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Current Protein & Peptide Science

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ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

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Mini-Review Article

Biological Functions and Applications of Antimicrobial Peptides

Author(s): Lei Wang, Linkai Qu, Sue Lin, Qinsi Yang, Xingxing Zhang, Libo Jin*, Hao Dong* and Da Sun*

Volume 23, Issue 4, 2022

Published on: 21 July, 2022

Page: [226 - 247] Pages: 22

DOI: 10.2174/1389203723666220519155942

Price: $65

Abstract

Despite antimicrobial resistance, which is attributed to the misuse of broad-spectrum antibiotics, antibiotics can indiscriminately kill pathogenic and beneficial microorganisms. These events disrupt the delicate microbial balance in both humans and animals, leading to secondary infections and other negative effects. Antimicrobial peptides (AMPs) are functional natural biopolymers in plants and animals. Due to their excellent antimicrobial activities and absence of microbial resistance, AMPs have attracted enormous research attention. We reviewed the antibacterial, antifungal, antiviral, antiparasitic, as well as antitumor properties of AMPs and research progress on AMPs. In addition, we highlighted various recommendations and potential research areas for their progress and challenges in practical applications.

Keywords: Antimicrobial peptides, microbial resistance, antimicrobial activity, action mechanism, achievement transformation, clinical application.

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