Quinones are redox-active cyclic chemical compounds with two carbonyl
groups in a six-membered ring structure, either contiguous or apart. Quinones are a
diverse group of natural compounds that have gained attention for their
pharmacological properties. This book chapter focuses on the design and synthesis of
natural product-inspired quinone-based glycohybrids. Glycohybrids can have a broad
variety of structural and functional properties, including protein-carbohydrate
interactions that are essential for the biology of mammals and some disease states.
These glycohybrids are designed based on the structures of bioactive aryl glycosides
and quinones, aiming to enhance their binding affinity, enhanced bioavailability, high
water solubility, low toxicity, and specificity toward cancer-related protein targets. This
book chapter consistsof the literature from January 2017 to December 2023 and
provides an overview of recent developments in the chemical synthesis of glycohybrids
based on natural product scaffold of quinones.
Keywords: 1, 4-naphthoquinone, Anticancer, Antiradical, Click chemistry glycohybrids, Cytotoxicity, Glycohybrids, Natural products, Synthetic methods, Quinone.
