<![CDATA[Supranuclear Palsy, Progressive]]> https://www.benthamscience.com RSS Feed for Disease Wise Article | BenthamScience EurekaSelect (+http://eurekaselect.com) Sun, 03 Dec 2023 08:03:31 +0000 <![CDATA[Supranuclear Palsy, Progressive]]> https://www.benthamscience.com https://www.benthamscience.com <![CDATA[PERK-opathies: An Endoplasmic Reticulum Stress Mechanism Underlying Neurodegeneration]]>https://www.benthamscience.comarticle/72615

The Protein Kinase R-like ER Kinase (PERK) pathway is one of three major branches in the UPR, and it is the only one to modulate protein synthesis as an adaptive response. The specific identification of prolonged PERK activity has been correlated with the progression of disorders such as diabetes, Alzheimer’s disease, and cancer, suggesting that PERK plays a role in the pathology of these disorders. For the first time, the term “PERK-opathies” is used to group these diseases in which PERK mediates detriment to the cell culminating in chronic disorders. This article reviews the literature documenting links between systemic disorders with the UPR, but with a specific emphasis on the PERK pathway. Then, articles reporting links between the UPR, and more specifically PERK, and neurodegenerative disorders are presented. Finally, a therapeutic perspective is discussed, where PERK interventions could be potential remedies for cellular dysfunction in chronic neurodegenerative disorders.]]> <![CDATA[Progressive Supranuclear Palsy: What Do We Know About it?]]>https://www.benthamscience.comarticle/65581 <![CDATA[ Genetic Bases of Progressive Supranuclear Palsy: The MAPT Tau Disease]]>https://www.benthamscience.comarticle/19276 <![CDATA[ Zolpidem Therapy for Movement Disorders]]>https://www.benthamscience.comarticle/27146 <![CDATA[ Protein Misfolding in Disease: Cause or Response?]]>https://www.benthamscience.comarticle/36711