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Frontiers in CNS Drug Discovery

Volume: 1

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Galantamine, a Natural Product for the Treatment of Alzheimer's Disease

Author(s): Luis Marco, Maria do Carmo Carreiras

Pp: 76-105 (30)

DOI: 10.2174/978160805159511001010076

* (Excluding Mailing and Handling)

Abstract

Galantamine is a natural product that has attracted the interest of a number of researchers in a collaborative effort aimed at designing novel biologically active compounds for the treatment of Alzheimer's disease. In this article we review and update the syntheses of racemic and enantiomerically pure galantamine.

Keywords: Galantamine, biogenetic-type synthesis, total synthesis, phenolic oxidative coupling, para-ortho coupling, PIFA, potassium ferricyanide, intramolecular heck reaction

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