífková, R.; Cleland, J.G.F.; Collet, J-P.; Coman, I.M.; de Leeuw, P.W.; Delgado, V.; Dendale, P.; Diener, H-C.; Dorobantu, M.; Fagard, R.; Farsang, C.; Ferrini, M.; Graham, I.M.; Grassi, G.; Haller, H.; Hobbs, F.D.R.; Jelakovic, B.; Jennings, C.; Katus, H.A.; Kroon, A.A.; Leclercq, C.; Lovic, D.; Lurbe, E.; Manolis, A.J.; McDonagh, T.A.; Messerli, F.; Muiesan, M.L.; Nixdorff, U.; Olsen, M.H.; Parati, G.; Perk, J.; Piepoli, M.F.; Polonia, J.; Ponikowski, P.; Richter, D.J.; Rimoldi, S.F.; Roffi, M.; Sattar, N.; Seferovic, P.M.; Simpson, I.A.; Sousa-Uva, M.; Stanton, A.V.; van de Borne, P.; Vardas, P.; Volpe, M.; Wassmann, S.; Windecker, S.; Zamorano, J.L.; Windecker, S.; Aboyans, V.; Agewall, S.; Barbato, E.; Bueno, H.; Coca, A.; Collet, J-P.; Coman, I.M.; Dean, V.; Delgado, V.; Fitzsimons, D.; Gaemperli, O.; Hindricks, G.; Iung, B.; Jüni, P.; Katus, H.A.; Knuuti, J.; Lancellotti, P.; Leclercq, C.; McDonagh, T.A.; Piepoli, M.F.; Ponikowski, P.; Richter, D.J.; Roffi, M.; Shlyakhto, E.; Simpson, I.A.; Sousa-Uva, M.; Zamorano, J.L.; Tsioufis, C.; Lurbe, E.; Kreutz, R.; Bochud, M.; Rosei, E.A.; Jelakovic, B.; Azizi, M.; Januszewics, A.; Kahan, T.; Polonia, J.; van de Borne, P.; Williams, B.; Borghi, C.; Mancia, G.; Parati, G.; Clement, D.L.; Coca, A.; Manolis, A.; Lovic, D.; Benkhedda, S.; Zelveian, P.; Siostrzonek, P.; Najafov, R.; Pavlova, O.; De Pauw, M.; Dizdarevic-Hudic, L.; Raev, D.; Karpettas, N.; Linhart, A.; Olsen, M.H.; Shaker, A.F.; Viigimaa, M.; Metsärinne, K.; Vavlukis, M.; Halimi, J-M.; Pagava, Z.; Schunkert, H.; Thomopoulos, C.; Páll, D.; Andersen, K.; Shechter, M.; Mercuro, G.; Bajraktari, G.; Romanova, T.; Trušinskis, K.; Saade, G.A.; Sakalyte, G.; Noppe, S.; DeMarco, D.C.; Caraus, A.; Wittekoek, J.; Aksnes, T.A.; Jankowski, P.; Polonia, J.; Vinereanu, D.; Baranova, E.I.; Foscoli, M.; Dikic, A.D.; Filipova, S.; Fras, Z.; Bertomeu-Martínez, V.; Carlberg, B.; Burkard, T.; Sdiri, W.; Aydogdu, S.; Sirenko, Y.; Brady, A.; Weber, T.; Lazareva, I.; Backer, T.D.; Sokolovic, S.; Jelakovic, B.; Widimsky, J.; Viigimaa, M.; Pörsti, I.; Denolle, T.; Krämer, B.K.; Stergiou, G.S.; Parati, G.; Trušinskis, K.; Miglinas, M.; Gerdts, E.; Tykarski, A.; de Carvalho Rodrigues, M.; Dorobantu, M.; Chazova, I.; Lovic, D.; Filipova, S.; Brguljan, J.; Segura, J.; Gottsäter, A.; Pechère-Bertschi, A.; Erdine, S.; Sirenko, Y.; Brady, A. ESC Scientific Document Group. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur. Heart J., 2018, 39(33), 3021-3104.
[] [PMID: 30165516]
Zhou, B.; Bentham, J.; Di Cesare, M.; Bixby, H.; Danaei, G.; Cowan, M.J.; Paciorek, C.J.; Singh, G.; Hajifathalian, K.; Bennett, J.E.; Taddei, C.; Bilano, V.; Carrillo-Larco, R.M.; Djalalinia, S.; Khatibzadeh, S.; Lugero, C.; Peykari, N.; Zhang, W.Z.; Lu, Y.; Stevens, G.A.; Riley, L.M.; Bovet, P.; Elliott, P.; Gu, D.; Ikeda, N.; Jackson, R.T.; Joffres, M.; Kengne, A.P.; Laatikainen, T.; Lam, T.H.; Laxmaiah, A.; Liu, J.; Miranda, J.J.; Mondo, C.K.; Neuhauser, H.K.; Sundström, J.; Smeeth, L.; Soric, M.; Woodward, M.; Ezzati, M.; Abarca-Gómez, L.; Abdeen, Z.A.; Rahim, H.A.; Abu-Rmeileh, N.M.; Acosta-Cazares, B.; Adams, R.; Aekplakorn, W.; Afsana, K.; Aguilar-Salinas, C.A.; Agyemang, C.; Ahmadvand, A.; Ahrens, W.; Al Raddadi, R.; Al Woyatan, R.; Ali, M.M.; Alkerwi, A.; Aly, E.; Amouyel, P.; Amuzu, A.; Andersen, L.B.; Anderssen, S.A.; Ängquist, L.; Anjana, R.M.; Ansong, D.; Aounallah-Skhiri, H.; Araújo, J.; Ariansen, I.; Aris, T.; Arlappa, N.; Aryal, K.; Arveiler, D.; Assah, F.K.; Assunção, M.C.F.; Avdicová, M.; Azevedo, A.; Azizi, F.; Babu, B.V.; Bahijri, S.; Balakrishna, N.; Bandosz, P.; Banegas, J.R.; Barbagallo, C.M.; Barceló, A.; Barkat, A.; Barros, A.J.D.; Barros, M.V.; Bata, I.; Batieha, A.M.; Baur, L.A.; Beaglehole, R.; Romdhane, H.B.; Benet, M.; Benson, L.S.; Bernabe-Ortiz, A.; Bernotiene, G.; Bettiol, H.; Bhagyalaxmi, A.; Bharadwaj, S.; Bhargava, S.K.; Bi, Y.; Bikbov, M.; Bjerregaard, P.; Bjertness, E.; Björkelund, C.; Blokstra, A.; Bo, S.; Bobak, M.; Boeing, H.; Boggia, J.G.; Boissonnet, C.P.; Bongard, V.; Braeckman, L.; Brajkovich, I.; Branca, F.; Breckenkamp, J.; Brenner, H.; Brewster, L.M.; Bruno, G.; Bueno-de-Mesquita, H.B.; Bugge, A.; Burns, C.; Bursztyn, M.; de León, A.C.; Cacciottolo, J.; Cameron, C.; Can, G.; Cândido, A.P.C.; Capuano, V.; Cardoso, V.C.; Carlsson, A.C.; Carvalho, M.J.; Casanueva, F.F.; Casas, J-P.; Caserta, C.A.; Chamukuttan, S.; Chan, A.W.; Chan, Q.; Chaturvedi, H.K.; Chaturvedi, N.; Chen, C-J.; Chen, F.; Chen, H.; Chen, S.; Chen, Z.; Cheng, C-Y.; Dekkaki, I.C.; Chetrit, A.; Chiolero, A.; Chiou, S-T.; Chirita-Emandi, A.; Cho, B.; Cho, Y.; Chudek, J.; Cifkova, R.; Claessens, F.; Clays, E.; Concin, H.; Cooper, C.; Cooper, R.; Coppinger, T.C.; Costanzo, S.; Cottel, D.; Cowell, C.; Craig, C.L.; Crujeiras, A.B.; Cruz, J.J.; D’Arrigo, G.; d’Orsi, E.; Dallongeville, J.; Damasceno, A.; Dankner, R.; Dantoft, T.M.; Dauchet, L.; De Backer, G.; De Bacquer, D.; de Gaetano, G.; De Henauw, S.; De Smedt, D.; Deepa, M.; Dehghan, A.; Delisle, H.; Deschamps, V.; Dhana, K.; Di Castelnuovo, A.F.; Dias-da-Costa, J.S.; Diaz, A.; Dickerson, T.T.; Do, H.T.P.; Dobson, A.J.; Donfrancesco, C.; Donoso, S.P.; Döring, A.; Doua, K.; Drygas, W.; Dulskiene, V.; Džakula, A.; Dzerve, V.; Dziankowska-Zaborszczyk, E.; Eggertsen, R.; Ekelund, U.; El Ati, J.; Ellert, U.; Elliott, P.; Elosua, R.; Erasmus, R.T.; Erem, C.; Eriksen, L.; de la Peña, J.E.; Evans, A.; Faeh, D.; Fall, C.H.; Farzadfar, F.; Felix-Redondo, F.J.; Ferguson, T.S.; Fernández-Bergés, D.; Ferrante, D.; Ferrari, M.; Ferreccio, C.; Ferrieres, J.; Finn, J.D.; Fischer, K.; Föger, B.; Foo, L.H.; Forslund, A-S.; Forsner, M.; Fortmann, S.P.; Fouad, H.M.; Francis, D.K.; Franco, M.C.; Franco, O.H.; Frontera, G.; Fuchs, F.D.; Fuchs, S.C.; Fujita, Y.; Furusawa, T.; Gaciong, Z.; Gareta, D.; Garnett, S.P.; Gaspoz, J-M.; Gasull, M.; Gates, L.; Gavrila, D.; Geleijnse, J.M.; Ghasemian, A.; Ghimire, A.; Giampaoli, S.; Gianfagna, F.; Giovannelli, J.; Goldsmith, R.A.; Gonçalves, H.; Gross, M.G.; Rivas, J.P.G.; Gottrand, F.; Graff-Iversen, S.; Grafnetter, D.; Grajda, A.; Gregor, R.D.; Grodzicki, T.; Grøntved, A.; Gruden, G.; Grujic, V.; Gu, D.; Guan, O.P.; Gudnason, V.; Guerrero, R.; Guessous, I.; Guimaraes, A.L.; Gulliford, M.C.; Gunnlaugsdottir, J.; Gunter, M.; Gupta, P.C.; Gureje, O.; Gurzkowska, B.; Gutierrez, L.; Gutzwiller, F.; Hadaegh, F.; Halkjær, J.; Hambleton, I.R.; Hardy, R.; Harikumar, R.; Hata, J.; Hayes, A.J.; He, J.; Hendriks, M.E.; Henriques, A.; Cadena, L.H.; Herrala, S.; Heshmat, R.; Hihtaniemi, I.T.; Ho, S.Y.; Ho, S.C.; Hobbs, M.; Hofman, A.; Dinc, G.H.; Hormiga, C.M.; Horta, B.L.; Houti, L.; Howitt, C.; Htay, T.T.; Htet, A.S.; Hu, Y.; Huerta, J.M.; Husseini, A.S.; Huybrechts, I.; Hwalla, N.; Iacoviello, L.; Iannone, A.G.; Ibrahim, M.M.; Ikram, M.A.; Irazola, V.E.; Islam, M.; Ivkovic, V.; Iwasaki, M.; Jackson, R.T.; Jacobs, J.M.; Jafar, T.; Jamrozik, K.; Janszky, I.; Jasienska, G.; Jelakovic, B.; Jiang, C.Q.; Joffres, M.; Johansson, M.; Jonas, J.B.; Jørgensen, T.; Joshi, P.; Juolevi, A.; Jurak, G.; Jureša, V.; Kaaks, R.; Kafatos, A.; Kalter-Leibovici, O.; Kamaruddin, N.A.; Kasaeian, A.; Katz, J.; Kauhanen, J.; Kaur, P.; Kavousi, M.; Kazakbaeva, G.; Keil, U.; Boker, L.K.; Keinänen-Kiukaanniemi, S.; Kelishadi, R.; Kemper, H.C.G.; Kengne, A.P.; Kersting, M.; Key, T.; Khader, Y.S.; Khalili, D.; Khang, Y-H.; Khaw, K-T.; Kiechl, S.; Killewo, J.; Kim, J.; Klumbiene, J.; Kolle, E.; Kolsteren, P.; Korrovits, P.; Koskinen, S.; Kouda, K.; Koziel, S.; Kristensen, P.L.; Krokstad, S.; Kromhout, D.; Kruger, H.S.; Kubinova, R.; Kuciene, R.; Kuh, D.; Kujala, U.M.; Kula, K.; Kulaga, Z.; Kumar, R.K.; Kurjata, P.; Kusuma, Y.S.; Kuulasmaa, K.; Kyobutungi, C.; Laatikainen, T.; Lachat, C.; Lam, T.H.; Landrove, O.; Lanska, V.; Lappas, G.; Larijani, B.; Laugsand, L.E.; Laxmaiah, A.; Bao, K.L.N.; Le, T.D.; Leclercq, C.; Lee, J.; Lee, J.; Lehtimäki, T.; Lekhraj, R.; León-Muñoz, L.M.; Levitt, N.S.; Li, Y.; Lilly, C.L.; Lim, W-Y.; Lima-Costa, M.F.; Lin, H-H.; Lin, X.; Linneberg, A.; Lissner, L.; Litwin, M.; Lorbeer, R.; Lotufo, P.A.; Lozano, J.E.; Luksiene, D.; Lundqvist, A.; Lunet, N.; Lytsy, P.; Ma, G.; Ma, J.; Machado-Coelho, G.L.L.; Machi, S.; Maggi, S.; Magliano, D.J.; Majer, M.; Makdisse, M.; Malekzadeh, R.; Malhotra, R.; Rao, K.M.; Malyutina, S.; Manios, Y.; Mann, J.I.; Manzato, E.; Margozzini, P.; Marques-Vidal, P.; Marrugat, J.; Martorell, R.; Mathiesen, E.B.; Matijasevich, A.; Matsha, T.E.; Mbanya, J.C.N.; Posso, A.J.M.D.; McFarlane, S.R.; McGarvey, S.T.; McLachlan, S.; McLean, R.M.; McNulty, B.A.; Khir, A.S.M.; Mediene-Benchekor, S.; Medzioniene, J.; Meirhaeghe, A.; Meisinger, C.; Menezes, A.M.B.; Menon, G.R.; Meshram, I.I.; Metspalu, A.; Mi, J.; Mikkel, K.; Miller, J.C.; Miquel, J.F.; Mišigoj-Durakovic, M.; Mohamed, M.K.; Mohammad, K.; Mohammadifard, N.; Mohan, V.; Yusoff, M.F.M.; Møller, N.C.; Molnár, D.; Momenan, A.; Mondo, C.K.; Monyeki, K.D.K.; Moreira, L.B.; Morejon, A.; Moreno, L.A.; Morgan, K.; Moschonis, G.; Mossakowska, M.; Mostafa, A.; Mota, J.; Motlagh, M.E.; Motta, J.; Muiesan, M.L.; Müller-Nurasyid, M.; Murphy, N.; Mursu, J.; Musil, V.; Nagel, G.; Naidu, B.M.; Nakamura, H.; Námešná, J.; Nang, E.E.K.; Nangia, V.B.; Narake, S.; Navarrete-Muñoz, E.M.; Ndiaye, N.C.; Neal, W.A.; Nenko, I.; Nervi, F.; Nguyen, N.D.; Nguyen, Q.N.; Nieto-Martínez, R.E.; Niiranen, T.J.; Ning, G.; Ninomiya, T.; Nishtar, S.; Noale, M.; Noboa, O.A.; Noorbala, A.A.; Noorbala, T.; Noto, D.; Al Nsour, M.; O’Reilly, D.; Oh, K.; Olinto, M.T.A.; Oliveira, I.O.; Omar, M.A.; Onat, A.; Ordunez, P.; Osmond, C.; Ostojic, S.M.; Otero, J.A.; Overvad, K.; Owusu-Dabo, E.; Paccaud, F.M.; Padez, C.; Pahomova, E.; Pajak, A.; Palli, D.; Palmieri, L.; Panda-Jonas, S.; Panza, F.; Papandreou, D.; Parnell, W.R.; Parsaeian, M.; Pecin, I.; Pednekar, M.S.; Peer, N.; Peeters, P.H.; Peixoto, S.V.; Pelletier, C.; Peltonen, M.; Pereira, A.C.; Pérez, R.M.; Peters, A.; Petkeviciene, J.; Pham, S.T.; Pigeot, I.; Pikhart, H.; Pilav, A.; Pilotto, L.; Pitakaka, F.; Plans-Rubió, P.; Polakowska, M.; Polašek, O.; Porta, M.; Portegies, M.L.P.; Pourshams, A.; Pradeepa, R.; Prashant, M.; Price, J.F.; Puiu, M.; Punab, M.; Qasrawi, R.F.; Qorbani, M.; Radic, I.; Radisauskas, R.; Rahman, M.; Raitakari, O.; Raj, M.; Rao, S.R.; Ramachandran, A.; Ramos, E.; Rampal, S.; Reina, D.A.R.; Rasmussen, F.; Redon, J.; Reganit, P.F.M.; Ribeiro, R.; Riboli, E.; Rigo, F.; de Wit, T.F.R.; Ritti-Dias, R.M.; Robinson, S.M.; Robitaille, C.; Rodríguez-Artalejo, F.; Rodriguez-Perez del Cristo, M.; Rodríguez-Villamizar, L.A.; Rojas-Martinez, R.; Rosengren, A.; Rubinstein, A.; Rui, O.; Ruiz-Betancourt, B.S.; Horimoto, A.R.V.R.; Rutkowski, M.; Sabanayagam, C.; Sachdev, H.S.; Saidi, O.; Sakarya, S.; Salanave, B.; Salazar Martinez, E.; Salmerón, D.; Salomaa, V.; Salonen, J.T.; Salvetti, M.; Sánchez-Abanto, J.; Sans, S.; Santos, D.; Santos, I.S.; dos Santos, R.N.; Santos, R.; Saramies, J.L.; Sardinha, L.B.; Margolis, G.S.; Sarrafzadegan, N.; Saum, K-U.; Savva, S.C.; Scazufca, M.; Schargrodsky, H.; Schneider, I.J.; Schultsz, C.; Schutte, A.E.; Sen, A.; Senbanjo, I.O.; Sepanlou, S.G.; Sharma, S.K.; Shaw, J.E.; Shibuya, K.; Shin, D.W.; Shin, Y.; Siantar, R.; Sibai, A.M.; Silva, D.A.S.; Simon, M.; Simons, J.; Simons, L.A.; Sjöström, M.; Skovbjerg, S.; Slowikowska-Hilczer, J.; Slusarczyk, P.; Smeeth, L.; Smith, M.C.; Snijder, M.B.; So, H-K.; Sobngwi, E.; Söderberg, S.; Solfrizzi, V.; Sonestedt, E.; Song, Y.; Sørensen, T.I.A.; Jérome, C.S.; Soumare, A.; Staessen, J.A.; Starc, G.; Stathopoulou, M.G.; Stavreski, B.; Steene-Johannessen, J.; Stehle, P.; Stein, A.D.; Stergiou, G.S.; Stessman, J.; Stieber, J.; Stöckl, D.; Stocks, T.; Stokwiszewski, J.; Stronks, K.; Strufaldi, M.W.; Sun, C-A.; Sundström, J.; Sung, Y-T.; Suriyawongpaisal, P.; Sy, R.G.; Tai, E.S.; Tammesoo, M-L.; Tamosiunas, A.; Tang, L.; Tang, X.; Tanser, F.; Tao, Y.; Tarawneh, M.R.; Tarqui-Mamani, C.B.; Taylor, A.; Theobald, H.; Thijs, L.; Thuesen, B.H.; Tjonneland, A.; Tolonen, H.K.; Tolstrup, J.S.; Topbas, M.; Topór-Madry, R.; Tormo, M.J.; Torrent, M.; Traissac, P.; Trichopoulos, D.; Trichopoulou, A.; Trinh, O.T.H.; Trivedi, A.; Tshepo, L.; Tulloch-Reid, M.K.; Tuomainen, T-P.; Tuomilehto, J.; Turley, M.L.; Tynelius, P.; Tzourio, C.; Ueda, P.; Ugel, E.; Ulmer, H.; Uusitalo, H.M.T.; Valdivia, G.; Valvi, D.; van der Schouw, Y.T.; Van Herck, K.; van Rossem, L.; van Valkengoed, I.G.M.; Vanderschueren, D.; Vanuzzo, D.; Vatten, L.; Vega, T.; Velasquez-Melendez, G.; Veronesi, G.; Verschuren, W.M.M.; Verstraeten, R.; Victora, C.G.; Viet, L.; Viikari-Juntura, E.; Vineis, P.; Vioque, J.; Virtanen, J.K.; Visvikis-Siest, S.; Viswanathan, B.; Vollenweider, P.; Voutilainen, S.; Vrdoljak, A.; Vrijheid, M.; Wade, A.N.; Wagner, A.; Walton, J.; Mohamud, W.N.W.; Wang, M-D.; Wang, Q.; Wang, Y.X.; Wannamethee, S.G.; Wareham, N.; Wedderkopp, N.; Weerasekera, D.; Whincup, P.H.; Widhalm, K.; Widyahening, I.S.; Wiecek, A.; Wijga, A.H.; Wilks, R.J.; Willeit, J.; Willeit, P.; Williams, E.A.; Wilsgaard, T.; Wojtyniak, B.; Wong, T.Y.; Wong-McClure, R.A.; Woo, J.; Woodward, M.; Wu, A.G.; Wu, F.C.; Wu, S.L.; Xu, H.; Yan, W.; Yang, X.; Ye, X.; Yiallouros, P.K.; Yoshihara, A.; Younger-Coleman, N.O.; Yusoff, A.F.; Yusoff, M.F.M.; Zambon, S.; Zdrojewski, T.; Zeng, Y.; Zhao, D.; Zhao, W.; Zheng, Y.; Zhu, D.; Zimmermann, E.; Zuñiga Cisneros, J. NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants. Lancet, 2017, 389(10064), 37-55.
[] [PMID: 27863813]
Kockskämper, J.; Pluteanu, F. Left atrial myocardium in arterial hypertension. Cells, 2022, 11(19), 3157.
[] [PMID: 36231118]
Kearney, P.M.; Whelton, M.; Reynolds, K.; Muntner, P.; Whelton, P.K.; He, J. Global burden of hypertension: Analysis of worldwide data. Lancet, 2005, 365(9455), 217-223.
[] [PMID: 15652604]
Bisogni, V.; Cerasari, A.; Pucci, G.; Vaudo, G. Matrix metalloproteinases and hypertension-mediated organ damage: Current insights. Integr. Blood Press. Control, 2020, 13, 157-169.
[] [PMID: 33173330]
Hung, C.S.; Chang, Y.Y.; Tsai, C.H.; Liao, C.W.; Peng, S.Y.; Lee, B.C.; Pan, C.T.; Wu, X.M.; Chen, Z.W.; Wu, V.C.; Wan, C.H.; Young, M.J.; Chou, C.H.; Lin, Y.H. TAIPAI Study Group. Aldosterone suppresses cardiac mitochondria. Transl. Res., 2022, 239, 58-70.
[] [PMID: 34411778]
Caligiuri, S.P.B.; Austria, J.A.; Pierce, G.N. Alarming prevalence of emergency hypertension levels in the general public identified by a hypertension awareness campaign. Am. J. Hypertens., 2017, 30(3), hpw136.
[] [PMID: 28057629]
Harvell, B.; Henrie, N.; Ernst, A.A.; Weiss, S.J.; Oglesbee, S.; Sarangarm, D.; Hernandez, L. The meaning of elevated troponin I levels: Not always acute coronary syndromes. Am. J. Emerg. Med., 2016, 34(2), 145-148.
[] [PMID: 26508391]
Uçar, H.; Gür, M.; Kivrak, A.; Koyunsever, N.Y.; Şeker, T.; Akilli, R.E.; Türkoğlu, C.; Kaypakli, O.; Şahin, D.Y.; Elbasan, Z.; Tanboğa, H.İ.; Çayli, M. High-sensitivity cardiac troponin T levels in newly diagnosed hypertensive patients with different left ventricle geometry. Blood Press., 2014, 23(4), 240-247.
[] [PMID: 24059745]
Afonso, L.; Bandaru, H.; Rathod, A.; Badheka, A.; Ali Kizilbash, M.; Zmily, H.; Jacobsen, G.; Chattahi, J.; Mohamad, T.; Koneru, J.; Flack, J.; Weaver, W.D. Prevalence, determinants, and clinical significance of cardiac troponin-I elevation in individuals admitted for a hypertensive emergency. J. Clin. Hypertens., 2011, 13(8), 551-556.
[] [PMID: 21806764]
Pervan, P.; Svaguša, T.; Prkačin, I.; Savuk, A.; Bakos, M.; Perkov, S. Urine high sensitive Troponin I measuring in patients with hypertension. Signa Vitae, 2017, 13(Suppl. 3), 62-64.
Chaulin, A.M. Diagnostic value of highly sensitive cardiac troponins and mechanisms of their increase in serum and urine in arterial hypertension. Riv. Ital. Med. Lab., 2021, 17(2), 99-107.
Potkonjak, A.M.; Sabolović Rudman, S.; Nikolac Gabaj, N.; Kuna, K.; Košec, V.; Stanec, Z.; Zovak, M.; Tučkar, N.; Djaković, I.; Prkačin, I.; Svaguša, T.; Bakoš, M. Urinary troponin concentration as a marker of cardiac damage in pregnancies complicated with preeclampsia. Med. Hypotheses, 2020, 144, 110252.
[] [PMID: 33254557]
Graham, E.; Bergmann, O. Dating the heart: Exploring cardiomyocyte renewal in humans. Physiology, 2017, 32(1), 33-41.
[] [PMID: 27927803]
Bergmann, O.; Bhardwaj, R.D.; Bernard, S.; Zdunek, S.; Barnabé-Heider, F.; Walsh, S.; Zupicich, J.; Alkass, K.; Buchholz, B.A.; Druid, H.; Jovinge, S.; Frisén, J. Evidence for cardiomyocyte renewal in humans. Science, 2009, 324(5923), 98-102.
[] [PMID: 19342590]
Chaulin, A.M.; Karslyan, L.S.; Grigorieva, E.V.; Nurbaltaeva, D.A.; Duplyakov, D.V. Metabolism of cardiac troponins (literature review). Complex Issues of Cardiovascular Diseases, 2019, 8(4), 103-115.
Gore, M.O.; Seliger, S.L.; deFilippi, C.R.; Nambi, V.; Christenson, R.H.; Hashim, I.A.; Hoogeveen, R.C.; Ayers, C.R.; Sun, W.; McGuire, D.K.; Ballantyne, C.M.; de Lemos, J.A. Age- and sex-dependent upper reference limits for the high-sensitivity cardiac troponin T assay. J. Am. Coll. Cardiol., 2014, 63(14), 1441-1448.
[] [PMID: 24530665]
Giannitsis, E.; Mueller-Hennessen, M.; Zeller, T.; Schuebler, A.; Aurich, M.; Biener, M.; Vafaie, M.; Stoyanov, K.M.; Ochs, M.; Riffel, J.; Mereles, D.; Blankenberg, S.; Katus, H.A. Gender-specific reference values for high-sensitivity cardiac troponin T and I in well-phenotyped healthy individuals and validity of high-sensitivity assay designation. Clin. Biochem., 2020, 78, 18-24.
[] [PMID: 31786204]
Chaulin, A.M.; Abashina, O.E.; Duplyakov, D.V. High-sensitivity cardiac troponins: Detection and central analytical characteristics. Cardiovasc. Ther. Prev., 2021, 20(2), 2590.
Neal, R.C.; Ferdinand, K.C.; Yčas, J.; Miller, E. Relationship of ethnic origin, gender, and age to blood creatine kinase levels. Am. J. Med., 2009, 122(1), 73-78.
[] [PMID: 19114174]
McEvoy, J.W.; Chen, Y.; Nambi, V.; Ballantyne, C.M.; Sharrett, A.R.; Appel, L.J.; Post, W.S.; Blumenthal, R.S.; Matsushita, K.; Selvin, E. High-sensitivity cardiac Troponin T and risk of hypertension. Circulation, 2015, 132(9), 825-833.
[] [PMID: 26152706]
Stabouli, S.; Kotsis, V.; Rizos, Z.; Toumanidis, S.; Karagianni, C.; Constantopoulos, A.; Zakopoulos, N. Left ventricular mass in normotensive, prehypertensive and hypertensive children and adolescents. Pediatr. Nephrol., 2009, 24(8), 1545-1551.
[] [PMID: 19444486]
Cheng, W.; Li, B.; Kajstura, J.; Li, P.; Wolin, M.S.; Sonnenblick, E.H.; Hintze, T.H.; Olivetti, G.; Anversa, P. Stretch-induced programmed myocyte cell death. J. Clin. Invest., 1995, 96(5), 2247-2259.
[] [PMID: 7593611]
Weil, B.R.; Suzuki, G.; Young, R.F.; Iyer, V.; Canty, J.M., Jr Troponin release and reversible left ventricular dysfunction after transient pressure overload. J. Am. Coll. Cardiol., 2018, 71(25), 2906-2916.
[] [PMID: 29929614]
Dalal, S.; Connelly, B.; Singh, M.; Singh, K. NF2 signaling pathway plays a pro-apoptotic role in β-adrenergic receptor stimulated cardiac myocyte apoptosis. PLoS One, 2018, 13(4), e0196626.
[] [PMID: 29709009]
Singh, K.; Xiao, L.; Remondino, A.; Sawyer, D.B.; Colucci, W.S. Adrenergic regulation of cardiac myocyte apoptosis. J. Cell. Physiol., 2001, 189(3), 257-265.
[] [PMID: 11748583]
Nikonorova, M.A.; Karbysheva, N.V.; Kozhevnikova, G.M.; Mamaev, A.N.; Shevchenko, V.V.; Beskhlebova, O.V. Parenteral viral hepatitis in people with hemophilia: ways to solve the problem. Bullet. Med. Sci., 2019, 1(1), 52-56.
Chaulin, A.M.; Abashina, O.E.; Duplyakov, D.V. Pathophysiological mechanisms of cardiotoxicity in chemotherapeutic agents. Russ. Open Med. J., 2020, 9(3), e0305.
Evdokimova, N.E.; Tsygankova, O.V.; Latyntseva, L.D. Evaluation of plasma creatine phosphokinase as a diagnostic dilemma. Russ. Med. J., 2021, 29(2), 18-25.
Fournier, S.; Iten, L.; Marques-Vidal, P.; Boulat, O.; Bardy, D.; Beggah, A.; Calderara, R.; Morawiec, B.; Lauriers, N.; Monney, P.; Iglesias, J.F.; Pascale, P.; Harbaoui, B.; Eeckhout, E.; Muller, O. Circadian rhythm of blood cardiac troponin T concentration. Clin. Res. Cardiol., 2017, 106(12), 1026-1032.
[] [PMID: 28856443]
Suárez-Barrientos, A.; López-Romero, P.; Vivas, D.; Castro-Ferreira, F.; Núñez-Gil, I.; Franco, E.; Ruiz-Mateos, B.; García-Rubira, J.C.; Fernández-Ortiz, A.; Macaya, C.; Ibanez, B. Circadian variations of infarct size in acute myocardial infarction. Heart, 2011, 97(12), 970-976.
[] [PMID: 21525526]
Chaulin, A.; Duplyakov, D. MicroRNAs in atrial fibrillation: Pathophysiological aspects and potential biomarkers. Int. J. Biom., 2020, 10(3), 198-205.
Chaulin, A.M.; Duplyakov, D.V. On the potential effect of circadian rhythms of cardiac troponins on the diagnosis of acute myocardial infarction. Signa Vitae, 2021.
Kapiotis, S.; Jilma, B.; Quehenberger, P.; Ruzicka, K.; Handler, S.; Speiser, W. Morning hypercoagulability and hypofibrinolysis. Diurnal variations in circulating activated factor VII, prothrombin fragment F1+2, and plasmin-plasmin inhibitor complex. Circulation, 1997, 96(1), 19-21.
[] [PMID: 9236409]
Montagnana, M.; Salvagno, G.; Lippi, G. Circadian variation within hemostasis: An underrecognized link between biology and disease? Semin. Thromb. Hemost., 2009, 35(1), 023-033.
[] [PMID: 19308890]
Chaulin, A.M.; Duplyakov, D.V. Cardiac troponins: Current data on the diagnostic value and analytical characteristics of new determination methods Cor Vasa, 2021, 63(4), 486-493.
Zenina, O.Y.; Makarova, I.I.; Ignatova, Y.P.; Aksenova, A.V. Chronophysiology and chronopathology of cardiovascular system (Literature Review). Èkol. Celov., 2017, 24(1), 25-33.
Tsareva, Y.O.; Mayskova, E.A.; Fedotov, E.A.; Shvarts, Y.G. Circadian rhythms of thyroid hormones in patients with ischemic heart disease, arterial hypertension, and atrial fibrillation. Kardiologiia, 2019, 59(3S), 23-29.
[] [PMID: 30990149]
Chaulin, A.M.; Grigorieva, J.V.; Suvorova, G.N.; Duplyakov, D.V. Experimental modeling of hypothyroidism: Principles, methods, several advanced research directions in cardiology. Russ. Open Med. J., 2021, 10(3), e0311.
Michailovich Chaulin, A. Current understanding of cardiac troponins metabolism: A narrative review. Curr. Med. Chem., 2022, 29(41), 6247-6275.
[] [PMID: 35702777]
Hessel, M.H.M.; Atsma, D.E.; van der Valk, E.J.M.; Bax, W.H.; Schalij, M.J.; van der Laarse, A. Release of cardiac troponin I from viable cardiomyocytes is mediated by integrin stimulation. Pflugers Arch., 2008, 455(6), 979-986.
[] [PMID: 17909848]
Chaulin, A.M. Phosphorylation and fragmentation of the cardiac Troponin T: Mechanisms, role in pathophysiology and laboratory diagnosis. Int. J. Biom., 2021, 11(3), 250-259.
Streng, A.S.; de Boer, D.; van der Velden, J.; van Dieijen-Visser, M.P.; Wodzig, W.K.W.H. Posttranslational modifications of cardiac troponin T: An overview. J. Mol. Cell. Cardiol., 2013, 63, 47-56.
[] [PMID: 23871791]
Ali, S.A.; Kazmi, S.; Jalal-Ud-Din, M.; Qasim, M.I.; Jadoon, Z.G. Frequency of elevated Troponin T in patients of hronic renal failure without clinically suspected acute myocardial infarction. J. Ayub Med. Coll. Abbottabad, 2019, 31(3), 364-367.
[PMID: 31535507]
Long, B.; Belcher, C.N.; Koyfman, A.; Bronner, J.M. Interpreting troponin in renal disease: A narrative review for emergency clinicians. Am. J. Emerg. Med., 2020, 38(5), 990-997.
[] [PMID: 31831340]
Zou, L.; Sun, W. Human urine proteome: A powerful source for clinical research. Adv. Exp. Med. Biol., 2015, 845, 31-42.
[] [PMID: 25355567]
Maeda, H.; Michiue, T.; Zhu, B.L.; Ishikawa, T.; Quan, L. Analysis of cardiac troponins and creatine kinase MB in cerebrospinal fluid in medicolegal autopsy cases. Leg. Med., 2009, 11(Suppl. 1), S266-S268.
[] [PMID: 19251459]
Wang, Q.; Michiue, T.; Ishikawa, T.; Zhu, B.L.; Maeda, H. Combined analyses of creatine kinase MB, cardiac troponin I and myoglobin in pericardial and cerebrospinal fluids to investigate myocardial and skeletal muscle injury in medicolegal autopsy cases. Leg. Med., 2011, 13(5), 226-232.
[] [PMID: 21683643]
Chaulin, A.M. Diagnostic considerations and analytical characteristics of methods for the determination of cardiac troponins: Traditional review. Turk. Klin. Cardiovasc. Sci., 2021, 33(3), 149-160.
Katrukha, I.A.; Kogan, A.E.; Vylegzhanina, A.V.; Serebryakova, M.V.; Koshkina, E.V.; Bereznikova, A.V.; Katrukha, A.G. Thrombin-mediated degradation of human cardiac troponin T. Clin. Chem., 2017, 63(6), 1094-1100.
[] [PMID: 28428352]
Derhaschnig, U.; Testori, C.; Riedmueller, E.; Aschauer, S.; Wolzt, M.; Jilma, B. Hypertensive emergencies are associated with elevated markers of inflammation, coagulation, platelet activation and fibrinolysis. J. Hum. Hypertens., 2013, 27(6), 368-373.
[] [PMID: 23254594]
Bunin, V.A.; Kozlov, K.L.; Linkova, N.S.; Paltseva, E.M. An increase in troponin-I concentration in the saliva of patients with coronary heart disease correlates with the stage of disease development. Complex Issues Cardiovasc. Dis., 2017, 6(S 4), 13-14.
Duque-Ossa, L.C.; García-Ferrera, B.; Reyes-Retana, J.A. Troponin I as a biomarker for early detection of acute myocardial infarction. Curr. Probl. Cardiol., 2021, 101067, 101067.
[] [PMID: 34826431]
Arshad, M.K.; Bin Mohamad Fathil, M.F.; Gopinath, S.C.; Ruslinda, A.R.; Md Nor, M.N.; Lam, H.Y.; Hashim, U. Cardiac biomarkers: Invasive to non-invasive assessments. Curr. Med. Chem., 2016, 23(37), 4270-4284.
[] [PMID: 27719655]
Chaulin, A.M. The importance of cardiac troponin metabolism in the laboratory diagnosis of myocardial infarction (Comprehensive Review). BioMed Res. Int., 2022, 2022, 1-24.
[] [PMID: 35402607]
Joharimoghadam, A.; Tajdini, M.; Bozorgi, A. Salivary B-type natriuretic peptide: A new method for heart failure diagnosis and follow-up. Kardiol. Pol., 2017, 75(1), 71-77.
[] [PMID: 27296284]
Chaulin, A.M.; Duplyakov, D.V. Increased natriuretic peptides not associated with heart failure. Russ. J. Cardiol., 2021, 25(4S), 4140.
Acosta, G.; Amro, A.; Aguilar, R.; Abusnina, W.; Bhardwaj, N.; Koromia, G.A.; Studeny, M.; Irfan, A. Clinical determinants of myocardial injury, detectable and serial troponin levels among patients with hypertensive crisis. Cureus, 2020, 12(1), e6787.
[] [PMID: 32140347]
Pattanshetty, D.J.; Bhat, P.K.; Aneja, A.; Pillai, D.P. Elevated troponin predicts long-term adverse cardiovascular outcomes in hypertensive crisis. J. Hypertens., 2012, 30(12), 2410-2415.
[] [PMID: 22990357]
Chaulin, A.M.; Sergeev, A.K. Modern concepts of the role of fine particles (PM 2.5) in the genesis of atherosclerosis and myocardial damage: Clinical and epidemiological data, the main pathophysiological mechanisms. Curr. Cardiol. Rev., 2022, 18
[] [PMID: 35980071]
Ayub, T.M.; Torres, C.; Del Cid, J.; Khan, M.S.; Rasool, W.; Aijaz, T.; Putta, A.; Singh, S.R.K.; Doukly, R. The prognostic significance of highly sensitive cardiac troponin i elevation in patients presenting with hypertensive crisis. Circulation, 2019, 140, A16333.
Chaulin, A. Clinical and diagnostic value of highly sensitive cardiac troponins in arterial hypertension. Vasc. Health Risk Manag., 2021, 17, 431-443.
[] [PMID: 34366667]
Ravichandran, J.; Woon, S.Y.; Quek, Y.S.; Lim, Y.C.; Noor, E.M.; Suresh, K.; Vigneswaran, R.; Vasile, V.; Shah, A.; Mills, N.L.; Sickan, J.; Beshiri, A.; Jaffe, A.S. High-sensitivity cardiac Troponin I levels in normal and hypertensive pregnancy. Am. J. Med., 2019, 132(3), 362-366.
[] [PMID: 30503877]

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