Quinones: A Privileged Moiety for Drug Discovery

Understanding Quinones with Reference to Biochemistry

Author(s): Adil Ali, Mohd Hasan Mujahid, Ankit Paul and Tarun Kumar Upadhyay *

Pp: 167-194 (28)

DOI: 10.2174/9798898810276125010010

* (Excluding Mailing and Handling)

Abstract

Quinones are a highly flexible group of organic molecules that are naturally present in a diverse range of organisms, such as plants, algae, bacteria, and fungi. These chemicals are also artificially produced in laboratories for diverse purposes. Quinones possess a distinctive chemical structure that allows them to get involved in redox cycling. This means they can easily switch between oxidized and reduced states, a property that underlies many of their biological and pharmacological functions. They have a crucial function in the electron transport chain in both cellular respiration and photosynthesis. They help transmit electrons, which is essential for energy production in cells. Quinones play a crucial role in cellular signaling pathways and defense mechanisms against oxidative stress due to their capacity to perform redox reactions. Quinones possess a diverse array of pharmacological properties, making them highly valuable in the field of medicine. One of the most important uses of these is in the field of anticancer treatments. Quinone-derived chemicals serve as the foundation for some of the most extensive and potent categories of anticancer medications. Their cytotoxic qualities, which allow them to cause cell death in cancer cells, are utilized in treatments for different types of malignancies. Quinones can be classified into several broad categories, including anthraquinones, benzoquinones, phenanthraquinones, and naphthoquinones. These categories consist of a wide range of molecules that have unique chemical structures and biological properties. These classes constitute the fundamental components of numerous natural and synthetic products utilized across multiple industries.


Keywords: Anticancer properties, Novel drug, Oxidative stress, Pharmacological properties, Quinones, Redox reaction.