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Review Article Section: Analytical Chemistry

Therapeutic Application of Bavachalcone in Chronic Diseases: A Concise Report on Medicinal Importance and Pharmacological Activities

Author(s): Dinesh Kumar Patel*

Volume 2, Issue 4, 2022

Published on: 24 March, 2022

Page: [257 - 262] Pages: 6

DOI: 10.2174/2210298102666220302094731

Abstract

Background: Psoralea corylifolia L. is an important herbal medicine mainly used for the treatment of coronary artery disease, osteoporosis, bacterial infections, vitiligo, and psoriasis. P. corylifolia contains numerous active phytochemicals, including bavachalcone. Polyphenolic compounds, including flavonoidal class phytochemicals, are secondary plant metabolites found in numerous plant species and reported to have multiple functions to counteract free radicals.

Methods: The aim of the present study is to review the medicinal importance and pharmacological activities of bavachalcone. To determine the therapeutic benefit of bavachalcone in medicine, here in the present work, we have attempted to provide scientific information related to bavachalcone. The present paper provides an overview of flavonoids and P. corylifolia, pharmacological activities of bavachalcone, and analytical aspects of bavachalcone. Bioanalytical aspects have been discussed for the development of analytical techniques for separation, isolation, and identification of bavachalcones. In the present work, numerous scientific databases, such as PubMed, Science Direct, Scopus, Google Scholar, and Google, have been searched.

Results: Scientific data analysis revealed bavachalcone to be an important phytochemical, found in P. corylifolia. Scientific data analysis revealed the biological importance and therapeutic benefit of bavachalcones in medicine. Pharmacological data analysis revealed their effectiveness against cancer, oxidative stress, Alzheimer's disease, angiogenesis, tissue repair, osteoclastogenesis, and various enzymes. Further pharmacokinetic and analytical data of bavachalcone have also been collected and analyzed in the present work.

Conclusion: Scientific data analysis revealed several molecular mechanisms to be responsible for the pharmacological activities of bavachalcone.

Keywords: P. corylifolia, bavachalcone, cancer, oxidative stress, alzheimer's disease, angiogenesis, osteoclastogenesis.

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