Title:The Association of 25-Hydroxy Vitamin D level with Mean Platelet Volume
in Patients with Acute Coronary Syndrome
Volume: 22
Issue: 1
Author(s): Behzad Hajimoradi*, Behnaz Hosseini, Toktam Alirezaei*Fatemeh Pourmotahari
Affiliation:
- Clinical Research Development Unit of Shohada-e-Tajrish Hospital, Shahid Beheshti Univesity of Medical Sciences,
Tehran, Iran
- Clinical Research Development Unit of Shohada-e-Tajrish Hospital, Shahid Beheshti Univesity of Medical Sciences,
Tehran, Iran
Keywords:
Acute Coronary Syndrome; Mean Platelet Volume; Vitamin D; ST-Elevation Myocardial Infarction, SYNTAX, UA.
Abstract:
Background: A better identification of the role of vitamin D in the thrombotic process
of the acute coronary syndrome (ACS) will help increase the therapeutic options for this important
clinical condition. There is little published evidence that 25-hydroxy vitamin D (25(OH)D) serum
levels can associate with platelet function and risk of thrombosis.
Methods: This prospective study was conducted on 200 patients with a diagnosis of ACS, including
patients with unstable angina (UA), non-ST segment elevation myocardial infarction (NSTEMI),
and ST-segment elevation myocardial infarction (STEMI). In addition to demographics and angiographic
data, serum concentrations of 25(OH)D and MPV were recorded in all patients.
Results: The types of ACS were STEMI (35%), NSTEMI (25%), and UA (40%). The concentrations
of 25(OH)D in patients with UA, NSTEMI, and STEMI were 23.53 ± 13.26, 19.25 ± 8.09 and
14.60 ± 8.24 ng/mL respectively (P < 0.001), and the values of MPV were 9.83 ± 1.35, 10.30 ±
1.21, and 11.56 ± 1.38 fL, respectively (P < 0.001).
There was a negative correlation between 25(OH)D and MPV (R = -0.320, P < 0.0001). ROC analysis
illustrated a moderate predictive value (AUC 0.706; 95% CI, 0.63–0.72) in identifying the discrimination
threshold of MPV (≥ 9.90 fL) for vitamin D deficiency (<20 ng/mL).
Conclusion: The current study shows an inverse association between MPV and vitamin D levels in
ACS patients, especially in the subgroup of STEMI. These findings propose the effect of vitamin D
on platelet size and function, suggesting its role in thrombosis and hemostasis, which might explain
the link between vitamin D deficiency and cardiovascular diseases.
