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Inhibition of Biofilm and Virulence Factors of Candida albicans by Partially Purified Secondary Metabolites of Streptomyces chrestomyceticus Strain ADP4

, 2018; 18(11): 925 - 945

Vartika Srivastava, Rajeev K. Singla and Ashok K. Dubey*


DOI: 10.2174/1568026618666180711154110



Emerging Virulence, Drug Resistance and Future Anti-fungal Drugs for Candida Pathogens

, 2018; 18(9): 759 - 778

Vartika Srivastava, Rajeev Kumar Singla and Ashok Kumar Dubey*


DOI: 10.2174/1568026618666180528121707



Backbone-Cyclized Peptides: A Critical Review

, 2018; 18(7): 526 - 555

Samuel J.S. Rubin and Nir Qvit*


DOI: 10.2174/1568026618666180518092333



Polyamines and Related Nitrogen Compounds in the Chemotherapy of Neglected Diseases Caused by Kinetoplastids

, 2018; 18(5): 321 - 368

Juan A. Bisceglia*, Maria C. Mollo, Nadia Gruber and Liliana R. Orelli*


DOI: 10.2174/1568026618666180427151338


Current Methods Applied to Biomaterials – Characterization Approaches, Safety Assessment and Biological International Standards

, 2018; 18(4): 256 - 274

Justine P.R. Oliveira*, H. Ivan Melendez-Ortiz, Emilio Bucio, Patricia Terra Alves, Mayara Ingrid Sousa Lima, Luiz Ricardo Goulart, Monica B. Mathor, Gustavo H.C. Varca and Ademar B. Lugao


DOI: 10.2174/1568026618666180410151518


Aurora Kinase Inhibitors in Head and Neck Cancer

, 2018; 18(3): 199 - 213

Guangying Qi, Jing Liu, Sisi Mi, Takaaki Tsunematsu, Shengjian Jin, Wenhua Shao, Tian Liu, Naozumi Ishimaru, Bo Tang* and Yasusei Kudo*


DOI: 10.2174/1568026618666180112163741



New Benzothiazole-based Thiazolidinones as Potent Antimicrobial Agents. Design, synthesis and Biological Evaluation

, 2018; 18(1): 75 - 87

Michelyne Haroun*, Christophe Tratrat, Katerina Kositzi, Evangelia Tsolaki, Anthi Petrou, Bandar Aldhubiab, Mahesh Attimarad, Sree Harsha, Athina Geronikaki*, Katharigatta N. Venugopala, Heba S. Elsewedy, Marina Sokovic, Jasna Glamoclija and Ana Ciric


DOI: 10.2174/1568026618666180206101814



Resveratrol as a Potential Therapeutic Candidate for the Treatment and Management of Alzheimer's Disease

, 2016; 16(17): 1951 - 1960

Nady Braidy, Bat-Erdene Jugder, Anne Poljak, Tharusha Jayasena, Hussein Mansour, Seyed Mohammad Nabavi, Perminder Sachdev and Ross Grant


DOI: 10.2174/1568026616666160204121431


Implications of Dynamic Occupancy, Binding Kinetics, and Channel Gating Kinetics for hERG Blocker Safety Assessment and Mitigation

, 2016; 16(16): 1792 - 1818

Robert A. Pearlstein, K. Andrew MacCannell, Gül Erdemli, Sarita Yeola, Gabriel Helmlinger, Qi-Ying Hu, Ramy Farid, William Egan, Steven Whitebread, Clayton Springer, Jeremy Beck, Hao-Ran Wang, Mateusz Maciejewski, Laszlo Urban and José S. Duca


DOI: 10.2174/1568026616666160315142156


Using Genomics for Natural Product Structure Elucidation

, 2016; 16(15): 1645 - 1694

Jonathan I. Tietz and Douglas A. Mitchell


DOI: 10.2174/1568026616666151012111439


Electronic Nose and Exhaled Breath NMR-based Metabolomics Applications in Airways Disease

, 2016; 16(14): 1610 - 1630

Giuseppe Santini, Nadia Mores, Andreu Penas, Rosamaria Capuano, Chiara Mondino, Andrea Trové, Francesco Macagno, Gina Zini, Paola Cattani, Eugenio Martinelli, Andrea Motta, Giuseppe Macis, Giovanni Ciabattoni and Paolo Montuschi


DOI: 10.2174/1568026616666151223113540


G Protein Coupled Receptors And Structure-Based Advances

, 2016; 16(13): 1489 - 1505

Maria Kontoyianni


DOI: 10.2174/1568026615666150915121324



Bispidine as a Privileged Scaffold

, 2016; 16(11): 1314 - 1342

Isabelle Tomassoli and Daniela Gündisch


DOI: 10.2174/1568026615666150915111434



Systems Biology Approaches to a Rational Drug Discovery Paradigm

, 2016; 16(9): 1009 - 1025

Philip Prathipati and Kenji Mizuguchi


DOI: 10.2174/1568026615666150826114524



Natural compound-derived epigenetic regulators targeting epigenetic readers, writers and erasers

, 2016; 16(7): 697 - 713

Anne Yuqing Yang, Hyuck Kim, Wenji Li and Ah-Ng Tony Kong


DOI: 10.2174/1568026615666150826114359



Formaldehyde as a trigger for protein aggregation and potential target for mitigation of age-related, progressive cognitive impairment

, 2016; 16(5): 472 - 484

Tao Su, Woodrow C. Monte, Xintian Hu, Yingge He and Rongqiao He


DOI: 10.2174/1568026615666150813142215



Improving Peptide Applications Using Nanotechnology

, 2016; 16(3): 253 - 270

Radhika Narayanaswamy, Tao Wang and Vladimir P. Torchilin


DOI: 10.2174/1568026615666150817100338



Mammalian Antimicrobial Peptides: Promising Therapeutic Targets Against Infection and Chronic Inflammation

, 2016; 16(1): 99 - 129

Pujarini Dutta and Santasabuj Das


DOI: 10.2174/1568026615666150703121819



An Overview of Recent Dipeptidyl Peptidase-IV Inhibitors: Linking their Structure and Physico-Chemical Properties with SAR, Pharmacokinetics and Toxicity

, 2015; 15(23): 2342 - 2372

Andrija Smelcerovic, Filip Miljkovic, Ana Kolarevic, Jelena Lazarevic, Aleksandra Djordjevic, Gordana Kocic and Marko Anderluh


DOI: 10.2174/1568026615666150619142731



Longevity Pathways (mTOR, SIRT, Insulin/IGF-1) as Key Modulatory Targets on Aging and Neurodegeneration

, 2015; 15(21): 2116 - 2138

Caio Henrique Mazucanti, Joao Victor Cabral-Costa, Andrea Rodrigues Vasconcelos, Diana Zukas Andreotti, Cristoforo Scavone and Elisa Mitiko Kawamoto


DOI: 10.2174/1568026615666150610125715


From Protein Communication to Drug Discovery

, 2015; 15(20): 2019 - 2031

Marco Persico, Antonio Di Dato, Nausicaa Orteca, Caterina Fattorusso, Ettore Novellino, Mirko Andreoli and Cristiano Ferlini


DOI: 10.2174/1568026615666150519102257


Biological Function and Medicinal Research Significance of G-Quadruplex Interactive Proteins

, 2015; 15(19): 1971 - 1987

Jun Qiu, Mingxue Wang, Yan Zhang, Ping Zeng, Tian-Miao Ou, Jia-Heng Tan, Shi-Liang Huang, Lin-Kun An, Honggen Wang, Lian-Quan Gu, Zhi-Shu Huang and Ding Li


DOI: 10.2174/1568026615666150515150803


Computer-Aided Drug Design of Bioactive Natural Products

, 2015; 15(18): 1780 - 1800

Veda Prachayasittikul, Apilak Worachartcheewan, Watshara Shoombuatong, Napat Songtawee, Saw Simeon, Virapong Prachayasittikul and Chanin Nantasenamat


DOI: 10.2174/1568026615666150506151101


Serotonergic 5-HT6 Receptor Antagonists: Heterocyclic Chemistry and Potential Therapeutic Significance

, 2015; 15(17): 1643 - 1662

Alka Bali and Shalu Singh


DOI: 10.2174/1568026615666150427110420


Magnetite: From Synthesis to Applications

, 2015; 15(16): 1622 - 1640

Gozde Unsoy, Ufuk Gunduz, Ovidiu Oprea, Denisa Ficai, Maria Sonmez, Marius Radulescu, Mihaela Alexie and Anton Ficai


DOI: 10.2174/1568026615666150414153928


Smart Synthetic Polymer Nanocarriers for Controlled and Site-Specific Drug Delivery

, 2015; 15(15): 1424 - 1490

Paul Catalin Balaure and Alexandru Mihai Grumezescu


DOI: 10.2174/1568026615666150414115852



Interlocked Systems in Nanomedicine

, 2015; 15(13): 1236 - 1256

Catia Ornelas-Megiatto, Tiago B. Becher and Jackson D. Megiatto


DOI: 10.2174/1568026615666150330111614



Homology Modeling of MDR1 Gene MDR1_ENTHI of E. histolytica & its Molecular Docking with Anti-Entamoeba Histolytica Agents

, 2015; 15(11): 980 - 989

Rajeev K. Singla


DOI: 10.2174/1568026615666150317222927



Cardiovascular Effects of Coumarins Besides their Antioxidant Activity

, 2015; 15(9): 830 - 849

Iveta Najmanova, Martin Dosedel, Radomir Hrdina, Pavel Anzenbacher, Tomas Filipsky, Michal Riha and Premysl Mladenka


DOI: 10.2174/1568026615666150220112437



Organic Toxins as Tools to Understand Ion Channel Mechanisms and Structure

, 2015; 15(7): 581 - 603

Sara Luz Morales-Lazaro, Enrique Hernandez-Garcia, Barbara Serrano-Flores and Tamara Rosenbaum


DOI: 10.2174/1568026615666150217110710



Antioxidant Effects of Coumarins Include Direct Radical Scavenging, Metal Chelation and Inhibition of ROS-Producing Enzymes

, 2015; 15(5): 415 - 431

Tomas Filipsky, Michal Riha, Katerina Macakova, Eva Anzenbacherova, Jana Karlickova and Premysl Mladenka


DOI: 10.2174/1568026615666150206152233



Molecularly Imprinted Sol-Gel Materials for Medical Applications

, 2015; 15(3): 199 - 222

Riccardo Concu, Mariana Ornelas and Manuel Azenha


DOI: 10.2174/1568026614666141229112246



Computational and Experimental Advances in Drug Repositioning for Accelerated Therapeutic Stratification

, 2015; 15(1): 5 - 20

Khader Shameer, Ben Readhead and Joel T. Dudley


DOI: 10.2174/1568026615666150112103510



Chemoenzymatic Synthesis of Carbohydrates as Antidiabetic and Anticancer Drugs

, 2014; 14(23): 2694 - 2711

Andres R. Alcantara, Vittorio Pace, Pilar Hoyos, Manuel Sandoval, Wolfgang Holzer and Maria J. Hernaiz


DOI: 10.2174/1568026614666141215151056



Development of Vitamin D Analogs Modulating the Pocket Structure of Vitamin D Receptor

, 2014; 14(21): 2378 - 2387

Keiko Yamamoto, Yasuaki Anami and Toshimasa Itoh


DOI: 10.2174/156802661421141223091909



Beyond Bile Acids: Targeting Farnesoid X Receptor (FXR) with Natural and Synthetic Ligands

, 2014; 14(19): 2129 - 2142

Andrea Carotti, Maura Marinozzi, Chiara Custodi, Bruno Cerra, Roberto Pellicciari, Antimo Gioiello and Antonio Macchiarulo


DOI: 10.2174/1568026614666141112094058



A Review on PARP1 Inhibitors: Pharmacophore Modeling, Virtual and Biological Screening Studies to Identify Novel PARP1 Inhibitors

, 2014; 14(17): 2020 - 2030

Sardar Shamshair Singh, Jagarlapudi A.R.P. Sarma, Lakshmi Narasu, Raveendra Dayam, Shili Xu and Nouri Neamati


DOI: 10.2174/1568026614666140929152123



Positive Allosteric Modulators for mGluR2 Receptors: A Medicinal Chemistry Perspective

, 2014; 14(15): 1771 - 1788

Gyorgy Szabo and Gyorgy Miklos Keseru


DOI: 10.2174/1568026614666140826120716



Medicinal Chemistry of Small Molecule CCR5 Antagonists for Blocking HIV-1 Entry: A Review of Structural Evolution

, 2014; 14(13): 1515 - 1538

Ye Tian, Dujuan Zhang, Peng Zhan and Xinyong Liu


DOI: 10.2174/1568026614666140827143934



Tuning hERG Out: Antitarget QSAR Models for Drug Development

, 2014; 14(11): 1399 - 1415

Rodolpho C. Braga, Vinicius M. Alves, Meryck F.B. Silva, Eugene Muratov, Denis Fourches, Alexander Tropsha and Carolina H. Andrade


DOI: 10.2174/1568026614666140506124442



PEGylated Polyester-Based Nanoncologicals

, 2014; 14(9): 1097 - 1114

Claudia Conte, Ivana d’Angelo, Agnese Miro, Francesca Ungaro and Fabiana Quaglia


DOI: 10.2174/1568026614666140329224243


Indole Alkaloids and Semisynthetic Indole Derivatives as Multifunctional Scaffolds Aiming the Inhibition of Enzymes Related to Neurodegenerative Diseases – A Focus on Psychotria L. Genus

, 2014; 14(8): 1056 - 1075

Luiz Carlos Klein-Junior, Carolina dos Santos Passos, Aline Pereira Moraes, Vinicius Galvao Wakui, Eduardo Luis Konrath, Alessandra Nurisso, Pierre-Alain Carrupt, Cecilia Maria Alves de Oliveira, Lucilia Kato and Amelia Teresinha Henriques


DOI: 10.2174/1568026614666140324142409


Decarboxylative Fluorination Strategies for Accessing Medicinally- Relevant Products

, 2014; 14(7): 966 - 978

Yupu Qiao, Lingui Zhu, Brett R. Ambler and Ryan A. Altman


DOI: 10.2174/1568026614666140202210850



Assembled Core-Shell Nanostructures of Gold Nanoparticles with Biocompatible Polymers Toward Biology

, 2014; 14(5): 595 - 616

Dongxiang Li, Qianru Li, Xiongwen Hao, Yaojun Zhang, Zhupeng Zhang and Chunfang Li


DOI: 10.2174/1568026614666140118204000



A Unique Industrial – Academic Collaboration Towards the Next Generation of Schizophrenia Therapeutics

, 2014; 14(3): 304 - 312

Gregor J. Macdonald and Craig W. Lindsley


DOI: 10.2174/1568026613666131127154443



Progress in the Discovery of Treatments for C. difficile Infection: A Clinical and Medicinal Chemistry Review

, 2014; 14(1): 152 - 175

Lissa S. Tsutsumi, Yaw B. Owusu, Julian G. Hurdle and Dianqing Sun


DOI: 10.2174/1568026613666131113154753



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