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Combinatorial Chemistry & High Throughput Screening

Combinatorial Chemistry & High Throughput Screening

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ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

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Research Article

Evaluation of Thiol/Disulfide Homeostasis in Pediatric Patients with Diabetic Ketoacidosis

Author(s): Mutlu U. Yazıcı*orcid of author, Ganime Ayarorcid of author, Semra Çetinkayaorcid of author, Meliksah Keskin, Ebru Azapağasıorcid of author, Saim Neşelioğluorcid of author, Özcan Erelorcid of author and Benan Bayrakçı

Volume 23, Issue 3, 2020

Page: [185 - 190] Pages: 6

DOI: 10.2174/1386207323666200218114331

Price: $65

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Abstract

Aims and Objective: This study aimed to investigate the value of Thiol/Disulfide homeostasis in pediatric diabetic ketoacidosis patients suffering from type 1 diabetes mellitus.

Materials and Methods: This study featured children who were diagnosed with diabetic ketoacidosis and who were consecutively admitted to pediatric intensive care within one year of their diagnosis. Thiol/disulfide homeostasis was evaluated in 45 pediatric patients suffering from DKA, as well as 45 healthy controls of parallel gender and age. Thiol/disulfide homeostasis parameters were measured using a novel automated measurement method and the correlation between demographic data and parameters was measured.

Results: Pediatric patients were found to have low native thiols, total thiols and disulfide levels with type 1 diabetes after DKA (331.82±106.40, 362.71±113.31, 17.02±5.33 μmol/L, respectively) as compared to the control group (445.08±24.41, 481.21± 28.47, 18.06±5.12 μmol/L, respectively).

Conclusion: Thiol/disulfide homeostasis was distorted in pediatric patients with DKA. Furthermore, it was found that they are not likely to return to normal, immediately after treatment.

Keywords: Thiol/disulfide homeostasis, diabetic ketoacidosis, type 1 diabetes mellitus, children, hyperglycemia, hyperketonemia.

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