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Mini-Reviews in Medicinal Chemistry

Volume 19, 20 Issues, 2019
ISSN: 1875-5607 (Online)
ISSN: 1389-5575 (Print)
This journal supports open access

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    Chemistry, Medicinal

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Co-Editors mrmc_eic_ata_001 Atta-ur-Rahman FRS Honorary Life Fellow Kings College University of Cambridge Cambridge UK Prof. Atta-ur-Rahman, Ph.D. in organic chemistry (Cambridge University, 1968), has over 1,055 international publications including 210 books. He won the UNESCO Science Prize (1999) and was elected Fellow of Royal Society (London, 2006). He was conferred honorary doctorate degrees by many universities including Cambridge University and many others. Furthermore, Prof. Atta-ur-Rahman was elected Honorary Life Fellow of Kings College, Cambridge University, and the Austrian government honoured him with its high civil award “Grosse Goldene Ehrenzeischen am Bande" (2007). He is the only scientist from the Muslim world to be Foreign Fellow (“Academician”) of Chinese and Korean Academies of Sciences. The University of Technology Mara (UiTM), Malaysia, has established “Atta-ur-Rahman Institute of Natural Product Discovery” in his honour. Prof. Atta-ur-Rahman was the Federal Minister of Science and Technology of Pakistan, and he is Chairman of UN Committee on Science, Technology and Innovation for UNESCAP region covering 62 countries. mrmc_ebm_iqbal_001 Choudhary M. Iqbal H.E.J. Research Institute of Chemistry University of Karachi Karachi Pakistan Dr. M. Iqbal Choudhary is a Distinguished National Professor of Organic Chemistry and Director at International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research). He is among the most prominent scientists of Pakistan, recognized for his original contributions in the fields of natural products and bioorganic chemistry. He has written and edited 50 books, most of which have been published in USA and Europe. He is also the author of over 900 research papers and chapters in top international science journals of the West, as well as 43 US patents. The cumulative impact factor of his publications is over 1,750. This is by far the largest number of quality publications from any scientist in Pakistan. He has been among the most cited scientists of Pakistan in last five years with citations exceeding 11,000 (h-Index: 41). mrmc_ebm_g-perry_001 Perry George College of Sciences The University of Texas at San Antonio Texas USA George Perry (born April 12, 1953 in Lompoc, California) is a neuroscientist recognized in the field of Alzheimer's disease research particularly for his work in oxidative stress. Dr. Perry has studied at many universities and holds multiple degrees including a Bachelor of Arts degree in Zoology from the University of California Santa Barbara and a PhD in Marine Biology from the Scripps Institution of Oceanography at San Diego. He is distinguished as one of the top Alzheimer’s disease researchers by Expertscape with over 1000 publications, more than 66,000 citations (H=129), one of the top 100 most-cited scientists in Neuroscience & Behavior and one of the top 25 scientists in free radical research. Dr. Perry is a Semmes Foundation Distinguished University Chair in Neurobiology and is an active participant in many other scientific associations. He is an elected member of the Academies of Sciences of Mexico, Portugal, and Spain. In addition, Perry is an Editor of numerous scientific journals including Journal of Alzheimer’s Disease which he founded in 1998. Today, Perry continues his love for research while working as Dean of the College of Sciences at The University of Texas at San Antonio. Associate Editors mrmc_ebm_david_001 David Lee Y.-W. Harvard Medical School Belmont MA USA Dr. Lee has worked on numerous drug discovery projects related to traditional Chinese medicine, contributing significantly to the development of alternative therapies for substance abuse and for osteoarthritis. He is the principal investigator on “Alternative Therapies for Alcohol and Drug Abuse,” a program project grant funded by the National Institutes of Health. Dr. Lee and his colleagues at McLean Hospital and Harvard Medical School are also looking into natural remedies for diabetes, depression, autism, schizophrenia, and Alzheimer’s disease. Dr. Lee received an institutional development award in 1985, has published 110 papers and holds 15 US and international patents. mrmc_ebm_w-h-chen_002 Chen W.-H. Wuyi University Jiangmen China Dr. Chen received his B.Sc in Chemistry from Sichuan University, China and Ph.D. in Pharmaceutical Chemistry from Nagasaki University, Japan. Dr. Chen ever worked as a CREST postdoctoral researcher at Nara Institute of Science and Technology, Japan, as an associate professor at Sun Yat-sen University, China and as a research scientist at Lehigh University, Pennsylvania, USA. Currently Dr. Chen is a full professor at Southern Medical University, China. He has published more than 90 peer-reviewed papers. Dr. Chen is currently the Associate Editor of Mini-Reviews in Medicinal Chemistry (MRMC), published by Bentham Science Publishers. Regional Editors North America Muthyala R. University of Minnesota Minneapolis MN USA Europe mrmc_ebm_barlocco_001 Barlocco D. University of Milano Milano Italy Daniela Barlocco earned her degree in Pharmacy (1969) and in Chemistry (1977) from the University of Pavia (Italy). She became Researcher at the University of Milan, faculty of Pharmacy, in 1980 and associate professor at the University of Modena in 1992. She got the title of full professor at the University of Milan in 2000. Her main research interests are addressed to the design of small molecules as enzyme inhibitors and to the comprehension of the protein-protein interactions. She has published about 150 scientific papers and several patents. She is in the Advisory Board of several journals. Bernard M. University of Namur Namur Belgium Gueiffier A. Universite Tours Tours France mrmc_ebm_husbands_001 Husbands S.M. University of Bath Bath UK Professor Husbands joined the Department of Pharmacy and Pharmacology at the University of Bath in 2000, was made a Fellow of the Royal Society of Chemistry in 2010 and then Professor in 2012. He has been Head of the Medicinal Chemistry group within the Department since 2013. Prof Husbands’ main research interests relate to neuropsychological diseases, in particular drug abuse, but also including depression and anxiety. Recent research interests have focussed on the development and therapeutic potential of ‘selectively promiscuous’ ligands and has been driven by the understanding that CNS disorders are rarely simple, requiring complex solutions. Prof Husbands has published >100 peer-reviewed scientific papers, mostly on CNS active molecules. mrmc_ebm_tagmaterchis_001 Tagmatarchis N. Theoretical and Physical Chemistry Institute Athens Greece Nikos Tagmatarchis is Deputy Director in the Theoretical and Physical Chemistry Institute, at the National Hellenic Research Foundation, in Athens, Greece. He has studied chemistry and received his PhD from the Chemistry Department, University of Crete, Greece (1997). Dr. Tagmatarchis accomplishments are reflected in over 180 scientific peer-reviewed research articles, while his work has been cited more than 8200 times associated with an h-index of 37. He has been recipient of the European Young Investigator Award (2004), Visiting Professor at the Chinese Academy of Sciences (2011-2012) and Invited Fellow by the Japan Society for the Promotion of Science in Japan (2013- 2014). Australia mrmc_ebm_mcgeary_001 Mcgeary R. The University of Queensland Brisbane Australia Dr McGeary is an Associate Professor in the School of Chemistry and Molecular Biosciences, and an Affiliate Associate Professor in the School of Pharmacy at The University of Queensland, Australia. Dr McGeary has authored over 75 publications, as well as 3 book chapters and 11 patents. His research interests encompass the development of new synthetic methodologies, and the design and synthesis of potent inhibitors of metalloenzymes. Asia mrmc_ebm_hwu_001 Hwu R.J. Tsing Hua University Hsinchu Taiwan Prof. Hwu obtained a doctorate (Ph.D.) in Chemistry from Stanford University, California, USA. He has been a Distinguished Chair Professor of National Tsing Hua University, Taiwan and served as the President of Asian Federation for Medicinal Chemistry in 2012 and 2013. He has published more than 200 scientific publications and is a named inventor of 49 issued patents internationally. Professor Hwu has been Fellows of TWAS, IUPAC, and The Royal Society of Chemistry, UK. Sarel S. The Hebrew University of Jerusalem Jerusalem Israel Section Editor mrmc_se_tuccinardi-tiziano_001 Tuccinardi Tiziano University of Pisa Pisa Italy Tiziano Tuccinardi is Associate Professor of Medicinal Chemistry at the Department of Pharmacy of the University of Pisa. Since July 2016 he is also Adjunct Associate Professor at the Department of Biology, Temple University’s College of Science and Technology, Philadelphia, PA, USA. He has published more than 130 papers, five patents and he is a scientific advisory board member of the Bio Future Medicine (BFM) start-up. His research interests include drug and lead discovery, with a focus on computer-assisted approaches and medicinal chemistry, including synthesis of small molecules, virtual and biomolecular screening. Computer-aided Drug Design Book Review Editor mrmc_ebm_kalasz_001 Kalasz H. Semmelweis University Budapest Hungary Dr. Kalász earned his PhD, and he was awarded the title of doctor of chemical sciences, and medical habilitation in pharmacology at Semmelweis University. Dr. Kalász is employed in the Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest. He was also working in Yale University (New Haven, CT, USA), University of Cincinnati, Cincinnati (Cincinnati, OH, USA) and United Arab Emirates University (Al Ain, UAE). He has several decades of experience in the isolation of natural products, identification of drug binding sites and in studies on pharmacokinetics and drug metabolism. Editorial Board Members mrmc_ebm_awad-h_001 Awad H. National Research Center Cairo Egypt G-3419-2011 mrmc_ebm_santo_001 Di Santo R. Sapienza University of Rome Rome Italy 7004256372 Roberto Di Santo is Full Professor of Medicinal Chemistry, School Pharmacy and Medicine, “Sapienza” University of Rome Italy. He hold Master degrees in Chemistry and in Pharmacy at “Sapienza” University of Rome. Prof. Di Santo research is focused primarily on drug design and synthesis of new molecular entities edowed with biological activities. He devoted particular efforts in the discovery of antimicrobial and antitumor agents. Most part of scientific activity is focuesed on compounds active against HIV targets like integrase, ribonuclease H and polymerase functions of the reverse transcriptase, and protease. Author or co-author of books and over 130 publications and patents, Prof. Di Santo is active member of EFMC and SCI. mrmc_ebm_manera-c_001 Manera C. University of Pisa Pisa Italy Dr. Clementina Manera received Research Doctorate (PhD) in Medicinal Chemistry and Master's Degree in Pharmaceutical Chemistry and Technology from the University of Pisa. Currently she is Associate Professor in Medicinal Chemistry at the Department of Pharmacy of the same University. She has authored/coauthored over ninety publications on peer reviewed pharmaceutical chemistry journals of international repute. She has over twenty years of experience in research and development of drug candidates for the treatment of neurodegenerative diseases and as anticancer. In recent years she focused on the design, synthesis and pharmacological evaluation of modulators of endocannabinoid system and on the development of new analytical methods for the determination of biologically active small organic molecules. mrmc_ebm_viegas-c-sh_001 Viegas Jr C. Federal University of Alfenas Alfenas Brazil L-3956-2016 Claudio Viegas Jr., currently an Associate Professor at Federal University of Alfenas, . In 1999 he turned to Araraquara (São Paulo State, Brazil) to develop his PhD Thesis on Natural Products and Medicinal Chemistry. Since 2016, He is the coordinator of the Program of Post-Graduation in Chemistry of the Federal University of Alfenas. Scientific Coordinator of the Laboratory of Research in Medicinal Chemistry (PeQuiM), his research focused the design, synthesis and evaluation of innovative drug candidates for neurodegenerative diseases, CNS disorders, neglected diseases, neurophatic and central pain and inflammation. Dr. Viegas-Jr. has published over 60 peer-reviewed manuscripts and review articles in these areas and is funded by multiple operating grants from the Brazilian Agencies Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG). mrmc_ebm_cui-m-_001 Cui M. Beijing Normal University Beijing China Dr. Cui received Ph.D. in Chemistry from Beijing Normal University (2011). Then, he was appointed Lecturer, and later Associate Professor (2014) at the College of Chemistry, Beijing Normal University. He has published more than 60 research papers in peer-reviewed journals and his research program has been fully funded by multiple grants from National Natural Science Foundation of China and other foundations. His fields of interest are the design, synthesis and bio-evaluation of molecular imaging probes (radiolabelled tracers for PET and SPECT; fluorophores for near-infrared imaging) for the diagnosis of diseases. mrmc_ebm_sham-y-sh_001 Sham Y. University of Minnesota Minneapolis MN USA Professor Yuk Sham received his PhD from the University of Southern California Chemistry Department and his post-doctoral trainings at the US National Cancer Institute and IBM TJ Watson Research Center. He joined University of Minnesota in 2002 as the scientific consultant specializes in biomolecular modeling, simulation and computer-aided drug design. He serves as the assistant professor and assistant director at the University of Minnesota Center for Drug Design from 2008-2016. He is currently the assistant professor at the University of Minnesota Department of Integrative Biology and Physiology and the director of graduate studies for the Bioinformatics and Computational Biology program. mrmc_ebm_jaitak-v_001 Jaitak V. Central University of Punjab Bathinda India Dr. Vikas Jaitak obtained his Ph.D. degree (2011) in Natural Product Chemistry from Institute of Himalayan Bioresource Technology, CSIR, Palampur (HP), India. He is currently working as Assistant Professor at Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda (Pb), India. He is a recipient of various research awards like Young Scientist Award from Department of Science and Technology, India. His skills and expertise mainly lie in the subject area of Natural Products and Medicinal Chemistry. Dr. Jaitak, as an author/co-author and has published more than 55 articles in various journals (having over 950 total citations). mrmc_ebm_romanelli-mn_001 Romanelli M.N. University of Florence Florence Italy Maria Novella Romanelli took her PhD in “Drug Chemistry” in 1989. She was appointed as Assistant professor in 1989 at the University of Florence, where she is presently full professor of Medicinal Chemistry at the department of Neurosciences, Psychology, Drug research and Child Health. Her research activity has been focused on the design and synthesis of modulators of neurotransmitter receptors (mainly cholinergic), of ion channels (L-type Calcium channels and HCN channels), and of enzymes (HDAC, Carbonic Anhydrase). Prof. Romanelli is co-author of more than 120 publications and co-inventor of four patent applications. mrmc_ebm_iqbal-j_001 Iqbal J. COMSATS University Abbottabad Pakistan Prof. Dr. Jamshed Iqbal (Tamgha-i-Imtiaz), FRSC is the Head of Pakistan’s finest drug research center CADR at COMSATS University, Abbottabad Campus since 2013. He has completed his early education from Pakistan, while his MS and PhD degree was from University of Strathclyde, Glasgow, UK and University of Bonn, Germany, respectively. After doing 2 Postdocs from Germany and China, he opted to serve Pakistan and joined Department of Pharmacy, CUI, Abbottabad Campus. He has innovatory contributions in Pharmaceutical/Chemical sciences. Prof. Iqbal has more than 190 publications (Impact factor >550) in several top international journals and 2 international patents. In 2017, Prof. Iqbal has been awarded PAS-Gold Medal by Pakistan Academy of Sciences. mrmc_ebm_torok-m_001 Török M. University of Massachusetts Boston Boston MA USA Marianna Török is an Assistant Professor of Chemistry at the University of Massachusetts Boston. After receiving her M.S. in Chemistry from University of Szeged, Faculty of Science (formerly known as József Attila University, Faculty of Science), she completed Ph.D. in Biological Sciences (Biochemistry) at the University of Szeged, Faculty of Medicine (formerly known as Albert Szent-Györgyi Medical University, Faculty of Medicine), Hungary. She did postdoctoral training in Structural Biology with Ralf Langen at the University of Southern California, Los Angeles, CA and in Peptide Chemistry with Daniel S. Kemp at the Massachusetts Institute of Technology, Cambridge, MA. Her current research interest includes Physical Biochemistry, Medicinal Chemistry, and Green Chemistry. mrmc_ebm_lv-pc_001 Lv P.C. Nanjing University Nanjing China Dr. Lv is currently an associate professor in Nanjing University. He obtained his Ph.D. in Medicinal Chemistry at Nanjing University. He was a postdoctoral research associate in both College of Pharmacy and Department of Chemistry at Purdue University, West Lafayette, Indiana. His research activities have been focused on rational design, synthesis and biological evaluation of small molecules as potential anticancer, antibacterial or anti-inflammatory agents. Dr. Lv has published more than 70 papers in peer-reviewed journals and is an inventor of 14 patents. mrmc_ebm_titinchi-sjj_001 Titinchi S.J.J. University of the Western Cape Cape Town South Africa Dr. Salam Titinchi is an Associate Professor at the Department of Chemistry, University of the Western Cape, Cape Town, South Africa. He obtained his PhD from Indian Institute of Technology Roorkee. He has published more than 60 scientific articles and conference proceedings in the field of catalysis, medicinal chemistry and nanomaterial and edited a book and authored two book chapters on drug delivery and catalysis. He serves on the editorial boards of an international scientific journal. His research interests lie in the field of design and synthesis of new potential anticancer compounds, coordination polymers and advanced nanomaterial for environmental applications and green chemistry. mrmc_ebm_mikhailov-sn_001 Mikhailov S.N. Engelhardt Institute of Molecular Biology RAS Moscow Russia Dr. Sergey N. Mikhailov has completed his PhD in 1976 and D.Sc. in1990 from Engelhard Institute of Molecular Biology of the Russian Academy of Sciences. In 1995, he was appointed as a head of a Lab at the same Institute. As a Postdoctoral fellow and visiting Professor, he worked in the famous chemical Labs of Czechoslovakia, Canada, Germany and Belgium. His research interests include chemistry and medicinal chemistry of nucleosides, nucleotides and oligonucleotides, their biological activity and physico-chemical investigations, substrate properties of these analogs in enzymatic reactions. He has published more than 250 research papers. mrmc_ebm_wuest-f_001 Wuest F. University of Alberta Edmonton AB Canada Frank Wuest is a Professor in the Department of Oncology at the University of Alberta in Canada. He obtained his training in chemistry and biochemistry from Dresden Technical University in Germany. He performed postdoctoral research studies at the School of Medicine in St. Louis from 1999-2001, and he worked as head of the PET-Tracer Department of the Research Centre Dresden-Rossendorf in Germany from 2001-2008. In 2008 he was appointed as the Dianne and Irving Kipnes Chair in Radiopharmaceutical Sciences at the University of Alberta. mrmc_ebm_lima-vl_001 Eifler-Lima V.L. Federal University of Rio Grande Do Sul Porto Alegre Brazil Dr. Vera Lucia Eifler-Lima is currently Associate Professor in Faculty of Pharmacy at UFRGS and Head of the Dept. of Produção de Matéria-Prima, FAR 1, Faculdade de Farmácia/UFRGS. Her research involves the design, synthesis and pharmacological/toxicological evaluation of heterocyclic compounds aiming the identification of new antitumor (inhibitors of Eg5 kinesin, 5'NT) and antiparasitic (leishmania and chagas, mainly) hits. She is head of the CNPq Research Group “Medicinal Organic Synthesis” and Coordinator of the Laboratory of Medicinal Organic Synthesis (LaSOM). mrmc_ebm_devi-kp_001 Devi K.P. Alagappa University (Science Campus) Karaikudi Tamil Nadu India Dr. Kasi Pandima Devi is currently working as Associate Professor in Department of Biotechnology, Alagappa University, Karaikudi, India where she is engaged in teaching for the Master Degree students of Biotechnology Programme and also carrying out active research in the field of Molecular Pharmacology of Natural Products. She obtained her PhD degree in Biochemistry from University of Madras, India and subsequently did her Post Doctoral research in National Institute of Immunology, India and CID-CSIC, Barcelona, Spain. She is a recipient of Young Women Scientist Award from the Government of Tamil Nadu, India and Women Scientist Award from the Biotech Research Society of India. She has published many research articles in reputed Journals and also co-authored many book chapters. mrmc_ebm_scotti-mt_001 Scotti M.T. Federal University of Paraíba João Pessoa Brazil Prof. Marcus Tullius Scotti obtained his Ph.D. degree (2008) in Organic Chemistry from University of São Paulo, Brazil. In January 2009, Prof. Scotti moved to João Pessoa and started to work as Professor of Organic Chemistry at Universidade Federal da Paraíba (Federal University of Paraíba), Brazil. He is currently working at this same university, and his skills and expertise mainly lie in the subject areas of Chromatography, Medicinal and Pharmaceutical Chemistry, Antioxidant Activity, Natural Product Chemistry, Density Functional Theory, Computational Chemistry, Phytochemicals, Drug Discovery, etc. Prof. Scotti, as an author/co-author, has published more than 145 articles in various journals, having over 1,125 total citations. mrmc_ebm_konkimalla-vb_001 Konkimalla V.B. National Institute of Science Education & Research (NISER) Bubhaneswar India Dr. Badireenath Konkimalla, Reader-F, National Institute of Science Education and Research (NISER), Bhubaneswar, India, has a Bachelor’s degree in Pharmacy from the Tamil Nadu Dr. M.G.R. Medical University, Chennai, India; an M. Tech. in Biotechnology from the Center for Biotechnology (CBT), Anna University, Chennai, India; and a Ph.D. in Biochemistry and Structural Biology from University of Heidelberg, Heidelberg, Germany. His research interests are in the interdisciplinary areas of pharmaceutical biology and drug development. He has been awarded the Mike Price fellowship award in the year 2009 by the European Association for Cancer Research (EACR), and Innovative Young Biotechnologist Award (IYBA) in the year 2012 by Department of Biotechnology (DBT), India. mrmc_ebm_khan-i_001 Khan I. The University of Manchester Manchester UK Imtiaz Khan received his Ph.D degree under the supervision of Prof. Hon Wai Lam, at The University of Nottingham, United Kingdom where he developed new synthetic methodologies involving C‒H functionalization of inert bonds for the synthesis of carbo- and heterocycles. Later, he worked as a postdoctoral research associate in the same group for one year. He then spent two years (2016-2018) as a Leverhulme Trust research fellow at Cardiff University, before joining The University of Manchester, United Kingdom in 2018. He has a good contribution towards the scientific and academic community with numerous research publications in highly prestigious international journals. He is also an editorial board member of EC Pharmacology and Toxicology, United Kingdom. mrmc_ebm_fajardo-ar_001 Fajardo A.R. Universidade Federal de Pelotas Pelotas Brazil Prof. André Ricardo Fajardo is graduated in Chemistry (2007), M.Sc. (2009) and Ph.D. (2013) degrees in Chemistry at Maringá State University (Brazil). Ph.D. with a sandwich period at CERMAV (Grenoble-France, 2012-2013). Currently, he is Professor at Universidade Federal Pelotas (Brazil). Research-leader in the Laboratory of Technology and Development of Composites and Polymeric Materials (LaCoPol). He is the author of approximate 50 papers with IF and his main research interests include polymer chemistry, polymeric biomaterials, polymeric composites, natural polymers, hydrogels, and absorbent materials. mrmc_ebm_jiang-s_001 Jiang S. China Pharmaceutical University Nanjing China Dr. Jiang obtained his Ph.D. degree from the Shanghai Institute of Organic Chemistry, CAS and he subsequently pursued postdoctoral studies at the National Cancer Institute in the National Institutes of Health (NIH). In 2008 he joined the Guangzhou Institute of Biomedicine and Health, CAS as a principal investigator in the Laboratory of Medicinal Chemistry. In 2017, Professor Jiang moved his research group to the China Pharmaceutical University. His scientific interest is mainly focused on development of novel small drug-like molecules and peptidomimetic derivatives acting on targets of epigenetics and immuno-oncology. He has authored more than 70 papers in refereed scientific journals, including J. Med. Chem and Angew. Chem. Int. Ed. mrmc_ebm_liu-jq_001 Liu J.-Q. Guangdong Medical University Dongguan China Jian-Qiang Liu received Ph.D from Northwest University. From 2015 to 2016, he gained postdoc at Tsinghua University (with Prof. Lin Mei). Until now, he is a full professor and is working at Guangdong Medical University. His research interests include multifunctional metal-organic framework nanomaterials, and stimuli-responsive (bio) polymers. More than 50 papers have been published. H-index = 22. He has been appointed as several editorial board members of the journals, such as: Interdisciplinary Journal of Chemistry; and EC Pharmacology and Toxicology, and so on. mrmc_ebm_mohanan-p_001 Mohanan P. Sree Chitra Tirunal Institute for Medical Sciences and Technology Thiruvananthapuram India Dr. P.V. Mohanan working as Scientist-G & Head, Toxicology Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Govt. of India. He is a visiting Professor at Toyo University, Japan and a Visiting Researcher at Bio-Nano Electronics Research Centre, Japan. Dr. Mohanan has a Post doctoral experience from the University of Tsukuba, Japan and Doctoral degree from the University of Kerala. As a toxicologist at SCTIMST with more than 30 years of experience, he has been intimately associated with all the medical devices/technologies developed at SCTIMST. He has authored 175 peer reviewed full papers, 4 book chapters, edited 3 books and 4 conference proceedings. mrmc_ebm_feng-ls_001 Feng L.-S. WuXi AppTec (Wuhan) CO., LTD Wuhan China Dr. Lian-Shun Feng obtained his PhD degree from Tsinghua University in 2011, and then worked as postdoctorial researcher in Peking University. Currently, Dr. Lian-Shun Feng work in WuXi AppTec as senior scientist, and supervise more than ten chemists. In 2017 and 2018, around 20 peer-reviewed SCI papers were published, and some of them were cited over 50 times in one year. Dormán G. Targetex Biosciences Dunakeszi Hungary Taliani S. University of Pisa Pisa Italy mrmc_ebm_t-mavromoustakos_001 Mavromoustakos T. Kapodistrian University of Athens Athens Greece Professor Thomas Mavromoustakos was born in Prastio-Morphou of Cyprus in 1960. He finished his undergraduate studies from the Department of Chemistry at the National and Kapodistrian University of Athens-NKUA, Greece (1980-1985), and he graduated from the Pharmacy Department of the University of Connecticut, USA (1985-1990). From 1991-2007, Prof. Mavromoustakos served as a Research Director at the National Hellenic Research Foundation. Later on, from 2007-2012, he served as an Associate Professor in the Chemistry Department of NKUA, and currently, from 2012 onwards, he is a regular professor in the same Department. In 2018, Prof. Mavromoustakos received his Ph.D. diploma from the Theology School of NKUA. mrmc_ebm_v-gentile_001 Gentile V. University of Campania "Luigi Vanvitelli" Naples Italy Dr. Gentile (Naples, Italy) is a recognized expert in the transglutaminase research area and has a strong background in the molecular biology and biochemical aspects of the transglutaminase (TG) enzymes expression, activity and function. His work has been focused to the tissue TG (TG2) characterization in normal and pathological cellular events (cell growth and differentiation, adhesion, apoptosis, neurodegeneration) by molecular biology, immunological and biochemical studies. Currently he works as associate professor at the University of Campania “Luigi Vanvitelli”. mrmc_ebm_e-lacivita_001 Lacivita E. University of Bari Bari Italy Dr.Enza Lacivita obtained her PhD in Medicinal Chemistry in 2001 at the University of Bari Aldo Moro. She was appointed as Assistant Professor in Medicinal Chemistry (2005) and as an Associate Professor in Medicinal Chemistry in 2017 (Department of Pharmacy – Drug Science) at the same University. Her research activities have been focused on the study of structure-activity relationships of “drug-like” ligands for GPCRs involved in neuropsychiatric disorders, such serotonin and dopamine receptors, and in neuroinflammatory processes. Dr. Lacivita is co-author of more than 70 papers in peer-reviewed journals and co-inventor of four patent applications. mrmc_ebm_b-rubis_001 Rubis B. Poznan University of Medical Sciences Poznań Poland Prof. Blazej Rubis is Head of the Department of Clinical Chemistry and Molecular Diagnostics at Poznan University of Medical Sciences, Poland. Prof. Rubis graduated in the year 2000 with majors in Biotechnology from the University of Natural Sciences, Poznan, Poland. He spent 2 years (2014-2016) for postdoctoral studies in the Department of Pathology and Laboratory Medicine at Brown University, Providence, RI, USA. His skills and expertise mainly lie in the subject areas of Molecular Biology, Cancer Research, Genetics, Cell Biology, Evolutionary Biology, and Structural Biology. Dr. Rubis, as an author/co-author, has published more than 50 articles in various journals, having over 475 total citations. mrmc_ebm_Ginaldi_001 Ginaldi L. L’Aquila University L’Aquila Italy Dr. Lia Ginaldi is a Full Professor of Applied Medical and Technical Sciences at the Department of Life, Health & Environmental Sciences of L’Aquila University. She is Director of the Clinical Immunology and Allergology Unit of Teramo Hospital. She is Head of the Regional Center of Excellence on Osteoporosis and Clinical and Scientific Coordinator of the “Woman’s Health” and “Gender Medicine” Local Projects. Dr. Ginaldi is also Coordinator of the Master of Gender Medicine and President of the Postgraduate Medical School for Specialists in Clinical Immunology and Allergology at the University of L’Aquila. mrmc_ebm_pittala-v_001 Pittalà V. University of Catania Catania Italy Dr. Pittalà attained her MSc in Chemical and Pharmaceutical Technologies, and subsequently completed her Ph.D. in Pharmaceutical Sciences at the University of Catania. Then, Dr. Pittalà moved to Milan to join Pharmacia Corporation as a research scientist. She worked as member of Combinatorial Chemistry Group and contributed to the discovery and identification of danusertib being co-inventor of bicyclopyrazoles chemicals. She currently hold the position of Assistant Professor at the University of Catania. Here major area of interest are the design and synthesis of heme oxygenase-1 inhibitors, and s receptor ligands as new antitumor agents. Her research resulted in 7 patents. Nurchi V.M. University of Cagliari 09042 Moneserrato-Cagliari Italy mrmc_ebm_h-xu_001 Xu H. Northwest A&F University Yangling P. R. China Dr. Hui Xu was born in Zhejiang Province, China. Currently, he is a professor at Research Institute of Pesticidal Design & Synthesis, Northwest A&F University. He obtained his Ph.D. degree from Zhejiang University. He then became a director of one Medicinal Research Group at Jiangsu Yangtze River Pharmaceutical Group, Jiangsu Province, China. In 2004, he joined the group of Professor Bruno Figadere, Faculty of Pharmacy, University of Paris-Sud 11 as a postdoctoral fellow. Since 2008 he holds the position of full professor at Northwest A&F University. Up to now, he has published over 80 peer-reviewed SCI articles. His main research interests are on the activity-guided isolation, structural modification and structure−activity relationships of bioactive natural products. Yew D.T. The Chinese University of Hong Kong Shatin Hong Kong Toropov A.A. Istituto Di Ricerche Farmacologiche Mario Negri Milano Italy mrmc_ebm_malan_001 Malan S.F. University of the Western Cape Bellville South Africa Sarel Malan obtained a Ph.D. in Pharmaceutical Chemistry, M.Sc. and B.Pharm. from the North-West University, Potchefstroom, South Africa. He is Professor and Director of the School of Pharmacy at the University of the Western Cape and is an Honorary Life Member of the Academy of Pharmaceutical Sciences and Fellow of the Pharmaceutical Society of South Africa. He has published more than 75 scientific papers and has authored or co-authored various papers and columns in professional journals, and conference contributions. mrmc_ebm_pohanka_001 Pohanka M. University of Defence Brno Czech Republic Miroslav Pohanka graduated from chemistry in Masaryk University Brno (Czech Republic) in 2003. In the Masaryk University, he achieved doctor of natural science (RNDr) from biochemistry in 2006 and PhD from biochemistry in 2008. After that, he achieved associated professor (docent) from toxicology at University of Defense, Czech Republic (2012) and doctor of sciences from analytical chemistry at Academy of Sciences, Czech Republic (2014) and professor from analytical chemistry at University of Pardubice (2016). He is an author of approx. 200 papers in journals with IF and his works were more than 1900 times cited according web of science. mrmc_ebm_mollica_001 Mollica A. University of G. d'Annunzio Chieti and Pescara Chieti Italy Dr. Adriano Mollica is Associate Professor of Medicinal Chemistry at the Univ. “G. d’ Annunzio” of Chieti-Pescara, Italy and PhD in “Pharmaceutical Sciences”. From 2013 he is Member of the Board of PhD program “Biomol. and Pharm. Sciences” and Tutor of several PhD students and Post-doctoral fellows. His research interests are focused on opioid peptides, neurodegeneration, treatment of chronic and neuropathic pain, multi-target compounds and nutraceuticals. He is co-author of 82 papers published in international journals, one European Patent and one Italian Patent. He is currently “Editor in Chief” of “Current Bioactive Compounds”, and Editorial Board Member of Mini rev. in Org. Chem. and of Prot. & Pept. Lett. mrmc_ebm_masarik_001 Masarik M. Masaryk University Brno Czech Republic Dr. Masarik obtained a doctorate (Ph.D.) in Molecular Biology from the Masaryk University, Brno, Czech Republic. Currently, Dr. Michal Masarik is an assistant professor at the Department of Pathological Physiology, Faculty of Medicine, Masaryk University in Brno and senior scientist in Research group of Submicron Systems and Nanodevices in Central European Institute of Technology, Brno University of Technology. His research is mainly focused on prostate and head and neck cancer development, analysis of tumor biomarkers and effect of selected cytostatic drugs on tumor cell lines. He has published more than 100 scientific publications with h-index 22 and 1201 citations according WoS. mrmc_ebm_kamil_001 Kamil K. University of Hradec Kralove Hradec Kralove Czech Republic Prof. Kamil Kuca has published more than 350 IF research papers. He is working with several companies as a scientific consultant. He has had various collaborations throughout the world (e.g. Korea, Croatia, United Arab Emirates, USA, France, Turkey, China, Singapore, Sweden, and Brazil). His h-index is 39, and the number of citations in WoS is over 4000. He has five patents to his credit. In 2015, he was awarded the 7th most cited European author (2005-2011) in pharmacology and toxicology, according to the list published by Lab Times (available at: Kanwar J. R. Deakin University Geelong Australia Jiang Z. Henan University Kaifeng China mrmc_ebm_habtemariam_001 Habtemariam S. Pharmacognosy Research Laboratories & Herbal Analysis Services UK Kent UK Dr Habtemariam received his BSc degree in Biology (minor - Chemistry) from the University of Addis Ababa and his Master’s degree (combined-studies) in Pharmacology and Phytochemistry from the University of Strathclyde, Glasgow, UK. He stayed at Strathclyde to study at doctoral level, studying on drug discovery researches and obtained his PhD in this area of research. After a number of years in teaching and post-doctoral research at the Strathclyde Institute for Drug Research and Strathclyde University, he joined the School of Science, University of Greenwich in September 1998. With a Principal Lecturer post at Greenwich, Dr Habtemariam has been a leader of programmes and researches taught on bioassays & natural products-based drug development. He has published more than 150 scientific publications and own 3 patents. Follo M.Y. University of Bologna Bolonga Italy mrmc_ebm_Ferraro_001 Ferraro L. University of Ferrara Ferrara Italy Dr. Luca Ferraro obtained the degree in Pharmacy at the University of Ferrara, Italy. He is actually Professor of Pharmacology at the Dept. of Life Sciences and Biotechnology, University of Ferrara. He is currently affiliated with the Laboratory for Technologies of Advanced Therapies (LTTA – Tecnopolo), University of Ferrara, as Head of Service of "Animal models in drug testing." Since 2012 he is a member of the research team of the IRET Foundation (Ozzano Emilia, Bologna) for the study of neurodegenerative diseases. Dr. Ferraro is author of about 150 publications in international journals in the field of Neuropharmacology and Neuroscience. Desideri A. University of Roma “ Tor Vergata “ Rome Italy Crisponi G. University of Cagliari Cagliari Italy mrmc_ebm_colotti_001 Colotti G. Sapienza University of Rome Rome Italy Ph.D. in Biochemistry, University Sapienza, Rome. Research Scientist, Group Leader at Institute of Molecular Biology and Pathology, Italian National Research Council. Author of about 60 publications in peer-reviewed international journals, member of the editorial board of several journals, Co-founder and member of the Foresight Group CNR and of qPMO (Quality and Project Management OpenLab) CNR. Focus on: - structure and function of proteins involved in human diseases; - drug delivery, drug targeting; drug discovery; - calcium signalling in cancer and neurodegenerative diseases; - mitochondrial tRNAs. mrmc_ebm_chiesa_001 Chiesa C. Sapienza University of Rome Rome Italy Claudio Chiesa is an Associate Professor at the Italian National Research Council. Dr. Chiesa obtained his medical degree at the "Sapienza" University of Rome, followed by a residency in Pediatrics (1976-79) and Infectious Diseases (1982-85). He has been Research Fellow at the Pasteur Institute, Paris, France; Mount Sinai Medical Center, New York, N.Y., Memorial Sloan-Kettering Cancer Center, New York, N.Y., and Rainbow Babies and Childrens' Hospital, Cleveland, Ohio,U.S.A.; Karolinska Institutet, Stockolm, Sweden. His major areas of research interest relate to emerging Pediatric and Neonatal infectious diseases, diagnostic tools for Neonatal infections, endocrine regulation of fetal/neonatal growth, and energy metabolism in children and metabolic factors contributing atherosclerosis and cardiovascular risk in children. mrmc_ebm_bobryshev_001 Bobryshev Y. University of New South Wales Sydney Australia Dr. Bobryshev obtained a doctorate (Ph.D.) from the Leningrad state University, Leningrad, in 1978. Currently Dr. Bobryshev is a Leading Scientist of Institute of Pathology and Pathophysiology, Moscow, and an Adjunct Associate Professor in the University of Western Sydney, Australia. He is author or co-author of more than 200 scientific publications. mrmc_ebm_sela_001 Bar-Sela G. Division of Oncology Rambam Health Care Campus Haifa Israel Professor Gil Bar-Sela is Deputy Director of the Division of Oncology and Head of the Palliative and Supportive Oncology Unit at Rambam Health Care Campus, Haifa, Israel. Professor Bar-Sela is also an Associate Professor at the Technion’s Ruth & Bruce Rapapport Faculty of Medicine. To date he has published more than 100 papers in medical journals and books. Professor Bar-Sela is currently a member of the Advisory Committee of the Israel Cancer Association on Palliative Care and the committee for professional guidance. He is also a member of the "Survivorship Committee" of the National Council for the Prevention, Diagnosis & Treatment of Cancer. mrmc_ebm_nicolotti-o_001 Nicolotti O. University of Bari Bari Italy Orazio Nicolotti graduated in Chemistry and Pharmaceutical Technology with full marks and honour in 1997 and received the Ph.D. in Drug Sciences in 2001. Major expertises in molecular and data modelling: drug design; QSAR; predictive toxicology; combinatorial library design; evolutionary algorithms; docking and molecular dynamics. So far author of more than 100 research papers, 3 book chapters, 1 international patent. Principal investigator of several research funded projects and industrial agreements for technology transfer. mrmc_ebm_martínez-a-r_001 Martínez A.R. Universidad Complutense de Madrid Madrid Spain Dr. Alejandro Romero is Associate Professor in the Department of Pharmacology and Toxicology at the Faculty of Veterinary Medicine of the Complutense University of Madrid (Madrid, Spain). Currently, he combines his interest and background on molecular toxicology in three well-stablished research lines; i) Evaluate and understand the molecular mechanisms of new molecules with therapeutic interest; ii) Identify the molecular mechanisms underlying the cell death pathways involved in the toxicity of xenobiotics; iii) Focus on novel melatonin-based therapies. Dr. Romero has related in 15 research projects, 100 national and international meetings and symposia, he has written 12 book chapters and he has published 79 research papers in peer-reviewed journals. mrmc_ebm_dal_ben_001 Dal Ben D. School of Pharmacy University of Camerino Italy Dr Ben got his PhD in Pharmaceutical Sciences at the University of Padova (Italy) then he moved to the University of Camerino (Italy) where he is currently Associate Professor of Medicinal Chemistry. His research work is to design and optimize bioactive compounds with molecular modelling tools. His studies are focused mainly to membrane proteins belonging to the GPCR (Purinergic P1 Receptors and others) and ion channel (Purinergic P2X Receptors) protein families. mrmc_ebm_lauria-a_001 Lauria A. University of Palermo Palermo Italy Dr. Lauria scientific career started in 1996 as Lecturer in medicinal chemistry at University of Palermo. In the first years, he worked on synthesis of heterocyclic compounds with antiproliferative activity. After the experience in USA, where he worked in the research group of Prof A.R. Katritzky, his interests were driven to molecular modelling.He is co-author of 93 papers published on ISI recognized international journals, with H-index 26. He has been involved in several research projects and he has actively participated in the elaboration of several of them. He is expert evaluator for HORIZON2020." mrmc_ebm_pieroni-m_001 Pieroni M. Università di Parma Parma Italy Marco Pieroni graduated in 2003 in Pharmacy. After his degree, he joined the medicinal chemistry group of Prof Fravolini in Perugia as a PhD student, working on the research of novel quinolone-like scaffolds for the treatment of resistant infections. After his PhD, he joined the group of Prof Alan P. Kozikowski at the UIC College of Pharmacy at Chicago, where he spent 3 years as research assistant professor and drug metabolism lecturer. In 2011, he was hired as research assistant professor at the University of Hawai’i at Hilo, collaborating with professor Ghee Tan in the synthesis of derivatives of natural compounds for the treatment of parasitic diseases. At the end of 2011, he joined the group of Prof Costantino, where he currently is assistant professor. Marco’s research is mostly focused on medicinal chemistry for the treatment of bacterial and parasitic infections, with emphasis on the treatment of susceptible and resistant M. tuberculosis. mrmc_ebm_baqi_001 Baqi Y. Sultan Qaboos University Muscat Oman Dr. Younis Baqi is Assistant Professor of Medicinal Chemistry at Sultan Qaboos University (SQU) and presently coordinator of the Applied Chemistry. His early training was in natural products chemistry at the University of Jordan (M.Sc. 2003) and pharmaceutical chemistry at Universität Bonn (Ph.D., 2008). After a research stay at the laboratory of Prof. E.J. Corey, Harvard University; MA, USA, he appointed as group leader within ERA-NET fellowship (2009–2011). Since 2012, he is holding the position of Assistant Professor of Chemistry at SQU, Oman. mrmc_ebm_akhunzada_001 Akhunzada Z.S. Pharmaceutical Product Development (PPD) New Brunswick NJ USA Dr. Zahir Shah Akhunzada, PPD Consultant is a Research Scientist in Drug Products Science and Technology (DPST) at Bristol-Myers Squibb, USA, where he is responsible for the analysis and characterization of proteins. Dr. Zahir studied chemistry in Germany, carried out research in the Netherlands and obtained his Ph. D from the HEJ Research Institute of Chemistry, Pakistan. He did his Post-Doctorate at the University of Tubingen, Germany. He has several research publications and co-Authored a Textbook with Prof. Atta-Ur-Rahman on,”Stereoselective Synthesis in Organic Chemistry”, Springer Verlag, USA. Dr. Akhunzada is the recipient of several awards, and certificates of Recognition including Shining Performance Awards (Schering Plough/Merck); Certificate of Honor (New York Academy of Sciences); Bravo Award (BMS). Dr. Akhunzada is Editorial Board Member for two International Journals: Medicinal Chemistry and Mini-Review in Medicinal Chemistry. mrmc_ebm_gomha_001 Gomha S.M. Cairo University Giza Egypt Professor Sobhi Mohamed Gomha carried out his M.Sc. and Ph.D. studies, in 2002 and 2006 respectively, at Cairo University in the field of organic synthesis. In 2011, he was promoted to Associate Professor and, in 2016, he was appointed as a Full Professor of Organic Chemistry at Cairo University. Prof. Gomha has published over 145 scientific papers in international journals in the fields of synthetic organic chemistry, chemistry of hydrazonoyl halides, chemistry of enaminones, bioactive heterocyclic chemistry, adopting green chemical technologies in heterocyclic synthesis by using Microwave Irradiation, Ultrasonic radiation, Grinding and Ionic Liquids. His publications have been cited more than 1640 times. mrmc_ebm_Rekka_001 Rekka E.A. Aristotelian University of Thessaloniki Thessaloniki Greece Dr. Eleni Rekka is a professor in Medicinal Chemistry, School of Pharmacy, Aristotelian, University of Thessaloniki, Greece. She did B.Sc. in Pharmacy in 1977 and Ph.D. in Medicinal Chemistry in 1986 from School of Pharmacy, Aristotle, University of Thessaloniki. She has worked for more than three years in Universities and Research Institutes of Europe, as research associate. Dr. Rekka has 102 publications, more than 100 presentations at international and national congresses, two patents and was the coordinator of three funded projects. Her fields of expertise are Drug design and synthesis, mechanism of action structure/activity relationships, Free radicals, oxidative stress and antioxidant agents and xenobiotic metabolism. mrmc_ebm_grande-f_001 Grande F. Università della Calabria Calabria Italy Dr Fedora Grande, after her honours graduation in Chemistry and Pharmaceutical Technology, at University of Calabria, got PhD degree “Metodologie per lo Sviluppo di Molecole di Interesse Farmacologico, XIX ciclo” in 2006. During the PhD course, and after, as Post Doc, she spent several secondments to the Department of Pharmaceutical Sciences, University of Southern California. Main goals of her research deal with the synthesis and the biological evaluation of small molecules endowed with pharmacological properties. More recently, she expanded her research interests on computer-based techniques toward the design of novel drugs. Since 2010, she is Assistant Professor in Pharmaceutical Chemistry, at the Department of Pharmacy, Health and Nutritional Sciences, University of Calabria. mrmc_ebm_saeedi-m_001 Saeedi Mina Tehran University of Medical Sciences Tehran Iran Mina Saeedi received her Ph.D. degree in Organic Chemistry in 2011 from Alzahra University under the direction of Professor Majid M. Heravi. The main focus of her Ph.D. research was synthesis of novel heterocyclic compounds. During a sabbatical leave, she joined Professor Lars Engman at Uppsala University, Sweden and worked on the synthesis of chalcogenide antioxidants. Then, she joined the group of Professor Abbas Shafiee at Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences (TUMS) as a postdoctoral fellow. Currently she is an Assistant Professor at TUMS, Persian Medicine and Pharmacy Research Center as well as Medicinal Plants Research Center at the Faculty of pharmacy. Her research has focused on the isolation and identification of organic compounds obtained from natural sources as well as design and synthesis of potentially bioactive compounds especially possessing anti-Alzheimer’s activity. mrmc_ebm_leopoldo_001 Leopoldo M. University of Bari Aldo Moro Bari Italy Marcello Leopoldo obtained the degree in Chemistry and Pharmaceutical Technologies (honors) at the University of Bari in 1991. At the same University, he was appointed Research Associate in Medicinal Chemistry (1992) and then Associate Professor (2001). He has received the Habilitation as Full Professor in 2015. He has published 115 papers focused on the development of selective ligands for dopamine, serotonin and formyl peptide receptors. Various selective 5-HT7 receptor agonists have been identified in his lab, including LP-211 which has been extensively used to explore the therapeutic potential of 5-HT7 receptor activation. He is inventor of eight patent applications. mrmc_ebm_ouyang-l_001 Ouyang L. Sichuan University Chengdu China Dr. Liang Ouyang obtained his Ph.D in medicinal chemistry from West China School of Pharmacy, Sichuan University in 2008 and 2010, respectively.He is working as a full professor in Sichuan University. His research area involves the discovery of novel anticancer and neurodegenerative diseases. So far he has published more than 84 SCI academic peer review papers, the total cited of his articles more than 1700 times, the single highest number of citations is 607, The H index is 20. mrmc_ebm_abell_001 Abell A. The University of Adelaide Adelaide Australia Professor Abell graduated from the University of Adelaide with BSc(Hon) and PhD and then undertook a postdoctoral fellowship at the University of Cambridge. He held a professorship at the University of Canterbury before returning to the University of Adelaide in 2007, where he is currently Professor of Chemistry and node director of the ARC Centre of Excellence for Nanoscale Biophotonics.. Co-founded an Calpain Therapeutics to develop macrocyclic protease inhibitors as a potential treatment for cataract and other conditions. Past Head of School of Chemistry and Physics at Adelaide and recipient of Royal Australian Chemical Institute Adrien Albert Prize and the Alexander R. Matzuk Prize and Lecture in Drug Discovery (Baylor College of Medicine, Houston). mrmc_ebm_zamyatnin_001 Zamyatnin A. A. Sechenov First Moscow State Medical University Moscow Russia Dr. Andrey A. Zamyatnin Jr. is currently a Professor and Head of the Institute of Molecular Medicine at Sechenov First Moscow State Medical University, Moscow, Russia. He earned his Ph.D. in Virology and later D.Sc. in Virology and Molecular Biology from Lomonosov Moscow State University, Moscow, Russia. His current research interests include molecular markers, molecular targets, development of immunotherapy and enzymatic therapy approaches. Additionally, his research interests include programmed cell death, RNAi, and virus-host interactions. Dr. Zamyatnin’s scientific publications include more than 50 articles in peer-reviewed journals. Furthermore, he acts as an Expert in several scientific funds. mrmc_ebm_losurdo_001 Losurdo G. University of Bari Bari Italy Dr. Giuseppe Losurdo graduated in Medicine in the year 2013. Currently, he is working in specialty school of Gastroenterolog, University of Bari. He is an active member of Young team of the Italian society ofGastroenterology. Dr. Losurdo’s main fields of interest are Helicobacter pylori infection, celiac disease and inflammatory bowel disease. Altel T.H. University of Sharjah Sharjah UAE mrmc_ebm_higelroth_001 Hilgeroth A. Martin-Luther-University Halle Germany Andreas Hilgeroth studied pharmacy in Düsseldorf, Germany, and received his PhD degree with Professor Uwe Kuckländer, in 1994. He has been a research group leader and has developed novel antiretroviral drugs, potential Alzheimer’s therapeutics, multikinase inhibitors and antibacterial agents. His research projects have been supported by several grants from the German Research Foundation (DFG) and the European Union (EU) in various action programs, e.g. COST and Marie Curie support. His research results have been documented in more than 80 publications in international journals with partly high impact factors like Angewandte Chemie – International Edition. 2015. mrmc_ebm_larinov_001 Larionov O. V. University of Texas at San Antonio San Antonio TX 78240 USA Dr. Oleg Larionov obtained his doctoral degree from Georg-August University in Göttingen, Germany. After postdoctoral work at Max-Plank Institut für Kohlenforschung and Harvard University he began his independent career at the University of Texas at San Antonio, where he is now an Associate Professor of Chemistry. His research interests span medicinal chemistry, total synthesis of natural products, organic photochemistry, heterocyclic chemistry, and catalysis. mrmc_ebm_rodriguez_001 Rodriguez J.B. Universidad de Buenos Aires Buenos Aires Argentina Dr. Rodriguez obtained a doctorate (Ph.D.) in Chemistry from the Universidad de Buenos Aires (1990). Then, he was a Postdoctoral Fellow at the National Institutes of Health (1992-1993) He was appointed Assistant Professor (1997), and then Professor (2005) both at the Department of Organic Chemistry, Universidad de Buenos Aires. He has published more than 70 scientific publications and is a named inventor of 5 U.S. patents. His fields of interest are the design of antiparasitic and antiviral agents as well as total synthesis of compounds of pharmacological importance. Zhang L. Beijing University of Chemical Technology Beijing China Associate Editorial Board Members mrmc_ebm_mbianda-x-y_001 Mbianda X. Y. University of Johannesburg Johannesburg South Africa Dr. Mbianda obtained his PhD in Chemistry from the University of Montpellier, France. Then he worked as postdoctoral fellow and research Associate in the department of Chemistry and Chemical Pathology at the University of Pretoria, South Africa respectively. Currently he is an Associate Professor in the Department of Applied Chemistry at the University of Johannesburg, South Africa. His research interest involved the synthesis of organic polymers, nanomaterials and their application in drug delivery systems. He has published over 50 research articles in peer-reviewed Journals, and 3 book chapters. He served as reviewer and/or guest editor in more than 15 international journals mrmc_ebm_shaoyong-k_001 Shaoyong K. Hubei Academy of Agricultural Sciences Wuhan China Dr. Shaoyong Ke is an Associate Professor in the National Biopesticide Engineering Research Center (NBERC). His research interests include the application of target-oriented and diversity-oriented syntheses of small molecules for drug discovery, and natural products-oriented discovery of novel active molecules as lead compounds for development of agrochemicals or drug. He has published more than 50 peer-reviewed journal articles/book chapters in the field of medicinal chemistry and pesticidal chemistry. Dr. Ke has served the scientific community as an editorial board member for three journals and as a reviewer for more than 25 journals. mrmc_ebm_liu-z_001 Liu Z. Central South University Changsha China Dr. Zhengchun Liu received his Ph.D. degree in Biomedical Engineering from Southeast University, Nanjing, China, in 2003. From 2004 to 2006, he was a postdoctoral fellow at Seoul National University, Seoul, South Korea. From 2014 to 2015, he was a visiting scholar at the University of Maryland, College Park, MD, USA. Dr. Liu joined Central South University as an Associate Professor in 2007, and has been Full Professor since 2010. Furthermore, he is Associate Editor for the international journal Nanoscience and Nanotechnology Letters. His major research interests focus on nanocarriers and nanosensors. mrmc_ebm_colovic-m_001 Čolović M. University of Belgrade Belgrade Serbia Dr. Mirjana B. Čolović, a research associate has been emoloyed at University of Belgrade, Serbia, from 2005. Her research activities are in the field of enzymology, toxicology, biosensors, physiologically active compounds and their interaction with biomolecules. She has published 36 papers in impacted international journals, 4 chapters in books, 3 articles in national scientific journals, and over 60 abstracts in international and national scientific meetings. She served as a reviewer in over 20 international journals and 9 projects. mrmc_ebm_obradovic-m_001 Obradovic M. Institute of Nuclear Sciences “Vinca” Belgrade Serbia Dr. Milan M. Obradovic is a senior research associate in the Department of Radiobiology and Molecular Genetics at Institute of Nuclear Sciences “Vinca”, University of Belgrade, Serbia. He received a PhD in molecular biology and endocrinology from the University of Belgrade, Serbia. He has experience in basic and clinical science research. His investigative interest is to clarify the role of different hormones in normal cardiovascular biology and in pathophysiological conditions such as obesity, insulin resistance, diabetes, metabolic syndrome and cardiovascular diseases. He serves as a member of editorial board and as a reviewer in a numerous scientific and medical journals. mrmc_ebm_lachowicz-ji_001 Lachowicz J.I. University of Cagliari Cagliari Italy Joanna Izabela Lachowicz received her MSc in biotecnology from University of Wroclaw in 2006, where she performed graduate research with Prof. Henryk Kozlowski. In 2010, Joanna Izabela obtained a PhD in chemistry from University of Cagliari, where she worked with Prof. Valeria M. Nurchi. In 2012, Joanna started her work at the University of Cagliari as PhD. In 2017, Italian National Habilitation Commision, gave Joanna Izabela Lachowicz the title of Associated Professor. Joanna focuses in her research on synthetic small organic molecules as metal chelating agents and metal-complex equilibria in water. Moreover, she is studing metal complex formation with peptides, as well as with known drugs in use. mrmc_ebm_zhao-l_001 Zhao L. Huazhong University of Science and Technology Wuhan China Lei Zhao, M.D & Ph.D., postdoc of Harvard Medical School, Professor, Chief Physician of Infectious Diseases in Union Hospital, Tongji Medical College, Huazhong University of Science and Technology. He is the head of the multidisciplinary collaboration platform for infection and inflammation in Wuhan Union Hospital. He participated in national major special projects, the National Natural Science Foundation of China, the Natural Science Foundation of Hubei Province, and published 39 papers in the SCI journals as the first author or correspondent author, and participated in 2 monographs. mrmc_ebm_li-q_001 Li Q. Central South University Changsha China Dr. Qianbin Li is a professor at the Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University. He received a BS degree in pharmacy in 2003 and a PhD in medicinal chemistry in 2008 from Shandong University. He joined the School of Pharmacy, Virginia Commonwealth University, as a postdoctoral fellow in February 2008. His current research projects focus on the development of innovative drugs of fibrosis-related disease, cancer, cardiovascular diseases and metabolic disease. Key areas of concentration within the group comprise chemical biology based target identification and validation, virtual screening, structure-based drug design or optimization, organic synthesis, molecular level mechanism of action and druggability study on potential candidates. mrmc_ebm_lu-x_001 Lu X. Jinan University Guangzhou China Dr. Xiaoyun Lu received her Ph.D. from China Pharmaceutical University in 2010. Now, Professor Lu is working at Jinan University. To date she has published more than 50 papers in medical journals. Major Research Interests are focused on the rational design and synthesis of medicinal lead compounds targeting major lung diseases, such as lung cancer, tuberculosis and lung injury, etc. mrmc_ebm_rana-s_001 Rana S. University of Nebraska Medical Center Omaha NE USA Sandeep Rana is working as a Research Assistant Professor at the Eppley Institute for Cancer Research and Allied Diseases, University of Nebraska Medical Center. Before joining UNMC, he completed a 2-year postdoctoral research position at Mayo Clinic, MN. He received his Master’s degree in Chemistry from the University of Delhi, India. After finishing his Master’s, he was awarded a research fellowship from the Council of Scientific and Industrial Research, New Delhi, to pursue his graduate studies. He moved to the United States, attended Kansas State University, and received his Ph.D. in Organic Chemistry under the guidance of Dr. Duy H. Hua in 2009. His research interests lie in medicinal chemistry and drug discovery in the area of cancer and neurodegenerative diseases. mrmc_ebm_chakraborty-s_001 Chakraborty S. Indian Association for the Cultivation of Sciences Kolkata India Dr. Sandipan Chakraborty completed his B.Sc. in Chemistry from University of Calcutta, India, and his M.Sc. in Bioinformatics from West Bengal University of Technology, India. Later on, he obtained his Ph.D. in Biophysics, Molecular Biology and Bioinformatics from University of Calcutta. Dr. Chakraborty is actively involved in teaching and doing research in drug discovery, atomistic simulation, spectoscopy and protein chemistry. He worked as an Assistant Professor in Chemistry at Saroj Mohan Institute of Technology, India, and is currently working as Research Associate at Indian Association for the Cultivation of Science, India. Dr. Chakraborty has published over 50 research articles in peer-reviewed international journals, and 3 book chapters. mrmc_ebm_teoh-sl_001 Teoh S.L. Universiti Kebangsaan Malaysia Medical Center (UKMMC) Kuala Lumpur Malaysia Dr. Seong-Lin Teoh is a senior lecturer in the Department of Anatomy, of Universiti Kebangsaan Malaysia. He is the coordinator of the Master of Medical Sciences (Anatomy), and the deputy secretary of the Malaysian Anatomical Association. His work has been focused to the characterization of different herbs in diabetic cutaneous wound healing; and neuroregeneration and neurodegeneration using zebrafish animal model.

Journal History

Mini-Reviews in Medicinal Chemistry was launched in 2001. Dr. Atta-ur-Rahman, Dr. M. Iqbal Choudhary and Dr. George Perry are the Co- Editors of the journal.
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