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Contents

Current Topics in Medicinal Chemistry, Volume 18 - Number 8


Review Article

An Update on MDMX and Dual MDM2/X Inhibitors

, 18(8): 647 - 660

Margarida Espadinha, Valentina Barcherini, Elizabeth A. Lopes and Maria M.M. Santos*


DOI: 10.2174/1568026618666180604080119



Review Article

Current Status and Future Prospects of Small–molecule Protein–protein Interaction (PPI) Inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL)

, 18(8): 661 - 673

Georgia Melagraki, Georgios Leonis, Evangelos Ntougkos, Vagelis Rinotas, Christos Papaneophytou, Thomas Mavromoustakos, George Kontopidis, Eleni Douni, George Kollias* and Antreas Afantitis*


DOI: 10.2174/1568026618666180607084430



Review Article

Toward Small-Molecule Inhibition of Protein–Protein Interactions: General Aspects and Recent Progress in Targeting Costimulatory and Coinhibitory (Immune Checkpoint) Interactions

, 18(8): 674 - 699

Damir Bojadzic and Peter Buchwald*


DOI: 10.2174/1568026618666180531092503



Review Article

A Structural Perspective on the Modulation of Protein-Protein Interactions with Small Molecules

, 18(8): 700 - 713

Habibe Cansu Demirel, Tunca Dogan and Nurcan Tuncbag*


DOI: 10.2174/1568026618666180601080824



Review Article

Prediction and Targeting of Interaction Interfaces in G-protein Coupled Receptor Oligomers

, 18(8): 714 - 746

Anke C. Schiedel, Meryem Kose, Carlos Barreto, Beatriz Bueschbell, Giulia Morra, Ozge Sensoy* and Irina S. Moreira*


DOI: 10.2174/1568026618666180604082610




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