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Current Pharmaceutical Design

Volume 27, 46 Issues, 2021
ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)
This journal supports open access

Aims & Scope

Current Pharmaceutical Design publishes timely in-depth/mini reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field.

Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

Current Pharmaceutical Design

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Volume 27

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Number 11







Review Article



Review Article

Marine Bioactive Peptides in Supplements and Functional Foods - A Commercial Perspective

, 27(11): 1353 - 1364

Ragnhild Dragøy Whitaker*, Themis Altintzoglou, Kjersti Lian and Estefania Noriega Fernandez


DOI: 10.2174/1381612824999201105164000




Research Article

Bioactive Peptides Originating from Gastrointestinal Endogenous Proteins in the Growing Pig: In Vivo Identification

, 27(11): 1382 - 1395

Lakshmi A. Dave, Maria Hayes, Leticia Mora, Shane M. Rutherfurd, Carlos A. Montoya and Paul J. Moughan*


DOI: 10.2174/1381612826666201207111209


General Review Article

New Drugs and Interventional Strategies for the Management of Hypertension

, 27(11): 1396 - 1406

Theodoros Christophides*, Alberto Somaschini*, Andrea Demarchi, Stefano Cornara, Maria Androulaki and Emmanuel Androulakis


DOI: 10.2174/1381612826666201106091527


General Review Article

XIST: A Meaningful Long Noncoding RNA in NSCLC Process

, 27(11): 1407 - 1417

Yujie Shen, Yexiang Lin, Kai Liu, Jinlan Chen, Juanjuan Zhong, Yisong Gao and Chengfu Yuan*


DOI: 10.2174/1381612826999201202102413


Current Pharmaceutical Design, Volume 27 (2021) - Number 16


This issue is in progress but contains articles that are final and fully citable.

Current Pharmaceutical Design, Volume 27 (2021) - Number 15


This issue is in progress but contains articles that are final and fully citable.

Current Pharmaceutical Design, Volume 27 (2021) - Number 14


This issue is in progress but contains articles that are final and fully citable.

Current Pharmaceutical Design, Volume 27 (2021) - Number 13


This issue is in progress but contains articles that are final and fully citable.

Current Pharmaceutical Design, Volume 27 (2021) - Number 12


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print




ADAMTS9-AS2: A Functional Long Non-coding RNA in Tumorigenesis


Wen Xu, Bei Wang , Yuxuan Cai, Jinlan Chen, Xing Lv , Chong Guo and Chengfu Yuan*


DOI: 10.2174/1381612827666210325105106
View Abstract View on PubMed


Recent Advances in Diagnostic and Therapeutic Approaches for Breast Cancer: A Comprehensive Review


Fatima Noor, Ayesha Noor, Ali Raza Ishaq, Iqra Farzeen, Muhammad Hamzah Saleem, Kanwal Ghaffar, Muhammad Farhan Aslam, Sidra Aslam* and Jen‐Tsung Chen*


DOI: 10.2174/1381612827666210303141416
View Abstract View on PubMed


Gender Disparities on Access to Care and Coronary Disease Management


Zorana Vasiljevic-Pokrajcic*, Gordana Krljanac, Ratko Lasica, Marija Zdravkovic, Sanja Stankovic, Predrag Mitrovic, Vladan Vukcevic and Milika Asanin


DOI: 10.2174/1381612827666210406144310
View Abstract View on PubMed




Statistically Designed Extraction of Herbs Using Ultrasound Waves: A Review


Ashwani Arya, Rubal Chahal, Arun Nanda, Deepak Kaushik, May Bin- Jumah, Md Habibur Rahman, Mohamed M Abdel-Daim* and Vineet Mittal*


DOI: 10.2174/1381612827666210222114441
View Abstract View on PubMed



Abstracts Ahead of Print


Genomic instability in cancer: molecular mechanisms and therapeutic potentials


Arash Salmaninejad, Khandan Ilkhani, Havva Marzan, Jamshid Gholizadeh Navashenaq, Samira Rahimirad, Fatemeh Radnia, Meysam Yousefi, Zahra Bahmanpour, Sara Azhdari and Amirhossein Sahebkar*


DOI: 10.2174/1381612827666210426100206
View Abstract


Association of Viruses in the Development of Cardiovascular Diseases


Bisma Rauff *, Arif Malik, Yasir Ali Bhatti , Shafiq Ahmad Chudhary, Kaneez Fatima, Shafquat Rafiq , Aisha Tahir, Sumaira Sharif and Ishtiaq Qadri


DOI: 10.2174/1381612827666210426094502
View Abstract



Lipid disorders in pregnancy


Anastasios Liberis*, Stamatis Petousis and Panagiotis Tsikouras


DOI: 10.2174/1381612827666210421103245
View Abstract



Genetic and Epigenetic Biomarkers For Diagnosis, Prognosis and Treatment Of Metabolic Syndrome


Rosaria V. Giglio*, Anca P Stoian*, Angelo M. Patti*, Ali A. Rizvi, Vasily Sukhorukov, Marcello Ciaccio, Alexander Orekhov and Manfredi Rizzo


DOI: 10.2174/1381612827666210412145915
View Abstract


Osteogenic differentiation factors of multipotent mesenchymal stromal cells in the current understanding


Kristina А. Yurova , Elena S. Melashchenko, Olga G. Khaziakhmatova, Vladimir V. Malashchenko, Olga B. Melashchenko, Egor O. Shunkin, Igor K. Norkin, Pavel A. Ivanov, Igor A. Khlusov and Larisa S. Litvinova*


DOI: 10.2174/1381612827666210406150027
View Abstract


The Role of Neurogenic Bioamines in Nerve Fibers of Uterus during the Postpartum Involution in Experimental Animal Models


Sergey V. Dindyaev, Narasimha M Beeraka, Denis V. Kasatkin, Elizaveta V. Mikhaylenko, Siva G. Somasundaram, Cecil E. Kirkland and Gjumrakch Aliev*


DOI: 10.2174/1381612827666210322141205
View Abstract



Published Contents

Editor's Choice

Bioactive Peptides Originating from Gastrointestinal Endogenous Proteins in the Growing Pig: In Vivo Identification

, 2021; 27(11): 1382 - 1395

Lakshmi A. Dave, Maria Hayes, Leticia Mora, Shane M. Rutherfurd, Carlos A. Montoya and Paul J. Moughan*


DOI: 10.2174/1381612826666201207111209



Prediction Models and Scores in Pulmonary Hypertension: A Review

, 2021; 27(10): 1266 - 1276

Sophia Anastasia Mouratoglou, Ahmed A. Bayoumy and Anton Vonk Noordegraaf*


DOI: 10.2174/1381612824999201105163437



The Computational Intervention of Macrolide Antibiotics in the Treatment of COVID-19

, 2021; 27(9): 1202 - 1210

Firoz Anwar*, Hisham N. Altayb, Fahad A. Al-Abbasi, Vikas Kumar and Mohammad A. Kamal*


DOI: 10.2174/1381612827666210125121954





Focus on MicroRNAs as Biomarker in Pediatric Diseases

, 2021; 27(6): 826 - 832

Giuseppe Lassandro, Loredana Ciaccia, Anna Amoruso, Valentina Palladino, Viviana V. Palmieri and Paola Giordano*


DOI: 10.2174/1381612826666201021125512





Exploring Potential of Alkaloidal Phytochemicals Targeting Neuroinflammatory Signaling of Alzheimer's Disease

, 2021; 27(3): 357 - 366

Md. Sahab Uddin*, Md. Tanvir Kabir, Abdullah Al Mamun, Tapan Behl, Rasha A. Mansouri, Akram Ahmed Aloqbi, Asma Perveen, Abdul Hafeez and Ghulam Md Ashraf*


DOI: 10.2174/1381612826666200531151004



Do Mitochondrial DNA Mutations Play a Key Role in the Chronification of Sterile Inflammation? Special Focus on Atherosclerosis

, 2021; 27(2): 276 - 292

Alexander N. Orekhov*, Elena V. Gerasimova, Vasily N. Sukhorukov, Anastasia V. Poznyak* and Nikita G. Nikiforov


DOI: 10.2174/1381612826666201012164330



Open Access Articles

Anti-malarial Drugs are Not Created Equal for SARS-CoV-2 Treatment: A Computational Analysis Evidence

, 2021; 27(10): 1323 - 1329

Simone Ronsisvalle, Federica Panarello, Rosaria Di Mauro, Renato Bernardini, Giovanni Li Volti* and Giuseppina Cantarella




Effects of an Integrative Mind-Body-Medicine Group Program on Breast Cancer Patients During Chemotherapy: An Observational Study

, 2021; 27(8): 1112 - 1120

Heidemarie Haller, Kyung-Eun Choi, Silke Lange, Sherko Kümmel, Anna Paul, Holger Cramer, Gustav Dobos and Petra Voiss*





The Pathogenic Subpopulation of Th17 Cells in Obesity

, 2021; 27: 1 - 15 (E-Pub Ahead of Print)

Natalia Todosenko, Maria Vulf*, Kristina Yurova, Daria Skuratovskaia, Olga Khaziakhmatova, Natalia Gazatova, Olga Melashchenko, Olga Urazova and Larisa Litvinova*




Exosome Limitations in the Treatment of Inflammatory Diseases

, 2021; 27: 1 - 17 (E-Pub Ahead of Print)

Daria Skuratovskaia*, Maria Vulf, Olga Khaziakhmatova, Vladimir Malashchenko, Aleksandra Komar, Egor Shunkin, Natalia Gazatova and Larisa Litvinova




Treatment of Anderson-Fabry Disease

, 2020; 26(40): 5089 - 5099

Irene Simonetta*, Antonino Tuttolomondo, Mario Daidone, Salvatore Miceli and Antonio Pinto




Nanostructured Lipid Carriers as Potential Drug Delivery Systems for Skin Disorders

, 2020; 26(36): 4569 - 4579

Tejashree Waghule, Vamshi Krishna Rapalli, Srividya Gorantla, Ranendra Narayan Saha, Sunil Kumar Dubey, Anu Puri and Gautam Singhvi*




A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats

, 2020; 26(31): 3884 - 3894

Branka Petković*, Srđan Kesić, Slavica Ristić, Željko Pavković, Jelena Podgorac, Gordana Stojadinović and Vesna Pešić





γ-Aminobutyric Acid and Derivatives Reduce the Incidence of Acute Pain after Herpes Zoster - A Systematic Review and Meta-analysis

, 2020; 26(25): 3026 - 3038

Wuttapon Sadaeng, Katalin Márta, Péter Mátrai, Péter Hegyi, Barbara Tóth, Balázs Németh, László M. Czumbel, Thanyaporn Sang-Ngoen, Zoltán Gyöngyi, Gábor Varga*, Péter Révész, István Szanyi, Kázmér Karádi and Gábor Gerber




Effects of Chlorine Dioxide on Oral Hygiene - A Systematic Review and Meta-analysis

, 2020; 26(25): 3015 - 3025

Beáta Kerémi, Katalin Márta, Kornélia Farkas, László M. Czumbel, Barbara Tóth, Zsolt Szakács, Dezső Csupor, József Czimmer, Zoltán Rumbus, Péter Révész, Adrienn Németh, Gábor Gerber, Péter Hegyi and Gábor Varga*




Artemia species: An Important Tool to Screen General Toxicity Samples

, 2020; 26(24): 2892 - 2908

Epole Ntungwe N, Eva M. Domínguez-Martín, Amilcar Roberto, Joana Tavares, Vera M. S. Isca, Paula Pereira, Maria-João Cebola and Patrícia Rijo*




Vaccinium myrtillus L. Fruits as a Novel Source of Phenolic Compounds with Health Benefits and Industrial Applications - A Review

, 2020; 26(16): 1917 - 1928

Tânia C. S. P. Pires , Cristina Caleja , Celestino Santos-Buelga , Lillian Barros* and Isabel C.F.R. Ferreira*







Most Cited Articles

Review Article

Emerging potential of naturally occurring autophagy modulators against neurodegeneration

, 2020; 26(7): 772-779.

Md. Ataur Rahman*, Md Rezanur Rahman, Toyfiquz Zaman, Md. Sahab Uddin, Rokibul Islam, Mohamed M. Abdel-Daim and Hyewhon Rhim*


DOI: 10.2174/1381612826666200107142541


Review Article

Exploring the multifunctional neuroprotective promise of rasagiline derivatives for multi-dysfunctional Alzheimer’s disease

, 2020; 26(37): 4690-4698.

Md. Sahab Uddin*, Md. Tanvir Kabir, Md. Habibur Rahman, Md. Abdul Alim, Md. Motiar Rahman, Anurag Khatkar, Abdullah Al Mamun, Abdur Rauf, Bijo Mathew and Ghulam Md. Ashraf


DOI: 10.2174/1381612826666200406075044


Review Article

Current nanoparticle approaches in nose to brain drug delivery and anticancer therapy-a review

, 2020; 26(11): 1128-1137.

Mohammad A. Ansari, Ill-Min Chung, Govindasamy Rajakumar, Mohammad A. Alzohairy, Mohammad N. Alomary, Muthu Thiruvengadam*, Faheem H. Pottoo and Niyaz Ahmad


DOI: 10.2174/1381612826666200116153912


Review Article

Lipid-based nanosystem as intelligent carriers for versatile drug delivery applications

, 2020; 26(11): 1167-1180.

Harshita, Md. Abul Barkat, Sabya S. Das, Faheem H. Pottoo, Sarwar Beg and Ziyaur Rahman*


DOI: 10.2174/1381612826666200206094529


Review Article

Polymer-lipid hybrid nanoparticles: A next-generation nanocarrier for targeted treatment of solid tumors

, 2020; 26(11): 1206-1215.

Md. Rizwanullah, Meraj Alam, Harshita, Showkat R. Mir, Mohd. M.A. Rizvi and Saima Amin*


DOI: 10.2174/1381612826666200116150426


Review Article

Nanomedicines in diagnosis and treatment of cancer: An update

, 2020; 26(11): 1216-1231.

Nafis Haider, Sana Fatima, Murtada Tahar, Md. Rizwanullah, Jamia Firdous, Rafeeque Ahmad , Faizan Mazhar and Mohammad A. Khan*


DOI: 10.2174/1381612826666200318170716


Review Article

Vaccinium myrtillus l. Fruits as a novel source of phenolic compounds with health benefits and industrial applications-a review

, 2020; 26(16): 1917-1928.

Tânia C. S. P. Pires , Cristina Caleja , Celestino Santos-Buelga , Lillian Barros* and Isabel C.F.R. Ferreira*


DOI: 10.2174/1381612826666200317132507


Review Article

Surface-engineered cancer nanomedicine: Rational design and recent progress

, 2020; 26(11): 1181-1190.

Javed Ahmad*, Ameeduzzafar, Mohammad Z. Ahmad and Habban Akhter


DOI: 10.2174/1381612826666200214110645


Review Article

Type 1 diabetes and physical exercise: Moving (forward) as an adjuvant therapy

, 2020; 26(9): 946-957.

Othmar Moser*, Max L. Eckstein, Daniel J. West, Nandu Goswami, Harald Sourij and Peter Hofmann


DOI: 10.2174/1381612826666200108113002


Review Article

Liposomes: Novel drug delivery approach for targeting Parkinson’s disease

, 2020; 26(37): 4721-4737.

Bhumika Kumar, Mukesh Pandey, Faheem H. Pottoo, Faizana Fayaz, Anjali Sharma and P.K. Sahoo*


DOI: 10.2174/1381612826666200128145124


Review Article

Inflammatory bowel diseases: The role of gut microbiota

, 2020; 26(25): 2951-2961.

Cristiana De Musis, Lucia Granata, Marcello Dallio, Agnese Miranda, Antonietta G. Gravina and Marco Romano*


DOI: 10.2174/1381612826666200420144128


Review Article (Mini-Review)

New insights about regulatory T cells distribution and function with exercise: The role of immunometabolism

, 2020; 26(9): 979-990.

Gilson P. Dorneles*, Aline A.Z. dos Passos, Pedro R.T. Romão and Alessandra Peres*


DOI: 10.2174/1381612826666200305125210


Research Article

Non-hormonal treatments for menopausal symptoms and sleep disturbances: A comparison between purified pollen extracts and soy isoflavones

, 2020; 26(35): 4509-4514.

Pasquale De Franciscis*, Anna Conte, Antonio Schiattarella, Gaetano Riemma, Luigi Cobellis and Nicola Colacurci


DOI: 10.2174/1381612826666200721002022


Review Article

Nanostructured lipid carriers as potential drug delivery systems for skin disorders

, 2020; 26(36): 4569-4579.

Tejashree Waghule, Vamshi Krishna Rapalli, Srividya Gorantla, Ranendra Narayan Saha, Sunil Kumar Dubey, Anu Puri and Gautam Singhvi*


DOI: 10.2174/1381612826666200614175236


Review Article

Recent nano-based therapeutic intervention of bioactive sesquiterpenes: Prospects in cancer therapeutics

, 2020; 26(11): 1138-1144.

Mohammad A. Ansari*, Khan F. Badrealam, Asrar Alam, Saba Tufail, Gulshan Khalique, Mohammad J. Equbal*, Mohammad A. Alzohairy, Ahmad Almatroudi, Mohammad N. Alomary and Faheem H. Pottoo


DOI: 10.2174/1381612826666200116151522



Most Accessed Articles

Comparative Analysis of Risk Stratification Scores in Atrial Fibrillation

, 2021; 27(10): 1298-1310.

Athanasios Samaras, Ioannis Doundoulakis *, Christina Antza, Stefanos Zafeiropoulos, Ioannis Farmakis and Apostolos Tzikas


DOI: 10.2174/1381612826666201210113328


Novel Phytochemical Constituents and their Potential to Manage Diabetes

, 2021; 27(6): 775-788.

Shaik I. Khalivulla*, Arifullah Mohammed* and Kokkanti Mallikarjuna


DOI: 10.2174/1381612826666201222154159


Risk Prediction Models and Scores in Hypertrophic Cardiomyopathy

, 2021; 27(10): 1254-1265.

Thomas D. Gossios*, Konstantinos Savvatis, Thomas Zegkos, Despina Parcharidou, Haralambos I. Karvounis and Georgios K. Efthimiadis


DOI: 10.2174/1381612827666210125121115


Cardio-protective Effects of Glucagon-like Peptide-1 Receptor Agonists: An Overview of Systematic Reviews and Publication Overlap

, 2021; 27(8): 1068-1079.

Stefanos Zafeiropoulos, Areti Pagiantza, Ioannis Doundoulakis, Nikolaos Stalikas, Ioannis Farmakis, Athanasios Samaras, Christina Antza and George Giannakoulas*


DOI: 10.2174/1381612827666210119103153


Mechanisms for Cardiorenal Protection of SGLT-2 Inhibitors

, 2021; 27(8): 1043-1050.

Panagiotis I. Georgianos, Vasilios Vaios, Evangelia Dounousi, Marios Salmas, Theodoros Eleftheriadis and Vassilios Liakopoulos*


DOI: 10.2174/1381612827666210119102409


Data Sharing and Privacy in Pharmaceutical Studies

, 2021; 27(7): 911-918.

Rufan Chen, Yi Zhang, Zuochao Dou, Feng Chen, Kang Xie and Shuang Wang*


DOI: 10.2174/1381612827999210112204732


Zacopride Exerts an Antiarrhythmic Effect by Specifically Stimulating the Cardiac Inward Rectifier Potassium Current in Rabbits: Exploration of a New Antiarrhythmic Strategy

, 2020; 26(44): 5746-5754.

Yuanyuan Lin, Junhu Li, Baozhong Zhu, Qinghua Liu, Xiaojie Bai, Bingmei Chang, Yanlin Guo, Qilong Feng*, Xuewen Li*, Bowei Wu and Jimin Cao


DOI: 10.2174/1381612826666200701135508




Naphthoquinones and Derivatives for Chemotherapy: Perspectives and Limitations of their Anti-trypanosomatids Activities

, 2021; 27(15): 1807-1824.

Luíza Dantas-Pereira, Edézio F. Cunha-Junior, Valter V. Andrade-Neto, John F. Bower, Guilherme A.M. Jardim, Eufrânio N. da Silva Júnior, Eduardo C. Torres-Santos and Rubem F.S. Menna-Barreto*


DOI: 10.2174/1381612826666201109111802


Basic Biology of Trypanosoma cruzi

, 2021; 27(14): 1671-1732.

Aline A. Zuma, Emile dos Santos Barrias and Wanderley de Souza*


DOI: 10.2174/1381612826999201203213527


Medicinal Applications of Cannabinoids Extracted from Cannabis sativa (L.): A New Route in the Fight Against COVID-19?

, 2021; 27(13): 1564-1578.

Shah Khalid*, Faisal A. Almalki, Taibi Ben Hadda*, Ammar Bader, Tareq Abu-Izneid, Malika Berredjem, Eman R. Elsharkawy and Ali M. Alqahtani*


DOI: 10.2174/1381612826666201202125807


miRNAs in SARS-CoV 2: A Spoke in the Wheel of Pathogenesis

, 2021; 27(13): 1628-1641.

Rohit Satyam, Tulika Bhardwaj, Sachin Goel, Niraj Kumar Jha*, Saurabh Kumar Jha, Parma Nand, Janne Ruokolainen, Mohammad Amjad Kamal and Kavindra Kumar Kesari


DOI: 10.2174/1381612826999201001200529


Trypanothione Metabolism as Drug Target for Trypanosomatids

, 2021; 27(15): 1834-1846.

María Dolores Piñeyro, Diego Arias, Adriana Parodi-Talice, Sergio Guerrero and Carlos Robello*


DOI: 10.2174/1381612826666201211115329


Impact of Guidelines on Hypertension Control in the Elderly

, 2021; 27(16): 1952-1959.

Del Pinto Rita*, Mirela Dobre, Silvia Pagliacci and Claudio Ferri*


DOI: 10.2174/1381612826666201207230956




Editor-in-Chief

graphic
Alessandro Antonelli
(12,288 citations)
Laboratory of Primary Human Cells
University of Pisa
Pisa
(Italy)
Biography
View Full Editorial Board

Executive Editor

graphic
Atta-ur-Rahman, FRS
(32052 citations)
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
(UK)
Biography

Nobel Laureates on Editorial Board

graphic
Andrew V. Schally
(USA)

COPE Compliant

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Journal History

Current Pharmaceutical Design was introduced in 1995 with the assistance of Dr. William A. Banks.

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