Bentham Science Logo

Drug Metabolism Letters

Volume 13, 3 Issues, 2019
ISSN: 1874-0758 (Online)
ISSN: 1872-3128 (Print)
This journal supports open access

Aims & Scope

Drug Metabolism Letters publishes letters, original research articles, mini-reviews, thematic issues based on mini-reviews and letters, commentaries, technical notes and drug clinical trial studies on major advances in all areas of drug metabolism and disposition.

In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; bioactivation; recent developments for the identification of drug metabolites, reactive intermediate and glutathione conjugates.

Drug Metabolism Letters

,

Volume 12

-

Number 2



Biography   Open Access



Research Article



Research Article



Research Article



Research Article



Research Article



Research Article



Research Article

Genistein Affects Expression of Cytochrome P450 (CYP450) Genes in Hepatocellular Carcinoma (HEPG2/C3A) Cell Line

, 12(2): 138 - 144

Sandra R. Lepri , Daniele Sartori , Simone C. Semprebon*, Adrivanio Baranoski , Giuliana C. Coatti and Mario S. Mantovani


DOI: 10.2174/1872312812666180709150440


Articles Ahead of Print

Imatinib Uptake into Cells is Not Mediated by Organic Cation Transporters OCT1, OCT2, or OCT3, But is Influenced by Extracellular pH


Jaurès Blanc Mettral, Nicolas Faller, Sandra Cruchon, Loïc Sottas, Thierry Buclin, Laurent Schild, Eva Choong, Aimable Nahimana and Laurent A. Decosterd*


View Abstract View on PubMed




“Branched Tail” Oxyquinoline Inhibitors of HIF Prolyl Hydroxylase: Early Evaluation of Toxicity and Metabolism Using Liver-on-a-chip


Andrey A. Poloznikov*, Sergey V. Nikulin, Arpenik A. Zakhariants, Anna Yu. Khristichenko, Dmitry M. Hushpulian, Ildar N. Gazizov, Vladimir I. Tishkov and Irina G. Gazaryan


View Abstract View on PubMed


Transport of Bupropion and its Metabolites by the Model CHO and HEK293 Cell Lines


Lyrialle W. Han, Chunying Gao, Yuchen Zhang, Joanne Wang and Qingcheng Mao*


View Abstract View on PubMed




Comparison of Rat and Human Pulmonary Metabolism Using Precisioncut Lung Slices (PCLS)


Yildiz Yilmaz*, Gareth Williams, Markus Walles, Nenad Manevski, Stephan Krahenbuhl and Gian Camenisch


View Abstract View on PubMed



Abstracts Ahead of Print

There are currently no Abstracts Ahead of Print available for this journal.

Editor's Choice










Open Access Articles

“Branched Tail” Oxyquinoline Inhibitors of HIF Prolyl Hydroxylase: Early Evaluation of Toxicity and Metabolism Using Liver-on-a-chip

, 2019; 13: 1 - 8 (E-Pub Ahead of Print)

Andrey A. Poloznikov*, Sergey V. Nikulin, Arpenik A. Zakhariants, Anna Yu. Khristichenko, Dmitry M. Hushpulian, Ildar N. Gazizov, Vladimir I. Tishkov and Irina G. Gazaryan




Transport of Bupropion and its Metabolites by the Model CHO and HEK293 Cell Lines

, 2019; 13: 1 - 12 (E-Pub Ahead of Print)

Lyrialle W. Han, Chunying Gao, Yuchen Zhang, Joanne Wang and Qingcheng Mao*





Imatinib Uptake into Cells is Not Mediated by Organic Cation Transporters OCT1, OCT2, or OCT3, But is Influenced by Extracellular pH

, 2019; 13: 1 - 9 (E-Pub Ahead of Print)

Jaurès Blanc Mettral, Nicolas Faller, Sandra Cruchon, Loïc Sottas, Thierry Buclin, Laurent Schild, Eva Choong, Aimable Nahimana and Laurent A. Decosterd*




A Practical Perspective on the Evaluation of Small Molecule CNS Penetration in Drug Discovery

, 2019; 13: 1 - 16 (E-Pub Ahead of Print)

Liyue Huang*, Mary C. Wells and Zhiyang Zhao




Using LC Retention Times in Organic Structure Determination: Drug Metabolite Identification

, 2018; 12(2): 93 - 100

William L. Fitch*, Cyrus Khojasteh, Ignacio Aliagas and Kevin Johnson




Quantitative Proteomics Reveals Changes in Transporter Protein Abundance in Liver, Kidney and Brain of Mice by Pregnancy

, 2018; 12(2): 145 - 152

Michael Z. Liao, Chunying Gao, Deepak Kumar Bhatt, Bhagwat Prasad and Qingcheng Mao*




Genistein Affects Expression of Cytochrome P450 (CYP450) Genes in Hepatocellular Carcinoma (HEPG2/C3A) Cell Line

, 2018; 12(2): 138 - 144

Sandra R. Lepri, Daniele Sartori, Simone C. Semprebon*, Adrivanio Baranoski, Giuliana C. Coatti and Mario S. Mantovani






In Vitro Drug-Drug Interaction Potential of Sulfoxide and/or Sulfone Metabolites of Albendazole, Triclabendazole , Aldicarb, Methiocarb, Montelukast and Ziprasidone

, 2018; 12(2): 101 - 116

Poonam Giri, Lakshmikant Gupta, Sneha Naidu, Vipul Joshi, Nirmal Patel, Shyamkumar Giri and Nuggehally R. Srinivas*







Comparison of Rat and Human Pulmonary Metabolism Using Precisioncut Lung Slices (PCLS)

, 2018; 12: 1 - 11 (E-Pub Ahead of Print)

Yildiz Yilmaz*, Gareth Williams, Markus Walles, Nenad Manevski, Stephan Krahenbuhl and Gian Camenisch





Most Cited Articles

Clinical Confirmation that the Selective JAK1 Inhibitor Filgotinib (GLPG0634) has a Low Liability for Drug-drug Interactions

, 2016; 10(1): 38-48.

Florence Namour*, Julie Desrivot, Annegret Van der Aa, Pille Harrison, Chantal Tasset and Gerben van`t Klooster


DOI: 10.2174/1872312810666151223103353


Non-Clinical Disposition and Metabolism of DM1, a Component of Trastuzumab Emtansine (T-DM1), in Sprague Dawley Rats

, 2015; 9(2): 119-131.

Ben-Quan Shen, Daniela Bumbaca, Qin Yue, Ola Saad, Jay Tibbitts, S. Cyrus Khojasteh and Sandhya Girish


DOI: 10.2174/1872312809666150602151922




In Vitro Evaluation of Reversible and Time-Dependent Inhibitory Effects of Kalanchoe crenata on CYP2C19 and CYP3A4 Activities

, 2015; 9(1): 48-62.

Charles Awortwe, Vamshi K. Manda, Cristina Avonto, Shabana I. Khan, Ikhlas A. Khan, Larry A. Walker, Patrick J. Bouic and Bernd Rosenkranz


DOI: 10.2174/1872312809666150119110200


Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability

, 2016; 10(2): 83-90.

Samantha J. Richardson, April Bai, Ashutosh A. Kulkarni and Mehran F. Moghaddam


DOI: 10.2174/1872312810666160223121836




Elucidating the Mechanism of Tofacitinib Oxidative Decyanation

, 2016; 10(2): 136-143.

Hoa Le, Peter W. Fan, Susan Wong, Shuguang Ma, James P. Driscoll, Cornelis E.C.A. Hop and S. Cyrus Khojasteh


DOI: 10.2174/1872312810666160427104954




Most Accessed Articles







Genistein Affects Expression of Cytochrome P450 (CYP450) Genes in Hepatocellular Carcinoma (HEPG2/C3A) Cell Line

, 2018; 12(2): 138-144.

Sandra R. Lepri, Daniele Sartori, Simone C. Semprebon*, Adrivanio Baranoski, Giuliana C. Coatti and Mario S. Mantovani


DOI: 10.2174/1872312812666180709150440


Alam K et al. (2018) Drug Metabolism Letters; 12, 24-32.

, 2018; 12(2): 153-153.

Tristan M. Sissung, Cindy Chau, Douglas K. Price and William D. Figg*


DOI: 10.2174/1872312812999180724145725





Related Journals

Related eBooks

eBooks Catalog