<![CDATA[CNS & Neurological Disorders - Drug Targets (Volume 23 - Issue 7)]]> https://www.benthamscience.com/journal/69 RSS Feed for Journals | BenthamScience EurekaSelect (+https://www.benthamscience.com) 2024-02-16 <![CDATA[CNS & Neurological Disorders - Drug Targets (Volume 23 - Issue 7)]]> https://www.benthamscience.com/journal/69 <![CDATA[Unraveling the Role of Neuroligin3 in Autism Spectrum Disorders: Pathophysiological Insights and Targeted Therapies]]>https://www.benthamscience.com/article/1332082024-02-16 <![CDATA[Evolutionary Unmasking Resuscitative Therapeutics Potential of Centhaquin Citrate in Hypovolemic Shock]]>https://www.benthamscience.com/article/1326462024-02-16 <![CDATA[Signalling Pathways Involved in Microglial Activation in Alzheimer’s Disease and Potential Neuroprotective Role of Phytoconstituents]]>https://www.benthamscience.com/article/1284042024-02-16 <![CDATA[Electrolyte Imbalance and Neurologic Injury]]>https://www.benthamscience.com/article/1295262024-02-16 <![CDATA[Oxidative Stress and Dopaminergic Metabolism: A Major PD Pathogenic Mechanism and Basis of Potential Antioxidant Therapies]]>https://www.benthamscience.com/article/1324442024-02-16 <![CDATA[Therapeutic Potential of Myricetin in the Treatment of Neurological, Neuropsychiatric, and Neurodegenerative Disorders]]>https://www.benthamscience.com/article/1329682024-02-16 <![CDATA[Navigated Transcranial Magnetic Stimulation (nTMS) based Preoperative Planning for Brain Tumor Treatment]]>https://www.benthamscience.com/article/1325612024-02-16 <![CDATA[Casein Kinase 2 Affects Epilepsy by Regulating Ion Channels: A Potential Mechanism]]>https://www.benthamscience.com/article/1326232024-02-16 <![CDATA[Neuroprotection or Sex Bias: A Protective Response to Traumatic Brain Injury in the Females]]>https://www.benthamscience.com/article/1337392024-02-16 <![CDATA[Intrathecal Baclofen Infusion-Botulinum Toxin Combined Treatment Efficacy in the Management of Spasticity due to Cerebral Palsy]]>https://www.benthamscience.com/article/1372332024-02-16 Background: Cerebral Palsy (CP) is a group of permanent, but not unchanging, disorders of movement and/or posture and motor function, which are due to a non-progressive interference, lesion, or abnormality of the developing/immature brain. One clinical presentation is muscle spasticity, which leads to a significant impact on the individual’s functionality and quality of life. Spasticity treatment is multidisciplinary and includes pharmacological and physical intervention; intrathecal baclofen shows a positive effect in severe spasticity and suboptimal response to oral drugs, while local injection of Botulinum toxin type A (BTXA) improves muscle tone, motion and pain.

Objective: The aim of this study was to evaluate the efficacy of the combined intrathecal baclofen infusion (ITB) - botulinum toxin treatment in the management of spasticity in CP.

Methods: 8 patients with spastic tetraparesis were enrolled. All patients were treated with intrathecal Baclofen; in lower limbs, no spastic symptoms appeared, while marked spasticity was noted in upper limbs. We injected the right and left Biceps Brachial (BB) and Flexor Digitorum Superficialis (FDS) muscles with botulinum toxin type A. All patients underwent Myometric measurement, Ashworth Scale, Numerical Rating Scale, and Visual Analogic Scale evaluation before infiltration (T0), 30 days after injection (T1), 60 days after injection (T2), and 90 days after treatment (T3).

Results: All data demonstrated an improvement in spasticity, pain, quality of life, and self-care during the study, with p < 0.05. No side effects appeared.

Conclusion: This study demonstrated the efficacy and safety of intrathecal baclofen infusion and botulinum toxin combined treatment in the management of spasticity, pain, quality of life, and selfcare in CP patients.

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