Quinones: A Privileged Moiety for Drug Discovery

Recent Study on Quinone Derivatives and their Applications

Author(s): Suryakant R. Rode and Ashutosh Kumar Dash *

Pp: 228-247 (20)

DOI: 10.2174/9798898810276125010012

* (Excluding Mailing and Handling)

Abstract

Quinone and its derivatives have manifold applications in pharmaceutical industries. In this chapter, we look over the current practices of quinones and their derivatives in several fields. Recent studies have found that quinone-enhanced humification in food waste composting is a strategy for hazard mitigation and nitrogen retention. Quinone derivatives such as diazanthraquinone dimers have been demonstrated as high-capacity organic cathode materials for rechargeable lithium batteries. Their preparation and advantage over conventional batteries have been explained. Quinone-chlorophyll conjugation synthesized by the Diels-alder approach as conformers, called atropisomers, is a recent invention. Currently, in the field of pharmacological practices, quinone and its class of molecules have demonstrated a wide range of therapeutic properties, such as anticancer, anti-inflammatory, and antibiotic. 


Keywords: Anticancer agents, Benzoquinone anthraquinone, Diel’s alder reaction, Lithium-ion batteries, Naphthoquinone, Pictet Spengler annulation, Quinone.