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                    <title><![CDATA[Movement Disorders]]></title>

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                    RSS Feed for Disease Wise Article | BenthamScience

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                    <pubDate>Fri, 15 May 2026 13:38:46 +0000</pubDate>

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                    <title><![CDATA[Movement Disorders]]></title>

                    <url>https://www.benthamscience.com</url>

                    <link>https://www.benthamscience.com</link>

                    </image><item><title><![CDATA[Understanding Eye Movements and Micro-Expressions]]></title><link>https://www.benthamscience.comchapter/25461</link><description><![CDATA[This chapter unravels the complexities of eye movements and microexpressions, delving into how these subtle cues reflect our true emotions and intentions. Eye behavior, including eye contact, blinking, and gaze aversion, plays a pivotal role in communication, with eye-tracking studies revealing how attention and focus can be deciphered. Micro-expressions, which are fleeting, involuntary facial movements, provide a window into concealed emotions, often escaping conscious control. The chapter explains the science behind these expressions and discusses how they can be detected and interpreted in various contexts, such as negotiation, security, and psychological analysis. By exploring both scientific theories and practical applications, readers will learn to recognize and analyze these subtle cues to gain deeper insights into people’s feelings and thoughts. Emphasis is placed on how cultural differences may affect the interpretation of eye behavior and micro-expressions, making cultural awareness crucial. Real-world examples and exercises offer opportunities for readers to sharpen their observational skills and apply this knowledge effectively.&nbsp;]]></description> </item><item><title><![CDATA[<i>In Silico</i> Tools to Leverage Rational Drug Design and Development in LMICs]]></title><link>https://www.benthamscience.comchapter/23780</link><description><![CDATA[Drug discovery and development is a time-consuming, complex, and expensive process. Usually, it takes about 15 years in the best scenario since drug candidates have a high attrition rate. Therefore, drug development projects rarely take place in low and middle-income countries (LMICs). Traditionally, this process consists of four sequential stages: (1) target identification and early drug discovery, (2) preclinical studies, (3) clinical development, and (4) review, approval and monitoring by regulatory agencies.<br><br>During the last decades, computational tools have offered interesting opportunities for Research and Development (R &amp; D) in LMICs, since these techniques are affordable, reduce wet lab experiments in the first steps of the drug discovery process, reduce animal testing by aiding experiment design, and also provide key knowledge involving clinical data management as well as statistical analysis. <br><br>This book chapter aims to highlight different computational tools to enable early drug discovery and preclinical studies in LMICs for different pathologies, including cancer. Several strategies for drug target selection are discussed: identification, prioritization and validation of therapeutic targets; particularly focusing on high-throughput analysis of different “omics” approaches using publicly available data sets. Next, strategies to identify and optimize novel drug candidates as well as computational tools for costeffective drug repurposing are presented. In this stage, chemoinformatics is a key emerging technology. It is important to note that additional computational methods can be used to predict possible uses of identified human-aimed drugs for veterinary purposes. Application of computational tools is also possible for predicting pharmacokinetics and pharmacodynamics as well as drug-drug interactions. Drug safety is a key issue and it has a profound impact on drug discovery success. Finally, artificial intelligence (AI) has also served as a potential tool for drug design and discovery, expected to be a revolution for drug development in several diseases.<br><br>It is important to note that the development of drug discovery projects is feasible in LMICs and in silico tools are expected to potentiate novel therapeutic strategies in different diseases.<br><br>This book chapter aims to highlight different computational tools to enable early drug discovery and preclinical studies in LMICs for different pathologies, including cancer. Several strategies for drug target selection are discussed: identification, prioritization and validation of therapeutic targets; particularly focusing on high-throughput analysis of different “omics” approaches using publicly available data sets. Next, strategies to identify and optimize novel drug candidates as well as computational tools for costeffective drug repurposing are presented. In this stage, chemoinformatics is a key emerging technology. It is important to note that additional computational methods can be used to predict possible uses of identified human-aimed drugs for veterinary purposes.<br><br>Application of computational tools is also possible for predicting pharmacokinetics and pharmacodynamics as well as drug-drug interactions. Drug safety is a key issue and it has a profound impact on drug discovery success. <br><br>Finally, artificial intelligence (AI) has also served as a potential tool for drug design and discovery, expected to be a revolution for drug development in several diseases.Application of computational tools is also possible for predicting pharmacokinetics and pharmacodynamics as well as drug-drug interactions. Drug safety is a key issue and it has a profound impact on drug discovery success. Finally, artificial intelligence (AI) has also served as a potential tool for drug design and discovery, expected to be a revolution for drug development in several diseases.<br><br>&nbsp;]]></description> </item><item><title><![CDATA[List of Contributors]]></title><link>https://www.benthamscience.comchapter/23779</link><description><![CDATA[]]></description> </item><item><title><![CDATA[Molecular Mechanisms Implicated with Depression and Therapeutic Intervention]]></title><link>https://www.benthamscience.comchapter/22447</link><description><![CDATA[Depression is a pervasive, arduous psychological condition with profound neurological ramifications. The parameters for leveraging depression involve the diagnosis and evaluation of depression, the endorsement to implement substantiated therapies and rigorous follow-up of the patients. Many individuals suffering from depression undertake a recurring or persistent therapy that correlates to a decline in cognitive processing. The underpinnings of exact aetiology and pathogenesis of melancholy are probably the outcome of a variety of mechanisms. These include physiological, behavioural, and socio-economic variables, all playing their roles. Multiple refinements to the treatments encompassing therapies, medications and medical interventions are employed, in relation to effective approaches reassuring the brighter side. In this chapter, we discuss more integrative and multifaceted aspects of psychological health, minimizing the segmented understanding to achieve a consensus on multiple possibilities for effective interventions.<br>]]></description> </item><item><title><![CDATA[Benefits of Seaweeds in Cardiac Diseases]]></title><link>https://www.benthamscience.comchapter/22348</link><description><![CDATA[Cardiovascular diseases encompass a wide range of disorders that can be categorized into several groups depending on different criteria. The prevalence of cardiac disease is rapidly accelerating in the world. Cardiovascular disorders are responsible for roughly 17.9 million annual fatalities, or nearly 32% of the total mortality globally. The etiology of cardiovascular disease is complex, consisting of both modifiable and non-modifiable risk factors, including metabolic abnormalities, aberrant protein function, genetic mutations, and other contributing elements. Atherosclerosis continues to be the most significant risk factor since it primarily defines the pathogenic processes of cardiovascular diseases. Both pharmacotherapy and surgical interventions are currently in use to alleviate disease symptoms and reduce fatalities. Nevertheless, they have limitations. Therefore, there is an urgent need to develop a novel treatment for cardiovascular disease. Seaweeds are comprised of bioactive compounds with different biological and chemical properties. These can be classified into two groups: primary metabolites and secondary metabolites. Constituents such as phlorotannins, polysaccharides (ulvan, fucoidan, carrageenan), peptides, sterols, and carotenoids (fucoxanthin and astaxanthin) have depicted beneficial effects in preventing cardiovascular diseases. Therefore, this chapter mainly focuses on the bioactive constituents derived from seaweeds and their composition that may benefit in preventing and treating cardiovascular diseases.<br>]]></description> </item><item><title><![CDATA[What is Seaweed? General Facts about Seaweeds]]></title><link>https://www.benthamscience.comchapter/22337</link><description><![CDATA[Seaweeds are rich sources of various nutrients and bioactive compounds, which offer several health benefits. They contain high levels of vitamins, minerals, fiber, and protein, making them a valuable addition to a balanced diet. Seaweeds are particularly rich in iodine, an essential mineral that plays a crucial role in thyroid function and overall metabolism. They also contain significant amounts of iron, calcium, magnesium, potassium, and other trace minerals that are essential for human health. Moreover, seaweeds are known for their bioactive compounds, such as polysaccharides, phlorotannins, carotenoids, and polyunsaturated fatty acids, which have been linked to several health benefits, including anti-inflammatory, antioxidant, antimicrobial, and anticancer properties. Studies have shown that consuming seaweed may help to reduce the risk of chronic diseases, such as cardiovascular disease, diabetes, and certain types of cancer. Seaweeds may also improve gut health by acting as a prebiotic, promoting the growth of beneficial gut bacteria. In the present chapter, the authors focus on briefly summarizing the bioactive properties of secondary metabolites identified from seaweeds and their therapeutic potential as supportive information for the next chapters in this book.&nbsp;<br>]]></description> </item><item><title><![CDATA[Molecular Biology of Sports]]></title><link>https://www.benthamscience.comchapter/22291</link><description><![CDATA[Molecular biology of sports is a rapidly evolving field that investigates the relationship between genetic and molecular factors and athletic performance. Research in this area aims to identify genes and molecules influencing physical traits such as strength, endurance, and speed. By understanding the underlying biology of athletic performance, scientists can develop new approaches to improve athletic training, injury prevention, and rehabilitation. The study of molecular biology in sports also provides insights into the relationship between genetics and lifestyle factors, such as diet and exercise, that affect overall health and well-being. This abstract will provide an overview of the current state of research in molecular biology of sports, including recent advances in genomics, transcriptomics, proteomics, and metabolomics, and how these techniques are applied to sports science.<br>]]></description> </item><item><title><![CDATA[The Geriatric COVID Patient]]></title><link>https://www.benthamscience.comchapter/22213</link><description><![CDATA[The COVID-19 pandemic resulted in a significant impact on healthcare across the world. The pandemic is caused by the coronavirus SARS-CoV-2 and is transmitted through respiratory secretions. The geriatric population comprised most morbidities and mortalities related to COVID-19. Common symptoms include fever, cough, dyspnea, myalgia, and culminating in acute hypoxic respiratory failure and acute myocardial injury. Geriatric patients with COVID-19 who require surgery are at a greater risk of postoperative complications. An assessment of the risks and benefits of surgical intervention relies on the degree of COVID-19 pathology and the type of surgery whether emergent or elective. The presence of COVID-19 does not warrant a change in the modality of anesthesia that would be performed for any given surgery in the absence of COVID-19.<br>]]></description> </item><item><title><![CDATA[Anesthetic Considerations for Patients with Chronic Neurologic Disorders]]></title><link>https://www.benthamscience.comchapter/22209</link><description><![CDATA[Chronic neurological disorders encompass a broad range of challenges for the surgical and anesthesiology team in the perioperative setting. According to the World Population Prospects 2019, by 2050, 1 in 6 people will be over 65, from 1 in 11 in 2019 [1]. As our population continues to age, our understanding and ability to provide medical and surgical services must improve as well. Perioperative strokes are rare, but they can greatly impact a patient's recovery and function when they occur. Dementia strongly predicts postoperative complications, higher hospital costs, and 30- day mortality [2]. Patients with Parkinson’s disease are at a higher risk of perioperative medical and surgical complications not to mention specific medication regimens that need to be adjusted to avoid worsening symptomatology. Although rare, a patient presenting with Amyotrophic lateral sclerosis (ALS), can present with a broad range of neurologic symptoms, and cardiovascular and pulmonary dysfunction that can be daunting for any anesthesia provider. In this chapter, we will explore the comprehensive approach to managing chronic neurologic disorders, including multidisciplinary care, early identification of potential complications, specialized medication management, and intraoperative considerations.<br>]]></description> </item><item><title><![CDATA[Postoperative Cognitive Dysfunction (POCD) in Geriatric Patients]]></title><link>https://www.benthamscience.comchapter/22200</link><description><![CDATA[As the world population ages, the number of older patients undergoing surgery will increase significantly. Postoperative cognitive dysfunction (POCD) and other perioperative neurocognitive disorders (PND) affecting patients after surgery have long been recognized in older patients and are considered some of the most common postoperative complications. POCD has been correlated with significant morbidity and mortality, and greater healthcare costs. Historically, the lack of standardized nomenclature used to describe cognitive change after surgery and anesthesia has made it challenging to conduct systematic reviews or analyze the results of similar studies to further understand the clinical implications of this disorder. This has led to minimal recognition of this disorder outside of the specialty of anesthesiology. Patient and surgery-related risk factors include old age, preexisting cognitive changes, and emergency surgery amongst others. Proposed etiologies include postsurgical neuroinflammation, impairment of neurotransmitter systems, and cerebral vascular events in the perioperative period. The medical literature offers little guidance to recommend a particular anesthetic to decrease the risk of POCD in the postoperative patient. Most studies found similar risks of POCD after general and regional anesthesia techniques. While there is no standardized test for diagnosing preoperative cognitive impairment, it is critical to identify high-risk patients so that timely interventions can be made to minimize POCD.<br>]]></description> </item><item><title><![CDATA[“Medianeras” Sidewalls - Gustavo Taretto]]></title><link>https://www.benthamscience.comchapter/22188</link><description><![CDATA[Medianeras, which is closely related to architects and urban actors, deals with many subjects such as the standardization of the individual, standard life, display windows, lost spaces, capitalism, digitalized world, and relations. The focus of the narrative in the film, “Medianeras” is defined as the empty and windowless side walls of the buildings adjacent to the neighboring blocks. While the side walls are shown as the cause of physical separation between people in the city, these surfaces are also figured as the dead and vacant spaces of each building that serve no purpose. The scenario of the film, which begins with the architectural representation and criticism of the capital city of Argentina, Buenos Aires, is built through the parallel lives of the two characters. The metaphor of “sidewalls” used spatially in the film corresponds to a show alternately of the two narratives at similar moments. This spatiotemporal narrative in the film is linearly fictionalized within the sections of “A Short Autumn”, “A Long Winter” and “Spring at Last” in the text. In the film, which reflects the architectural differences of the city of Buenos Aires through the subjective narrative of the characters Martin and Mariana, similar relationships are defined between urban structures and people living in the city. The internal monologues quoted through the voices of Martin and Mariana touch upon many universal city and urbanite problems on the axis of the individual-society world through the life experiences of the characters. By establishing a similarity between human life and building, the unplanned development and architecture of the city are held responsible as the cause of social and physical problems. By establishing a similarity between human life and building, the unplanned development and architecture of the city are held responsible as the cause of social and physical problems. In the face of the legitimation of the internet as a communication technology, it connects the feeling of loneliness and virtual-real-world contradictions with unplanned urbanization in metropolises caused by unplanned urbanization. Whereas the architectural representation of the city is expressed in the space-time coexistence of the characters, it facilitates comprehension by emphasizing the experiences of private living spaces and urban public spaces.&nbsp;<br>]]></description> </item><item><title><![CDATA[CRISPR-Cas for Genome Editing - Molecular Scissors for Combating Pathogens]]></title><link>https://www.benthamscience.comchapter/22109</link><description><![CDATA[Clustered Regularly Interspaced Short Palindromic Repeats, abbreviated as CRISPR, is a genome-editing technology that permits the creation of precise knock-out mutants by aiding the modification of gene sequences devoid of the steps involving the insertion of foreign DNA into pathogenic microorganisms. The microorganisms are ubiquitous in nature and harbor in the complex ecosystem of the human being. Cas (acronym for CRISPR-associated) genes are present in many microbial genomes. The variable nature of the microbial genome has been utilized as an integral typing tool in epidemiologic, diagnostic, and evolutionary analyses of the prokaryotic species. The past decade has seen an accumulating growth in the development of gene-editing tools utilizing the CRISPR-Cas system, which essentially is a part of the prokaryotic immune system. The development of these unique gene-editing techniques has empowered researchers to alter and investigate organisms with ease and efficiency as never before. This editing tool can efficiently be programmed and delivered into the bacterial populations to explicitly eliminate members of a targeted micro biome. Manipulation of the gene expression and regulation of the synthesis of metabolites and proteins can be achieved by utilizing an engineered CRISPR-Cas system. Put together, these tools present with the exhilarating opportunity to explore the complex interaction between the individual species of the microbiome and the host organism and thereby reveal novel avenues for the generation of drugs to selectively target the microbiome. CRISPR-Cas technology has been employed to cope with antibiotic resistance in intracellular and extracellular pathogens. The widespread use of antibiotics and the escalation of multidrug-resistant (MDR) bacteria boost the prospect of a post-antibiotic era, which emphasizes the need for novel strategies to target MDR pathogens. The development of permissive synthetic biology techniques offers favorable solutions to carry through safe and efficient antibacterial therapies.<br>]]></description> </item><item><title><![CDATA[Therapeutic Applications and Pharmacological Practices of Essential Oils]]></title><link>https://www.benthamscience.comchapter/22104</link><description><![CDATA[When referring to a drug's active component as “Quinta essential,” Paracelsus von Hohenheim, a Swiss physician used the word “essential oil” for the very first time in the sixteenth century. Plant oils and extracts have been utilised for a variety of purposes for thousands of years. Essential oils have long been used in traditional medicine and by practitioners of alternative rejuvenation approaches. Because of their considerable immunomodulatory and antibacterial action, they have been used for many years to treat various ailments. Many volatile chemicals generated by plant secondary metabolism combine to make essential oils. Components of essential oil may be classified into two related types on a biosynthetic level. The two primary groups are terpene or terpenoid inchoation compounds, as well as aromatic and aliphatic components. Since the Middle Ages, essential oils have been utilized for antibacterial, biocidal, anti-fungal, antiprotozoal, and antifeedant purposes, as well as painkiller, calming, anti-inflammatory, anti-spasmodic, and locally anesthetic therapy.<br><br>However, little is understood about how essential oils function. Plant oils and extracts' antimicrobial characteristics have served as the foundation for a variety of enterprises, including pharmaceuticals, alternative medicine, and herbal treatments. <br>]]></description> </item><item><title><![CDATA[Appendix A]]></title><link>https://www.benthamscience.comchapter/22091</link><description><![CDATA[]]></description> </item><item><title><![CDATA[Modulatory Mechanism of NLRP3 Inflammasome in Heart Diseases: “An Enigma Wrapped in a Riddle”]]></title><link>https://www.benthamscience.comchapter/21912</link><description><![CDATA[Despite breakthroughs in therapy over the prior two decades, heart failure is considered the foremost cause of mortality globally. The inflammasome plays a pivotal role in the advancement of heart failure, abdominal aortic aneurysm, atherosclerosis, diabetic cardiomyopathy, hypertension, dilated cardiomyopathy, cardiac remodeling and calcific aortic valve disease. The NLRP3 inflammasome is a crucial multi-protein signaling platform that tightly regulates inflammatory responses. It regulates antimicrobial host defense, which causes pyroptosis through caspase-1 activation by the eventual production of pro-inflammatory cytokines. The investigation of the NLRP3 inflammasome in various cardiovascular diseases may reveal critical disease triggers and endogenous modulators, leading to the development of new therapeutic interventions in the future. The target of this chapter is to summarise the recent literature describing the activation mechanism of the NLRP3 inflammasome by implicating different inflammatory pathways in the pathophysiology of heart failure.<br>]]></description> </item><item><title><![CDATA[Advancing Data Science: A New Ray of Hope to Mental Health Care]]></title><link>https://www.benthamscience.comchapter/21878</link><description><![CDATA[Mental health care has unique challenges and needs, unlike other medical fields. Complex biopsychosocial causation of psychiatric disorders demands advanced computational models for scientific probing. Artificial intelligence and machine learning (AI/ML) are showing promising leads in improvising psychiatry nosology, which in the current state lacks biological validity. Increasing mental health care needs can be addressed only with the appropriate use of advancing technologies. Increased accessibility to personal digital devices demonstrates the scope for sensitive behavioral evaluation amidst gathering large amounts of data. Patterns in, thus acquired, digital phenotypes can be effectively evaluated only through big data analysis techniques. This has the potential to open newer avenues of preventive as well as therapeutic psychiatry. Unique legal and ethical conundrums in clinical and research domains of psychiatry arise while managing one of the most vulnerable populations with health care needs, who may often approach facilities in a state of illness, unawareness, and diminished decision-making capacity. Secure blockchain technology amalgamating with AI/ML can enhance the applicability in such conditions in improving compliance, individualizing treatment, and enhancing research without compromising ethical standards. AI/ML is hoped to guide Interventional psychiatry, an evolving promising field that relies on neuroscientific approaches using multimodal data and neuromodulation techniques. The current chapter reviews the contributions of AI/ML and blockchain in various mental healthcare system domains; and proposes its potential in many other uncharted territories in this field.<br>]]></description> </item><item><title><![CDATA[Enhancing the Communication of Speech-Impaired People Using Embedded Vision-based Gesture Recognition through Deep Learning]]></title><link>https://www.benthamscience.comchapter/21877</link><description><![CDATA[Communication between people is the key to delivering a message. It is easier for normal people to have a communication medium (language) known between them. A person with speech impairment or hearing difficulty cannot communicate with others like a normal human. Sign language helps people with disabilities to communicate with each other. In sign language systems, there is no de facto standard followed by all the countries in the world. It is not easy to get recognized using sign language alone. Hence, recognition systems are required to improve their communication capabilities. The rapid growth in the field of Artificial Intelligence motivated us to build a gesture recognition system based on machine learning and/or deep learning techniques for improved performance. In this chapter, an image-based recognition system for American Sign Language (ASL) is designed using 1. Handcrafted features classified by Machine Learning algorithms, 2. classification using a pre-trained model through transfer learning and 3. classification of deep features extracted from a particular layer by machine learning classifiers. Among these three approaches, deep features extracted from DenseNet and classification using K-Nearest Neighbor (K-NN) yield the highest accuracy of about 99.2%. To make this system handy, low cost, and available to needy people, the Resnet 50 model is deployed in a Raspberry Pi 3b + microcontroller.<br>]]></description> </item><item><title><![CDATA[Metaverse and the Future of Work Transforming Industries and Employment]]></title><link>https://www.benthamscience.comchapter/21864</link><description><![CDATA[This chapter explores the metaverse and its profound implications for industries and employment in the future of work. The metaverse, a concept rooted in virtual reality and augmented reality technologies, is reshaping the way we interact, conduct business, and collaborate. By providing a comprehensive understanding of the metaverse and its components, this chapter delves into the transformative potential it holds for various industries. The chapter begins by defining the metaverse and tracing its origins, establishing a foundation for subsequent discussions. It then explores the metaverse's impact on key industries, such as entertainment and media, retail and ecommerce, healthcare, and education. Through immersive experiences, virtual events, personalized shopping, medical simulations, and virtual classrooms, the metaverse is revolutionizing the way we consume, learn and access services. This chapter explores the metaverse's influence on the future of employment. It examines the evolution of remote work and distributed teams, highlighting the benefits of collaboration and productivity in virtual environments. The metaverse also presents new career opportunities, including platform development, virtual design, and other creative roles. However, challenges such as privacy, security, inclusivity, and accessibility must be addressed to ensure a responsible and equitable metaverse.<br>]]></description> </item><item><title><![CDATA[Pathogenesis of Atherosclerosis and Coronary Heart Disease: Epidemiology, Diagnostic Biomarkers and Prevention by Nutraceuticals, Functional Foods, and Plant-Derived Therapies]]></title><link>https://www.benthamscience.comchapter/21850</link><description><![CDATA[Atherosclerosis is characterized by hardening/narrowing of arteries and reduction of blood flow to vital organs. Animal models and human research show that endothelial dysfunction and plaque development precede the pathogenesis of atherosclerosis, and related coronary heart disease, neurological, and renal disorders. Cardiac CT-scans are used to detect atherosclerosis. Early diagnosis of atherosclerosis reduces mortality, morbidity, and healthcare expenditures. Biomarkers like C-reactive protein, IL-6, IL-8, phospholipase A2, cardiac troponin, MicroRNA, miR-21, and other endothelial inflammation biomarkers are novel targets for monitoring atherosclerosisrelated cardiovascular disorders. Anti-platelet and anti-cholesterol drugs are used in the treatment of atherogenesis and blood vessel clots. However, cholesterol-lowering drugs may cause serious adverse effects. Thus, safe and cost-effective non-pharmacological anti-atherogenic and anticoagulant therapies are urgently needed. Nutraceuticals, functional foods, plant-derived therapies, antioxidant/anti-inflammation, foods/fruits/vegetables, and lifestyle changes (e.g., physical activity, less alcohol, smoking cessation) reduce atherogenesis, diabetes mellitus, obesity, hypertension, LDL, and C-reactive protein in all age groups, especially younger people. Overwhelming evidence suggests that regular physical activity (30 min/day), cessation of cigarette smoking, and consumption of antioxidant nutraceuticals rich in flavonoids and retinoids, fresh vegetables and fruits, omega-3 PUFA, culinary spices, probiotics, Mediterranean-type diet, and “DASH DIET” lower the risk of atherogenesis and cardiovascular diseases. This review summarizes current advances in the diagnosis and management of atherosclerosis and related cardiovascular illnesses with plant-based and wholesome diets, including the Mediterranean diet, DASH DIET, and lifestyle changes. New preventative measures and alternative therapies, including dietary interventions and plant-based foods may be the most cost-effective ways to manage atherosclerosis and cardiovascular illnesses. <br>]]></description> </item><item><title><![CDATA[Propitious Effects of Natural Bioactives for Osteoporosis: Special Emphasis From Marine Source]]></title><link>https://www.benthamscience.comchapter/21849</link><description><![CDATA[Osteoporosis is one of the most significant health issues on the globe. The activity of osteoclast cells is connected to altered hormone levels and other factors such as age. The condition is characterized by increased bone fragility and loss of bone tissue. Osteoporosis, osteopetrosis, and Paget's disease are frequently caused by an imbalance in the production and function of osteoclasts and osteoblasts. The disease's early signs are scarcely noticeable. It results in gradual bone loss, which eventually makes the patients more prone to fractures. Osteoporosis must be avoided since the fractures caused by it have substantial medical expenses and morbidity. Bisphosphonates are used in the treatment of osteoporosis, along with hormone therapy, selective estrogen receptor modulators (SERMs), calcitonin, strontium ranelate (SR), and other treatments. Marine Natural Products (MNPs) have also had a significant impact on bone metabolism by preventing osteoclastogenesis. These MNPs are generated from a variety of marine resources, including marine cyanobacteria, soft corals, mollusks, fish, dinoflagellates, algae, sponges, and mangroves. Numerous plant and herb species are also effective in the treatment of osteoporosis. We check if these plant-based bio-actives may replace hormonal and synthetic drug-based treatments. This chapter also throws light on any possible effect of COVID-19 that might be on the body, particularly the musculoskeletal system.&nbsp;<br>]]></description> </item><item><title><![CDATA[Pharmacokinetic and Pharmacodynamic Modeling (PK/PD) in Pharmaceutical Research: Current Research and Advances]]></title><link>https://www.benthamscience.comchapter/21797</link><description><![CDATA[The development of more intricately constructed molecules and drug delivery systems as a result of technological breakthroughs has increased our understanding of the complexities of disease and allowed us to identify a wide range of therapeutic targets. New drug combinations can be designed by correctly using dynamical systems-based PK/PD models. The unswerving approach that offers a better knowledge and understanding of therapeutic efficacy and safety is the use of pharmacokinetic-pharmacodynamic (PK-PD) modeling in drug research. In vivo, animal testing or in vitro bioassay is used to forecast efficacy and safety in people. Model-based simulation using primary pharmacodynamic models for direct and indirect responses is used to elucidate the assumption of a fictitious minimal effective concentration or threshold in the exposure-response relationship of many medicines. In this current review, we have abridged the basic PK-PD modeling concepts of drug delivery and documented how they can be used in current research and development.&nbsp;<br>]]></description> </item><item><title><![CDATA[Introduction to Computer-Based Simulations and Methodologies in Pharmaceutical Research]]></title><link>https://www.benthamscience.comchapter/21791</link><description><![CDATA[&nbsp;Pharmaceutical research is increasingly using computer-based simulations and approaches to hasten the identification and development of new drugs. These methods make use of computational tools and models to forecast molecular behavior, evaluate therapeutic efficacy, and improve drug design. Molecular modeling is a key application of computer-based simulations in pharmaceutical research. It allows researchers to build virtual models of molecules and simulate their behavior, which provides insights into their interactions and properties. Molecular docking is a computational method used in Computer-Aided Drug Design (CADD) to predict the binding mode and affinity of a small molecule ligand to a target protein receptor. Quantitative structure-activity relationship (QSAR) modeling is another pharmaceutical research tool. QSAR models predict molecular activity based on the chemical structure and other attributes using statistical methods. This method prioritizes and optimizes drug candidates for specific medicinal uses, speeding up drug discovery. Another effective use of computer-based simulations in pharmaceutical research is virtual screening. It entails lowering the time and expense associated with conventional experimental screening methods by employing computational tools to screen huge libraries of chemicals for prospective therapeutic candidates. While computer-based techniques and simulations have many advantages for pharmaceutical research, they also demand a lot of processing power and knowledge. Also, they are an addition to conventional experimental procedures rather than their replacement. As a result, they frequently work in tandem with experimental techniques to offer a more thorough understanding of drug behavior and efficacy. Overall, computer-based simulations and methodologies enable pharmaceutical researchers to gather and analyze data more efficiently, bringing new medications and therapies to market.<br>]]></description> </item><item><title><![CDATA[Eosinophilic Fasciitis]]></title><link>https://www.benthamscience.comchapter/21787</link><description><![CDATA[]]></description> </item><item><title><![CDATA[Parry-Romberg Syndrome]]></title><link>https://www.benthamscience.comchapter/21784</link><description><![CDATA[]]></description> </item><item><title><![CDATA[Classification]]></title><link>https://www.benthamscience.comchapter/21769</link><description><![CDATA[]]></description> </item><item><title><![CDATA[The Role of Age in Pediatric Tumors of the Central Nervous System]]></title><link>https://www.benthamscience.comchapter/21742</link><description><![CDATA[Pediatric tumors of the central nervous system (CNS) are the second most common type of solid childhood cancer. As such, they have a major effect on the rates of morbidity and mortality in children. CNS tumors originate from abnormal cells in the brain and/or spinal cord, which can be classified as either benign or malignant. They can be further subdivided into different categories based on several principal aspects, such as tumor location, histopathology, and developmental age. Among these various characteristics, age is one of the most consequential determinants for CNS tumors. Specific groups between 0 and 21 years of age, for instance, have radically divergent landscapes in terms of their tumor incidence and unique biology. Depending on the age of the child, key case features may differ like the clinical evaluation, medical diagnosis and prognosis, recommended therapy and treatment courses, anticipated responses and tolerability to treatment, and management of side effects. Effective teamwork is another crucial component for the successful management of pediatric CNS tumors. In patient-and-family-centered care, ensuring a detailed education of the children and their families, as well as their involvement in the decision-making process where appropriate, is imperative. To determine the best available options for the patient, multidisciplinary medical teams will often deliberate over all of the possible procedures. The holistic care provided by these interprofessional collaborations for this vulnerable population will depend on the age of the child, in addition to the level of patient and family participation. Evidence shows that support and counseling of the patient and their family during the entire treatment process can have a significant impact on outcomes. This chapter will review the essential diagnostic and prognostic considerations of childhood CNS tumors, with special emphasis placed on favorable therapies and treatments, including in-depth discussions around the multi-faceted responses to treatment and the management of its side effects. In particular, this content will highlight the critical role that age, and interdisciplinary healthcare teams play in comprehensive disease management.<br>]]></description> </item><item><title><![CDATA[Role of Gut Microbiota in Neuroinflammation and Neurological Disorders]]></title><link>https://www.benthamscience.comchapter/21741</link><description><![CDATA[The prevalence of neurological diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and Multiple sclerosis (MS) are growing in the world, but their pathogenesis is unclear and effective treatment does not exist. Neuroinflammation is associated with many neurodegenerative mechanisms involved in neurodegenerative diseases. The human gut microbiota is an aggregate of microorganisms that live in the gastrointestinal tract (GIT) that plays a crucial role in maintaining human health and the pathogenesis disease condition. The microbiota can affect neuronal function through neurotransmitters, vitamins, and neuroactive microbial metabolites like shortchain fatty acids. The change in gut microbiota architecture causes increased permeability of the intestine and immune system activation, contributing to systemic inflammation, neurological injury, and eventually neurodegeneration. Available data suggest that the microbiota send signals to the central nervous system (CNS) by activating afferent neurons of the vagus nerve via neuroendocrine and neuroimmune pathways. The molecular interaction between the gut/microbiome and CNS is complex and bidirectional, ensuring gut homeostasis and proper digestion. Evidence suggests that dysfunction of the gut-brain axis could be a significant factor leading to many disorders of CNS. In this chapter, we explore how the gut microbiome may affect brain function and the development of neurological disorders. In addition, we are also trying to highlight the recent advances in improving neurological disease by supplemental probiotics and faecal microbiota transplantation via the concept of the gut-brain axis to combat brain-related dysfunction.<br>]]></description> </item><item><title><![CDATA[Neurobiology of Placebo: Interpreting its Evolutionary Origin, Meaning, Mechanisms, Monitoring, and Implications in Therapeutics]]></title><link>https://www.benthamscience.comchapter/21740</link><description><![CDATA[Placebo is defined as the therapeutic response to inert treatment. However, this is a bit simplistic because comprehending the biological basis of the placebo effect requires understanding the entire therapeutic context and the patient immersed in it. Placebo does not cure the disease but alleviates symptoms. The placebo impact must be seen in the context of the recipients’ cultural milieu, psychosocial background, the tone and tenor of the accompanying verbal communication (caring, indifferent, unfriendly), therapeutic rituals (e.g., tablet, injection, or a procedure, including diagnostic tests), symbols (white coat, syringe, the diagnostic paraphernalia), and its meanings to the patient (past experiences and personal hope). Placebo is the inert treatment juxtaposed against the broad context of the accompanying sensory and sociocultural inputs that signal benefit. It could also be the harm in the case of nocebo. A major objective of a standard clinical trial is to eliminate or at least minimise the influence of placebo. Many methods have been devised to measure and eliminate placebo responders in the trial populations. The neurological basis of the placebo effect is complex and must have an evolutionary basis because the susceptibility to placebos may be traced back to animals and birds. The placebo effect probably owes its evolutionary origin to signalling sickness and the ability to draw comfort from winning sympathetic attention and care from conspecifics. Pain being a complex sensory experience with a strong affective component, the neuronal pathways that reflect both sensory experience and the affective components have been explored in the study of the placebo effect. Placebo research, having expanded from psychology to neurology, presently involves research tools that include pharmacology, brain imaging, genetics, animal models, etc. This review will discuss multiple dimensions of the placebo effect, including evolutionary, cultural, psychosocial, and neurological aspects, in addition to providing cues for transformational implications in clinical trials and therapeutic modalities that benefit&nbsp;society. Contemporary medicine is demonising placebo because it is a confounder in clinical trials. It would be much more useful if the healthcare system can harness the therapeutic potential of the placebo effect by manipulating the therapeutic context.<br>]]></description> </item><item><title><![CDATA[Recent Drugs Tested in Clinical Trials for Alzheimer´s and Parkinson´s Diseases Treatment: Current Approaches in Tracking New Drugs]]></title><link>https://www.benthamscience.comchapter/21739</link><description><![CDATA[Affecting more than 50 million people worldwide and with high global costs annually, neurological disorders such as Alzheimer's disease (AD) and Parkinson’s disease (PD) are a growing challenge all over the world. Globally, only in 2018, AD costs reached an astonishing $ 1 trillion and, since the annual costs of AD are rapidly increasing, the projections estimate that these numbers will double by 2030. Considering the industrial perspective, the costs related to the development of new drugs are extremely high when compared to the expected financial return. One of the aggravating factors is the exorbitant values for the synthesis of chemical compounds, hindering the process of searching for new drug candidates. In the last 10-year period, an average of 20 to 40 new drugs were approved per year, representing a success rate of less than 6%. However, the number of referrals for new drug orders and/or applications remained at approximately 700 each year, reinforcing the difficulty in the process of identifying and developing novel drugs. Regarding neurodegenerative diseases, the FDA (USA) approved 53 new therapies in 2019, including 48 new molecules and, from these, three are medicines and two are vaccines. The main drugs recommended for the treatment of these disorders are included in the following classes: Dopamine supplement (Levodopa), Monoamine oxidase (MAO) inhibitor (Selegiline, Rasagiline), Dopamine agonist (Apomorphine, Pramipexole), and Acetylcholinesterase inhibitor (Donepezil, Rivastigmine, Galantamine). Additionally, the current pharmacological treatments are not able to cure these patients and considering the etiological complexity and the prevalence of neurological disorders, scientists have a great challenge in exploring new therapies and new molecules to find an adequate and viable treatment for these diseases. Clinical trials are essential in this process and thus, this chapter describes the most important drugs that were targets of phase III and IV clinical studies in the last five years, associated with the most common neurological disorders worldwide, AD and PD. Information about mechanisms of action, experimental studies in other diseases that support their use, and chemical structure of the drugs are included in this chapter. Additionally, nature as a source of valuable chemical entities for PD and AD therapeutics was also revised, as well as future advances in the field regarding tracking new drugs to get successful results and critical opinions in the research and clinical investigation.<br>]]></description> </item><item><title><![CDATA[Biomaterials and Mesenchymal Stem Cells]]></title><link>https://www.benthamscience.comchapter/21645</link><description><![CDATA[Mesenchymal stem/stromal cells are splendid cell sources for tissue engineering and regenerative medicine attributed to the unique hematopoietic-support and immunomodulatory properties as well as the multi-dimensional differentiation potential towards adipocytes, osteoblasts, and chondrocytes in vitro and in vivo. To date, MSCs have been identified from various approaches, such as perinatal tissues, and adult tissues, and even derived from human pluripotent stem cells (hPSCs). Longitudinal studies have indicated the ameliorative effect and therapeutic efficacy upon a variety of refractory and recurrent disorders such as acute-on-chronic liver failure (ACLF), acute myeloid leukemia (ACLF), premature ovarian failure (POF), and intractable wounds. To date, MSCs have been a to have various origins, including mesoderm, endoderm and ectoderm. In this chapter, we mainly focus on the concepts, and biological and therapeutic properties of MSCs, together with the standardizations for industrial transformation. Overall, the descriptions would help promote a better understanding of MSCs in disease pathogenesis and management and benefit the preclinical and clinical applications in the future.<br>]]></description> </item><item><title><![CDATA[Promising Pharmaceutical Compounds of Marine Fishes: Their Chemistry and Therapeutic Applications]]></title><link>https://www.benthamscience.comchapter/21603</link><description><![CDATA[This chapter deals with the bioactive potential of the different groups of marine fishes viz. cartilaginous, bony, and jawless fish species.<br>]]></description> </item><item><title><![CDATA[Micropropagation of Actinidia deliciosa (A. Chev.) C.F.Liang & A.R.Ferguson]]></title><link>https://www.benthamscience.comchapter/21571</link><description><![CDATA[Actinidia deliciosa, commonly known as Kiwifruit (Chinese gooseberry), belongs to the family Actinidiaceae. The edible and fleshy fruit has gained popularity over the past few decades owing to its high nutritive value, and medicinal and potential curative properties. The fruit is rich in vitamin C, folate, vitamin E, dietary fibers, antioxidants, enzymes, phytonutrients, etc. The presence of actinide in Kiwis helps in regulating gastric abnormalities, hypertension, cardiovascular inflammation, hemostatic disorder, and abnormal glucose metabolism, and prevents cancer. Consequently, the fruit holds a considerable market value that has led to the establishment of industrial organizations comprising growers and distributors. For the purpose of fulfilling the constant market demands, it is crucial to maintain quality standards, timely production, and an abundance of planting material. This chapter discusses the various in vitro propagation methods, including diverse and detailed approaches for both the direct and indirect organogenesis for large-scale production of good-quality kiwi plants, along with ex vitro hardening and acclimatization processes. It is apparent that the plant tissue culture techniques can be suitably applied for the mass production of kiwi fruit, while other in vitro manipulations and further biological research are needed to improve the field performance and post-harvest life of the fruit and its plant.<br>]]></description> </item><item><title><![CDATA[Current Status of Micropropagation of Operculina turpethum (L.) Silva Manso – An Endangered Medicinal Plant]]></title><link>https://www.benthamscience.comchapter/21566</link><description><![CDATA[The use of cutting-edge biotechnological methods such as in vitro propagation enables the large-scale production of disease-free plant material, rapid cloning, and conservation of the elite genotype within a very short period. Additionally, the technique has enormous potential for the production of pharmacologically significant secondary metabolites and plant-based medicines of high quality. Operculina turpethum (L.) Silva Manso is an important medicinal plant of the family Convolvulaceae and is used to treat several health ailments. Overexploitation and inadequate conservation strategies have put the plant on the verge of extinction. This chapter provides a concise overview of the current status of the endangered medicinal plant Operculina turpethum with special attention given to the in vitro propagation and conservation of the immense medicinal plant.<br>]]></description> </item><item><title><![CDATA[Moringa oleifera Lam.: An Updated Review on Micropropagation and Pharmacological Properties]]></title><link>https://www.benthamscience.comchapter/21563</link><description><![CDATA[Moringa oleifera Lam. tree is considered a miracle tree due to its nutrientrich profile. This plant has been widely cultivated throughout the world for its medicinal and nutritional benefits. Moringa plant contains a significant amount of various phytochemicals such as alkaloids, flavonoids, saponins, tannins, and phenolics that are responsible for their various medicinal, nutritional, and other applications. The use of moringa in pharmacological drugs not only increases cultivation but also increases the over-exploitation of this tree. As the conventional methods of moringa reproduction are not much effective, we require additional alternative strategies to multiply moringa plants. Micro-propagation is considered an effective method to produce a large number of transplants within a short time period. This chapter explores the micro-propagation approaches of M. oleifera together with its nutritional profile and biological activities.&nbsp;<br>]]></description> </item><item><title><![CDATA[Hormoneal Therapy]]></title><link>https://www.benthamscience.comchapter/21551</link><description><![CDATA[Treatments that involve the use of hormones or their antagonists are commonly referred to as hormone therapy or hormonal therapy. Oncologic hormone therapy, hormone replacement therapy (HRT), androgen replacement therapy (ART), oral contraceptive pills and gender-affirming hormone therapy are the major classes of hormonal therapy in addition to a few others. Some hormonal therapies will be discussed in detail under different chapters including oncologic hormone therapy, glucocorticoids and mineralocorticoids and insulin under antineoplastic agents, antiinflammatory steroids and antidiabetic agents, respectively. After studying this chapter, students will be able to: <br><br>• Define and classify hormonal therapy and differentiate between hormonal therapy and treatment. <br><br>• Explain all types of hormone replacement therapy including menopausal, androgens, and oral contraceptives.<br><br>&nbsp;• Discuss the use of androgen replacement therapy (ART) in males with low levels of testosterone due to disease or aging. <br><br>• Describe gender-affirming hormone therapy such as feminizing hormone therapy and masculinizing hormone therapy. • Identify appropriate growth hormone therapy for growth hormone deficiency. <br><br>• Demonstrate understanding of thyroid hormone replacement in hypothyroidism and antithyroid therapy in hyperthyroidism. <br><br>• Demonstrate clear guidance to the use of oral contraceptive pills for various purposes including birth control.&nbsp;<br>]]></description> </item><item><title><![CDATA[Diabetes and Antidiabetic Drugs]]></title><link>https://www.benthamscience.comchapter/21550</link><description><![CDATA[This chapter is a comprehensive account of diabetes and the medicinal chemistry of antidiabetic drugs. It provides the mechanism of disease progression and drug action and detailed structure-activity relationships (SAR) of antidiabetic drugs to give the knowledge base for pharmacists. After studying this chapter, students will be able to: <br><br>• Discuss the epidemiology and etiology of diabetes. <br><br>• Describe the clinical features of diabetes and differentiate between type I and type II diabetes. <br><br>• Discuss various risk factors and corresponding mechanisms responsible for the development of diabetes.<br><br>&nbsp;• Review biosynthesis of insulin, its metabolic outcomes, regulation of insulin secretion, and insulin signaling.<br><br>&nbsp;• Explain in detail the pathophysiologic mechanisms responsible for the clinical features of diabetes. <br><br>• Evaluate the clinical role of natural human insulin and commercially available other insulin products and discuss its mechanism of action, pharmacokinetics, adverse effects, motor complications, drug interactions, contraindications, and precautions. <br><br>• Discuss the mechanism of action, pharmacokinetics, adverse effects, motor complications, drug interactions, contraindications, and precautions for each class of antidiabetic drugs listed below. <br><br>o Sulfonylureas: tolbutamide (Orinase® ), tolazamide (Tolinase® ), chlorpropamide (Diabinese® ), and acetohexamide (Dymelor® ), glyburide (Diabeta® ), glipizide (Glucotrol® ), and glimepiride (Amaryl® ). <br><br>o Meglitinides: repaglinide (Prandin® ), nateglinide (Starlix® ). <br><br>o Biguanides: metformin (Glucophage® , Glucophage XR).<br><br>o Peroxisome proliferator activated receptor (PPAR) agonists/Thiazolidinediones: pioglitazone (Actos® ), rosiglitazone (Avandia® ).<br><br>&nbsp;o Alpha glucosidase inhibitors: acarbose (Precose® ). <br><br>o Glucagon-like peptide-1 (GLP-1) agonists: dulaglutide (Trulicity® ), exenatide (Bydureon® , Byetta® ), liraglutide (Victoza® ), lixisenatide (Adlyxin® ), semalgutide (Ozempic® , Rybelsus® ). <br><br>o Dipeptidyl peptidase-4 (DPP-4) inhibitors: alogliptin (Nesina® ), linagliptin (Tradjenta® ), saxagliptin (Onglyza® ), sitagliptin (Januvia® ).<br><br>&nbsp;o Amylin agonist: pramlintide (Symlin® ).<br><br>&nbsp;o Sodium-glucose cotransporter-2 (SGLT2) inhibitors: empagliflozin (Jardiance® ), canagliflozin (Invokana® ), dapagliflozin (Farxiga® ), ertugliflozin (Steglatro® ). <br><br>o Miscellaneous agents. <br>]]></description> </item><item><title><![CDATA[Cellulose Nanocrystals-Based Hydrogels for Drug Delivery]]></title><link>https://www.benthamscience.comchapter/21441</link><description><![CDATA[Recently, cellulose nanocrystals (CNC) have gained attention from researchers around the world due to their favourable properties such as low cost, nontoxicity, biodegradability, biocompatibility, and as small, strong hydrophilic materials, which render them favourable candidates for the preparation of hydrogels. The incorporation of CNC within a hydrogel matrix enables the hydrogel to sustain its shape during swelling-deswelling. Besides absorbing and retaining large amounts of water, hydrogels also respond to specific external environmental factors, such as temperature, pH, the presence of ions, and concentration, making them appealing to be engineered for drug delivery applications. In addition, CNCs also confer high mechanical strength and thermal stability to the hydrogels, which expand their potential in biomedical applications. This chapter focuses on the synthesis of nano cellulosebased hydrogels for drug delivery applications, including the extraction of CNC from various sources, fabrication of hydrogels using chemical and radiation crosslinking, the chemical, physical, and ‘smart’ properties of the hydrogels, and their application in controlled drug delivery.<br>]]></description> </item><item><title><![CDATA[Recombinant DNA Techniques]]></title><link>https://www.benthamscience.comchapter/21381</link><description><![CDATA[Following the success of the human genome project with 99.99% sequence accuracy, with no gaps, biotechnology has been revolutionized. Recombinant DNA technology comprises a battery of experimental procedures to isolate (clone) pieces of DNA containing specific genes. The usage of restriction enzymes for manipulating DNA and producing recombinant DNA along with advances in gene editing technology has paved way for diagnosing the candidate disease genes and treating human genetic disorders by restoring functional genes through the modification of the mutant gene or by introduction of a functional gene by Gene therapy. Array technology helps in the validation of recognized sequences, proteins, other biomolecules, drugs, etc. on a miniaturized platform. Quality management in the lab along with lab safety plans for biomedical labs requires adherence to various governmental regulations for protecting health and safety of lab employees and for the maintenance of safe working environment.<br><br>Genome analysis is carried out by genome mapping. Genetic maps can be linkage, cytogenetic or physical maps. Gene expression can be analyzed by genomics and proteomics Microarrays are emerging as useful closed systems for genomic (DNA microarray) and proteome (protein chip) analysis.<br>]]></description> </item><item><title><![CDATA[OCT-A Findings and Usefulness in Alzheimer's Disease, Parkinson's Disease, and Systemic Lupus Erythematosus]]></title><link>https://www.benthamscience.comchapter/21361</link><description><![CDATA[The eye is a window to the brain because of its inherent connection to the central nervous system (CNS). Several brain disorders manifest as ophthalmic abnormalities and can be detected through a detailed assessment of the eyes. In the last decade, extensive evaluation of retinal microvascular changes using optical coherence tomography angiography (OCT-A) has been performed for several diseases, such as Parkinson's disease, Alzheimer's disease, and systemic lupus erythematosus. Although the results from the available studies are conflicting (mainly due to heterogeneous study populations), they agree on the applicability of this technology for the early identification of these diseases. This chapter summarizes the OCT-A screening and monitoring uses for these diseases and hypotheses for the potential identification of disease characteristics.<br>]]></description> </item><item><title><![CDATA[References]]></title><link>https://www.benthamscience.comchapter/21342</link><description><![CDATA[]]></description> </item><item><title><![CDATA[Glossary]]></title><link>https://www.benthamscience.comchapter/21341</link><description><![CDATA[]]></description> </item><item><title><![CDATA[Sexual Dysfunction]]></title><link>https://www.benthamscience.comchapter/21338</link><description><![CDATA[]]></description> </item><item><title><![CDATA[Non-Genital Sources of Arousal and Orgasm]]></title><link>https://www.benthamscience.comchapter/21331</link><description><![CDATA[]]></description> </item><item><title><![CDATA[Introduction]]></title><link>https://www.benthamscience.comchapter/21322</link><description><![CDATA[]]></description> </item><item><title><![CDATA[Healthcare Applications Centered on AIoT]]></title><link>https://www.benthamscience.comchapter/21304</link><description><![CDATA[The Internet of Things (IoT) is a quickly expanding environment which combines software, hardware, physical components, as well as computing tools for data collection, sharing, or rather interaction. The IoT enables a unified platform for humans to interact with a wide range of physical and virtual objects, like personalised healthcare domains. Due to the explosive growth and advancement of the internet, traditional patient care strategies have enhanced with the replacing e-medical records mechanisms. The use of IoT technology provides medical modern healthcare equipment device setting for both physicians and clients. IoT devices and Artificial Intelligence are beneficial in many implementations, starting with remote weather monitoring to mechanical mechanisation. Furthermore, medical care applications are showing a strong interest in IoT devices due to cost savings, easiness of using it, and an increase in service quality. The most recent services for IoT-based healthcare, which have been investigated and are still facing challenges in the clinical setting, are required for intellectual, creative solutions. An exploration of prospects for artificial intelligence and the internet of things in the medical sector is provided in this chapter.&nbsp;<br>]]></description> </item><item><title><![CDATA[Applications of AI-enabled Robotics in Healthcare]]></title><link>https://www.benthamscience.comchapter/21302</link><description><![CDATA[Robotics began roughly 30 years ago in medical applications, but it is still relatively young for biological applications. Because of the precision, accuracy and reproducibility of robotic technology, robotic interventions in medical fields, such as robotic surgery, can enable doctors to work inside the human body, which is either non-invasive or minimally invasive, with improved surgical results. The importance of medical robots in the medical sector is intended to deliver good outcomes to assist people in doing complex tasks that need a significant amount of time, accuracy, concentration, and other routines that cannot be accomplished solely through human capability. Due to advancements in AI and IoT and their convergence to AIoT, the potential of medical robots has tremendously increased in the healthcare industry. The chapter outlines the various applications of robotics in the healthcare sector, including surgical, rehabilitation, telemedicine, and diagnostic. The advantages of robotics in Healthcare are highlighted, along with the discussion on the current and future challenges in their deployment and adoption. The role of AIoT in enhancing these healthcare robots' cognitive and other capabilities is also discussed. Finally, the future of robotics in Healthcare is explored, including emerging trends and technologies, their impact on the healthcare industry, and the potential for innovation and growth.&nbsp;<br>]]></description> </item><item><title><![CDATA[Early prediction in AI-enabled IoT environment]]></title><link>https://www.benthamscience.comchapter/21293</link><description><![CDATA[IoT is intelligent sensors and actuators which assemble to form an IoT device. The algorithms employed make the system make up a wise decision. These systems can use artificial Intelligence algorithms to make intelligent decisions. The previous work employs devices that compute normal from abnormal heart rates. These devices are intelligent machines that are carried with the individual. They are also used to calculate the ECG of the personnel. This information understands the behavior of the personnel. The knowledge is sensed and passed to the devices using the Bluetooth technique. This data segment into healthy or unwell being sections. The processing amalgamates transformation, conversion w.r.t format, and section labeling. The iforest approach excludes the outliers from the data set. The suggestion improves the previous work by predicting the abnormality before in hand by 17.5%. Many lives can be saved, and will help improve their lives by adopting this method.]]></description> </item><item><title><![CDATA[IoT Based Sleeping Disorder Recognition System for Cognitive Impairment Diseases]]></title><link>https://www.benthamscience.comchapter/21290</link><description><![CDATA[In the present scenario, healthcare has made significant progress with the assistance of smart devices involving effective sensors and Internet of Things devices. In context to this, the combination of IoT and cloud architectures are rigorously exploited in order to process the large amount of data that would be generated by the wearable sensor networks in near real-time applications by making use of Artificial Intelligence supporting smart healthcare systems. In the current scenario of globalization, in addition to the increased facilities, a wide variety of other challenges are worked upon for providing quality and efficient healthcare benefits and facilities by making use of cost-effective instruments and world class technologies.<br><br>&nbsp;An important factor for the physical and mental health of a human being, the performance throughout the day as well as safety is the sleep quality. Effective quality of sleep can help avoid the risk of mental depression and chronic diseases. Sleep promotes the brain to actively get associated with the activity that is being performed and helps in preventing various accidents that might be caused due to falling asleep. For the analysis of the sleep quality, a continuous monitoring system is necessary which generates effective results. With the aid of rapid improvisation of mobile and sensor technology as well as the emerging trends of Internet of things technology, there is a good opportunity of development of a reliable and effective sleep quality monitoring system. This chapter effectively describes the background and applicability of Internet of things for such systems involved in sleep monitoring. The study begins with the review of the quality of sleep, the importance related to the monitoring of sleep quality, the employability of Internet of things in this and its relevant field, as well as the open issues and challenges in this and its related fields. <br><br>The IoT technology supports the preamble which would promote a cost effective and consistent system in order to monitor the quality of sleep-in individuals. There are several existing systems for the same purpose which involves a large amount of cost and are cumbersome to implement. To overcome the same issue, the chapter narrates an inventive system for monitoring and analyzing sleep patterns by making use of effective parameters. In this domain, a combination of clinical medicine, bioengineering, neuroscience, epidemiology, mHealth, Computer Science, as well as Human Computer interactio,n in order to approach the challenge of digitization of sleep from a multidisciplinary perspective. This chapter describes the state of art technologies involved in sleep monitoring and discusses the challenges and opportunities involved from the initial step of acquiring the data to the applicability of the acquired data based on the consumer level and clinical settings. <br>]]></description> </item><item><title><![CDATA[Nomenclature and Current Indications of Optical Coherence Tomography Angiography in Diseases of the Choroid and Retina]]></title><link>https://www.benthamscience.comchapter/21247</link><description><![CDATA[One of the most significant developments in ocular imaging in the last century was optical coherence tomography (OCT). OCT angiography (OCT-A), an extension of OCT technology, offers depth-resolved images of the blood flow in the choroid-retina that are much more detailed than those produced by earlier imaging techniques such as fluorescein angiography (FA). Due to its requirements of novel tools and processing methods, the prevailing imaging constraints, the rapid improvements in imaging technology, and our knowledge of the imaging and relevant pathology of the retina and choroid, this novel modality has been challenging to implement in daily clinical practice. Even those familiar with dye-based ocular angiography will find that mastering OCT-A technology requires a steep learning curve due to these issues. Potential applications of OCT-A include almost all diseases of the choroid and retina, as well as anterior segment diseases. Currently, the most common indications are age-related macular degeneration and ischemic retinopathies, including diabetic retinopathy and retinal occlusive vascular disorders. Incorporating OCT-A into multimodal imaging for the comprehensive assessment of retinal pathology is a fast-growing area, and it has expanded our knowledge of these complex diseases in terms of diagnosis and treatment. This review describes the current main indications of OCT-A in retinal and choroidal diseases.<br>]]></description> </item><item><title><![CDATA[Principles of Optical Coherence Tomography Angiography in Ophthalmology]]></title><link>https://www.benthamscience.comchapter/21244</link><description><![CDATA[&nbsp;Optical coherence tomography (OCT) has proven to be an effective diagnostic technique for evaluating ocular structures, particularly for studying retinal layers and other areas of the posterior segment of the eye. The incorporation of strategies and algorithms that allow the observation of the retinal microvasculature and the flow of red blood cells currently represents important advances in the diagnosis and treatment of inflammatory, neural, and vascular retinal diseases. The advantage is that OCT is a non-invasive method that does not require the use of contrast dyes. For this reason, OCT combined with angiography (OCTA) is one of the most important techniques for the study of vitreoretinal disorders. Its optical principle, which is based on the Doppler technique, allows us to understand how OCTA equipment acquires and processes images to facilitate visualization and interpretation through their two- and three-dimensional reconstructions. In addition, OCTA allows the identification of signal alterations that could appear as artifacts on each tomography or angiographic scan. This chapter aims to explore the characteristics and further applications of OCTA in addition to its relevance in ophthalmological clinical practice.<br>]]></description> </item><item><title><![CDATA[Carbon Nanostructures and Medicinal Plants]]></title><link>https://www.benthamscience.comchapter/21239</link><description><![CDATA[<div>It has been a decade since the widespread usage of carbon nanostructures</div><div>(CNSs) in biomedical research. A few examples are the use of CNSs in medication, for</div><div>protein administration and in instruments to provide nucleic acids to treat cancer and</div><div>other chronic diseases. The near-infrared optical characteristics of CNSs allowed them</div><div>to be used in diagnostics and in non-invasive and very sensitive imaging equipment. In</div><div>recent years, the scientific and industrial sectors have paid increasing attention to the</div><div>physical and chemical properties of various nanomaterials. Structure, electronics,</div><div>water, and more may all be derived from them. This chapter will focus on carbon</div><div>nanomaterials and related nanostructures, which are designed to give the most up-t-</div><div>-date research results. There is a broad acceptance of traditional medicine in many</div><div>societies, with over 60 percent of the world's population and over 80 percent of the</div><div>population in developing countries depending on medicinal plants for medical reasons.</div><div>Among the many reasons for this are the ease of use, affordability, and low cost. It is</div><div>believed that nanotechnology will play a significant role in medicinal plant research</div><div>and drug delivery in the near future. These nano-drug delivery devices may boost the</div><div>activity of medicinal plants, but also solve some of their limitations. Nanocarriers</div><div>aiding in the treatment of cancer, diabetes, and other life-threatening illnesses by</div><div>delivering herbal chemicals will also be discussed in this chapter.</div>]]></description> </item><item><title><![CDATA[Microbiomes in Phytotherapeutics: Pros and Cons]]></title><link>https://www.benthamscience.comchapter/21218</link><description><![CDATA[This chapter highlights the significance of microbiomes especially plant<br>microbiomes in the field of therapeutics. The Plant microbiome comprises epiphytes<br>and endophytes inhabiting the surface as well as inside of the tissues of the host. These<br>microbial communities occupy a well-defined habitat and perform various activities<br>developing certain interactions with the host such as commensalism, mutualism, and<br>parasitism. For the establishment and functioning of the plant microbiome, plant root<br>releases exudate according to the nutritional requirement of particular microbial<br>species. In response to the stimulus, microbes chemotactically move towards the roots,<br>colonize and move to other parts of the plant. Microbes also adopt certain mechanisms<br>not only to colonize and multiply in specific hosts but also to promote the growth of the<br>host by secreting various plant growth hormones and exopolysaccharides. The<br>numerous compounds produced by microbes make plants tolerant of biotic and abiotic<br>stresses. The microbial communities in plant microbiome have an active role in<br>maintaining the health, ecology and physiology of the host. As a major portion of the<br>world’s population is dependent on phytotherapeutic medicines according to the World<br>Health Organization, the pharmacological characteristics of major medicinal plants<br>such as Aesculus hippocastanum and Ginkgo biloba are described in detail. This<br>chapter highlights the significance of the core role of the microbiome associated with<br>plants in the synthesis of various medicinal compounds. The phytotherapeutic potential<br>of plant microbiome revealed that endophytes and epiphytes isolated from various plant<br>species showed great potential for the production of antimicrobial as well as antiinflammatory<br>substances. The medicinally rich compounds such as antibacterial<br>proteins, phenols, saponin glycosides, flavonoids, terpenoids, carbohydrates and fatty<br>acids isolated from plant-associated microbes have various applications in the<br>treatment of fetal diseases and also exhibit anti-inflammatory action. Certain public<br>concerns are raised about the side effects of medicinal plants used in phytotherapeutics.<br>A relevant case study about public concerns along with preventative measures such as<br>rigorous testing is provided in this chapter.<br><br>]]></description> </item><item><title><![CDATA[An Intersectional Neuroscience Approach for Disadvantageous Populations: Meditation Practice as a Possible Support Option for Women with Breast Cancer?]]></title><link>https://www.benthamscience.comchapter/21181</link><description><![CDATA[Mindfulness and compassion meditation have a positive impact on cognition, mood, behavior, and general health, based on recent studies in neuroscience. However, the research methodology is still insufficient to determine and measure different mental states during meditation, especially in minority populations. Intersectional Neuroscience, which is an innovative research model, may provide some solutions since it adapts modern research procedures to include disadvantageous groups of participants (e.g., ethnic minorities, patients with chronic diseases, like cancer, heart disease, or depression). Evaluating Multivariate Maps of BODY Awareness (EMBODY) is a task designed to accommodate diverse neural structures and functions, using the multi-voxel pattern analysis (MVPA) classifiers, with functional magnetic resonance imaging (fMRI). The EMBODY task applies individualized artificial intelligence algorithms to the fMRI data, in order to identify mental states during breath-focused meditation, a basic skill that stabilizes attention. This chapter describes a potential application of the Intersectional Neuroscience (IN) approach to developing useful metrics of meditation practice, including participants from disadvantageous groups. Hopefully, these findings can be explored in-depth, and possibly applied to patients with triple-negative breast cancer (TNBC), in the future.&nbsp;<br>]]></description> </item><item><title><![CDATA[Molecular Simulation in Drug Design: An Overview of Molecular Dynamics Methods]]></title><link>https://www.benthamscience.comchapter/21058</link><description><![CDATA[Molecular interaction is the basis for protein and cellular function. Careful inhibition or modulation of these is the main goal of therapeutic compounds. In the pharmaceutical field, this process is referred to as pharmacodynamics. Over the years, there have been several hypotheses attempting to describe this complex phenomenon. From a purely biophysical point of view, molecular interactions may be attributed to pairwise contributions such as charge angles, torsions, and overall energy. Thus, the computation of binding affinity is possible, at least in principle. Over the last half of the past century, molecular simulation was developed using a combination of physics, mathematics, and thermodynamics. Currently, these methods are known as structure-based drug design (SBDD) and it has become a staple of computer-aided drug design (CADD). In this chapter, we present an overview of the theory, current advances, and limitations of molecular dynamics simulations. We put a special focus on their application to virtual screening and drug development.&nbsp;<br>]]></description> </item><item><title><![CDATA[Musculoskeletal System Examination]]></title><link>https://www.benthamscience.comchapter/20988</link><description><![CDATA[The musculoskeletal system constitutes a demanding part of the physical examination in terms of both knowledge and time. The skillful examiner focuses this critical task through information obtained in a careful history. The examiner should take the opportunity to observe the patient’s posture and mobility when he or she first enters the examination room. Musculoskeletal exam nearly exclusively relies on inspection and palpation of the joints and some specialized tests involving those techniques. Rarely do percussion and auscultation play a role in the musculoskeletal exam. The key features to note and record on the examination of the joints are swelling, tenderness, and loss of motion.&nbsp;<br>]]></description> </item><item><title><![CDATA[Neurological Examination]]></title><link>https://www.benthamscience.comchapter/20987</link><description><![CDATA[A neurological exam, also called a neuro exam, is an evaluation of a person's nervous system that can be done in the physcians. It may be done with instruments, such as lights and reflex hammers. It usually does not cause any pain to the patient. The nervous system consists of the brain, the spinal cord, and the nerves from these areas. There are many aspects of this exam, including an assessment of motor and sensory skills, balance and coordination, mental status (the patient's level of awareness and interaction with the environment), reflexes, and functioning of the nerves. The extent of the exam depends on many factors, including the initial problem that the patient is experiencing, the age of the patient, and the condition of the patient.&nbsp;<br>]]></description> </item><item><title><![CDATA[Real World Applications of Machine Learning in Health Care]]></title><link>https://www.benthamscience.comchapter/20834</link><description><![CDATA[Machine learning (ML), a subset of artificial intelligence, is used to construct algorithms for monitoring, diagnosing, forecasting, and predicting clinical results. Health is a major concern for human beings. The current success in ML is due to deep learning (DL), using huge artificial neural networks. In the past, machine learning has demonstrated its usefulness and skills in detecting cancer. It is one of the most feasible solutions for top healthcare pioneers to detect anomalies. When healthcare companies succeed in using predictive models, they face challenges in demonstrating their value and gaining trust across the company. Recently, established standards for reporting machine learning-based clinical research will aid in connecting the clinical and computer science communities and realizing the full potential of machine learning techniques. The researchers have many objectives in the design of machine Learning Algorithms for different applications. Many papers discussed how machine learning algorithms are involved in health monitoring which will be updated so that patients, doctors, or any individuals can view the information. The main goal of this paper is to discuss basic types of Machine Learning and the challenges faced by Artificial intelligence (AI) in health care. The possible risks in clinical research give practical information on how to accurately and effectively analyze performance and avoid frequent pitfalls, particularly when dealing with applications for health and wellness contexts.<br>]]></description> </item><item><title><![CDATA[Subject Index]]></title><link>https://www.benthamscience.comchapter/20770</link><description><![CDATA[]]></description> </item><item><title><![CDATA[Bone Water: Effects of Drugs on Bone Hydration Status]]></title><link>https://www.benthamscience.comchapter/20767</link><description><![CDATA[Water is the most crucial nutrient that constitutes roughly 20% of the cortical bone by volume, yet most ignored in health and nutrition areas. Hydration significantly influences the mechanical properties and tissue quality of bone, whereas bone dehydration causes an increase in its elastic modulus. Moreover, the low water content in the trabecular skeleton changes its construction (shrinkage) and leads to a significant alteration in mechanical properties. Numerous internal (a lack of thirst sensation) or external (polypharmacy or chronic consumption of certain drugs) factors cause hypohydration. Unfortunately, frail elderly individuals are more vulnerable to developing dehydration particularly, due to a decrease in the fat-free mass, which contains 73% of total body water. Today, technical advancements have led to an emerging understanding of how bone water changes in various conditions including aging, diabetes, osteoporosis, and osteogenesis imperfecta. Drugs may also change the impression of hypohydration through the increase of water elimination causing diarrhoea, diuresis, or sweat; a decrease in thirst sensation or appetite; or affecting the central thermoregulation mechanism. However, research on the interaction between bone hydration status and drugs/excipients has been insufficient. In the present review, we evaluate studies that focus on the significance of bone hydration and the effects of drugs/excipients on hydration status.&nbsp;<br>]]></description> </item><item><title><![CDATA[Case Study: Impact of Industry 4.0 and Its Impact on Fighting COVID–19]]></title><link>https://www.benthamscience.comchapter/20744</link><description><![CDATA[&nbsp;The emerging development in industrial technology for automation and data sharing is known as Industry 4.0. It incorporates the Internet of Things, Cyber-physical systems, and Cloud computing, all of which contribute to the development of a “smart factory”. Customers, distributors, vendors, and stakeholders in the supply chain would be capable of connecting and can exchange data easily through Industry 4.0. The COVID-19 pandemic is quickly spreading and posing a threat to people all over the world. Employment and activities in all markets have been disrupted, putting economies all over the world in serious jeopardy. To combat the pandemic, retailers will benefit from Industry 4.0 because it will help to mitigate the impact of identified risks. I4.0 executives were focused on gaining a competitive edge, rising efficiency, lowering prices, and, ensuring profitability as their primary aim was to enhance the productivity of business during the time before the COVID-19 crisis. Our Government has imposed new behavioral trends including social distancing, isolation and, lockdown. The Government needs additional financial resources to combat pandemics as a result of these actions, there has been a global economic slowdown. This chapter enlightens the significance and technologies of Industry 4.0, showing how those technologies and applications help in attaining a better society. It also explains how Industry 4.0 helps in accomplishing sustainable manufacturing and the management tactics it used to boost the company's efficiency, as well as the effects of COVID-19.&nbsp;<br>]]></description> </item><item><title><![CDATA[AI based Clinical Analysis of COVID-19 Infected Patients]]></title><link>https://www.benthamscience.comchapter/20743</link><description><![CDATA[Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is an unknown beta coronavirus that comes under the B genus, which causes Coronavirus Disease 2019 (COVID-19), a declared universal epidemic, posing a serious menace to human health irrespective of the nationality. According to the World Health Organization (WHO) statistics, as of September 10, 2021, there were 223,022,539 positive cases of COVID-19 with 4,602,883 fatalities reported worldwide. A total of 5,352,927,297 vaccine doses have been facilitated since September 5, 2021. This pandemic has become a ravaging illness because of its highly contractible nature and mutations. Many types of research in diverse fields of science have been initiated to suppress the effects and manage the havoc. Artificial Intelligence (AI) is classified as a subdomain of science, which most certainly contributed to numerous applications in confronting the present state at a broader level. In this chapter, we have tried to explore state-of-the-art AI techniques implemented in the perspective of COVID-19 across multiple subjects of concern. The AI approaches are utilized in the treatment, diagnosis, prediction of recovery, severity and mortality of patients, chest X-Ray and computed tomography-based analysis, pandemic prediction, its control and management, pharmaceutical research, COVID-19 text corpus processing, and virus apprehension. Thus, the comprehension of various applications is meant to enlighten the status of AI in this pandemonium. Finally, we conclude with some suggestions and remarks to tackle the disaster in an improved way.&nbsp;<br>]]></description> </item><item><title><![CDATA[Analytical Methods in the Characterization of Green Nanomaterials]]></title><link>https://www.benthamscience.comchapter/20667</link><description><![CDATA[A new class of diagnostic and therapeutic tools for various diseases has been made possible by advancements in polymeric nanoparticles as innovative nanomedicines. Although there are many benchtop studies in the nanoworld, their application to already marketed goods is still in its infancy. Problems with nanomedicine characterization cause this lack of transference, among other things. Three nanoscale characterization approaches may be distinguished: physicochemical property characterization, biological interactions of nanomaterials, and analytical characterization and purification procedures. Physical qualities may be assessed using a variety of methods in many situations. Choosing the best appropriate method is made more difficult by many advantages and disadvantages of each methodology; frequently, a combinatorial characterization approach is required. Scientists from many domains must find answers to the difficulties in reliable characterization of the nanomaterials after their fabrication and various systematic stages.<br>]]></description> </item><item><title><![CDATA[Biological Functions of Elements of Main Groups]]></title><link>https://www.benthamscience.comchapter/20659</link><description><![CDATA[]]></description> </item><item><title><![CDATA[Occurrence and Classification of Chemical Elements]]></title><link>https://www.benthamscience.comchapter/20658</link><description><![CDATA[]]></description> </item><item><title><![CDATA[Vitiligo and Treatment Protocols]]></title><link>https://www.benthamscience.comchapter/20622</link><description><![CDATA[Vitiligo is an abiding acquired skin disorder caused by the epidermal disappearance of pigment cells of localized and general skin mucosa, characterized by the appearance of symmetrical patches on the skin. The exact cause of this disorder is unknown, but genetic susceptibility, melanocyte growth factor deficiency, autoimmunity, and some neurological and environmental factors are believed to play a triggering role. Although no drugs are completely successful in managing this disorder, many different approaches, such as topical corticosteroids, calcineurin inhibitors, transplantation, newly emerged phototherapy, or the combination approaches, however, have shown positive results and have helped to restore skin tone in people with small areas of depigmentation. The association of the adverse effects such as redness, itching, burning, pruritis, xerosis cutis, or potential risk of skin cancer and the high treatment cost with these therapies has necessitated the development of other newer treatment approaches such as phytotherapy for vitiligo. Also, novel drugs are being developed that either stimulate the melanocytes, like afamelanotide, or help control or protect the melanocytes. Many herbal drugs have been reported beneficial in the treatment of vitiligo, which has been shown to stimulate melanogenesis, proliferation or migration of melanocytes or have immunomodulatory properties. Further research on herbal drugs should be extended to develop safe, effective and affordable treatments for vitiligo.&nbsp;<br>]]></description> </item><item><title><![CDATA[Medical Futility in Pediatrics: Challenges, Hopes, and New Perspectives]]></title><link>https://www.benthamscience.comchapter/20539</link><description><![CDATA[The concept of medical futility is explored, particularly in relation to the challenge of defining futile treatments, and the difficulties in identifying patient subgroups that strictly match the criteria for treatment futility. The issue of categorizing perinatal disorders as fatal is an important topic, with a focus on the moral and legal repercussions of identifying lethal malformation. The identification of a lethal malformation often has moral and legal repercussions, and the phrase “lethal” should be avoided unless it is precisely defined, used consistently, and covered in transparency in perinatal counseling following prenatal diagnosis. We argue that a nuanced and carefully considered approach is required, one that takes into account the complex medical and ethical issues involved, and that focuses on the best interests of the patient and their family. Overall, we highlight the importance of ethical considerations and effective communication in the provision of perinatal palliative care for fetuses with genetic disorders and congenital defects. Also, while there is much that remains uncertain and controversial in this field, continued research and discussions are necessary to ensure that the best possible care is provided for all patients and their families.<br>]]></description> </item><item><title><![CDATA[Autism Spectrum Disorder during Infancy: Implications for Diagnosis, Prognosis, and Therapeutic Approaches]]></title><link>https://www.benthamscience.comchapter/20538</link><description><![CDATA[Autism spectrum disorder (ASD) is a complex psychiatric and neurodevelopmental issue related to delays in the acquisition of behavioral and social skills. The main symptoms of ASD are impairments in communication, limited interest and skills in social interactions, and repetitive behavior. In the present chapter about ASD during infancy, we reviewed the behavioral indicators of ASD, different ways of diagnosis, and the significance of an early and correct diagnosis. While children with ASD are usually diagnosed between ages 2-4, many pediatricians and psychiatrists are interested in understanding the developmental course of ASD in early infancy and infancy. Such an understanding would help both infants with ASD and their family members to identify useful interventions to cope more favorably with difficulties related to the infants’ symptoms of ASD. We highlighted that ASD traits unfavorably impact a child’s and their family’s social, behavioral, and the family’s economic status and conditions. Given this, an early diagnosis and timely and appropriate interventions should mitigate ASD-related issues in everyday life. To this end, assessing a child’s behavior is the gold standard for ASD diagnosis. Most of the symptoms appear in the second year of life; often language acquisition is impaired. Considering the signs of ASD in infancy, promising perspectives on ASD diagnosis will be introduced in the future.<br>]]></description> </item><item><title><![CDATA[Fetal Tumors: Diagnosis and Management]]></title><link>https://www.benthamscience.comchapter/20537</link><description><![CDATA[Tumors can be formed in any organ throughout life. The fetal period is no exception to this fact, and it is important to diagnose these tumors as soon as possible to provide timely care to patients. If management is halted, tumors can cause complications in delivery, child development and even death. In this chapter, we discuss the diagnosis and management of several common fetal tumors. We also overview possible future directions in the management of tumors found during the fetal period.<br>]]></description> </item><item><title><![CDATA[Performance Simulation of a Solar-Powered and Hand Gesture Controlled Lawn Robot using Dynamic Movement Primitives (DMP)]]></title><link>https://www.benthamscience.comchapter/20445</link><description><![CDATA[Hand-gesture interpretation and control in robotics describe the interconnection between human and machine elements in the computer vision world. Pruning a structured environment is time-consuming and labor-intensive. Therefore, it requires management by a self-propelled machine. The path planning mode allows the robot to move along a specified path. Various studies on lawn mower robots focus more on obstacle avoidance with hand gesture interpretation and control implemented to take care of path definition. This study targets the development of a solar-powered lawn mower robot using hand gesture control as a path-planning technique. The robotic system continuously operates using charged batteries via solar energy stored in photovoltaic cells. The robot control mechanism was implemented via the use of infrared sensors to avoid obstruction on its path, and hand gesture interpretation via a DSP processor for path planning. The performance evaluation of the robot was based on field experiments and simulations using SolidWorks, defined in terms of area covered, lawn availability, energy utility, and optimum turning velocity. The evaluation revealed that the machine’s efficiency is almost 100% based on the area covered, the percentage availability of the robot is 95%, and the average energy utility of 7.7 KWh was also obtained. The optimum turning velocity of 0.096 m/s at work with a completion time of 20 minutes was obtained by simulation. This robot is useful for any environment, both structured and semi-structured.<br>]]></description> </item><item><title><![CDATA[Microplastic as a Multiple Stressor]]></title><link>https://www.benthamscience.comchapter/20343</link><description><![CDATA[The presence of microplastics (MPs) throughout the world causes a serious threat to the functionality and vigor of the ecosystem, which is present in almost all habitats, such as in aquatic, atmospheric and terrestrial habitats, and is also found in human consumables. Recently it has been found that MPs have entered the human body through the food chain from terrestrial agriculture. Migration and retention of MPs in the soil are controlled by the interaction between MPs and various environmental factors. There is an immense need in real-world environments to understand the migration properties and key mechanisms of MPs. Various organisms such as plants, animals, different microorganisms present in the soil, etc. are impacted by the presence of toxic MPs in the environment. Therefore, to ensure food safety and sustainable agriculture, MPs should be treated as a future threat and attention should be given to understand the mechanisms of transport and ecotoxicological effects of contaminants released from MPs. The aim of the present chapter is to emphasize the impact of MPs on various organisms present in the ecosystem and their interaction with other contaminants.<br>]]></description> </item><item><title><![CDATA[Role of Artificial Intelligence in Healthcare Management]]></title><link>https://www.benthamscience.comchapter/20312</link><description><![CDATA[Artificial intelligence (AI) has recently become one of the most heavily debated themes in the technological world. AI is active in numerous fields and now it has lately entered the healthcare sector. In addition to biomarkers, the use of AI is increasing in a variety of applications such as genetic editing, disease prediction and diagnostics, drug development, personalized treatment, and so on. Accuracy in disease diagnostics is essential for effective and efficient treatment as well as patient safety. Artificial intelligence is a wide and varied field of data, analytics and continuously evolving insights that meet the needs of the healthcare sector as well as patients. The purpose of the many subsections in this book chapter is to shed light on how AI integrated with machine learning (ML) &amp; Deep-learning (DL) techniques operate in various disease diagnosis domains, medication discovery, medical visualization, digital health records, and electro-medical equipment.&nbsp;<br>]]></description> </item><item><title><![CDATA[Role of Wearable Biosensors in Healthcare]]></title><link>https://www.benthamscience.comchapter/20267</link><description><![CDATA[These days, wearable biosensors are a very valuable tool for tracking the start of various acute and chronic diseases. Wearable biosensors (WBSs) are small, electrical devices that coordinate and collect sensations into the human body and can be present in the form of tattoos, gloves, clothing and inserts. WBSs are a flexible and practical tool for use in the healthcare industry, thanks to their ability to detect information, record it and estimate it accurately. WBSs help patients and doctors to communicate in both directions. It is simple to do painless evaluations of bodily fluids using various biochemical markers such as spit, sweat, skin, and tears. As the continuous state of capabilities of wearable and adaptable sensors continues to advance, the creation of new wearable gadgets that can fill the gap and handle the advantage of human well-being checking and clinical application is advancing. Blood is still the most crucial bio-liquid for assessing a person’s health, even though more attention has been paid to other bodily fluids that are naturally secreted and severe functions that are similar to those of blood. There has been a lot of interest in the capacity of compact biosensing devices to identify the analyte in bio-liquids for the early detection of human well-being.<br>]]></description> </item><item><title><![CDATA[Application of Flow Cytometry in Biological Sciences]]></title><link>https://www.benthamscience.comchapter/20222</link><description><![CDATA[Flow cytometry is one of the sophisticated tools with its applications in different biological disciplines. It is potentially efficient in the characterization of mixed populations of cells present in biological samples, including blood cells, lymphocytes, microorganisms, sperms, cancer cells, metabolites, antibodies, DNA/RNA content, proteins, toxins, plant spores, etc. Flow cytometry is widely applied in the determination of cellular characteristics and cellular components profiling like cell size, intracellular pH, DNA, RNA, proteins, surface receptors, membrane potential, calcium, and others. Currently, flow cytometry is pragmatic in basic as well as applied plant research and plant industrial applications like plant breeding. Flow cytometry has been considered a reliable, rapid, efficient, and accurate tool for analysis of ploidy level and nuclear genome size estimation. It is also subjected to taxonomy to study population/subpopulation dynamics. Gender determination from pollen grain is also possible due to flow cytometry.&nbsp;<br>]]></description> </item><item><title><![CDATA[Child Abuse and Neglect]]></title><link>https://www.benthamscience.comchapter/20209</link><description><![CDATA[Child abuse and neglect are synonymous with the current term “Child maltreatment”, a multifactorial problem affecting the health and well-being of large numbers of children worldwide. “Child Abuse and Neglect” has been discussed from public health and a professional perspective, focusing on global problems. It narrates the consequences of being exposed to this form of brutality on the minds and bodies of the child, their detection and measures being taken to prevent these types of violence. Also, the extent of the problems, the risk factors, the consequences of child abuse, and what is being done to avoid child abuse and neglect have also been discussed.<br>]]></description> </item><item><title><![CDATA[Regulatory Affairs in Herbal Products]]></title><link>https://www.benthamscience.comchapter/20185</link><description><![CDATA[Various parameters/guidelines regulating the safety and efficacy of herbal pharmaceuticals, as well as their manufacturing and distribution, have been strongly implemented by regulatory bodies. To understand the pre-marketing requirements, the legislative status of herbal drugs/products was analyzed in this chapter for various countries in Southeast Asia, Africa, America, Europe, and Austria. Apart from the challenges of herb availability and conservation, it has been shown that there is a lack of harmony in the regulatory requirements for herbal products across the world. A critical evaluation was performed in order to detect the obstacles in the harmonization of herbal products. The worldwide trade and development of herbal products are being hampered by these issues. The herbal drug industry is inadequately regulated in most countries, and herbal medicines are often neither registered nor controlled. Quality compliance and assurance of the safety and efficacy of the marketed herbal drugs are major issues faced by developing as well as developed countries across the globe. The problem arises when herbal medication is utilized without legitimate permission, or in huge dosages, or in combination with other drugs for a longer period, or without discussion with a doctor, and produced properly. Taking these factors into account, the World Health Organization's International Drug Monitoring Program (WHO) has published standards for herbal assessment and quality control testing in order to improve the safety and efficacy of herbal-based therapeutics. This chapter covers the importance of regulatory affairs to be used in the processing of herbs and herbal products, and a comparative study of regulatory situations in different countries<br>]]></description> </item><item><title><![CDATA[Anatomy and Physiology of the Brain: Pathophysiology of Brain Tumor]]></title><link>https://www.benthamscience.comchapter/20161</link><description><![CDATA[The brain is an efficient processor of information. It is the most complex and sensitive organ in the body and is responsible for all functions of the body, including serving as the coordinating center for all sensations, mobility, emotions, and intellect. The magnitude of its myriad function is often realized usually when there is a disruption of the nervous system due to injury, disease, or inherited predispositions. Neuroscience is the field of study that endeavors to make sense of such diverse questions; at the same time, it points the way toward the effective treatment of dysfunctions. The two-way channel of information: findings from the laboratory leading towards stricter criteria for diagnosing brain disorders and more effective methods for treating them and in turn, the clinician's increasingly acute skills of diagnosis and observation that supply the research scientist with more precise data for study in the lab diligently expands the field of neuroscience. Tumors of the brain produce neurological manifestations through several mechanisms. Stronger hypotheses about the mechanism of a disease can point the way toward more effective treatments and new possibilities for a cure. In highly complex disorders of the brain, in which many factors genetic, environmental, epidemiological, even social and psychological—play a part, broadly based hypotheses are exceedingly useful. With the advancements in technology and a better understanding of brain anatomy and physiology, the quest to discover an efficient cure for life-threatening tumors of the brain is underway.<br>]]></description> </item><item><title><![CDATA[Molecular Mechanisms of Flavonoids Mediated Therapy and Chemoprevention of Cancer]]></title><link>https://www.benthamscience.comchapter/20132</link><description><![CDATA[Flavonoids derived from daily dietary source and plant products play a crucial role in the prevention and treatment of various degenerative diseases and cancer. Flavonoids are further subdivided into subclasses such as flavones, flavan-3- ols, flavonols, flavanones, isoflavones and anthocyanidins. There has been a resurgence in the research on flavonoids due to enhancement in the evidence that proves the health benefits of flavonoids. Several preclinical and epidemiological studies revealed that dietary intake of flavonoids may be found helpful in the reduction of risk of tumors like colon, breast, lung, pancreas and prostate. It also acts on the reactive oxygen species, and cellular signal transduction pathways associated with cellular proliferation, angiogenesis and apoptosis. Flavonoids are non-toxic in nature, so intensively studied the broad, vast aspect of their efficacy in biological activities that in turn promotes health benefits and also added to its availability in abundance in our daily diets, for instance, fruits, green leaves, tea, red wine and vegetables. Overall, the exciting data obtained so far elicit that dietary flavonoids have been considered a beneficial cancer preventive approach. This chapter unravels the molecular mechanisms involved in potential cancer preventive efficacy accomplished by the novel biological approach of flavonoids.<br>]]></description> </item><item><title><![CDATA[Allium Species: A Remarkable Repertoire of Nutraceuticals with Anti-cancer Properties]]></title><link>https://www.benthamscience.comchapter/20126</link><description><![CDATA[Cancer - the name evokes fear and anxiety. Researchers are working tirelessly to bring hope to countless patients by developing prevention and treatment strategies. One approach is dietary modulation - which is documented to reduce the risk of cancer and increase the benefit of anti-cancer therapy. Allium species are a part of the daily diet in most parts of the world. Important members of this genus - chives, garlic, onions, and shallots add flavour and nutrition to food. These are prized for their organosulphur compounds and flavonoid content which are responsible for their diverse pharmacological activities. Traditional and scientific literature shows that dietary intake of Allium species prevents and aids the treatment of different cancers. In this review, based on an extensive search of available databases, the role of Allium species as nutraceuticals for cancer management was examined to ascertain the truth in the popular claims. Preclinical and clinical investigations show that consumption of the Allium members as a part of the diet and also the functional components (e.g., allicin, diallyl disulphide, diallyl trisulphide, ajoene, S-allyl cysteine, S-allyl mercaptocysteine, tuberoside M, onionin A, fisetin, quercetin, etc.) reduce risk of cancer and have significant antitumor activities. These act by varied mechanisms, including inhibition of gene expression, promotion of apoptosis of cancer cells, antiproliferative activity, and anti-oxidant and anti-inflammatory effects. It is emphasised that standardization of Allium products, their efficacy, dosage, safety profiles and interactions should be ascertained to corroborate their use. This article highlights the importance of Allium species for their prophylactic, therapeutic and immune-boosting ability in cancer management.<br>]]></description> </item><item><title><![CDATA[Representation of Knowledge in Taxonomies and Ontologies and their Application in Advance Analysis to Cognitive Computing]]></title><link>https://www.benthamscience.comchapter/20078</link><description><![CDATA[This chapter focuses on how ontologies and semantic web technology can be used in artificial intelligence or systems engineering. Technological trends imply that future digital technology approaches and tools will use AI and ML technology. Logicbased reasoning and semantic modeling assist in classification, customization, and relationship detection but struggle to describe how decisions are made. Knowledge acquisition plays a vital role in using this form of AI. Ontologies are methods for mode modeling of reasoning domains required for digital fields instantiated in Digital System Models (DSM). They grow as digital twins and evolve with the physical instantiations of a DSM over time. Semantic innovations and ontologies codify knowledge of systems engineering as a prerequisite for reasoning using interoperable ontologies. This chapter explores the technologies behind advanced analytics and how they can be leveraged in a knowledge-driven cognitive environment. Advanced analytics help gaining deeper insights and predict outcomes more accurately and insightfully.&nbsp;<br>]]></description> </item><item><title><![CDATA[Polymer Composites for Energy Storage Application]]></title><link>https://www.benthamscience.comchapter/20048</link><description><![CDATA[The chapter discusses the role and application of polymers (polymers and composites) in energy storage devices. Lithium-ion batteries and supercapacitors are the two main energy storage intermittents. The chapter underscores the utilization of polymers in various roles in these devices and their effect on performance, in addition to related future aspects and expectations.<br>]]></description> </item><item><title><![CDATA[Nano-cosmetics and Nano-medicines]]></title><link>https://www.benthamscience.comchapter/20004</link><description><![CDATA[In today’s fast-moving scenario, nanotechnology has already spread its wings to nanocosmetics and nanomedicines due to the wide range of physical and chemical properties associated with nanoparticles. Different types of nanoparticles, like nanoliposomes, fullerenes, solid lipid nanoparticles etc., have made their entrance into the nanocosmetic industry. However, the safety concern of nanoparticles has forced the cosmetic industry to limit their applications. The pharmaceutical industry has explored the benefits of nanotechnology; it has developed dendrimers, micelles, drug conjugates, metallic nanoparticles etc. The brief explanation of these nanoparticles provides a salient glimpse of why they are used in nano pharmaceutical and medicinal chemistry. • Metallic nanoparticles: Used for drug delivery, cancer treatment, and also in biosensors. • Nano-liposomes: Bio-compatible and possess entrapment efficiency. • Nano-emulsions: Used for controlled delivery of bioactive materials.&nbsp;<br>]]></description> </item><item><title><![CDATA[Chromosome X]]></title><link>https://www.benthamscience.comchapter/19986</link><description><![CDATA[X Chromosome is the sex chromosome that is found in many organisms. Both males and females, including mammalians, have X Chromosomes. Females have XX sets of chromosomes, and males have XY sets of chromosomes. X Chromosome aids in identifying the sex of the organism. The Human X chromosome contains approximately 1500 genes. These genes may undergo some genetic alterations and eventually lead to complex diseases. Genetic mutations in some of the genes of the X chromosome are associated with cancer. Some specific mutations are observed in human cancer cells. This chapter specifically relayed on X chromosomal genes that are associated with different types of cancer and gave information on the location of the gene in the X chromosome. Moreover, the function of the specific gene and information regarding how many types of cancers were associated with a particular gene, has also been provided.<br>]]></description> </item><item><title><![CDATA[Application of Dincharya, Rutucharya and Yoga for the Prevention and Management of Cancer]]></title><link>https://www.benthamscience.comchapter/19890</link><description><![CDATA[Cancer is a group of diseases having an uncontrolled unregulated division of abnormal cells that tend to spread to all other parts of the body. It is observed that about 80-90 percent of the causes of cancer include unhealthy diet, behavioral habits, and environmental factors that can be prevented. Cancer is not described in Ayurveda, but in Brihatatrayi, there is a description of Granthi and Arbuda, which can be correlated with cancer due to the similarity in nature and clinical course. In Ayurveda, there are three major causes of any ailment: Kala Parinam, Pragyaparadha, and AsatmendriyarthaSamyoga. All of this can be prevented by adopting a healthy lifestyle. Hence there is a need to focus on a healthy lifestyle to manage and prevent cancer. Concept of Primordial prevention: The holistic approaches of Swasthavritta like Healthy dietary and behavioral habits, Dincharya, Ritucharya, not restraining nonsuppressible urges and holding suppressible desires, Good conduct, Yoga, Pranayama, Meditation, and Shatkarma purifying procedures, all come under primordial prevention. This is the prevention of the risk factors by optimizing lifestyles associated with cancer by following the holistic principles of Ayurveda. Various research studies also proved that these principles of Ayurveda are helpful in the prevention and recovery of cancer patients. On the basis of the conclusion from the literature and available research on cancer, it can be said that adopting the holistic principles of Ayurveda is beneficial in preventing the risk of various types of cancers.&nbsp;<br>]]></description> </item><item><title><![CDATA[Use of Genomics in the Diagnosis and Treatment of Livestock and Animal Diseases]]></title><link>https://www.benthamscience.comchapter/19876</link><description><![CDATA[The use of biotechnology has proved to be a key factor in handling different livestock problems. Many issues have proved to be silent killers, and their appropriate diagnosis and treatment are the need of the hour. Advancement in biotechnology and genomics is being used in preventive and clinical medicine, production of recombinant biotechnology-derived vaccines, molecular gene cloning, application of polymerase chain reaction (PCR), Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), Real-time polymerase chain reaction (RT-PCR), gene therapy and many more. This chapter will cover the use of genomics and biotechnology in veterinary medicine. <br>]]></description> </item><item><title><![CDATA[Subject Index]]></title><link>https://www.benthamscience.comchapter/19860</link><description><![CDATA[]]></description> </item><item><title><![CDATA[Current Trends and Future Perspective of Skin-Based Tissue Engineering]]></title><link>https://www.benthamscience.comchapter/19839</link><description><![CDATA[The skin regulates several important physiological processes which have a significant clinical influence on wound healing. Tissue-engineered substitutes may be used to help patients with skin damage to regenerate their epidermis and dermis. Skin replacements are also gaining popularity in the cosmetics and pharmaceutical sectors as a viable alternative to animal models for product testing. Recent biomedical advances, ranging from cellular-level therapies like mesenchymal stem cell or growth factor delivery to large-scale biofabrication techniques like 3D printing, have enabled the use of novel strategies and biomaterials to mimic the biological, architectural, and functional complexity of native skin. This chapter elaborates on some of the most recent methods of skin regeneration and biofabrication that use tissue engineering techniques. Current problems in manufacturing multilayered skin are discussed, as well as opinions on attempts and methods to overcome such constraints. Commercially accessible skin substitute technologies are also investigated, as an effort to mimic native physiology, the function of regulatory authorities in facilitating translation, and current clinical requirements. Tissue engineering may be used to develop better skin replacements for in vitro testing and clinical applications by addressing each of these viewpoints.<br>]]></description> </item><item><title><![CDATA[Injectable In Situ Hydrogels for Regenerative Medicine Applications]]></title><link>https://www.benthamscience.comchapter/19834</link><description><![CDATA[Regenerative medicine (RM) is a field of study that helps repair or restore native tissue function which has lost its functionality due to chronic diseases and trauma. The regeneration process can be promoted by constructing biomimetic systems, which can support cellular growth and proliferation. In this regard, the development of injectable hydrogels has gained enormous attention in recent times. An arrangement of cells and bioactive molecules in the three-dimensional extracellular matrix created by injectable gels is favorable for the regeneration of damaged tissues. Ideally, the injectable hydrogel remains in the solution form before injection and rapidly undergoes gelation at the physiological condition. A high water content, mechanical strength, scope of improved functionalization, injectability, and ease of implantation make the injectable hydrogel an ideal candidate for tissue-specific repair. This chapter aims to concisely summarize the mechanism and recent fabrication advancement of the injectable hydrogel that is being used in RM applications. A vast number of injectable hydrogels have been discovered for bone, cartilage, skin, and cardiovascular tissue regeneration, which are discussed in detail in the chapter. In gist, it is expected that injectable hydrogels will become a promising tool for a variety of tissue repair applications shortly.<br>]]></description> </item><item><title><![CDATA[A Comprehensive Review on Anticancer and Antitumor Potentials of Indigenous Plants Found in North East India]]></title><link>https://www.benthamscience.comchapter/19825</link><description><![CDATA[Cancer is a malign disease that accounts for about 9.6 million deaths around the world and is the second largest leading cause of death after cardiovascular disease. Chemotherapeutic drugs administered to treat cancer show great potency but falter, causing many severe side effects. Hence, the paradigm of cancer drug research has shifted towards plant and plant-derived natural compounds as they are reported to deliver maximal effectiveness with lesser side effects. Indigenous plants and their derivatives have been an integral part of ethnomedicine in India. The traditional knowledge of utilizing medicinal plants has been used to treat numerous metabolic disorders and diseases since immemorial. Indigenous plants have also been shown to possess high potency in the treatment of cancer as well. The natural landscape of northeast India has some of the most diverse and unique plant species, which have been traditionally used in ethnomedicine and have been studied for their anticancer and antitumor potentials. The aim of the present review is to highlight some of the natural and indigenous plant species of Northeast India that have been reported to have anticancer and anti-tumor effects identified either in-vivo or in-vitro.<br>]]></description> </item><item><title><![CDATA[Exploring the Traditional System of Medicine With Special Emphasis on the Indigenous Practice of Herbal Remedy by the Tribals of North-East India]]></title><link>https://www.benthamscience.comchapter/19816</link><description><![CDATA[The tribal people of India consider North-East India to be a hotspot. It contains eight states: Arunachal Pradesh, Assam, Manipur, Mizoram, Meghalaya, Nagaland, Tripura and Sikkim, and it borders international boundaries with Bhutan, Tibet, China, Burma and Bangladesh. The Indo-Burma biodiversity hotspot, which is home to a broad spectrum of unusual flora, fauna and microorganisms, is located in the Northeast Region. The region has the evergreen forest of the Brahmaputra River valley, wide leaf forest, dense bamboo and pine forest and the world's wettest location (Cherrapunji and Mawsynram), all of which help to maintain the region's unique biodiversity. North East region is the inhabitant of more than 145 significant tribal communities with the most dominating primitive societies, including the Abor, Mishing, Rabha, Khasi, Kuki, Naga, Meitei, Apatani, etc. Most of these communities are culturally and linguistically diverse. The NER's tribal population is literate compared to other parts of the country, and it's worth noting that the literacy rates in Mizoram, Meghalaya, Nagaland, Sikkim and Manipur are all higher than the national average. Despite their high literacy rate, India's North-Eastern states continue to have poor transportation, power and medical services. The healthcare system is in bad shape, with only a few hospitals and nursing homes. As a result, the people residing in this area rely exclusively on a traditional system of medicines made by traditional healers from plants, animals and mineral resources. It was stated that medicinal herbs are prepared using traditional methods, such as maceration, decoction, and infusion, either alone or in combination with other plants. The key species of medicinal plants often employed by the traditional healers of the region are Acorus calamus, Aegle marmelos, Asparagus racemosus, Averrhoa carambola, Bryophyllum calycinum, Costus speciosus, Euphorbia neriifolia, Justicia adhatoda, Melia azadarachta, Plumeria acutifolia, Sida cordifolia, Sida rhombifolia and Swertia chirata. This extensive work will aid the researcher in locating previously unknown medicinal plants in order to build a new therapeutic method for isolating new chemical entities that are safe, pharmacologically active, and cost-effective.&nbsp;<br>]]></description> </item><item><title><![CDATA[Subject Index]]></title><link>https://www.benthamscience.comchapter/19801</link><description><![CDATA[]]></description> </item><item><title><![CDATA[Bite Marks: A Pragmatic Approach in Identification]]></title><link>https://www.benthamscience.comchapter/19800</link><description><![CDATA[Teeth can be used as a weapon when an individual tries to harm another, or can be used by the victim attempting to protect themselves from an attacker. Bite marks are a clinical representation of intraoral structures (tooth and other soft tissues) on any object by an animal or human. Bite mark assessment can play a critical role in the identification of persons in forensic-related cases. Bite marks are usually found in various crime scenes, such as sexual assault, rape, murder, cases of child abuse and during sports activities. This chapter reviews the basics of the bite mark pattern, characteristics, and significance of bite marks in forensic science to solve crimes.<br>]]></description> </item><item><title><![CDATA[Oral Autobiography: A New Paradigm for Identification]]></title><link>https://www.benthamscience.comchapter/19799</link><description><![CDATA[&nbsp;Identity is central to an individual’s personality and his/her existence. The face is synonymous with identity. Identity needs to be proven in daily life transactions for security reasons. Identity (be it of the victim or the suspect) is also a paramount investigative question for which the answer is not straightforward. The orofacial region is packed with individualistic information ready to be explored in different areas, such as disasters, crimes, civil matters, and access to property (biometrics). The orofacial structures offer diverse solutions to the common questions of identity. The choice of a specific technique is governed by the circumstances that call for identification and the advantages-disadvantages of the technique.&nbsp;<br>]]></description> </item><item><title><![CDATA[Plant Cardenolides: Multifunctional Medicinal Agents]]></title><link>https://www.benthamscience.comchapter/19784</link><description><![CDATA[Cardenolides are a class of compounds steroidal in nature, belonging to the cardiac glycoside group of secondary metabolites. They consist of a sugar part and a non-sugar part consisting of a steroidal cyclopentanoperhydrophenanthrene ring with lactone substitution at the β-17 position. Cardenolides are found in angiosperm plant families like Plantiginaceae, Asclepiadaceae, Apocynaceae, Brassicaceae, Cruciferae, Liliaceae, Moraceae, Ranunculaceae, and Scrophulariaceae. These include some important glycosides, such as digitoxin, digoxin, Ouabain, Calotropin, etc. with profound pharmacological potential. Moreover, cardenolides have toxic effects for which these have been used in poison arrows and for self-harm purposes. Traditionally, these were used to treat congestive heart failure. However, recently they have emerged as promising agents to exhibit anticancer, antiviral, anti-inflammatory, neuroprotective, and various other therapeutic roles. Cardenolides like Digoxin and Digitoxin have been used in the treatment of heart failure and atrial fibrillation. Toxicarioside A, and Calotropin have been reported to suppress tumor growth and are used as anticancer agents, Strophalloside and Oubain are reported to be involved in apoptosis. Oleandrin is an antiproliferative agent and can inhibit IL-8 which is responsible for cystic fibrosis.<br>]]></description> </item><item><title><![CDATA[Chromosome 8]]></title><link>https://www.benthamscience.comchapter/19707</link><description><![CDATA[Chromosome 8 spans more than 146 million DNA base pairs, and represents between 4.5 and 5 percent of the total DNA in cells. Sixteen percent of these genes and their mutations have been identified to play a role in cancer development. Cancer is a genetic disease at the somatic cell level. Multiple gene mutations usually precede them throughout one’s life. Oncogenes such as Myc, Lyn, Atad2, etc., from chromosome 8 promoted cancer cell proliferation, invasion, and migration. The increased expression of these proteins can transform a normal cell into a cancer cell. Chromosome 8 also houses multiple tumor suppressor genes, such as Dlc1, E2f5, Gata4, Ido1, etc. These proteins, when expressed, reduce the chances of tumor initiation within cells. Thus, mutations leading to the reduced expression of these genes are associated with multiple cancers. Mutation of other functional genes like Ank1, Ctsb, Ext1, Il7, etc., has also been implicated in various cancers for their role in increasing the invasive nature of cancers by regulating angiogenesis and facilitating cancer metastasis. Cancers can also stem from the translocational mutations of genes in chromosome 8. This chapter explains essential cancer genes, genetic mutations, and gene variations that can cause an increased risk of cancer and its progression.<br>]]></description> </item><item><title><![CDATA[Ionic Liquids in Decontamination of Toxic Metals Impurities]]></title><link>https://www.benthamscience.comchapter/19635</link><description><![CDATA[The wide use of noxious and non-degradable metals due to industrialization has become a major factor in rising health concerns. Diseases associated may involve cardiovascular disorders, brain damage, cancer, etc., and this leads to the development of certain methods for the sole purpose of cleaning water, soil, air, etc., to remove metals categorized as toxic ones. Ionic liquids with remarkable thermal stability, association ability, exhibiting low vapour emission, etc., are considered eco-friendly for the decontamination of toxic metal impurities. These ionic liquids involve certain modes of interactions like an electrostatic, dipole, van der Waals, etc., for the effective separation and extraction of metals. Also, the property of reusability associated with ionic liquids makes them be used on a wide scale.<br>]]></description> </item><item><title><![CDATA[Probiotics as Potential Remedy for Restoration of Gut Microbiome and Mitigation of Polycystic Ovarian Syndrome]]></title><link>https://www.benthamscience.comchapter/19569</link><description><![CDATA[Polycystic ovarian syndrome (PCOS) is the most frequent endocrine disorder currently plaguing women. There are many factors associated with high androgenicity in the female body. Dysbiosis of gut microbiota may be one of the primary reasons that initiate PCOS. Emerging evidence suggests that some plastics, pesticides, synthetic fertilizers, electronic waste, food additives, and artificial hormones that release endocrine-disrupting chemicals (EDCs) cause microbial Dysbiosis. It is reported that the permeability of the gut is increased due to an increase of some Gram-negative bacteria. It helps to promote the lipopolysaccharides (LPS) from the gut lumen to enter the systemic circulation resulting in inflammation. Due to inflammation, insulin receptors' impaired activity may result in insulin resistance (IR), which could be a possible pathogenic factor in PCOS development. Good bacteria produce short-chain fatty acids (SCFAs), and these SCFAs have been reported to increase the development of Mucin-2 (MUC-2) mucin in colonic mucosal cells and prevent the passage of bacteria. Probiotic supplementation for PCOS patients enhances many biochemical pathways with beneficial effects on changing the colonic bacterial balance. This way of applying probiotics in the modulation of the gut microbiome could be a potential therapy for PCOS.<br>]]></description> </item><item><title><![CDATA[Activity Methods for Endometriosis]]></title><link>https://www.benthamscience.comchapter/19560</link><description><![CDATA[Endometriosis is an estrogen-dependent disease that causes pelvic pain and reduces fertility by developing inflammatory lesions outside the uterine. Although many studies have been performed to investigate the etiopathogenesis of endometriosis, there is still no direct evidence. Endometriosis, a common gynecological disease, often recurs even if treated. In vivo studies are used to investigate its etiopathogenesis and potential treatment methods. Hormonal therapy is generally used for endometriosis cases. This conventional therapy aims to lower estrogen levels in the body, however, it can be inadequate for the treatment and has numerous negative effects. The urgency of finding novel and cheap long-term safety therapies for endometriosis is highlighted by the need to manage it as a chronic disease. Medicinal plants and natural plant-derived compounds are interesting options for this purpose. Indeed, there is an increasing interest in using herbal therapy to treat endometriosis. Several studies have been conducted on natural products to find a drug candidate for the management of the mentioned problem. Many of these drugs have a pleiotropic action profile, meaning they block multiple processes involved in endometriosis pathogenesis, including proliferation, inflammation, reactive oxygen species (ROS) production, and angiogenesis. As a result, including them in multimodal treatment approaches may help to improve therapeutic efficiency and reduce adverse effects in future endometriosis treatments. Several methods have been described for the assessment of the potential effectiveness of the bioactive agents against endometriosis. In the present chapter, we aimed to give general information regarding endometriosis, the use of plant products in the treatment of this disease, and the methods that have been used for the activity investigation.<br>]]></description> </item><item><title><![CDATA[Microbial Indicators for Environmental Pollution]]></title><link>https://www.benthamscience.comchapter/19538</link><description><![CDATA[Environmental pollution has become a serious issue of concern across the world. Intensive agriculture, industrialization, and consumerism have resulted in the degradation of environmental quality. The presence of pollutants like fertilizers, pesticides, persistent organic pollutants (PoPs), polyaromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), heavy metals, synthetic dyes, etc. have not only polluted soil, air, and water but also invaded the food-chain via bioaccumulation and biomagnification, and have emerged as potential threats to various organisms including humans. Several organisms, including plants, animals, and microbes, indicate the presence of contaminants and environmental pollution. Among these, microbes have emerged as one of the potential indicators of environmental pollution, as they are more sensitive to trace levels of pollutants than plants/ animals/other organisms. The natural abundance of these indicator microbes has given us an opportunity to monitor environmental pollution before any major undesirable accidents occur. Based on these microbial indicators, various easy and rapid biosensors have been developed to monitor environmental pollution. Microbial indicators are the treasures of nature that have immense potential to monitor and predict environmental quality for society's safe and sustainable development.&nbsp;<br>]]></description> </item><item><title><![CDATA[Innovative Approaches to Prosthetics and Implants]]></title><link>https://www.benthamscience.comchapter/19503</link><description><![CDATA[The use of prosthesis plays an important role in rehabilitation in the case of congenital absence or loss of an extremity. Apart from lower and upper extremity prostheses, there is a wide variety of prostheses used in different parts of the body. Unlike limb prostheses, these are permanently placed in the body by surgical intervention and are also called implants. New studies emerge every day in the development of innovative prostheses and implants. These innovations include material selection, new material development, control strategies, feedback system development, sensor and actuator development, power supply methods, and power equipment development work. Besides, many studies aim to increase user comfort as well as acceptance rate and the useful life of prostheses. Some researchers are working to develop prostheses exclusively for the use of children. Innovative developments in prostheses and implants are examined in this section. Developments are presented from various aspects, and information is given about the research that has made significant contributions to the field. As an example of technological development in prosthetics, an autonomic tumor prosthesis developed for children with bone cancer is introduced at the end of the section as a case study.<br>]]></description> </item><item><title><![CDATA[Abnormalities of Fetal Skeleton]]></title><link>https://www.benthamscience.comchapter/19491</link><description><![CDATA[]]></description> </item></channel></rss>