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Current Topics in Medicinal Chemistry

Volume 22, 32 Issues, 2022
ISSN: 1873-4294 (Online)
ISSN: 1568-0266 (Print)
This journal supports open access

Aims & Scope

Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.

Current Topics in Medicinal Chemistry, Volume 22 (2022) - Number 8


This issue is in progress but contains articles that are final and fully citable.

Current Topics in Medicinal Chemistry, Volume 22 (2022) - Number 7


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Flavonoids as Sirtuin Modulators


Fatma Sezer Şenol Deniz, Gökçen Eren and Ilkay Erdogan Orhan*


DOI: 10.2174/1568026622666220422094744
View Abstract View on PubMed




Potential Neuroprotective Effect of Cannabinoids in COVID-19 Patients


José Luis Cortes-Altamirano, Ariadna Yáñes-Pizaña, Samuel Reyes-Long, González-Maciel Angélica, Cindy Bandala, Herlinda Bonilla-Jaime and Alfonso Alfaro-Rodríguez*


DOI: 10.2174/1568026622666220405143003
View Abstract View on PubMed


Computational Modeling on Binding Interactions of Cyclodextrins with the Human Multidrug Resistance P-glycoprotein Toward Efficient Drug-Delivery System Applications


Michael González-Durruthy, Riccardo Concu*, Laura F. Osmari Vendrame, Mirkos Ortiz Martins, Ivana Zanela, Juan Manuel Ruso and Maria Natália Dias Soeiro Cordeiro


DOI: 10.2174/1568026622666220303115102
View Abstract View on PubMed


Advancement in Nanoparticle-Based Biosensors for Point-of-Care In Vitro Diagnostics


Sumera Khizar, Abdelhamid Elaissari*, Amal Ali Al-Dossary, Nadia Zine, Nicole Jaffrezic-Renault and Abdelhamid Errachid


DOI: 10.2174/1568026622666220401160121
View Abstract View on PubMed


Probing the Interaction of Selonsertib with Human Serum Albumin: In Silico and In Vitro Approaches


Mohammad Hassan Baig*, Preeti Gupta, Mohd. Imran Khan, Mohamed F. Alajmi, Afzal Hussain, Md. Imtaiyaz Hassan and Jae-June Dong


DOI: 10.2174/1568026622666220330012032
View Abstract View on PubMed



Medicinal Chemistry of Inhibitors Targeting Resistant Bacteria


Kadja Luana Chagas Monteiro, Osmar Nascimento Silva, Igor José dos Santos Nascimento*, Francisco Jaime Bezerra Mendonça Júnior, Pedro Gregório Vieira Aquino, Edeildo Ferreira da Silva-Júnior and Thiago Mendonça de Aquino


DOI: 10.2174/1568026622666220321124452
View Abstract View on PubMed



Abstracts Ahead of Print

Prospective Medicines against the Widespread, Emergent and Multidrug-Resistant Opportunistic Fungal Pathogen Candida auris: A Breath of Hope.


Lívia de Souza Ramos, Laura Nunes Silva, Thaís Pereira de Mello, Heloísa Freire Frota, Marta Helena Branquinha and André Luis Souza dos Santos*


DOI: 10.2174/1568026622666220520153748
View Abstract




COVID-19 in G6PD-deficient patients, oxidative stress, and neuropathology


Beatriz Hernández-Ochoa, Daniel Ortega-Cuellar, Abigail González-Valdez, Noemí Cárdenas-Rodríguez, Julieta Griselda Mendoza-Torreblanca, Itzel Jatziri Contreras-García, Luz Adriana Pichardo-Macías, Cindy Bandala and Saúl Gómez-Manzo*


DOI: 10.2174/1568026622666220516111122
View Abstract


A concise review on the role of natural and synthetically derived peptides involved in colorectal cancer


Alakesh Das, Dikshita Deka, Antara Banerjee, Arun Kumar Radhakrishnan, Hong Zhang, Xiao-Feng Sun and Surajit Pathak*


DOI: 10.2174/1568026622666220516105049
View Abstract


Radiopharmacokinetics of graphene quantum dots nanoparticles in vivo: comparing the pharmacokinetics parameters in long and short periods


Matheus Keuper Bastos, Martha Sahylí Ortega Pijeira, Ana Paula dos Santos Matos, Eduardo Ricci-Junior, Pierre B. A. Fechine, Luciana Magalhães Rebelo Alencar, Sara Gemini-Piperni, Frank Alexis, Mohamed F. Attia, Ralph Santos-Oliveira* and Juliana Helena Sobrinho


DOI: 10.2174/1568026622666220512150625
View Abstract


Impact of Indazole scaffold as Antibacterial and Antifungal agent


Om Prakash Panda, Tapas Kumar Mohapatra, Sridevi Chigurupati, Md. Imran Hossain, Sitansu Sekhar Nanda* and Dong Kee Yi


DOI: 10.2174/1568026622666220512145646
View Abstract




Personalization of pharmacological treatments for ADHD: Why it is advisable and possible options to achieve it


Wendy Verónica Herrera-Morales, Leticia Ramírez-Lugo, Roger Cauich-Kumul, Eric Murillo-Rodríguez and Luis Núñez-Jaramillo*


DOI: 10.2174/1568026622666220509155413
View Abstract


Published Contents

Editor's Choice


Parallelization of Molecular Docking: A Review

, 2018; 18(12): 1015 - 1028

Dong Dong, Zhijian Xu, Wu Zhong and Shaoliang Peng*


DOI: 10.2174/1568026618666180821145215




A Review on Plant Antimicrobials of Past Decade

, 2018; 18(10): 812 - 833

Preet Amol Singh, Sapna D. Desai and Jasbir Singh*


DOI: 10.2174/1568026618666180516123229




Prediction and Targeting of Interaction Interfaces in G-protein Coupled Receptor Oligomers

, 2018; 18(8): 714 - 746

Anke C. Schiedel, Meryem Kose, Carlos Barreto, Beatriz Bueschbell, Giulia Morra, Ozge Sensoy* and Irina S. Moreira*


DOI: 10.2174/1568026618666180604082610






Current Methods Applied to Biomaterials – Characterization Approaches, Safety Assessment and Biological International Standards

, 2018; 18(4): 256 - 274

Justine P.R. Oliveira*, H. Ivan Melendez-Ortiz, Emilio Bucio, Patricia Terra Alves, Mayara Ingrid Sousa Lima, Luiz Ricardo Goulart, Monica B. Mathor, Gustavo H.C. Varca and Ademar B. Lugao


DOI: 10.2174/1568026618666180410151518



Open Access Articles

Beyond DNA-targeting in Cancer Chemotherapy. Emerging Frontiers - A Review

, 2021; 21(1): 28 - 47

Simon N. Mbugua, Lydia W. Njenga, Ruth A. Odhiambo, Shem O. Wandiga and Martin O. Onani*




Peptide Receptor Radionuclide Therapy: Looking Back, Looking Forward

, 2020; 20(32): 2959 - 2969

Danny Feijtel, Marion de Jong and Julie Nonnekens*




Learning the Edit Costs of Graph Edit Distance Applied to Ligand-Based Virtual Screening

, 2020; 20(18): 1582 - 1592

Carlos Garcia-Hernandez, Alberto Fernández* and Francesc Serratosa




Telomere-related Markers for Cancer

, 2020; 20(6): 410 - 432

Xiaotian Yuan*, Mingkai Dai and Dawei Xu*




Discovery and Development of Anti-HIV Therapeutic Agents: Progress Towards Improved HIV Medication

, 2019; 19(18): 1621 - 1649

Kenji Maeda*, Debananda Das, Takuya Kobayakawa, Hirokazu Tamamura and Hiroaki Takeuchi*




Ensemble-Based Modeling of Chemical Compounds with Antimalarial Activity

, 2019; 19(11): 957 - 969

Ana Yisel Caballero-Alfonso, Maykel Cruz-Monteagudo, Eduardo Tejera, Emilio Benfenati, Fernanda Borges, M. Natália D.S. Cordeiro, Vinicio Armijos-Jaramillo and Yunierkis Perez-Castillo*





Treatment of Toxoplasmosis and Neosporosis in Farm Ruminants: State of Knowledge and Future Trends

, 2018; 18(15): 1304 - 1323

Roberto Sánchez-Sánchez, Patricia Vázquez, Ignacio Ferre and Luis Miguel Ortega-Mora*




Analyzing of Molecular Networks for Human Diseases and Drug Discovery

, 2018; 18(12): 1007 - 1014

Tong Hao, Qian Wang, Lingxuan Zhao, Dan Wu, Edwin Wang* and Jinsheng Sun*





Ubiquitin Proteasome System as a Potential Drug Target for Malaria

, 2018; 18(5): 315 - 320

Pedro H. Scarpelli Pereira, Chiara Curra and Celia R.S. Garcia*




Metabolomics Applications in Precision Medicine: An Oncological Perspective

, 2017; 17(24): 2740 - 2751

Leonor Puchades-Carrasco and Antonio Pineda- Lucena*




InsP3 Signaling in Apicomplexan Parasites

, 2017; 17(19): 2158 - 2165

Celia R.S. Garcia*, Eduardo Alves, Pedro H. S. Pereira, Paula J. Bartlett, Andrew P. Thomas, Katsuhiko Mikoshiba, Helmut Plattner and L. David Sibley




LncRNA as a Therapeutic Target for Angiogenesis

, 2017; 17(15): 1750 - 1757

Mohan M. Kumar and Ravi Goyal*






Most Cited Articles

Review Article

Molecular hybridization as a tool for designing multitarget drug candidates for complex diseases

, 2019; 19(19): 1694-1711.

Viktoriya Ivasiv, Claudia Albertini, Ana E. Gonçalves, Michele Rossi and Maria L. Bolognesi*


DOI: 10.2174/1568026619666190619115735





Review Article

Biological signatures of alzheimer’s disease

, 2020; 20(9): 770-781.

Poornima Sharma, Anjali Sharma, Faizana Fayaz, Sharad Wakode* and Faheem H. Pottoo


DOI: 10.2174/1568026620666200228095553


Review Article

Discovery and development of anti-HIV therapeutic agents: Progress towards improved HIV medication

, 2019; 19(18): 1621-1649.

Kenji Maeda*, Debananda Das, Takuya Kobayakawa, Hirokazu Tamamura and Hiroaki Takeuchi*


DOI: 10.2174/1568026619666190712204603


Review Article

STAT3: A potential drug target for tumor and inflammation

, 2019; 19(15): 1305-1317.

Yang Sheng Hu, Xu Han and Xin Hua Liu*


DOI: 10.2174/1568026619666190620145052


Review Article

Biological activities of artemisinin derivatives beyond malaria

, 2019; 19(3): 205-222.

Xiaoyan Liu, Jianguo Cao, Guozheng Huang*, Qingjie Zhao* and Jingshan Shen


DOI: 10.2174/1568026619666190122144217



Review Article

Virtual screening techniques in drug discovery: Review and recent applications

, 2019; 19(19): 1751-1767.

Sheisi F.L. da Silva Rocha, Carolina G. Olanda, Harold H. Fokoue and Carlos M.R. Sant'Anna*


DOI: 10.2174/1568026619666190816101948



Review Article

Mycobacterial tuberculosis Enzyme Targets and their Inhibitors

, 2019; 19(5): 337-355.

Anil Kumar Saxena* and Anamika Singh


DOI: 10.2174/1568026619666190219105722


Review Article

Zinc-depend ent deacetylase (HDAC) inhibitors with different zinc binding groups

, 2019; 19(3): 223-241.

Yan Li, Fang Wang, Xiaoxue Chen, Jie Wang, Yonglong Zhao, Yongjun Li and Bin He*


DOI: 10.2174/1568026619666190122144949





Most Accessed Articles

A Review on Natural Sources Derived Protein Nanoparticles as Anti-cancer Agents

, 2021; 21(12): 1014-1026.

Bhattacharya, Tanima; Maishu, Samka P.; Akter, Rokeya; Rahman, Md. H.; Akhtar, Muhammad F.; Saleem, Ammara; Bin-Jumah, May; Kamel, Mohamed; Abdel-Latif, Mervat A.; Abdel-Daim, Mohamed M.


DOI: 10.2174/1568026621666210412151700


Bioactive Compounds Effective Against Type 2 Diabetes Mellitus: A Syste- matic Review

, 2021; 21(12): 1067-1095.

Egbuna, Chukwuebuka; Awuchi, Chinaza G.; Kushwaha, Garima; Rudrapal, Mithun; Patrick-Iwuanyanwu, Kingsley C.; Singh, Omkar; Odoh, Uchenna E.; Khan, Johra; Jeevanandam, Jaison; Kumarasamy, Suresh; Chukwube, Vincent O.; Narayanan, Mathiyazhagan; Palai, Santwana; Gaman, Mihnea-Alexandru; Uche, Chukwuemelie Z.; Ogaji, Daprim S.; Ezeofor, Nebechi J.; Mtewa, Andrew G.; Patrick-Iwuanyanwu, Chinyere C.; Kesh, Shyam S.; Shivamallu, Chandan; Saravanan, Kaliyaperumal; Tijjani, Habibu; Akram, Muhammad; Ifemeje, Jonathan C.; Olisah, Michael C.; Chikwendu, Chukwudi J.


DOI: 10.2174/1568026621666210509161059











Docking Paradigm in Drug Design

, 2021; 21(6): 507-546.

Sulimov, Vladimir B.; Kutov, Danil C.; Taschilova, Anna S.; Ilin, Ivan S.; Tyrtyshnikov, Eugene E.; Sulimov, Alexey, V


DOI: 10.2174/1568026620666201207095626


Tuberculosis: An Update on Pathophysiology, Molecular Mechanisms of Drug Resistance, Newer Anti-TB Drugs, Treatment Regimens and Host-Directed Therapies

, 2021; 21(6): 547-570.

Borah, Pobitra; Deb, Pran Kishore; Venugopala, Katharigatta N.; Al-Shar'i, Nizar A.; Singh, Vinayak; Deka, Satyendra; Srivastava, Amavya; Tiwari, Vinod; Mailavaram, Raghu Prasad


DOI: 10.2174/1568026621999201211200447


ENTPDases from Pathogenic Trypanosomatids and Purinergic Signaling: Shedding Light towards Biotechnological Applications

, 2021; 21(3): 213-226.

da Silva, Walmir; Torres, Nancy da Rocha; Agripino, Joice de Melo; Ferraz da Silva, Victor Hugo; Alves de Souza, Anna Claudia; Ribeiro, Isadora Cunha; de Oliveira, Tatiana Aparecida; de Souza, Luciana Angelo; Ramos Andrade, Lethicia Kelly; Badaro de Moraes, Joao Victor; Diogo, Marcel Arruda; de Castro, Raissa Barbosa; Poleto, Marcelo Depolo; Crocco Afonso, Luis Carlos; Rangel Fietto, Juliana Lopes


DOI: 10.2174/1568026620666201005125146





Editor-in-Chief

graphic
Jia Zhou
Chemical Biology Program
Department of Pharmacology and Toxicology
University of Texas Medical Branch
Galveston, TX
(USA)
Biography
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Journal History

Current Topics in Medicinal Chemistry was introduced in 2001 with the assistance of Dr. Allen B. Reitz, who served as the editor-in-chief from 2001 to 2020. Currently, Dr. Jia Zhou is the Editor-in-Chief of the journal.

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