Indopathy for Neuroprotection: Recent Advances

Role of Withania somnifera (Ashwagandha) in Neuronal Health

Author(s): Ambarish Kumar Sinha, Hagera Dilnashin, Hareram Birla and Gaurav Kumar *

Pp: 281-298 (18)

DOI: 10.2174/9789815050868122010016

* (Excluding Mailing and Handling)


 Neurodegenerative disease refers to the progressive deterioration of neurologic function which leads to loss of speech, vision, hearing, and movement. It is also associated with seizures, eating difficulties, and memory impairment. Natural products have emerged as potential neuroprotective agents for the treatment of neurodegenerative diseases due to the enormous adverse effects associated with pharmacological drugs. Withania somnifera (Ashwagandha) is a traditional Ayurvedic medicine, used in India as a general tonic. It contains withanolides, and phytochemicals that may have adaptogenic properties. Studies show that W. somnifera is a neuroprotective agent and can protect the brain from oxidative stress and inflammation. This explains its ability to protect from mood disorders. In this review, we have reviewed the available evidence of W. somnifera and its phytochemicals for neurodegenerative disorders. 

Keywords: Ayurvedic medicine, Chinese medicine, Neurological diseases, Phytochemicals, Withania somnifera.

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