Title:Chemo-drug Controlled-release Strategies of Nanocarrier in the Development of Cancer Therapeutics
Volume: 28
Issue: 31
Author(s): Yunyi Liu, Hailong Ou, Xiaming Pei, Bin Jiang, Yihan Ma, Naiyu Liu, Chaoqi Wen, Cheng Peng and Xiaoxiao Hu*
Affiliation:
- Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Biology, Aptamer Engineering Center of Hunan Province, Changsha, Hunan 410082,China
Keywords:
Nanoparticles, controlled-release, chemotherapeutics, microenvironment, cancer, target therapeutics.
Abstract: Nanoparticles are widely used in cancer therapy because of their nanoscale, high
surface ratio, multifunctionality and so on. With specific construction of nanoparticles, by
choosing magnetic nanomaterials or citric acid-coated nanoparticle, scientists can kill tumor
cells effectively and accurately, importantly reducing the side effects of conventional chemotherapy.
Scientists not only have designed nanoparticles loaded with therapeutic drugs, but
also those equipped with targeted molecules. These works have made nanoparticles multifunctional
nanocarriers. As multifunctional nanocarriers, nanoparticles play an important role
of drug delivery and normally, enabling drug delivery to tumor tissues is a difficult task. During
the period of internal circulation, it is hard to maintain the stability of the nanocarriers not
attached to normal cells or serum. With the application of stimulus-responsive nanomaterials,
scientists have developed many nanocarriers with controllable drug release. These controllable
drug delivery systems can quickly respond to microenvironmental changes (PH, enzyme,
etc.) or external stimuli (photo, heat, magnetic or electric fields). Thus, to overcome the side
effects of controllable drug delivery systems in vivo, in this article, we summarize the various
kinds of stimulus-responsive nanocarriers for cancer therapy and discuss the possibilities and
challenges in future application.
