Medicinal Chemistry of Drugs Affecting Cardiovascular and Endocrine Systems

The Prostanoids

Author(s): M. O. Faruk Khan* and Karrie Murphy

Pp: 353-381 (29)

DOI: 10.2174/9789815179729124030011

* (Excluding Mailing and Handling)


This chapter is a comprehensive account of the medicinal chemistry of drugs arising from structural modifications of prostanoids, which are naturally occurring eicosanoids. These drugs are used for a variety of diseases including but not limited to glaucoma, pulmonary arterial hypertension, and peptic ulcers. This chapter provides the mechanism of drug action and structure-activity relationships (SAR) of these drugs. After studying this chapter, students will be able to:

• Describe the historical background of prostanoids as clinical agents.

• Explain the structure, functions, classifications and biosynthesis of eicosanoids.

• Discuss in detail the chemistry and SAR of the prostanoids involved in the treatment of glaucoma, pulmonary arterial hypertension, peptic ulcer, and other diseases.

 • Delineate the clinical significance and therapeutic evaluations of these classes of drugs by solving case studies.

• Explain the discovery process of latanoprost and zafirlukast.

Keywords: Prostaglandins, Prostacyclin, Pulmonary arterial hypertension (PAF), Glaucoma, Structure-activity relationship (SAR), Drug receptor interaction, Intraocular pressure.

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