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Medicinal Chemistry

Volume 15, 8 Issues, 2019
ISSN: 1875-6638 (Online)
ISSN: 1573-4064 (Print)
This journal supports open access

Aims & Scope

Medicinal Chemistry a peer-reviewed journal, aims to cover all the latest outstanding developments in medicinal chemistry and rational drug design. The journal publishes original research, full-length/mini-review articles and guest edited thematic issues covering recent research and developments in the field. Articles are published rapidly by taking full advantage of Internet technology for both the submission and peer review of manuscripts. Medicinal Chemistry is an essential journal for all involved in drug design and discovery.

Medicinal Chemistry

,

Volume 15

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Number 4



Biography   Open Access



Research Article

Rational Design of Colchicine Derivatives as anti-HIV Agents via QSAR and Molecular Docking

, 15(4): 328 - 340

Apilak Worachartcheewan*, Napat Songtawee, Suphakit Siriwong, Supaluk Prachayasittikul*, Chanin Nantasenamat and Virapong Prachayasittikul


DOI: 10.2174/1573406414666180924163756


Research Article

Phenolic Imidazole Derivatives with Dual Antioxidant/Antifungal Activity: Synthesis and Structure-Activity Relationship

, 15(4): 341 - 351

Ana P. Bettencourt, Marián Castro, João P. Silva, Francisco Fernandes, Olga P. Coutinho, Maria J. Sousa, Maria Fernanda Proença* and Filipe M. Areias*


DOI: 10.2174/1573406414666181005143431


Research Article



Research Article

New N,C-Diaryl-1,2,4-triazol-3-ones: Synthesis and Evaluation as Anticancer Agents

, 15(4): 360 - 372

Dolores Santa María*, Rosa M. Claramunt, José Elguero, Miguel Carda, Eva Falomir and Celia Martín-Beltrán


DOI: 10.2174/1573406414666180821103604


Research Article



Research Article



Research Article

Synthesis and Evaluation of Antifungal and Antitrypanosomastid Activities of Symmetrical 1,4-Disubstituted-1,2,3-Bistriazoles Obtained by CuAAC Conditions

, 15(4): 400 - 408

Mauricio M. Victor*, Ravir R. Farias, Danielle L. da Silva, Paulo H.F. do Carmo, Maria A. de Resende-Stoianoff, Cláudio Viegas, Patrícia F. Espurie and Marcos J. Marquese


DOI: 10.2174/1573406414666181024111522


Medicinal Chemistry, Volume 15 (2019) - Number 5


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Helminthicidal and Larvicidal Potentials of Biogenic Silver Nanoparticles Synthesized from Medicinal Plant Momordica charantia


Amruta Shelar, Jaiprakash Sangshetti, Shampa Chakraborti*, Ajay Vikram Singh, Rajendra Patil* and Suresh Gosavi


View Abstract


Novel Amide Derivatives as Potent Tyrosinase Inhibitors; In-vitro, In-vivo Antimelanogenic Activity and Computational Studies


Anser Ali, Zaman Ashraf, Muhammad Rafiq, Ajeet Kumar, Farukh Jabeen, Geon Joon Lee, Fahad Nazir, Mushtaq Ahmed, Myungchull Rhee and Eun Ha Choi*


View Abstract View on PubMed


Structure Activity Relationship of 4-Amino-2-thiopyrimidine Derivatives as Platelet Aggregation Inhibitors


Barbara Cacciari*, Pamela Crepaldi, Chun Yan Cheng, Elena Bossi , Giampiero Spalluto, Stephanie Federico, Kenneth A. Jacobson and Marco Cattaneo


View Abstract View on PubMed


Recent Advances in Therapeutic Applications of Bisbenzimidazoles


Smita Verma , V. Ravichandiran, Nihar Ranjan and S. J.S Flora*


View Abstract View on PubMed


Antiglycation Activity of Triazole Schiff’s Bases Against Fructosemediated Glycation: In vitro and in silico Study


Muniza Shaikh, Salman Siddiqui, Humaira Zafar, Uzma Naqeeb, Fakiha Subzwari, Rehan Imad, Khalid Mohammed Khan and M. Iqbal Choudhary*


View Abstract View on PubMed




Synthesis, Biological Evaluation and Molecular Dynamics Simulation Studies of Novel Diphenyl Ethers


Amol B. Khade, Sidhartha S. Kar, A Cinu Thomas , Ashutosh Tiwari, Mradul Tiwari, K. E. Vandana , Pritesh Bhat, G. Varadaraj Bhat and G. Gautham Shenoy*


View Abstract View on PubMed



New Copper Compounds with Antiplatelet Aggregation Activity


Mirthala Flores-Garcia, Juan Manuel Fernández-G, Cristina Busqueta-Griera, Elizabeth Gomez, Simon Hernandez-Ortega, Jean Christian Daniel Lamothe-Flores, Virginia Gomez-Vidales, Ana Maria Mejia-Dominguez, Eduardo Angles-Cano and Aurora de la Pena-Diaz*


View Abstract View on PubMed


Abstracts Ahead of Print

Thiazole Compounds as Antiviral Agents: An Update


Inder Pal Singh*, Shiv Gupta and Sanjay Kumar


View Abstract



New Serotoninergic Ligands Containing Indolic and Methyl Indolic Nuclei: Synthesis and in Vitro Pharmacological Evaluation


Elisa Magli, Beatrice Severino*, Angela Corvino, Elisa Perissutti, Francesco Frecentese, Irene Saccone, Flavia Giordano, Marian Castro, Josè Brea, Marian Isabel Loza, Vincenzo Santagada, Giuseppe Caliendo and Ferdinando Fiorino


View Abstract


Synthesis, Anticancer Activity on Prostate Cancer Cell Lines and Molecular Modeling Studies of Flurbiprofen-Thioether Derivatives as Potential Target of MetAP (type II)


ÖZGÜR YILMAZ, Burak Bayer, HATİCE BEKÇİ, Abdullah Ibrahim Uba, AHMET CUMAOĞLU, Kemal YELEKCI and S. GÜNİZ KÜÇÜKGÜZEL


View Abstract


Design, synthesis and biological evaluation of anti-tuberculosis agents based on Bedaquiline structure


Chengjun Wu*, Jinghan Luo, Mengtong Wu, Fanzhen Meng, Zhiqiang Cai, Yu Chen and Tiemin Sun


View Abstract


2-Mercapto Benzothiazole Derivatives: As Potential Leads for the Diabetic Management


Saeed Ullah, Salma Mirza, Uzma Salar, Shafqat Hussain, Kulsoom Javaid, Khalid Mohammed Khan*, Ruqaiya Khalil, Atia Tul Wahab, Zaheer Ul-Haq, Shahnaz Perveen and M. Iqbal Choudhary


View Abstract


Synthesis, In vitro α-Glucosidase Inhibitory Potential and Molecular Docking Studies of 2-Amino-1,3,4-Oxadiazole Derivatives


Hayat Ullah, Fazal Rahim*, Muhammad Taha, Raffaqat Hussain, Abdul Wadood, Mohsan Nawaz, Zainul Wahab, Kanwal and Khalid Mohammed Khan


View Abstract





Published Contents

Open Access Articles

Day/Night and Summer/Winter Changes in Serum Total Antioxidant Capacity

, 2018; 14(3): 225 - 229

Armando L. Morera-Fumero*, Pedro Abreu-Gonzalez, Manuel Henry-Benitez, Lourdes Fernandez-Lopez, Estefania Diaz-Mesa, Maria del Rosario Cejas-Mendez and Fernando Guillen-Pino




IRS-1 pY612 and Akt-1/PKB pT308 Phosphorylation and Antiinflammatory Effect of Diindolylmethane in Adipocytes Cocultured with Macrophages

, 2017; 13(8): 727 - 733

Alfonso Lopez-Vazquez, Jesus J. Garcia-Banuelos*, Angelica S. Gonzalez-Garibay, Pedro E. Urzua-Lozano, Susana Del Toro-Arreola, Miriam R. Bueno-Topete, Sergio Sanchez-Enriquez, Jose F. Munoz-Valle, Luis F. Jave-Suarez, Juan Armendariz-Borunda and Blanca E. Bastidas-Ramirez*




Long Term Stability Evaluation of Prostacyclin Released from Biomedical Device through Turbiscan Lab Expert

, 2015; 11(4): 391 - 399

Christian Celia, Marcello Locatelli, Felisa Cilurzo, Donato Cosco, Emanuela Gentile, Daniela Scalise, Maria Carafa, Cinzia Anna Ventura, Mathias Fleury, Christelle Tisserand, Renato. C Barbacane, Massimo Fresta, Luisa Di Marzio and Donatella Paolino




Practical Application of Antidiabetic Efficacy of Lycium barbarum Polysaccharide in Patients with Type 2 Diabetes

, 2015; 11(4): 383 - 390

Huizhen Cai, Fukang Liu, Pingguo Zuo, Guiling Huang, Zhixiu Song, Tingting Wang, Huixia Lu, Fei Guo, Chao Han and Guiju Sun





Synthesis of New Thiazolo[4,5-d]pyrimidines as Corticotropin Releasing Factor Modulators

, 2015; 11(1): 50 - 59

Bhimanna Kuppast, Katerina Spyridaki, Christophina Lynch, Yueshan Hu, George Liapakis, Gareth E. Davies and Hesham Fahmy





Most Cited Articles

Review Article

USP7: Target validation and drug discovery for cancer therapy

, 2018; 14(1): 3-18.

Jin Zhou*, Jinzheng Wang, Chao Chen, Haoliang Yuan, Xiaoan Wen* and Hongbin Sun*


DOI: 10.2174/1573406413666171020115539


Research Article

Cell cycle arrest and apoptosis induction activity of nitidine chloride on acute myeloid leukemia cells

, 2018; 14(1): 60-66.

Peng Li, Shuxin Yan, Xin Dong, Zhao Li, Yu Qiu, Chunyan Ji, Jingru Zhang, Min Ji, Wei Li, Hongchun Wang, Zhi Liu, Xing L. Wang, Jingjing Ye* and Daoxin Ma


DOI: 10.2174/1573406413666170620091543




Research Article

Biology-oriented synthesis (BIOS) of piperine derivatives and their comparative analgesic and antiinflammatory activities

, 1 May 2018; 14(3): 269-280.

Ammar Yasir, Saiqa Ishtiaq, Muhammad Jahangir, Muhammad Ajaib, Uzma Salar and Khalid M. Khan*


DOI: 10.2174/1573406413666170623083810




Research Article

Quinolinic carboxylic acid derivatives as potential multi-target compounds for neurodegeneration: Monoamine oxidase and cholinesterase inhibition

, 2018; 14(1): 74-85.

Nehal A. Khan, Imtiaz Khan, Syed M.A. Abid, Sumera Zaib, Aliya Ibrar, Hina Andleeb, Shahid Hameed* and Jamshed Iqbal*


DOI: 10.2174/1573406413666170525125231


Research Article

Molecular interaction and computational analytical studies of pinocembrin for its antiangiogenic potential targeting VEGFR-2: A persuader of metastasis

, 2018; 14(6): 626-640.

Neha Sharma, Mala Sharma, Eram Shakeel, Qazi M.S. Jamal, Mohammad A. Kamal, Usman Sayeed, Mohammad K.A. Khan, Mohammad H. Siddiqui, Jamal M. Arif and Salman Akhtar*


DOI: 10.2174/1573406414666180416125121


Research Article

In vitro and in silico evaluation of non-quaternary reactivators of AChE as antidotes of organophosphorus poisoning - A new hope or a blind alley?

, 1 May 2018; 14(3): 281-292.

Ondrej Soukup, Jan Korabecny, David Malinak, Eugenie Nepovimova, Ngoc L. Pham, Kamil Musilek, Martina Hrabinova, Vendula Hepnarova, Rafael Dolezal, Petr Pavek, Petr Jost, Tereza Kobrlova , Jana Jankockova, Lukas Gorecki, Miroslav Psotka, Thuy D. Nguyen, Karl Box, Breeze Outhwaite, Martina Ceckova, Ales Sorf, Daniel Jun* and Kamil Kuca*


DOI: 10.2174/1573406414666180112105657


Review Article

Managing neuropathic pain in multiple sclerosis: Pharmacological interventions

, 1 March 2018; 14(2): 106-119.

Samuel S. Duffy*, Justin G. Lees, Chamini J. Perera and Gila Moalem-Taylor*


DOI: 10.2174/1573406413666170906122508



Review Article

Is there a link between Vitamin B and multiple sclerosis?

, 1 March 2018; 14(2): 170-180.

Natalie Nemazannikova, Kathleen Mikkelsen, Lily Stojanovska, Gregory L. Blatch and Vasso Apostolopoulos*


DOI: 10.2174/1573406413666170906123857


Review Article

New perspectives of Alzheimer disease diagnosis - The most popular and future methods

, 11 January 2018; 14(1): 34-43.

Katarzyna Pietrzak, Kamila Czarnecka, Elzbieta Mikiciuk-Olasik and Pawel Szymanski*


DOI: 10.2174/1573406413666171002120847


Research Article

Pyrano[3,2-c]quinoline derivatives as new class of α-glucosidase inhibitors to treat type 2 diabetes: Synthesis, in vitro biological evaluation and kinetic study

, 2019; 15(1): 8-16.

Zahra Heydari, Maryam Mohammadi-Khanaposhtani, Somaye Imanparast, Mohammad A. Faramarzi, Mohammad Mahdavi *, Parviz R. Ranjbar* and Bagher Larijani


DOI: 10.2174/1573406414666180528110104



Most Accessed Articles

Predicting the Activity of Antimicrobial Peptides with Amino Acid Topological Information

, 2013; 9(1): 32-44.

Mao Shu, Rui Yu, Yunru Zhang, Juan Wang, Li Yang, Li Wang and Zhihua Lin


DOI: 10.2174/1573406411309010032


USP7: Target Validation and Drug Discovery for Cancer Therapy

, 2018; 14(1): 3-18.

Jin Zhou*, Jinzheng Wang, Chao Chen, Haoliang Yuan, Xiaoan Wen* and Hongbin Sun*


DOI: 10.2174/1573406413666171020115539


Phenolic Imidazole Derivatives with Dual Antioxidant/Antifungal Activity: Synthesis and Structure-Activity Relationship

, 2019; 15(4): 341-351.

Ana P. Bettencourt, Marián Castro, João P. Silva, Francisco Fernandes, Olga P. Coutinho, Maria J. Sousa, Maria Fernanda Proença* and Filipe M. Areias*


DOI: 10.2174/1573406414666181005143431


Rational Design of Colchicine Derivatives as anti-HIV Agents via QSAR and Molecular Docking

, 2019; 15(4): 328-340.

Apilak Worachartcheewan*, Napat Songtawee, Suphakit Siriwong, Supaluk Prachayasittikul*, Chanin Nantasenamat and Virapong Prachayasittikul


DOI: 10.2174/1573406414666180924163756


New Perspectives of Alzheimer Disease Diagnosis – the Most Popular and Future Methods

, 2018; 14(1): 34-43.

Katarzyna Pietrzak, Kamila Czarnecka, Elzbieta Mikiciuk-Olasik and Pawel Szymanski*


DOI: 10.2174/1573406413666171002120847


New N,C-Diaryl-1,2,4-triazol-3-ones: Synthesis and Evaluation as Anticancer Agents

, 2019; 15(4): 360-372.

Dolores Santa María*, Rosa M. Claramunt, José Elguero, Miguel Carda*, Eva Falomir and Celia Martín-Beltrán


DOI: 10.2174/1573406414666180821103604



Antiprotozoal Activities of Tetrazole-quinolines with Aminopiperidine Linker

, 2019; 15(4): 409-416.

Patrick Hochegger, Johanna Faist, Werner Seebacher, Robert Saf, Pascal Mäser, Marcel Kaiser and Robert Weis*


DOI: 10.2174/1573406414666181015115101


Ligand-Based Drug Design: Synthesis and Biological Evaluation of Substituted Benzoin Derivatives as Potential Antitumor Agents

, 2019; 15(4): 417-429.

Dima A. Sabbah*, Ameerah H. Ibrahim, Wamidh H. Talib, Khalid M. Alqaisi, Kamal Sweidan, Sanaa K. Bardaweel, Ghassan A. Sheikha, Haizhen A. Zhong, Eveen Al-Shalabi, Reema A. Khalaf and Mohammad S. Mubarak


DOI: 10.2174/1573406414666180912111846





Editor-in-Chief

Dimitra Hadjipavlou-Litina
Aristotle University of Thessaloniki
Thessaloniki
Greece

Biography View Full Editorial Board

Journal History

Medicinal Chemistry Journal was launched in 2005. Dr. Dimitra Hadjipavlou-Litina serves as the Editor-in-Chief of the journal.
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