<![CDATA[Dementia]]> https://www.benthamscience.com RSS Feed for Disease Wise Article | BenthamScience EurekaSelect (+http://eurekaselect.com) Tue, 19 May 2026 21:31:24 +0000 <![CDATA[Dementia]]> https://www.benthamscience.com https://www.benthamscience.com <![CDATA[<i>In Silico</i> Tools to Leverage Rational Drug Design and Development in LMICs]]>https://www.benthamscience.comchapter/23780
During the last decades, computational tools have offered interesting opportunities for Research and Development (R & D) in LMICs, since these techniques are affordable, reduce wet lab experiments in the first steps of the drug discovery process, reduce animal testing by aiding experiment design, and also provide key knowledge involving clinical data management as well as statistical analysis.

This book chapter aims to highlight different computational tools to enable early drug discovery and preclinical studies in LMICs for different pathologies, including cancer. Several strategies for drug target selection are discussed: identification, prioritization and validation of therapeutic targets; particularly focusing on high-throughput analysis of different “omics” approaches using publicly available data sets. Next, strategies to identify and optimize novel drug candidates as well as computational tools for costeffective drug repurposing are presented. In this stage, chemoinformatics is a key emerging technology. It is important to note that additional computational methods can be used to predict possible uses of identified human-aimed drugs for veterinary purposes. Application of computational tools is also possible for predicting pharmacokinetics and pharmacodynamics as well as drug-drug interactions. Drug safety is a key issue and it has a profound impact on drug discovery success. Finally, artificial intelligence (AI) has also served as a potential tool for drug design and discovery, expected to be a revolution for drug development in several diseases.

It is important to note that the development of drug discovery projects is feasible in LMICs and in silico tools are expected to potentiate novel therapeutic strategies in different diseases.

This book chapter aims to highlight different computational tools to enable early drug discovery and preclinical studies in LMICs for different pathologies, including cancer. Several strategies for drug target selection are discussed: identification, prioritization and validation of therapeutic targets; particularly focusing on high-throughput analysis of different “omics” approaches using publicly available data sets. Next, strategies to identify and optimize novel drug candidates as well as computational tools for costeffective drug repurposing are presented. In this stage, chemoinformatics is a key emerging technology. It is important to note that additional computational methods can be used to predict possible uses of identified human-aimed drugs for veterinary purposes.

Application of computational tools is also possible for predicting pharmacokinetics and pharmacodynamics as well as drug-drug interactions. Drug safety is a key issue and it has a profound impact on drug discovery success.

Finally, artificial intelligence (AI) has also served as a potential tool for drug design and discovery, expected to be a revolution for drug development in several diseases.Application of computational tools is also possible for predicting pharmacokinetics and pharmacodynamics as well as drug-drug interactions. Drug safety is a key issue and it has a profound impact on drug discovery success. Finally, artificial intelligence (AI) has also served as a potential tool for drug design and discovery, expected to be a revolution for drug development in several diseases.

 ]]> <![CDATA[List of Contributors]]>https://www.benthamscience.comchapter/23779 <![CDATA[Molecular Mechanisms Implicated with Depression and Therapeutic Intervention]]>https://www.benthamscience.comchapter/22447]]> <![CDATA[Client-Centered, Person-Centered, and Resilience-Based Approaches to Trauma-Informed Care]]>https://www.benthamscience.comchapter/22231]]> <![CDATA[Subject Index]]>https://www.benthamscience.comchapter/22215 <![CDATA[Common Surgical Procedures in Geriatric Patients]]>https://www.benthamscience.comchapter/22214]]> <![CDATA[The Geriatric COVID Patient]]>https://www.benthamscience.comchapter/22213]]> <![CDATA[Female Geriatric Patients]]>https://www.benthamscience.comchapter/22212]]> <![CDATA[Ethics and Legal Issues in Geriatric Anesthesia]]>https://www.benthamscience.comchapter/22211]]> <![CDATA[Anesthetic Considerations for Patients with Chronic Neurologic Disorders]]>https://www.benthamscience.comchapter/22209]]> <![CDATA[Geriatric Pain Patient]]>https://www.benthamscience.comchapter/22205]]> <![CDATA[Postoperative Cognitive Dysfunction (POCD) in Geriatric Patients]]>https://www.benthamscience.comchapter/22200]]> <![CDATA[Pre-Operative Evaluation and Optimization of Geriatric Patient]]>https://www.benthamscience.comchapter/22198 <![CDATA[Genome Editing Against Bacterial Plant Pathogens]]>https://www.benthamscience.comchapter/22110]]> <![CDATA[Future Perspective of Aromatherapy in Skin and Cancer Therapeutics]]>https://www.benthamscience.comchapter/22105]]> <![CDATA[Essential Oils’ Biosynthesis and their Application]]>https://www.benthamscience.comchapter/22101]]> <![CDATA[Plant as Potential Resources for Efficacious Essential Oils: Underpinning Aromatherapy Evolution]]>https://www.benthamscience.comchapter/22099]]> <![CDATA[Physician-Assisted Suicide - The Ethical Insights]]>https://www.benthamscience.comchapter/22066]]> <![CDATA[Nicotine]]>https://www.benthamscience.comchapter/22011]]> <![CDATA[Alcohol]]>https://www.benthamscience.comchapter/22010]]> <![CDATA[Methamphetamine]]>https://www.benthamscience.comchapter/22006]]> <![CDATA[Heroin and its Effects on the Brain]]>https://www.benthamscience.comchapter/22003]]> <![CDATA[Pathogenesis of Atherosclerosis and Coronary Heart Disease: Epidemiology, Diagnostic Biomarkers and Prevention by Nutraceuticals, Functional Foods, and Plant-Derived Therapies]]>https://www.benthamscience.comchapter/21850]]> <![CDATA[Oxidative Stress and Protein Misfolding in Skin Aging]]>https://www.benthamscience.comchapter/21845]]> <![CDATA[Food Color, Taste, Smell, Culinary Plate, Flavor, Locale, and their Impact on Nutrition: Present and Future Multisensory Food Augmentation and Noncommunicable Disease Prevention: An Overview]]>https://www.benthamscience.comchapter/21844]]> <![CDATA[Human Diseases and Recent Biotechnology Breakthroughs in Curbing Diseases]]>https://www.benthamscience.comchapter/21755]]> <![CDATA[Drug Repurposing in CNS and Clinical Trials: Recent Achievements and Perspectives Focusing on Epilepsy and Related Comorbidities]]>https://www.benthamscience.comchapter/21743]]> <![CDATA[Role of Gut Microbiota in Neuroinflammation and Neurological Disorders]]>https://www.benthamscience.comchapter/21741]]> <![CDATA[Recent Drugs Tested in Clinical Trials for Alzheimer´s and Parkinson´s Diseases Treatment: Current Approaches in Tracking New Drugs]]>https://www.benthamscience.comchapter/21739]]> <![CDATA[Prognosis of Dementia using Machine Learning]]>https://www.benthamscience.comchapter/21730]]> <![CDATA[Preface]]>https://www.benthamscience.comchapter/21722 <![CDATA[Biomaterials and Mesenchymal Stem Cells]]>https://www.benthamscience.comchapter/21645]]> <![CDATA[The Role of Emerging Technologies in Smart Health Care]]>https://www.benthamscience.comchapter/21612]]> <![CDATA[Promising Pharmaceutical Compounds of Marine Cnidarians: Their Chemistry and Therapeutic Applications]]>https://www.benthamscience.comchapter/21598]]> <![CDATA[Moringa oleifera Lam.: An Updated Review on Micropropagation and Pharmacological Properties]]>https://www.benthamscience.comchapter/21563]]> <![CDATA[Hormoneal Therapy]]>https://www.benthamscience.comchapter/21551
• Define and classify hormonal therapy and differentiate between hormonal therapy and treatment.

• Explain all types of hormone replacement therapy including menopausal, androgens, and oral contraceptives.

 • Discuss the use of androgen replacement therapy (ART) in males with low levels of testosterone due to disease or aging.

• Describe gender-affirming hormone therapy such as feminizing hormone therapy and masculinizing hormone therapy. • Identify appropriate growth hormone therapy for growth hormone deficiency.

• Demonstrate understanding of thyroid hormone replacement in hypothyroidism and antithyroid therapy in hyperthyroidism.

• Demonstrate clear guidance to the use of oral contraceptive pills for various purposes including birth control. 
]]> <![CDATA[Animal Models of Alzheimer's Disease]]>https://www.benthamscience.comchapter/21465]]> <![CDATA[Diagnosis and Potential Strategies to Discover New Drugs for the Treatment of Alzheimer’s Disease (AD)]]>https://www.benthamscience.comchapter/21420
Therapy of AD includes inhibitors of choline esterases, and antagonists at NMDA receptors. From the studies it is shown that these drugs just offer relief from symptoms rather than alleviating the progression of disease. Multiple pathological processes contribute for AD, like oxidative stress, dysregulation of neurotransmitters, inflammation of neurons, aggregation β-amyloid, phosphorylation of tau protein. It is essential to target multiple causes for an effective outcome in the treatment of AD. Early diagnosis is also crucial as it reduces disease progression thereby cost involved in AD therapy.

This review focuses on non-invasive, patient affordable diagnosis methods and also potential targets to discover new drugs beyond conventional and available drugs.
]]> <![CDATA[Novel Treatment for Alzheimer’s Disease: Tapping the Somatostatin-evoked Aβ Catabolism via α-endosulfine-K<sub>ATP</sub> Channel Pathway]]>https://www.benthamscience.comchapter/21419]]> <![CDATA[Effects of Carbonic Anhydrase Inhibitors on Mitochondrial Dysfunction and Consequently on Alzheimer’s Disease]]>https://www.benthamscience.comchapter/21418]]> <![CDATA[Promising Nano-Carriers-Based Targeted Drug Delivery Approaches for the Effective Treatment of Alzheimer’s Disease]]>https://www.benthamscience.comchapter/21417]]> <![CDATA[Tau Protein: Targets And Development Against Alzheimer’s Disease]]>https://www.benthamscience.comchapter/21416]]> <![CDATA[Enzymatic Targets for Drug Discovery Against Alzheimer's Disease]]>https://www.benthamscience.comchapter/21415]]> <![CDATA[Memantine and Glutamate Antagonists in the Treatment of Alzheimer's Disease: Current Updates]]>https://www.benthamscience.comchapter/21414]]> <![CDATA[Tubulin Modifying Enzymes as Target for the Treatment of Alzheimer's Disease: Old Perspective With A New Angle]]>https://www.benthamscience.comchapter/21413]]> <![CDATA[TMP21 in Alzheimer’s Disease: An Important Target For Effective Treatment Approach]]>https://www.benthamscience.comchapter/21412]]> <![CDATA[Recent Advances In Tacrine-Based Anti-Alzheimer’s Drug Design]]>https://www.benthamscience.comchapter/21411]]> <![CDATA[Epigenetics of Alzheimer’s Disease: Past, Present and Future]]>https://www.benthamscience.comchapter/21410]]> <![CDATA[An Overview of In Vivo Imaging Techniques]]>https://www.benthamscience.comchapter/21377]]> <![CDATA[OCT-A Findings and Usefulness in Alzheimer's Disease, Parkinson's Disease, and Systemic Lupus Erythematosus]]>https://www.benthamscience.comchapter/21361]]> <![CDATA[Applications of AI-enabled Robotics in Healthcare]]>https://www.benthamscience.comchapter/21302]]> <![CDATA[Geofencing For Elderly]]>https://www.benthamscience.comchapter/21299]]> <![CDATA[Neurological Examination]]>https://www.benthamscience.comchapter/20987]]> <![CDATA[The Place of Mature Drugs in COVID-19 Era]]>https://www.benthamscience.comchapter/20887]]> <![CDATA[Machine Learning Techniques in Image Segmentation]]>https://www.benthamscience.comchapter/20825]]> <![CDATA[Narrative Review of Mobile Technology: Evidence from Older Adults]]>https://www.benthamscience.comchapter/20799]]> <![CDATA[The Adoption of Mobile App for the Elderly in the 21st Century]]>https://www.benthamscience.comchapter/20798]]> <![CDATA[Dietary Patterns and Rheumatoid Arthritis]]>https://www.benthamscience.comchapter/20768]]> <![CDATA[The Traditional Immune Boosting Recipes]]>https://www.benthamscience.comchapter/20696]]> <![CDATA[Biological Functions of Elements of Main Groups]]>https://www.benthamscience.comchapter/20659 <![CDATA[Fast Foods: Chemical Composition and Implications for Health]]>https://www.benthamscience.comchapter/20639]]> <![CDATA[Role of Dental Chairside Assistant in Minor Surgery]]>https://www.benthamscience.comchapter/20506]]> <![CDATA[Breast Cancer Detection Using Machine Learning Concepts]]>https://www.benthamscience.comchapter/20404]]> <![CDATA[Role of Artificial Intelligence in Healthcare Management]]>https://www.benthamscience.comchapter/20312]]> <![CDATA[Biosensors for Neurodegenerative Diseases]]>https://www.benthamscience.comchapter/20269]]> <![CDATA[Theranostics Micelles for Brain Tumor Diagnosis and Treatment]]>https://www.benthamscience.comchapter/20167]]> <![CDATA[Barriers to Targeted Drug Delivery Strategies in Brain]]>https://www.benthamscience.comchapter/20162]]> <![CDATA[Role of Functional Foods in the Amelioration of Alzheimer's and Related Diseases]]>https://www.benthamscience.comchapter/20142]]> <![CDATA[Chromenes and Nutraceuticals]]>https://www.benthamscience.comchapter/19916]]> <![CDATA[Sterols, Carotenoid and Polyprenols]]>https://www.benthamscience.comchapter/19857]]> <![CDATA[A Comprehensive Overview of Estrogen: Physiological and Pathological Insights]]>https://www.benthamscience.comchapter/19783]]> <![CDATA[Terpenes, Terpenoids and Steroids: Properties, Biosynthesis and Functions]]>https://www.benthamscience.comchapter/19778]]> <![CDATA[Prevention of Reperfusion Injury in Acute Myocardial Infarction: A “flashback” Journey of Novel Strategies Based on the Potential Therapeutic Role of Antioxidants]]>https://www.benthamscience.comchapter/19773]]> <![CDATA[The Emerging Role of Microbiome in Cardiovascular Diseases]]>https://www.benthamscience.comchapter/19771]]> <![CDATA[Natural Immunomodulators for Infections and Other Diseases]]>https://www.benthamscience.comchapter/19255]]> <![CDATA[A Survey on Brain-Computer Interface and Related Applications]]>https://www.benthamscience.comchapter/19213]]> <![CDATA[Alzheimer’s Disease and Physical Activity, Will the Symptoms Improve?]]>https://www.benthamscience.comchapter/19181]]> <![CDATA[Phytosome for Targeted Delivery of Natural Compounds: Improving Efficacy, Bioavailability, and Delivery across BBB for the Treatment of Alzheimer's Disease]]>https://www.benthamscience.comchapter/19180]]> <![CDATA[Neuroprotective Activities of Cinnamic Acids and their Derivatives]]>https://www.benthamscience.comchapter/19179]]> <![CDATA[Multi-functional Ligands and Molecular Hybridization: Conceptual Aspects and Application in the Innovative Design of Drug Candidate Prototypes for Neurodegenerative Diseases]]>https://www.benthamscience.comchapter/19177]]> <![CDATA[Classification and Diagnosis of Alzheimer’s Disease using Magnetic Resonance Imaging]]>https://www.benthamscience.comchapter/19048]]> <![CDATA[Feature Extraction and Diagnosis of Dementia using Magnetic Resonance Imaging]]>https://www.benthamscience.comchapter/19041]]> <![CDATA[Taurine and the Mitochondrion]]>https://www.benthamscience.comchapter/18973]]> <![CDATA[Molar Incisor Hypoplasia (MIH)]]>https://www.benthamscience.comchapter/18941]]> <![CDATA[Assistive Technology for Home Comfort and Care]]>https://www.benthamscience.comchapter/18851]]> <![CDATA[Overview, Category and Ontology of Assistive Devices]]>https://www.benthamscience.comchapter/18848]]> <![CDATA[Subject Index]]>https://www.benthamscience.comchapter/18847 <![CDATA[Subject Index]]>https://www.benthamscience.comchapter/18785 <![CDATA[Neuroprotective Effect of Natural Products in Attenuation of Aging-associated Neurodegeneration]]>https://www.benthamscience.comchapter/18784]]> <![CDATA[Natural Herbs Polishing Memory: Neuroprotection against Alzheimer's Disease]]>https://www.benthamscience.comchapter/18783]]> <![CDATA[Neuroprotective Effects of Berberine in Neurodegenerative and Neuropsychiatric Disorders]]>https://www.benthamscience.comchapter/18780]]> <![CDATA[Tinospora cordifolia in Neurodegeneration: A Strong Antioxidant and Anti-inflammatory Phytotherapeutic Drug Candidate]]>https://www.benthamscience.comchapter/18775]]> <![CDATA[Neuroprotective Role of Medicinal Plants from North Eastern Region of India]]>https://www.benthamscience.comchapter/18774]]> <![CDATA[Delineating the Neuroinflammatory Crosstalk in Neurodegeneration and Probing the Near Future Therapeutics]]>https://www.benthamscience.comchapter/18771]]> <![CDATA[Sleep Medicine in Hong Kong – Development, Knowledge Gaps and Future Challenges]]>https://www.benthamscience.comchapter/18691]]> <![CDATA[Nanomedicine Technology Trends in Pharmacology]]>https://www.benthamscience.comchapter/18649]]> <![CDATA[Smart Wearable Sensor Design Techniques For Mobile Health Care Solutions]]>https://www.benthamscience.comchapter/18638]]> <![CDATA[Subject Index]]>https://www.benthamscience.comchapter/18609 <![CDATA[Health Promoting Properties of Grewia asiatica and Grewia tenax Berries: A Potential Role in Cancer, Diabetes, and Liver Diseases Prevention]]>https://www.benthamscience.comchapter/18602]]> <![CDATA[Himalayan Herbs: A Promising Medication Source for Neurodegenerative Diseases]]>https://www.benthamscience.comchapter/18600
Progressive loss of nerve cells/neurons in terms of structure and function is termed neurodegeneration. Selective loss of neurons leads to nervous disorders referred to as Neurodegenerative disorders/diseases, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, etc., are some of the major health issues suffered by individuals in the current situation. Plant-derived bioactive molecules or phytomedicines have been in practice for many years and have been found to be effective in managing/treating these disorders.

This chapter aims at highlighting some of the Himalayan herbs, which exhibit a promising role in managing neurodegenerative diseases. For example, Acorus calamus is well known for its brain rejuvenating ability. It has been found that A. calamus possesses neuroprotective activity against stroke. Asparagus racemosus, known for its anti-aging activity, has been observed to protect the brain from oxidative damage, thereby preventing neurodegenerative diseases. Calotropis procera is ethnomedicinally used to treat mental disorders. Sida cordifolia, another perennial shrub found in the Himalayan region used for treating many ailments related to the respiratory system is also used for treating patients suffering from Parkinson’s disease. There are many more plants found in the Himalayan region, which have the potential for treating brainrelated disorders.

The rising cases of neurodegenerative disorders need a better understanding of plants rich in neuroprotective phytochemicals. Plants are one of the promising medication sources with the least side effects, which will help in providing an ethnopharmacological aspect and managing/treating neurodegenerative disorders. 
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