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Medicinal Chemistry

Volume 15, 8 Issues, 2019
ISSN: 1875-6638 (Online)
ISSN: 1573-4064 (Print)
This journal supports open access

Aims & Scope

Medicinal Chemistry a peer-reviewed journal, aims to cover all the latest outstanding developments in medicinal chemistry and rational drug design. The journal publishes original research, full-length/mini-review articles and guest edited thematic issues covering recent research and developments in the field. Articles are published rapidly by taking full advantage of Internet technology for both the submission and peer review of manuscripts. Medicinal Chemistry is an essential journal for all involved in drug design and discovery.

Medicinal Chemistry

,

Volume 15

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Number 3



Biography   Open Access



Review Article

Identification, Prediction and Data Analysis of Noncoding RNAs: A Review

, 15(3): 216 - 230

Abbasali Emamjomeh*, Javad Zahiri, Mehrdad Asadian, Mehrdad Behmanesh, Barat A. Fakheri and Ghasem Mahdevar


DOI: 10.2174/1573406414666181015151610


Research Article

Design, Synthesis and Anticancer Evaluation of Novel Series of Indibulin Analogues

, 15(3): 231 - 239

Ebrahim S. Moghadam, Farhad Saravani, Seyednasser Ostad, Shohreh Tavajohi, Morteza P. Hamedani and Mohsen Amini*


DOI: 10.2174/1573406414666181015145945


Research Article

Synthesis of New Thiosemicarbazones and Semicarbazones Containing the 1,2,3-1H-triazole-isatin Scaffold: Trypanocidal, Cytotoxicity, Electrochemical Assays, and Molecular Docking

, 15(3): 240 - 256

Bianca N.M. Silva, Policarpo A. Sales Junior, Alvaro J. Romanha, Silvane M.F. Murta, Camilo H.S. Lima, Magaly G. Albuquerque, Eliane D'Elia, José G.A. Rodrigues, Vitor F. Ferreira, Fernando C. Silva, Angelo C. Pinto and Bárbara V. Silva*


DOI: 10.2174/1573406414666180912120502


Research Article

Synthesis and Biological Evaluation of 3-cyano-4H-chromene Derivatives Bearing Carbamate Functionality

, 15(3): 257 - 264

Fatma Boukattaya, Amal Daoud, Fabien Boeda, Morwenna S.M. Pearson-Long, Néji Gharsallah, Adel Kadri, Philippe Bertus* and Houcine Ammar


DOI: 10.2174/1573406414666181009124449


Research Article

Synthesis, 2D-QSAR Studies and Biological Evaluation of Quinazoline Derivatives as Potent Anti-Trypanosoma cruzi Agents

, 15(3): 265 - 276

Mariela Bollini, Ana M. Bruno*, María E. Niño, Juan J. Casal, Leandro D. Sasiambarrena, Damián A.G. Valdez, Leandro Battini, Vanesa R. Puente and María E. Lombardo


DOI: 10.2174/1573406414666181005145042


Research Article



Research Article

Synthesis & Anticancer Evaluation of New Substituted 2-(3,4- Dimethoxyphenyl)benzazoles

, 15(3): 287 - 297

Cigdem Karaaslan , Yalcin Duydu, Aylin Ustundag , Can O. Yalcin, Banu Kaskatepe and Hakan Goker*


DOI: 10.2174/1573406414666180711130012


Medicinal Chemistry, Volume 15 (2019) - Number 4


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Design and Synthesis of New Substituted Pyrazolopyridines with Potent Antiproliferative Activity


Vassiliki Giannouli, Nikolaos Lougiakis, Ioannis K. Kostakis, Nicole Pouli*, Panagiotis Marakos, Alexios-Leandros Skaltsounis, David A. Horne, Sangkil Nam, Katerina Gioti and Roxane Tenta


View Abstract View on PubMed


Chemistry, Alpha-glucosidase and Radical Scavenging Properties of Uranyl(VI) Hydrazide Complexes


Parveen Akhter, Uzma Ashiq*, Rifat Ara Jamal, Zara Shaikh, Mohammad Mahroof-Tahir, Mehreen Lateef and Rooma Badar


View Abstract View on PubMed





The Effects of Trifluoromethylated Derivatives on Prostaglandin E2 and Thromboxane A2 Production in Human Leukemic U937 Macrophages


Ivana Beara*, Tatjana Majkić, Stefania Fioravanti, Laura Trulli, Neda Mimica-Dukić, Lucio Pellacani and Luciano Saso


View Abstract View on PubMed




Discovery and Optimization of a Series of Sulfonamide Inverse Agonists for the Retinoic Acid Receptor-related Receptor-α


Christelle Doebelin, Yuanjun He, Sean Campbell, Philippe Nuhant, Naresh Kumar, Marcel Koenig, Ruben Garcia-Ordonez, Mi Ra Chang, William R. Roush, Li Lin, Susan Kahn, Michael D. Cameron, Patrick R. Griffin, Laura A. Solt* and Theodore M. Kamenecka*


View Abstract View on PubMed


Design, Synthesis, and Biological Evaluation of Novel C5-Modified Pyrimidine Ribofuranonucleosides as Potential Antitumor or/and Antiviral Agents


Nikolaos Kollatos, Christos Mitsos, Stella Manta, Niki Tzioumaki, Christos Giannakas, Tania Alexouli, Aggeliki Panagiotopoulou, Dominique Schols, Graciela Andrei and Dimitri Komioti*


View Abstract View on PubMed


Abstracts Ahead of Print



Recent Advances in Therapeutic Applications of Bisbenzimidazoles


Smita Verma , V. Ravichandiran, Nihar Ranjan and S. J.S Flora*


View Abstract


Synthesis of β-Ketosulfone Derivatives As New Non-Cytotoxic Urease Inhibitors In Vitro


Sarosh Iqbal*, Ajmal Khan, Rashid Nazir, Shumaila Kiran, Shahnaz Perveen, Khalid Mohammed Khan* and M. Iqbal Choudhary*


View Abstract


Synthesis and biological evaluation of 5-benzyl-3-pyridyl-1H-1,2,4-triazole derivatives as xanthine oxidase inhibitors


Song-ye Li , Ting-jian Zhang , Qing-xia Wu, O Kamara Mohamed, Yi Zhang and Fan-hao Meng*


View Abstract



Synthesis and Cytotoxicity Evaluation of Novel Indole Derivatives as Potential Anti-Cancer Agents


Mona Monir Kamel, Mohamed Kamal Abdel-hameid, Hala Bakr ElNassan* and Eman Adel El-Khouly


View Abstract


Design and Synthesis of New Sulfonamides–Based Flt3 Inhibitors


Reem Fawaz Abutayeh, Jehad Almaliti and Mutasem O. Taha*


View Abstract


First example of antiparasitic activity influenced by thermochromism: Leishmanicidal evaluation of 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine metal complexes


José M. Méndez-Arriaga*, Itziar Oyarzabal, Álvaro Martín-Montes, Judith García-Rodríguez, Miguel Quirós and Manuel Sánchez-Moreno


View Abstract


Novel amide derivatives as potent tyrosinase inhibitors; in-vitro, in-vivo antimelanogenic activity and computational studies


Anser Ali, Zaman Ashraf, Muhammad Rafiq, Ajeet Kumar, Farukh Jabeen, Geon Joon Lee, Fahad Nazir, Mushtaq Ahmed, Myungchull Rhee and Eun Ha Choi*


View Abstract


Open Access Articles

Day/Night and Summer/Winter Changes in Serum Total Antioxidant Capacity

, 2018; 14(3): 225 - 229

Armando L. Morera-Fumero*, Pedro Abreu-Gonzalez, Manuel Henry-Benitez, Lourdes Fernandez-Lopez, Estefania Diaz-Mesa, Maria del Rosario Cejas-Mendez and Fernando Guillen-Pino




IRS-1 pY612 and Akt-1/PKB pT308 Phosphorylation and Antiinflammatory Effect of Diindolylmethane in Adipocytes Cocultured with Macrophages

, 2017; 13(8): 727 - 733

Alfonso Lopez-Vazquez, Jesus J. Garcia-Banuelos*, Angelica S. Gonzalez-Garibay, Pedro E. Urzua-Lozano, Susana Del Toro-Arreola, Miriam R. Bueno-Topete, Sergio Sanchez-Enriquez, Jose F. Munoz-Valle, Luis F. Jave-Suarez, Juan Armendariz-Borunda and Blanca E. Bastidas-Ramirez*




Long Term Stability Evaluation of Prostacyclin Released from Biomedical Device through Turbiscan Lab Expert

, 2015; 11(4): 391 - 399

Christian Celia, Marcello Locatelli, Felisa Cilurzo, Donato Cosco, Emanuela Gentile, Daniela Scalise, Maria Carafa, Cinzia Anna Ventura, Mathias Fleury, Christelle Tisserand, Renato. C Barbacane, Massimo Fresta, Luisa Di Marzio and Donatella Paolino




Practical Application of Antidiabetic Efficacy of Lycium barbarum Polysaccharide in Patients with Type 2 Diabetes

, 2015; 11(4): 383 - 390

Huizhen Cai, Fukang Liu, Pingguo Zuo, Guiling Huang, Zhixiu Song, Tingting Wang, Huixia Lu, Fei Guo, Chao Han and Guiju Sun





Synthesis of New Thiazolo[4,5-d]pyrimidines as Corticotropin Releasing Factor Modulators

, 2015; 11(1): 50 - 59

Bhimanna Kuppast, Katerina Spyridaki, Christophina Lynch, Yueshan Hu, George Liapakis, Gareth E. Davies and Hesham Fahmy





Most Cited Articles




miRNAs as Circulating Biomarkers for Alzheimer’s Disease and Parkinson’s Disease

, 2016; 12(3): 217-225.

Gohar Mushtaq, Nigel H. Greig, Firoz Anwar, Mazin A. Zamzami, Hani Choudhry, Munvar M. Shaik, Ian A. Tamargo and Mohammad A. Kamal


DOI: 10.2174/1573406411666151030112140


Growth Factors and Astrocytes Metabolism: Possible Roles for Platelet Derived Growth Factor

, 2016; 12(3): 204-210.

Ricardo Cabezas, Marco Avila-Rodriguez, Nelson E. Vega-Vela, Valentina Echeverria, Janneth González, Oscar A. Hidalgo, Altair B. Santos, Gjumrakch Aliev and George E. Barreto


DOI: 10.2174/1573406411666151019120444


Recent Updates on the Association Between Alzheimer’s Disease and Vascular Dementia

, 2016; 12(3): 226-237.

Ghulam M. Ashraf, Sandesh Chibber, Mohammad, Syed K. Zaidi, Shams Tabrez, Ausaf Ahmad, Shazi Shakil, Gohar Mushtaq, Saleh S. Baeesa and Mohammad A. Kamal


DOI: 10.2174/1573406411666151030111820


Discovery of Flexible Naphthyltriazolylmethane-based Thioacetic Acids as Highly Active Uric Acid Transporter 1 (URAT1) Inhibitors for the Treatment of Hyperuricemia of Gout

, 2017; 13(3): 260-281.

Xiansheng Zhang, Jingwei Wu, Wei Liu, Yuqiang Liu, Yafei Xie, Qian Shang, Zhixing Zhou, Weiren Xu, Lida Tang, Jianwu Wang and Guilong Zhao*


DOI: 10.2174/1573406412666160915163002



New N,N,N’,N’-tetradentate Pyrazoly Agents: Synthesis and Evaluation of their Antifungal and Antibacterial Activities

, 2016; 12(1): 83-89.

Farid Abrigach, Btissam Bouchal, Olivier Riant, Yohan Mace, Abdelilah Takfaoui, Smaail Radi, Abdelouahad Oussaid, Mohammed Bellaoui and Rachid Touzani


DOI: 10.2174/1573406411666150519111800



Most Accessed Articles

USP7: Target Validation and Drug Discovery for Cancer Therapy

, 2018; 14(1): 3-18.

Jin Zhou*, Jinzheng Wang, Chao Chen, Haoliang Yuan, Xiaoan Wen* and Hongbin Sun*


DOI: 10.2174/1573406413666171020115539


New Perspectives of Alzheimer Disease Diagnosis – the Most Popular and Future Methods

, 2018; 14(1): 34-43.

Katarzyna Pietrzak, Kamila Czarnecka, Elzbieta Mikiciuk-Olasik and Pawel Szymanski*


DOI: 10.2174/1573406413666171002120847


Pyrano[3,2-c]quinoline Derivatives as New Class of α-glucosidase Inhibitors to Treat Type 2 Diabetes: Synthesis, in vitro Biological Evaluation and Kinetic Study

, 2019; 15(1): 8-16.

Zahra Heydari, Maryam Mohammadi-Khanaposhtani, Somaye Imanparast, Mohammad A. Faramarzi, Mohammad Mahdavi *, Parviz R. Ranjbar* and Bagher Larijani


DOI: 10.2174/1573406414666180528110104


Antimicrobial Evaluation of Erythrinan Alkaloids from Erythrina cristagalli L.

, 2018; 14(8): 784-790.

Janaína M. de Ávila, Ionara I. Dalcol*, Alessandra O. Pereira, Eveline W. Santos, Adriano Ferraz, Maura Z. Santos, Marco A. Mostardeiro and Ademir F. Morel


DOI: 10.2174/1573406414666180524081650




Synthesis and Evaluation of the in vitro Antimicrobial Activity of Triazoles, Morpholines and Thiosemicarbazones

, 2019; 15(1): 38-50.

Felipe R.S. Santos, Jéssica T. Andrade, Carla D.F. Sousa, Joice S. Fernandes, Lucas F. Carmo, Marcelo G.F. Araújo, Jaqueline M.S. Ferreira and José A.F.P. Villar*


DOI: 10.2174/1573406414666180730111954


4-Hydroxy-2-pyridone Derivatives and the δ-pyrone Isostere as Novel Agents Against Mycobacterium smegmatis Biofilm Inhibitors

, 2019; 15(1): 28-37.

Maheshkumar R. Borkar, Santosh Nandan*, Harish K.M. Nagaraj, Jayashree Puttur, Jisha Manniyodath, Dipankar Chatterji and Evans C. Coutinho *


DOI: 10.2174/1573406414666180525075755


Crystal Structure of Mistletoe Lectin I (ML-I) from Viscum album in Complex with 4-N-Furfurylcytosine at 2.85 Å Resolution

, 2018; 14(8): 754-763.

Malik S. Ahmad*, Saima Rasheed, Sven Falke, Binish Khaliq, Markus Perbandt, Muhammad I. Choudhary, Wojciech T. Markiewicz, Jan Barciszewski and Christian Betzel*


DOI: 10.2174/1573406414666180524095946


Synthesis of Nucleosides and Non-nucleosides Based 4,6-disubstituted-2-oxo-dihydropyridine-3-carbonitriles as Antiviral Agents

, 2018; 14(8): 791-808.

Tarek S. Ibrahim, Hassan A. El-Sayed, Maan T. Khayat, Amany M.M. AL-Mahmoudy, Ahmed H. Moustafa*, Ayat K.S. El-Deen, Sherif A.F. Rostom and Siva S. Panda*


DOI: 10.2174/1573406414666180522123524



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