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Fused Bis-lactams to Spirolactams: A New Member of the Family of Ring- Contraction Reaction NEWS RELEASE: 13-01-2019

The article by Isabelle Parrot and colleagues is published in Letters in Organic Chemistry, Volume 15, Issue 12, 2018

Researchers from the University of Montpellier have worked on a process for a new ring contraction of fused bis-lactams, which converts them into spirolactams. The team performed a clean conversion of some fused bicycles into spirocycles with good yields, in the presence of a triflate catalyst in various solvents under microwave irradiation. The method involves the use of activated 2,5-diketopiperazines as starting materials and demonstrates the wide range of applications of ring contraction reactions.

The article can be obtained from the following link:

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