Cell Biology: Basics to Breakthroughs

Golgi Apparatus: Shaping and Shipping Cellular Proteins

Author(s): S. Sahasra, Sanjana Dhayalan, K. Kumaran and K. N. Aruljothi *

Pp: 61-76 (16)

DOI: 10.2174/9798898812430125010009

* (Excluding Mailing and Handling)

Abstract

The Golgi body is an organelle in charge of altering proteins and lipids after translation and getting them ready for transport to spots within and outside the cell. This part of our study investigates its makeup, focusing on three key sections— cis side, middle section, and trans side, and how they contribute to sugar attachment to proteins, lipid processing, and protein arrangement. Furthermore, the chapter discusses how it plays a role in cell functions like secretion and creating lysosomes, and its impact on diseases like neurodegenerative conditions, infections, and cancer. It also covers progress in treatments and research related to the Golgi apparatus, including its involvement in the dynamics of COVID-19.


Keywords: Cancer, Cisternae, COVID-19, Golgi Apparatus, Lysosome Formation, Neurodegenerative Diseases, Phosphorylation, Post-Translational Modification, Protein Sorting, RAB GTPase, Sphingomyelin, TGN (Trans Golgi Network), Α-Synuclein.