<![CDATA[Recent Advances in Inflammation & Allergy Drug Discovery (Volume 18 - Issue 1)]]> https://www.benthamscience.com/journal/203 RSS Feed for Journals | BenthamScience EurekaSelect (+https://www.benthamscience.com) 2024-03-22 <![CDATA[Recent Advances in Inflammation & Allergy Drug Discovery (Volume 18 - Issue 1)]]> https://www.benthamscience.com/journal/203 <![CDATA[Preface]]>https://www.benthamscience.com/article/1385872024-03-22 <![CDATA[Insights into Prospects of Novel NSAID Prodrugs in the Management of Gastrointestinal Toxicity: A Perspective Review]]>https://www.benthamscience.com/article/1377342024-03-22 <![CDATA[Modulation of the Immune System Mechanisms using Probiotic Bacteria in Allergic Diseases: Focus on Allergic Retinitis and Food Allergies]]>https://www.benthamscience.com/article/1351352024-03-22 <![CDATA[From Traditional Medicine to Advanced Therapeutics: The Renaissance of Phyto-nano Interventions in Psoriasis]]>https://www.benthamscience.com/article/1355932024-03-22 <![CDATA[Decrypting the Pathological Pathways in IgA Nephropathy]]>https://www.benthamscience.com/article/1354112024-03-22 <![CDATA[Antibacterial and Antimalarial Therapeutic Agents: A Patent Perspective]]>https://www.benthamscience.com/article/1355792024-03-22Background: Antibacterial and antimalarial drugs play a critical role in combating infectious diseases. It is a continuous work to develop new types of antibacterial and antimalarial drugs.

Objective: To better understand current landscape and association of antibacterial and antimalarial agents, the European patent analysis was performed.

Methods: Antibacterial and antimalarial agents were analyzed by patent analysis. Patent documents from January 2003 to May 2022 were retrieved and analyzed.

Results: The present study indicated there were virtually three therapeutic approaches for antibacterial agents, including chemical drugs, biological products and siRNA technology. Chemical drugs were a mainstream therapeutic approach for development of both antibacterial and antimalarial agents. However, the present study found that in contrast to antimalarials, siRNA technology had been initially explored as therapeutic strategy for antibacterial agents. Also, our study is the first to show that there is a low correlation between antibacterial and antimalarial agents.

Conclusion: Globally, our study is the first one to show that it may be not a fast approach to discover antimalarial drugs from antibacterial agents based on drug repurposing. siRNA technology as therapeutic strategy had been explored and used in antibacterial field.

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<![CDATA[Olfactory Dysfunction in Healthcare Workers with COVID-19: Prevalence and Associated Factors]]>https://www.benthamscience.com/article/1354282024-03-22Background: The COVID-19 pandemic is a real global health crisis. Its clinical presentation has evolved over time with an increasing number of symptoms. Olfactory dysfunction (OD) has recently been recognized as a frequent symptom relevant to screening for COVID-19, especially in pauci-asymptomatic forms. However, the underlying mechanisms of OD are not yet fully understood.

Aim: To determine the prevalence of OD in healthcare workers with SARS-CoV-2 and to identify its associated factors.

Methods: This is a cross-sectional, analytical study, carried out during a period of six months and including all healthcare workers at Farhat Hached Academic Hospital (Tunisia) who were diagnosed with SARS-CoV-2 by PCR, RAT, or chest CT scan.

Results: A total of 474 healthcare workers were included, representing a participation rate of 85.4%. The mean age was 41.02±10.67 years with a sex ratio of 0.2. The distribution of this population by department noted that it was mainly maternity (13.9%). The most presented workstation was nursing (31.4%). OD represented 39.2% of the reasons for consultation. Hospitalization was indicated in 16 patients (3.4%). The average duration of hospitalization was 8.87 ± 7.8 days. The average time off work was 17.04 ± 11.6 days. OD persisted for more than 90 days in 35 patients (7.4%). After multiple binary logistic regression, OD was statistically associated with female gender (p =0.001; OR 95% CI: 2.46 [1.4-4.2]) and blue-collar occupational category (p =0.002; OR IC95%:3.1 [1.5-6.5]). A significant association was also noted between OD and professional seniority and absence from work duration (p =0.019; OR 95% CI: 0.97 [0.95-0.99] and p =0.03; OR 95% CI: 0.97 [0.95-0.99]) respectively.

Conclusion: OD is common in COVID-19 patients. The identification of its associated factors may contribute to enhancing the understanding of its mechanism and drive therapeutic options.

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