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Letters in Drug Design & Discovery

Volume 16, 12 Issues, 2019
ISSN: 1875-628X (Online)
ISSN: 1570-1808 (Print)
This journal supports open access

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  • 57th of 61 in

    Chemistry, Medicinal

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Aims & Scope

Letters in Drug Design & Discovery publishes letters, full-length/mini-reviews, highlights and guest edited thematic issues in all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis is on publishing quality papers very rapidly by taking full advantage of latest Internet technology for both submission and review of manuscripts. The online journal is an essential reading to all pharmaceutical scientists involved in research in drug design and discovery.

Letters in Drug Design & Discovery

,

Volume 16

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Number 7



Biography   Open Access



Research Article



Research Article

Design and Synthesis of Benzopyranopyrimidinyl Phosphonates as Cytotoxic and Antioxidant Agents

, 16(7): 721 - 733

Sarva Santhisudha, Gundluru Mohan , Tenkayala Sobha Rani, Peddaiahgari Vasu Govardhana Reddy and Cirandur Suresh Reddy*


DOI: 10.2174/1570180815666180606083418


Research Article



Research Article

QSAR and Molecular Modeling Studies on a Series of Pyrrolidine Analogs Acting as BACE-1 Inhibitors

, 16(7): 746 - 760

Richa Arya, Satya Prakash Gupta*, Sarvesh Paliwal, Seema Kesar, Achal Mishra and Yenamandra Subrahmanya Prabhakar


DOI: 10.2174/1570180815666180627124422


Research Article

Structure Based Identification of Potential Inhibitors of NS3 Protein of Zika Virus

, 16(7): 761 - 774

Md. Imam Faizan, Abu Turab Naqvi , Md. Imtaiyaz Hassan, Mohd. Abdullah, Ayesha Tazeen, Zoya Shafat, Malik Hisamuddin, Aftab Alam, Shahnawaz Ali, Sher Ali, Anam Farooqui, Abu Hamza, Nazish Parveen, Farah Deeba, Anwar Ahmed and Shama Parveen*


DOI: 10.2174/1570180815666180821105012


Research Article



Research Article



Articles Ahead of Print

In vitro and In Vivo Evaluation of Quinoxaline 1,4-di-N-oxide Against Giardia lamblia


Elizabeth Barboza-Cabrera, Rosa Moo-Puc, Antonio Monge, Alma D. Paz-Gonzalez, Virgilio Bocanegra-Garc and Gildardo Rivera*


DOI: 10.2174/1570180816666190618115854
View Abstract



Evaluating Radioprotection of Rat’s Jejunum by A Combination of Melatonin and Metformin


Nasim Ahmadi Azar, Abdolreza Javadi, Masoud Najafi*, Alireza Shirazi*, Elham Tajabadi, Dheyauldeen Shabeeb and Ahmed Eleojo Musa


DOI: 10.2174/1570180816666190617153004
View Abstract


Synthesis of Piperidine Conjugated Dihydroquinazolin-4(1H)-ones and their Antiproliferative Activity, Molecular Docking Studies and DFT Calculations


Kereyagalahally H. Narasimhamurthy, Chandra, Toreshettahally R. Swaroop, Swamy Jagadish and Kanchugarakoppal S. Rangappa*


DOI: 10.2174/1570180816666190613120349
View Abstract




Antiglycation Activity of N, N-Diethylthiobarbiturates Derivatives


Momin Khan*, Ghulam Ahad, Ajmal Khan, Uzma Salar, Sana Shah, Syed Muhammad Salman, Kanwal, Syed Muhammad Salman and Khalid Mohammed Khan*


DOI: 10.2174/1570180816666190516111516
View Abstract




Synthesis of New 4-Chloro-6-Methylpyrimidin-2-yl-Aminophosphonates as Potential DU145 and A549 Cancer Cell Inhibitors


Gajjala Raghavendra Reddy, Chinta Raveendra Reddy, Gopireddy Venkata Subba Reddy, Pasupuleti Visweswara Rao, Meenakshisundaram Swaminathan and Cirandur Suresh Reddy*


DOI: 10.2174/1570180816666190329223207
View Abstract


Abstracts Ahead of Print

Synthesis, Characterization, and Molecular Docking Studies of N-Acylated Butyro- and Valerolactam Derivatives with Antiproliferative and Cytotoxic Activities


Mark Tristan J. Quimque, Mark John P. Mandigma, Justin Allen K. Lim, Simon Budde, Hans-Martin Dahse, Oliver B. Villaflores, Arnold V. Hallare and Allan Patrick G. Macabeo*


DOI: 10.2174/1570180816666190716141524
View Abstract



Cytotoxic activity and DNA binding property of new aminopyrimidine derivatives


Hamidreza Akrami, Bibi Fatemeh Mirjalili, Omidreza Firuzi, Azadeh Hekmat, Ali Akbar Saboury, Ramin Miri, Omid Sabzevari, Morteza Pirali-Hamedani, Fereshteh Jeivad, Setareh Moghimi, Saeed Emami, Alireza Foroumadi* and Mehdi Khoobi*


DOI: 10.2174/1570180816666190712102119
View Abstract


Synthesis and Evaluation of Anticonvulsant Activities of 4-Phenylpiperidin-2-one Derivatives


Shi-Ben Wang*, Hui Liu, Guang-Yong Li, Kang Lei, Xiao-Jing Li, Zhe-Shan Quan and Xue-Kun Wang*


DOI: 10.2174/1570180816666190710142848
View Abstract



Synthesis, In Silico And In Vivo Evaluation Of Novel 1, 3, 4-Thiadiazole Derivatives As Potent Anticancer Agent


Byran Gowramma*, Swathi Krishna, Manal Mohammed, Thaggikuppe K Praveen, Rajagopal Kalirajan and L Kaviarasan


DOI: 10.2174/1570180816666190710145939
View Abstract


Microwave synthesis and docking studies of phenylureas as potential leads for the drug design against the biological warfare agent Yersinia pestis


Tanos Celmar Costa França*, Leonardo da Costa Bastos, Teobaldo Cuya, Mehdi Sirouspour, Franklin Chacón-Huete, David Bendahan and Pat Forgione


DOI: 10.2174/1570180816666190710144212
View Abstract


Synthesis of Spiro[cycloalkane-pyridazinones] with High Fsp3 Character


Csilla Sepsey Für, Gergő Riszter, János Gerencsér, Áron Szigetvári, Miklós Dékány, László Hazai, György Keglevich and Hedvig Bölcskei*


DOI: 10.2174/1570180816666190710130119
View Abstract



Design, Synthesis, Insecticidal Assay and Modeling Studies on 1,4,6,7-tetrahydropyrazolo[3,4-d][1,3]oxazine Derivatives: A Scaffold Hopping Example on Fipronil


Guanglong Li, Cong Zhou, Chengchun Zhu, Lujue He, Xiaoyang Li, Zhiping Xu, Xiaoyong Xu, Xusheng Shao, Zhong Li* and Jiagao Cheng


DOI: 10.2174/1570180816666190701101734
View Abstract


Published Contents

Editor's Choice



Potential of Nanoparticles in Combating Candida Infections

, 2019; 16(5): 478 - 491

Faizan Abul Qais, Mohd Sajjad Ahmad Khan, Iqbal Ahmad* and Abdullah Safar Althubiani


DOI: 10.2174/1570180815666181015145224





Synthesis and Antichlamydial Activity of Novel Phenazines

, 2019; 16(2): 174 - 181

Xiaofeng Bao, Xiaowei Yu, Chao Xia, Ningjing Yang, Shengju Yang* and Yu Zhao*


DOI: 10.2174/1570180815666180518112952



A New Class of Pure Estrogen Alpha Receptor Antagonists; Design, Synthesis and in-vitro Screening

, 2019; 16(1): 66 - 81

Akbar John Jameera Begam, Katike Ahamed Basheer, Selvaraj Jubie*, Srikanth Jupudi, Mohammed Afzal Azam and Palanisamy Dhanabal


DOI: 10.2174/1570180815666180327124634



Preparation and Characterization of GLUT1-mediated Novel Brain Targeting Magnetic Nanoparticles

, 2018; 15(12): 1308 - 1313

Li Zhang, Yi Zhao, Qiming Yue, Qiuyi Fu, Li Hai, Li Guo, Qiantao Wang* and Yong Wu*


DOI: 10.2174/1570180815666180322113934



Synthesis and Mosquiticidal Activity of Novel Hydrazone Containing Pyrimidine Derivatives against Aedes aegypti

, 2018; 15(9): 951 - 956

Zhong-Hua Shen, Zhao-Hui Sun, James J. Becnel, Alden Estep, David E. Wedge*, Cheng-Xia Tan, Jian-Quan Weng, Liang Han and Xing-Hai Liu*


DOI: 10.2174/1570180815666180102141640



Inhibitory Effects of 1,4-disubstituted Thiosemicarbazide Derivatives on Streptococcus mutans and Streptococcus sanguinis Mono-species Biofilms

, 2018; 15(8): 843 - 850

Malgorzata Miazga-Karska, Maciej Wos, Agnieszka A. Kaczor, Anna Pachuta-Stec, Grazyna Ginalska and Monika Pitucha*


DOI: 10.2174/1570180814666171012164241



Open Access Articles

In Vitro and In Vivo Profiles and Characterization of Insulin Nanocarriers Based in Flexible Liposomes Designed for Oral Administration

, 2019; 16(8): 948 - 960

Sara Melisa Arciniegas Ruiz, María Josefa Josefa Bernad Bernad, Raquel Lopez Arellano C, Roberto Diaz Torres, Sara Del Carmen Caballero Chacón and Dinorah Vargas Estrada




A Study on the Synthesis of Risedronic Acid: The Role of an Ionic Liquid Additive

, 2019; 16(3): 238 - 244

Dávid Illés Nagy, Alajos Grün, Júlia Sinkovicz, Sándor Garadnay, István Greiner and György Keglevich*




Synthesis and Biological Evaluation of Some Novel Thiophene-bearing Quinazoline Derivatives as EGFR Inhibitors

, 2019; 16(2): 102 - 110

Min Zou, Bo Jin, Yanrong Liu, Huiping Chen, Zhuangli Zhang, Changzheng Zhang, Zhihong Zhao and Liyun Zheng*




Efficient Synthesis of Ibandronate in the Presence of an Ionic Liquid

, 2018; 15(7): 713 - 720

David Illes Nagy, Alajos Grun, Oliver Pavela, Sandor Garadnay, Istvan Greiner and Gyorgy Keglevich*




Challenges in the Discovery and Optimization of mGlu2/4 Heterodimer Positive Allosteric Modulators

, 2018; 15: 1 - 7 (E-Pub Ahead of Print)

Mark G. Fulton, Matthew T. Loch, Caroline A. Cuoco, Alice L. Rodriguez, Emily Days, Paige N. Vinson, Krystian A. Kozek, C David Weaver, Anna L. Blobaum, Jeff Conn, Colleen M. Niswender and Craig W. Lindsley*




L-carnitine Supplementation Improves Self-rating Depression Scale Scores in Uremic Male Patients Undergoing Hemodialysis

, 2017; 14(6): 737 - 742

Kyoko Tashiro, Yusuke Kaida, Sho-ichi Yamagishi, Hideharu Tanaka, Miyuki Yokoro, Junko Yano, Kazuko Sakai, Yuka Kurokawa, Kensei Taguchi, Yosuke Nakayama, Takahiro Inokuchi and Kei Fukami*




The Synthesis of (Iodobenzyl)oxybenzaldehydes, Useful Intermediates for Biologically Active Targets

, 2017; 14(2): 233 - 239

Hedvig Bölcskei, Andrea Német-Hanzelik, István Greiner, Zsófia Dubrovay, Viktor Háda and György Keglevich




In Vitro and In Vivo Investigations into the Carbene Gold Chloride and Thioglucoside Anticancer Drug Candidates NHC-AuCl and NHC-AuSR

, 2017; 14(2): 125 - 134

Wolfgang Walther, Oyinlola Dada, Cillian O’Beirne, Ingo Ott, Goar Sánchez-Sanz, Claudia Schmidt, Carsta Werner, Xiangming Zhu and Matthias Tacke




Efficient Synthesis of Pamidronic Acid Using an Ionic Liquid Additive

, 2016; 13(6): 475 - 478

Alajos Grun, Dávid Illés Nagy, Sándor Garadnay, István Greiner and Gyorgy Keglevich






4-Substituted-2-Methoxyphenol: Suitable Building Block to Prepare New Bioactive Natural-like Hydroxylated Biphenyls

, 2015; 12(2): 131 - 139

Maria Antonietta Dettori, Davide Fabbri, Marina Pisano, Carla Rozzo, Giuseppe Palmieri, Alessandro Dessi, Roberto Dallocchio and Giovanna Delogu




Design and Synthesis of New Dual Binding Site Cholinesterase Inhibitors: in vitro Inhibition Studies with in silico Docking

, 2014; 11(3): 331 - 338

Muhammad Yar, Marek Bajda, Rana Atif Mehmood, Lala Rukh Sidra, Nisar Ullah, Lubna Shahzadi, Muhammad Ashraf, Tayaba Ismail, Sohail Anjum Shahzad, Zulfiqar Ali Khan, Syed Ali Raza Naqvi and Nasir Mahmood




Optimized Synthesis of Etidronate

, 2013; 10(8): 733 - 737

Rita Kovacs, David Illes Nagy, Alajos Grün, Gyorgy Tibor Balogh, Sandor Garadnay, Istvan Greiner and Gyorgy Keglevich






Most Cited Articles

Research Article

Synthesis and mosquiticidal activity of novel hydrazone containing pyrimidine derivatives against aedes aegypti

, 2018; 15(9): 951-956.

Zhong-Hua Shen, Zhao-Hui Sun, James J. Becnel, Alden Estep , David E. Wedge*, Cheng-Xia Tan, Jian-Quan Weng, Liang Han and Xing-Hai Liu*


DOI: 10.2174/1570180815666180102141640


Research Article

Synthesis, nematicidal activity and docking study of novel pyrazole-4-carboxamide derivatives against meloidogyne incognita

, 2018; 16(1): 29-35.

Long Cheng, Wen Zhao, Zhong-Hua Shen, Tian-Ming Xu, Hong-Ke Wu, Wei-Li Peng* and Xing-Hai Liu*


DOI: 10.2174/1570180815666180326150827


Research Article

Synthesis and antifungal activity of some 6-tert-butyl-8-chloro-2, 3-dimethylquinolin-4-ol derivatives against Pyricularia oryae

, 2018; 15(12): 1314-1318.

Yue-Ming Fang, Rui-Rui Zhang, Zhong-Hua Shen, Cheng-Xia Tan, Jian-Quan Weng, Tian-Ming Xu*, Xing-Hai Liu*, Hong-Ying Huang and Hong-Ke Wu


DOI: 10.2174/1570180815666180313121735


Research Article

Novel azole-functionalited flouroquinolone hybrids: Design, conventional and microwave irradiated synthesis, evaluation as antibacterial and antioxidant agents

, 2018; 15(1): 46-64.

Meltem Mentese, Neslihan Demirbas*, Arif Mermer, Serpil Demirci, Ahmet Demirbas and Faik Ahmet Ayaz


DOI: 10.2174/1570180814666170823163540


Research Article

Synthesis, biological evaluation and docking studies of 1,3,4-oxadiazole fused benzothiazole derivatives for anticancer drugs

, 2018; 15(12): 1299-1307.

Madala Subramanyam, Reddymasu Sreenivasulu, Rambabu Gundla, Mandava V.B. Rao and Koya Prabhakara Rao *


DOI: 10.2174/1570180815666180219165119


Research Article

Synthesis and biological evaluation of new quinoline-based thiazolyl hydrazone derivatives as potent antifungal and anticancer agents

, 1 February 2018; 15(2): 193-202.

Ali Erguc, Mehlika Dilek Altintop*, Ozlem Atli, Belgin Sever, Gokalp Iscan, Gozde Gormus and Ahmet Ozdemir


DOI: 10.2174/1570180814666171003145227


Letter

Synthesis, characterization and evaluation of gemfibrozil-stilbene hybrid as antioxidant agent

, 2018; 15(11): 1230-1238.

Rosa Amoroso, Lidia Leporini, Ivana Cacciatore, Lisa Marinelli, Alessandra Ammazzalorso, Isabella Bruno, Barbara De Filippis, Marialuigia Fantacuzzi, Cristina Maccallini, Luigi Menghini, Antonio Di Stefano and Letizia Giampietro*


DOI: 10.2174/1570180815666180321163246


Research Article

Biological activities and docking studies on novel bis 1,4-DHPS linked to arene core via ether or ester linkage

, 2018; 15(10): 1036-1045.

Nada S. Ibrahim, Magda F. Mohamed, Ahmed H. M. Elwahy* and Ismail A. Abdelhamid*


DOI: 10.2174/1570180815666180105162323




Research Article

6-methoxy-3,4-dihydronaphthalenone chalcone-like derivatives as potent tyrosinase inhibitors and radical scavengers

, 2018; 15(11): 1170-1179.

Sara Ranjbar, Abdolhossein Akbari, Najmeh Edraki, Mahsima Khoshneviszadeh, Hajar Hemmatian, Omidreza Firuzi and Mehdi Khoshneviszadeh*


DOI: 10.2174/1570180815666180219155027


Research Article

Design, synthesis, and screening of hybrid benzothiazolyl-oxadiazoles as anticonvulsant agents

, 1 April 2018; 15(4): 398-405.

Sheikh Murtuja, Mohammad Shaquiquzzaman and Mohammad Amir*


DOI: 10.2174/1570180814666170526154914


Research Article

Microwave-assisted synthesis and antifungal activity of novel 1,2,4-triazole thioether derivatives containing pyrimidine moiety

, 1 April 2018; 15(4): 347-352.

Meng Xu, Ya-Bo Zhu, Mei Wang, Ikhlas A. Khan, Xing-Hai Liu and Jian-Quan Weng*


DOI: 10.2174/1570180814666170602082440


Research Article

Efficient synthesis of ibandronate in the presence of an ionic liquid

, 1 January 2018; 15(7): 713-720.

David Illes Nagy, Alajos Grun, Oliver Pavela, Sandor Garadnay, Istvan Greiner and Gyorgy Keglevich*


DOI: 10.2174/1570180814666171027160324


Research Article

Synthesis and antioxidant evaluation of a new class of thienopyrimidinerhodanine hybrids

, 1 February 2018; 15(2): 118-126.

Kerru Nagaraju , Venkata H.S.S. Bhaskaruni, Ravada Kishore , Suresh Maddila*, Parvesh Singh and Sreekantha B. Jonnalagadda


DOI: 10.2174/1570180814666170710161844



Most Accessed Articles



Novel 1,3,4-Oxadiazole Fused Thiadiazole Derivatives: Synthesis and study of Anticancer Activities

, 2019; 16(6): 656-662.

Zanjam Spandana, Reddymasu Sreenivasulu, Tadigiri MalathiRekha and Mandava Venkata Basaveswara Rao*


DOI: 10.2174/1570180816666181031125946








Design, Synthesis and Evaluation of Thiourea Derivatives as Antimicrobial and Antiviral Agents

, 2019; 16(6): 618-624.

Veerasamy Ravichandran*, Sivadasan Shalini, Krishnan Suresh Kumar, Harish Rajak and Ram Kishore Agrawal


DOI: 10.2174/1570180815666180801120440



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