Abstract
Alzheimer's disease (AD) is characterized by a complex pathological landscape, necessitating a comprehensive treatment approach. This concise review paper delves into the idea of addressing multiple mechanisms in AD, summarizing the latest research findings on pathogenesis, risk factors, diagnostics, and therapeutic strategies. The etiology of AD is multifaceted, involving genetic, environmental, and lifestyle factors. The primary feature is the accumulation of amyloid-- beta and tau proteins, leading to neuroinflammation, synaptic dysfunction, oxidative stress, and neuronal loss. Conventional single-target therapies have shown limited effectiveness, prompting a shift toward simultaneously addressing multiple disease-related processes. Recent advancements in AD research underscore the potential of multifaceted therapies. This review explores strategies targeting both tau aggregation and amyloid-beta, along with interventions to alleviate neuroinflammation, enhance synaptic function, and reduce oxidative stress. In conclusion, the review emphasizes the growing importance of addressing various pathways in AD treatment. A holistic approach that targets different aspects of the disease holds promise for developing effective treatments and improving the quality of life for Alzheimer's patients and their caregivers.
Keywords: Amyloid plaque, Tau protein, Acetyl cholinesterase (AChE), Butyl cholinesterase (BuChE), N-methyl Di-Aspartate enzyme (NMDA), JNK Signalling, Glycogen synthase kinase-3β (GSK-3β), Cyclin-dependent kinase (CDK-5), Monoamine oxidase (MAO).
Current Topics in Medicinal Chemistry
Title:The Unveiling of Therapeutic Targets for Alzheimer’s Disease: An Integrative Review
Volume: 24 Issue: 10
Author(s): Pratiksha Madar*, Pooja Nagalapur, Somdatta Chaudhari, Devesh Sharma, Akshada Koparde, Rahul Buchade, Sandip Kshirsagar, Pravin Uttekar, Shailaja Jadhav and Praveen Chaudhari
Affiliation:
- Department of Pharmaceutical Chemistry, Modern College of Pharmacy, Savitribai Phule Pune University, Pune, India
Keywords: Amyloid plaque, Tau protein, Acetyl cholinesterase (AChE), Butyl cholinesterase (BuChE), N-methyl Di-Aspartate enzyme (NMDA), JNK Signalling, Glycogen synthase kinase-3β (GSK-3β), Cyclin-dependent kinase (CDK-5), Monoamine oxidase (MAO).
Abstract: Alzheimer's disease (AD) is characterized by a complex pathological landscape, necessitating a comprehensive treatment approach. This concise review paper delves into the idea of addressing multiple mechanisms in AD, summarizing the latest research findings on pathogenesis, risk factors, diagnostics, and therapeutic strategies. The etiology of AD is multifaceted, involving genetic, environmental, and lifestyle factors. The primary feature is the accumulation of amyloid-- beta and tau proteins, leading to neuroinflammation, synaptic dysfunction, oxidative stress, and neuronal loss. Conventional single-target therapies have shown limited effectiveness, prompting a shift toward simultaneously addressing multiple disease-related processes. Recent advancements in AD research underscore the potential of multifaceted therapies. This review explores strategies targeting both tau aggregation and amyloid-beta, along with interventions to alleviate neuroinflammation, enhance synaptic function, and reduce oxidative stress. In conclusion, the review emphasizes the growing importance of addressing various pathways in AD treatment. A holistic approach that targets different aspects of the disease holds promise for developing effective treatments and improving the quality of life for Alzheimer's patients and their caregivers.
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Madar Pratiksha*, Nagalapur Pooja, Chaudhari Somdatta, Sharma Devesh, Koparde Akshada, Buchade Rahul, Kshirsagar Sandip, Uttekar Pravin, Jadhav Shailaja and Chaudhari Praveen, The Unveiling of Therapeutic Targets for Alzheimer’s Disease: An Integrative Review, Current Topics in Medicinal Chemistry 2024; 24 (10) . https://dx.doi.org/10.2174/0115680266282492240220101049
DOI https://dx.doi.org/10.2174/0115680266282492240220101049 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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