Title:Evaluation of Thiol/Disulfide Homeostasis in Pediatric Patients with Diabetic Ketoacidosis
Volume: 23
Issue: 3
Author(s): Mutlu U. Yazıcı*, Ganime Ayar, Semra Çetinkaya, Meliksah Keskin, Ebru Azapağası, Saim Neşelioğlu, Özcan Erel and Benan Bayrakçı
Affiliation:
- Department of Pediatrics, University of Health Sciences, Pediatric Intensive Care Unit, Dr. Sami Ulus Maternity and Children Training and Research Hospital, Ankara,Turkey
Keywords:
Thiol/disulfide homeostasis, diabetic ketoacidosis, type 1 diabetes mellitus, children, hyperglycemia, hyperketonemia.
Abstract:
Aims and Objective: This study aimed to investigate the value of Thiol/Disulfide
homeostasis in pediatric diabetic ketoacidosis patients suffering from type 1 diabetes mellitus.
Materials and Methods: This study featured children who were diagnosed with diabetic
ketoacidosis and who were consecutively admitted to pediatric intensive care within one year of
their diagnosis. Thiol/disulfide homeostasis was evaluated in 45 pediatric patients suffering from
DKA, as well as 45 healthy controls of parallel gender and age. Thiol/disulfide homeostasis
parameters were measured using a novel automated measurement method and the correlation
between demographic data and parameters was measured.
Results: Pediatric patients were found to have low native thiols, total thiols and disulfide levels
with type 1 diabetes after DKA (331.82±106.40, 362.71±113.31, 17.02±5.33 μmol/L, respectively)
as compared to the control group (445.08±24.41, 481.21± 28.47, 18.06±5.12 μmol/L,
respectively).
Conclusion: Thiol/disulfide homeostasis was distorted in pediatric patients with DKA.
Furthermore, it was found that they are not likely to return to normal, immediately after treatment.
