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Drug Metabolism Letters

Volume 14, 3 Issues, 2020
ISSN: 1874-0758 (Online)
ISSN: 1872-3128 (Print)
This journal supports open access

In the current pandemic scenario, publication process of all articles related to Coronavirus will be expedited, for timely publication of much needed research

Aims & Scope

Drug Metabolism Letters publishes letters, original research articles, mini-reviews, thematic issues based on mini-reviews and letters, commentaries, technical notes and drug clinical trial studies on major advances in all areas of drug metabolism and disposition.

In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; bioactivation; recent developments for the identification of drug metabolites, reactive intermediate and glutathione conjugates.

Drug Metabolism Letters

,

Volume 13

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Number 2



Biography   Open Access



Review Article   Open Access



Review Article   Open Access



Research Article   Open Access

Imatinib Uptake into Cells is Not Mediated by Organic Cation Transporters OCT1, OCT2, or OCT3, But is Influenced by Extracellular pH

, 13(2): 102 - 110

Jaurès B. Mettral, Nicolas Faller, Sandra Cruchon, Loïc Sottas, Thierry Buclin, Laurent Schild, Eva Choong, Aimable Nahimana and Laurent A. Decosterd*


DOI: 10.2174/1872312813666190207150207


Research Article   Open Access



Research Article   Open Access



Research Article   Open Access



Acknowledgement   Open Access



Articles Ahead of Print





Pharmacokinetics of Darolutamide in Mouse - Assessment of the Disposition of the Diastereomers, Key Active Metabolite and Interconversion Phenomenon: Implications to Cancer Patients


Neeraj Kumar Saini, Bhavesh Babulal Gabani, Umesh Todmal, Suresh P Sulochana, Vinay Kiran, Mohd Zainuddin, Narayanan Balaji, Sai Babu Polina, Nuggehally R Srinivas and Ramesh Mullangi*


DOI: 10.2174/1872312814666200521091236
View Abstract



Abstracts Ahead of Print

There are currently no Abstracts Ahead of Print available for this journal.

Editor's Choice











Open Access Articles





The Effects of Special Patient Population Plasma on Pharmacokinetic Quantifications Using LC-MS/MS

, 2019; 13(2): 111 - 122

Dongmei Zhou*, Lifang Sun, Mai Nguyen, Li- Tain Yeh and David M. Wilson




Imatinib Uptake into Cells is Not Mediated by Organic Cation Transporters OCT1, OCT2, or OCT3, But is Influenced by Extracellular pH

, 2019; 13(2): 102 - 110

Jaurès Blanc Mettral, Nicolas Faller, Sandra Cruchon, Loïc Sottas, Thierry Buclin, Laurent Schild, Eva Choong, Aimable Nahimana and Laurent A. Decosterd*





Comparison of Rat and Human Pulmonary Metabolism Using Precision-cut Lung Slices (PCLS)

, 2019; 13(1): 53 - 63

Yildiz Yilmaz*, Gareth Williams, Markus Walles, Nenad Manevski, Stephan Krähenbühl and Gian Camenisch




“Branched Tail” Oxyquinoline Inhibitors of HIF Prolyl Hydroxylase: Early Evaluation of Toxicity and Metabolism Using Liver-on-a-chip

, 2019; 13(1): 45 - 52

Andrey A. Poloznikov*, Sergey V. Nikulin, Arpenik A. Zakhariants, Anna Y. Khristichenko, Dmitry M. Hushpulian, Ildar N. Gazizov, Vladimir I. Tishkov and Irina G. Gazaryan






Transport of Bupropion and its Metabolites by the Model CHO and HEK293 Cell Lines

, 2019; 13(1): 25 - 36

Lyrialle W. Han, Chunying Gao, Yuchen Zhang, Joanne Wang and Qingcheng Mao*





Using LC Retention Times in Organic Structure Determination: Drug Metabolite Identification

, 2018; 12(2): 93 - 100

William L. Fitch*, Cyrus Khojasteh, Ignacio Aliagas and Kevin Johnson




Quantitative Proteomics Reveals Changes in Transporter Protein Abundance in Liver, Kidney and Brain of Mice by Pregnancy

, 2018; 12(2): 145 - 152

Michael Z. Liao, Chunying Gao, Deepak Kumar Bhatt, Bhagwat Prasad and Qingcheng Mao*





Most Cited Articles


Research Article

Comparison of rat and human pulmonary metabolism using precision-cut lung slices (PCLS)

, 2019; 13(1): 53-63.

Yildiz Yilmaz*, Gareth Williams, Markus Walles, Nenad Manevski, Stephan Krähenbühl and Gian Camenisch


DOI: 10.2174/1872312812666181022114622


Research Article

Imatinib uptake into cells is not mediated by organic cation transporters OCT1, OCT2, or OCT3, but is influenced by extracellular pH

, 2019; 13(2): 102-110.

Jaurès B. Mettral, Nicolas Faller, Sandra Cruchon, Loïc Sottas, Thierry Buclin, Laurent Schild, Eva Choong, Aimable Nahimana and Laurent A. Decosterd*


DOI: 10.2174/1872312813666190207150207




Research Article

Transport of bupropion and its metabolites by the model CHO and HEK293 cell lines

, 2019; 13(1): 25-36.

Lyrialle W. Han, Chunying Gao, Yuchen Zhang, Joanne Wang and Qingcheng Mao*


DOI: 10.2174/1872312813666181129101507



Research Article

The effects of special patient population plasma on pharmacokinetic quantifications using LC-MS/MS

, 2019; 13(2): 111-122.

Dongmei Zhou*, Lifang Sun, Mai Nguyen, Li- Tain Yeh and David M. Wilson


DOI: 10.2174/1872312813666191015162634





Research Article

“Branched tail” oxyquinoline inhibitors of HIF prolyl hydroxylase: Early evaluation of toxicity and metabolism using liver-on-a-chip

, 2019; 13(1): 45-52.

Andrey A. Poloznikov*, Sergey V. Nikulin, Arpenik A. Zakhariants, Anna Y. Khristichenko, Dmitry M. Hushpulian, Ildar N. Gazizov, Vladimir I. Tishkov and Irina G. Gazaryan


DOI: 10.2174/1872312813666181129100950



Preface

Preface

, 2019; 13(1): 2-2.

Suresh Balani


DOI: 10.2174/187231281301190430103757



Most Accessed Articles


Induction of Cytochrome P450 3A by the Ginkgo biloba Extract and Bilobalides in Human and Rat Primary Hepatocytes

, 2008; 2(1): 60-66.

Shu-Feng Zhou, Ying Deng, Hui-chang Bi, Li-zi Zhao, Xue-ding Wang, Jie Chen, Zhi-min Ou, Liang Ding, Le-jia Xu, Su Guan, Xiao Chen and Min Huang


DOI: 10.2174/187231208783478489





A Review of Pharmacokinetic Parameters of Metabolites and Prodrugs

, 2013; 7(2): 105-116.

Michel Leandro de Campos, Elias Carvalho Padilha and Rosangela Goncalves Peccinini


DOI: 10.2174/1872312808666140317155008


Transport of Bupropion and its Metabolites by the Model CHO and HEK293 Cell Lines

, 2019; 13(1): 25-36.

Lyrialle W. Han, Chunying Gao, Yuchen Zhang, Joanne Wang and Qingcheng Mao*


DOI: 10.2174/1872312813666181129101507


Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability

, 2016; 10(2): 83-90.

Samantha J. Richardson, April Bai, Ashutosh A. Kulkarni and Mehran F. Moghaddam


DOI: 10.2174/1872312810666160223121836





Editor-in-Chief

Zhiyang Zhao
Alliance Pharma
Malvern, PA
(USA)
Biography
View Full Editorial Board

COPE Compliant

Journal History

Drug Metabolism Letters was launched in 2007. Dr. Zhiyang Zhao serves as the Editor-in-Chief of the journal.
Scopus CiteScore Metrics: 1.01

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