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Letters in Drug Design & Discovery

Volume 16, 12 Issues, 2019
ISSN: 1875-628X (Online)
ISSN: 1570-1808 (Print)
This journal supports open access

Aims & Scope

Letters in Drug Design & Discovery publishes letters, full-length/mini-reviews, highlights and guest edited thematic issues in all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis is on publishing quality papers very rapidly by taking full advantage of latest Internet technology for both submission and review of manuscripts. The online journal is an essential reading to all pharmaceutical scientists involved in research in drug design and discovery.

Letters in Drug Design & Discovery

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Volume 16

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Number 5



Editorial   Open Access



Review Article

Potential of Nanoparticles in Combating Candida Infections

, 16(5): 478 - 491

Faizan Abul Qais, Mohd Sajjad Ahmad Khan, Iqbal Ahmad* and Abdullah Safar Althubiani


DOI: 10.2174/1570180815666181015145224


Review Article



Research Article

Phenolic Composition and Antifungal Effect of Costus cf. arabicus L Against Yeast of the Candida Genus

, 16(5): 502 - 511

Antonia Thassya Lucas Dos Santos , Antonio Júdson Targino Machado, Maria Audilene De Freitas, Irwin Rose Alencar De Menezes, Henrique Douglas Melo Coutinho, Francisco Assis Bezerra Da Cunha, Djair Dos Santos De Lima E Souza, Aline Augusti Boligon, Adeliana Silva De Oliveira, Andressa De Alencar Silva and Maria Flaviana Bezerra Morais-Braga*


DOI: 10.2174/1570180815666180827122526


Research Article



General Research Article

Synthesis and Anticancer Activity of New Hydrazide-hydrazones and Their Pd(II) Complexes

, 16(5): 522 - 532

Bedia Kocyigit-Kaymakcioglu*, Senem Sinem Yazici, Fatih Tok, Miriş Dikmen, Selin Engür , Emine Elçin Oruc-Emre and Aysegul Iyidogan


DOI: 10.2174/1570180815666180816124102


General Research Article



General Research Article



Articles Ahead of Print

Synthesis And Herbicidal ActivitiesOf Novel Thiazole PPO Inhibitors


Guihua Ren, Dan Pei, Fan Zhang, Jie Liu, Shu Chen, Donglin Zhang, Ren Yang, Jianjun Shi, Tianming Xu and Chengxia Tan*


View Abstract


Studies on the pIC50 of 4,5-Diarylisoxazole as HSP90 Inhibitors


Jing Ouyang, Xiaoqian Liu, Yutao Zhao, Ying Liu, Hongzong Si* and Honglin Zhai


View Abstract


3D-QSAR and Docking Studies on Pyrimidine Derivatives as CSF-1R inhibitors


Ya-ting Deng, Jun-wei Wang, Han Chu, Juan Wang, Yong Hu, Yong lin, Mao Shu and Zhi-hua Lin*


View Abstract



An Efficient Protocol for the Synthesis, Biological Screening and Molecular Docking Studies of 3,4-Dihydropyrimidine-2-one/thione Derivatives


Ehsan Ullah Mughal*, Hafiz Umar Farooq, Amina Sadiq, Hummera Rafique, Sajjad Hussain Sumrra, Muhammad Naveed Zafar, Nighat Fatima, Syed Aun Muhammad, Abdul Manan, Chaudhary Omer Javed and Muhammad Tayyab


View Abstract


Drug Discovery of Acetophenone Derivatives as BRD4 Inhibitors


Zhimin Zhang, Wenhai Huang, Xiaoliang Zheng, Chuansheng Li and Zhengrong Shen*


View Abstract



Recursive Partitioning Analysis and Anti-Tubercular Screening of 3- Aminopyrazine-2-Carbohydrazide Derivatives


Pankaj B. Miniyar*, Anand A. Mahajan, Dattatray D. Anuse, Ashish S. Kumar, Mahesh A. Barmade, Dhiman Sarkar, Manisha Arkile and Vijay M. Khedkar


View Abstract


A Series of Furan-Based Hydrazones: Design, Synthesis, and Evaluation of Antimicrobial Activity, Cytotoxicity and Genotoxicity


Mehlika Dilek Altıntop*, Belgin Sever, Özlem Atlı Eklioğlu, Merve Baysal, Rasime Demirel and Ahmet Özdemir


View Abstract



Abstracts Ahead of Print

Synthesis of New 4-Chloro-6-methylpyrimidin-2-yl-aminophosphonates as Potential DU145 and A549 Cancer Cell Inhibitors


Gajjala Raghavendra Reddy, Chinta Raveendra Reddy, Gopireddy Venkata Subba Reddy, Pasupuleti Visweswara Rao, Meenakshisundaram Swaminathan and Cirandur Suresh Reddy*


View Abstract


Published Contents

Editor's Choice

Potential of Nanoparticles in Combating Candida Infections

, 2019; 16(5): 478 - 491

Faizan Abul Qais, Mohd Sajjad Ahmad Khan, Iqbal Ahmad* and Abdullah Safar Althubiani


DOI: 10.2174/1570180815666181015145224





Synthesis and Antichlamydial Activity of Novel Phenazines

, 2019; 16(2): 174 - 181

Xiaofeng Bao, Xiaowei Yu, Chao Xia, Ningjing Yang, Shengju Yang* and Yu Zhao*


DOI: 10.2174/1570180815666180518112952



A New Class of Pure Estrogen Alpha Receptor Antagonists; Design, Synthesis and in-vitro Screening

, 2019; 16(1): 66 - 81

Akbar John Jameera Begam, Katike Ahamed Basheer, Selvaraj Jubie*, Srikanth Jupudi, Mohammed Afzal Azam and Palanisamy Dhanabal


DOI: 10.2174/1570180815666180327124634



Preparation and Characterization of GLUT1-mediated Novel Brain Targeting Magnetic Nanoparticles

, 2018; 15(12): 1308 - 1313

Li Zhang, Yi Zhao, Qiming Yue, Qiuyi Fu, Li Hai, Li Guo, Qiantao Wang* and Yong Wu*


DOI: 10.2174/1570180815666180322113934



Synthesis and Mosquiticidal Activity of Novel Hydrazone Containing Pyrimidine Derivatives against Aedes aegypti

, 2018; 15(9): 951 - 956

Zhong-Hua Shen, Zhao-Hui Sun, James J. Becnel, Alden Estep, David E. Wedge*, Cheng-Xia Tan, Jian-Quan Weng, Liang Han and Xing-Hai Liu*


DOI: 10.2174/1570180815666180102141640



Inhibitory Effects of 1,4-disubstituted Thiosemicarbazide Derivatives on Streptococcus mutans and Streptococcus sanguinis Mono-species Biofilms

, 2018; 15(8): 843 - 850

Malgorzata Miazga-Karska, Maciej Wos, Agnieszka A. Kaczor, Anna Pachuta-Stec, Grazyna Ginalska and Monika Pitucha*


DOI: 10.2174/1570180814666171012164241



Enhancement Antimicrobial Activity of Clarithromycin by Amine Functionalized Mesoporous Silica Nanoparticles as Drug Delivery System

, 2018; 15(7): 787 - 795

Pegah Khosravian, Mehdi Khoobi, Mehdi Shafiee Ardestani, Mohammad Porgham Daryasari, Malihe Hassanzadeh, Payam Ghasemi-Dehkordi, Massoud Amanlou and Hamid Akbari Javar*


DOI: 10.2174/1570180815666180117155818



Synthesis and Mosquitocidal Activity of a Series of Hydrazone Derivatives against Aedes aegypti

, 2018; 15(6): 671 - 677

Mehlika Dilek Altintop*, Nurhayat Tabanca, James J. Becnel, Jeffrey R. Bloomquist, Zafer Asim Kaplancikli and Ahmet Ozdemir


DOI: 10.2174/1570180814666171002155548



Open Access Articles

A Study on the Synthesis of Risedronic Acid: The Role of an Ionic Liquid Additive

, 2019; 16(3): 238 - 244

Dávid Illés Nagy, Alajos Grün, Júlia Sinkovicz, Sándor Garadnay, István Greiner and György Keglevich*




Synthesis and Biological Evaluation of Some Novel Thiophene-bearing Quinazoline Derivatives as EGFR Inhibitors

, 2019; 16(2): 102 - 110

Min Zou, Bo Jin, Yanrong Liu, Huiping Chen, Zhuangli Zhang, Changzheng Zhang, Zhihong Zhao and Liyun Zheng*




Efficient Synthesis of Ibandronate in the Presence of an Ionic Liquid

, 2018; 15(7): 713 - 720

David Illes Nagy, Alajos Grun, Oliver Pavela, Sandor Garadnay, Istvan Greiner and Gyorgy Keglevich*




Challenges in the Discovery and Optimization of mGlu2/4 Heterodimer Positive Allosteric Modulators

, 2018; 15: 1 - 7 (E-Pub Ahead of Print)

Mark G. Fulton, Matthew T. Loch, Caroline A. Cuoco, Alice L. Rodriguez, Emily Days, Paige N. Vinson, Krystian A. Kozek, C David Weaver, Anna L. Blobaum, Jeff Conn, Colleen M. Niswender and Craig W. Lindsley*




L-carnitine Supplementation Improves Self-rating Depression Scale Scores in Uremic Male Patients Undergoing Hemodialysis

, 2017; 14(6): 737 - 742

Kyoko Tashiro, Yusuke Kaida, Sho-ichi Yamagishi, Hideharu Tanaka, Miyuki Yokoro, Junko Yano, Kazuko Sakai, Yuka Kurokawa, Kensei Taguchi, Yosuke Nakayama, Takahiro Inokuchi and Kei Fukami*




The Synthesis of (Iodobenzyl)oxybenzaldehydes, Useful Intermediates for Biologically Active Targets

, 2017; 14(2): 233 - 239

Hedvig Bölcskei, Andrea Német-Hanzelik, István Greiner, Zsófia Dubrovay, Viktor Háda and György Keglevich




In Vitro and In Vivo Investigations into the Carbene Gold Chloride and Thioglucoside Anticancer Drug Candidates NHC-AuCl and NHC-AuSR

, 2017; 14(2): 125 - 134

Wolfgang Walther, Oyinlola Dada, Cillian O’Beirne, Ingo Ott, Goar Sánchez-Sanz, Claudia Schmidt, Carsta Werner, Xiangming Zhu and Matthias Tacke




Efficient Synthesis of Pamidronic Acid Using an Ionic Liquid Additive

, 2016; 13(6): 475 - 478

Alajos Grun, Dávid Illés Nagy, Sándor Garadnay, István Greiner and Gyorgy Keglevich






4-Substituted-2-Methoxyphenol: Suitable Building Block to Prepare New Bioactive Natural-like Hydroxylated Biphenyls

, 2015; 12(2): 131 - 139

Maria Antonietta Dettori, Davide Fabbri, Marina Pisano, Carla Rozzo, Giuseppe Palmieri, Alessandro Dessi, Roberto Dallocchio and Giovanna Delogu




Design and Synthesis of New Dual Binding Site Cholinesterase Inhibitors: in vitro Inhibition Studies with in silico Docking

, 2014; 11(3): 331 - 338

Muhammad Yar, Marek Bajda, Rana Atif Mehmood, Lala Rukh Sidra, Nisar Ullah, Lubna Shahzadi, Muhammad Ashraf, Tayaba Ismail, Sohail Anjum Shahzad, Zulfiqar Ali Khan, Syed Ali Raza Naqvi and Nasir Mahmood




Optimized Synthesis of Etidronate

, 2013; 10(8): 733 - 737

Rita Kovacs, David Illes Nagy, Alajos Grün, Gyorgy Tibor Balogh, Sandor Garadnay, Istvan Greiner and Gyorgy Keglevich







Most Cited Articles

Microwave Assisted Synthesis and Antifungal Activity of Some Novel Thioethers Containing 1,2,4-triazolo[4,3-a] pyridine Moiety

, 2016; 13(6): 521-525.

Zhi-Wen Zhai, Yan-Xia Shi, Ming-Yan Yang, Wen Zhao, Zhao-Hui Sun, Jian-Quan Weng, Cheng-Xia Tan, Xing-Hai Liu, Bao-Ju Li and Yong-Gang Zhang


DOI: 10.2174/157018081306160618181757








Synthesis of Novel C3-Linked β-Carboline-Pyridine Derivatives Employing Khronke Reaction: DNA-binding Ability and Molecular Modeling Studies

, 2016; 13(4): 335-342.

Nagula Shankaraiah, Pankaj Sharma, Srinivas Pedapati, Shalini Nekkanti, Vunnam Srinivasulu, Niggula Praveen Kumar and Ahmed Kamal


DOI: 10.2174/157018081304160303180050



Prediction of Caco-2 Cell Permeability Using Bilinear Indices and Multiple Linear Regression

, 2016; 13(2): 161-169.

Huong Le-Thi-Thu, Yudith Canizares-Carmenate, Yovani Marrero-Ponce, Francisco Torrens and Juan A. Castillo-Garit


DOI: 10.2174/1570180812666150630183511


Synthesis and Antimicrobial Evaluation of Amphipathic Peptide Models

, 2016; 13(7): 715-724.

Marianna Sakka, Alexandra Balliou, Asimina Marianou, Dimitris Krikorian, Margarita Tsirogianni, Artemis Tsiligianni, Katerina Vartzeli, Anna-Irini Koukkou, Maria Sakarellos-Daitsiotis and Eugenia Panou- Pomonis


DOI: 10.2174/1570180813666160616122410


Efficient Synthesis of Pamidronic Acid Using an Ionic Liquid Additive

, 2016; 13(6): 475-478.

Alajos Grun, Dávid Illés Nagy, Sándor Garadnay, István Greiner and Gyorgy Keglevich


DOI: 10.2174/1570180812666151022221805


Design, Synthesis and Mode of Action of Some New 2-(4'-aminophenyl) benzothiazole Derivatives as Potent Antimicrobial Agents

, 2016; 13(5): 429-437.

Meenakshi Singh, Sudhir Kumar Singh, Mayank Gangwar, Satheeshkumar Sellamuthu, Gopal Nath and Sushil K. Singh


DOI: 10.2174/1570180812666150821003220



Design and Synthesis of Novel Spiro-Piperidinyl Pyrazolone Derivatives and Their Potential Antiviral Activity

, 2016; 13(2): 149-160.

Rajagopalan Srinivasan, Badiadka Narayana, Balladka Kunhanna Sarojini, Veerakyathappa Bhanuprakash, Chenna Govindaraju Darshan Raj and Prakash S. Nayak


DOI: 10.2174/1570180812666150630182740



Most Accessed Articles

Synthesis and Biological Evaluation of Some Novel Thiophene-bearing Quinazoline Derivatives as EGFR Inhibitors

, 2019; 16(2): 102-110.

Min Zou, Bo Jin, Yanrong Liu, Huiping Chen, Zhuangli Zhang, Changzheng Zhang, Zhihong Zhao and Liyun Zheng*


DOI: 10.2174/1570180815666180803125935





Synthesis and Biological Evaluation of Novel Bioisosteric Analogues of Dimebon™

, 2010; 7(6): 446-451.

Alexandre Vasilevich Ivachtchenko, Eugene Borisovich Frolov, Oleg Dmitrievich Mitkin, Sergey Evgenevich Tkachenko and Alexandre Khvat


DOI: 10.2174/157018010791306579


Copper-catalyzed Convenient Synthesis and SAR Studies of Substituted-1,2,3-triazole as Antimicrobial Agents

, 2019; 16(1): 3-10.

Aniket P. Sarkate*, Kshipra S. Karnik, Pravin S. Wakte, Ajinkya P. Sarkate, Ashwini V. Izankar and Devanand B. Shinde


DOI: 10.2174/1570180815666180326153322


Synthesis, Molecular Modelling and Antibacterial Activity Against Helicobacter pylori of Novel Diflunisal Derivatives as Urease Enzyme Inhibitors

, 2019; 16(4): 392-400.

Göknil Pelin Coşkun, Teodora Djikic, Sadık Kalaycı, Kemal Yelekçi, Fikrettin Şahin and Ş. Güniz Küçükgüzel*


DOI: 10.2174/1570180815666180627130208




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