https://www.benthamscience.com/journal/19 RSS Feed for Journals | BenthamScience EurekaSelect (+https://www.benthamscience.com) 2026-03-16 https://www.benthamscience.com/journal/19 https://www.benthamscience.com/article/1489482026-03-16 https://www.benthamscience.com/article/1504712026-03-16 https://www.benthamscience.com/article/1485542026-03-162CO₃) and a microwave-assisted synthesis method. The targeted acetoguanamine crown ether derivatives were synthesized using green chemistry's ecofriendly (microwave-assisted synthesis) method in mild conditions, with quite high yields. After purification, the synthesized macrocyclic 2,4-diamino-6-methyl-1,3,5-triazine crown ether derivatives were characterized structurally using Fourier-Transform Infrared Spectroscopy (FTIR), Nuclear Magnetic Resonance (NMR), and tandem mass spectrometry - Liquid Chromatography (LC-MS/MS) methods. The synthesized compounds were investigated for their antioxidant and DNA damage-protective properties. Experimental tests showed that among the compounds, only S1 exhibited a radical scavenging effect (mean 5.62%), and none of the compounds affected the applied DNA plasmid, or demonstrated a DNA protection effect.]]> https://www.benthamscience.com/article/1501602026-03-16in vitro against the Plasmodium falciparum FCR-3 strain and in silico molecular docking simulations targeting the PfATP6 protein. As a result, the structural modification at the C-3 position with 2-furoyl moiety (2b) shows a moderate activity with IC50 = 20.8 ± 0.7 μM, compared to its precursor lupeol (2), which shows a weak activity with IC₅₀ = 122.1 ± 0.3 μM (positive control chloroquine; IC₅₀ = 15.0 ± 0.1 μM). Molecular docking demonstrated a good interaction between 2b and the active site of PfATP6 protein, with a binding energy of - 8.0 ± 0.0 kcal mol-1. The 2-furoyl ring in 2b shows the binding interaction with the Asn1039 residue via hydrogen bonds. Therefore, compound 2b is identified as a promising candidate as a lead compound for further antiplasmodial studies.]]>