Bentham Science Logo
Journal Cover

Track Your Manuscript:


Current Pharmaceutical Design

Volume 27, 46 Issues, 2021
ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)
This journal supports open access

Aims & Scope

Current Pharmaceutical Design publishes timely in-depth/mini reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field.

Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

Current Pharmaceutical Design

,

Volume 27

-

Number 4





Review Article

Jaceosidin: A Natural Flavone with Versatile Pharmacological and Biological Activities

, 27(4): 456 - 466

Bushra Nageen, Azhar Rasul*, Ghulam Hussain, Muhammad A. Shah*, Haseeb Anwar, Syed M. Hussain, Md. Sahab Uddin, Iqra Sarfraz, Ammara Riaz and Zeliha Selamoglu


DOI: 10.2174/1381612826666200429095101


Review Article

Fascinating Chemopreventive Story of Wogonin: A Chance to Hit on the Head in Cancer Treatment

, 27(4): 467 - 478

Rajesh Kumar, Seetha Harilal, Della G.T. Parambi, Siju E. Narayanan, Md. Sahab Uddin, Akash Marathakam, Jobin Jose, Githa E. Mathew and Bijo Mathew*


DOI: 10.2174/1385272824999200427083040


Review Article

The Anticancer Potential of Apigenin Via Immunoregulation

, 27(4): 479 - 489

Lu Xu, Mohamed Y. Zaky, Waleed Yousuf, Anwar Ullah, Gehad R. Abdelbaset, Yingqiu Zhang, Osama M. Ahmed, Shuyan Liu* and Han Liu*


DOI: 10.2174/1381612826666200713171137


Review Article

Kolaviron: A Biflavonoid with Numerous Health Benefits

, 27(4): 490 - 504

Ochuko L. Erukainure, Veronica F. Salau, Chika I. Chukwuma and Md. Shahidul Islam*


DOI: 10.2174/1381612826666201113094303


Review Article

Flavonoids from Marine-Derived Actinobacteria as Anticancer Drugs

, 27(4): 505 - 512

Wael N. Hozzein*, Mohamed Mohany, Sana M.M. Alhawsawi, Mohamed Y. Zaky, Salim S. Al-Rejaie and Dalal H.M. Alkhalifah


DOI: 10.2174/1381612826666201216160154


Review Article



General Review Article

The Effects of P75NTR on Learning Memory Mediated by Hippocampal Apoptosis and Synaptic Plasticity

, 27(4): 531 - 539

Jun-Jie Tang, Shuang Feng, Xing-Dong Chen, Hua Huang, Min Mao, Hai-Yan Wang, Sen Li, Xiu-Min Lu* and Yong-Tang Wang*


DOI: 10.2174/1381612826666200916145142


Current Pharmaceutical Design, Volume 27 (2021) - Number 6


This issue is in progress but contains articles that are final and fully citable.

Current Pharmaceutical Design, Volume 27 (2021) - Number 5


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print


Gender Disparities in the Prevalence, Awareness, Treatment, and Control of High Blood Pressure


Maria Dorobantu, Oana-Florentina Gheorghe-Fronea*, Alexandru Scafa-Udriste, Sebastian Onciul, Calin Pop, Lucian Dorobantu and Roxana Darabont


DOI: 10.2174/1381612827666210125154749
View Abstract View on PubMed


Polycystic Ovary Syndrome: A Contemporary Clinical Approach


Jelica Bjekić-Macut*, Tamara Vukašin, Zelija Velija-Ašimi, Azra Bureković, Marija Zdravković, Zoran Andrić, Marija Branković, Slobodanka Crevar-Marinović, Tatjana Madić, Olivera Stanojlović, Danijela Vojnović Milutinović, Sarantis Livadas and George Mastorakos


DOI: 10.2174/1381612827666210119104721
View Abstract View on PubMed


In Silico Prediction and Designing of Potential siRNAs to be used as Antivirals Against SARS-CoV-2


Sayed Sartaj Sohrab*, Sherif Aly El-Kafrawy, Aymn T. Abbas, Leena H. Bajrai and Esam Ibraheem Azhar


DOI: 10.2174/1381612827999210111194101
View Abstract View on PubMed



Administration of Antioxidants in Infertile Male: When it may have a Detrimental Effect?


Fotios Dimitriadis *, Evangelos N. Symeonidis, Panagiota Tsounapi , Aris Kaltsas, Georgios Hatzichristodoulou, Ioannis Sokolakis, Athanasios Zachariou , Atsushi Takenaka and Nikolaos Sofikitis


DOI: 10.2174/1381612827666210204160248
View Abstract View on PubMed



Exploring the Anti-Neuroinflammatory Potential of Steroid and Terpenoid-Derived Phytochemicals to Combat Alzheimer's Disease


Md. Tanvir Kabir, Md. Sahab Uddin*, Sonia Zaman, Md. Sohanur Rahman, Tapan Behl, Ausaf Ahmad, Abdul Hafeez, Asma Perveen and Ghulam Md Ashraf*


DOI: 10.2174/1381612826666210101152352
View Abstract View on PubMed


The Pathogenic Subpopulation of Th17 Cells in Obesity


Natalia Todosenko, Maria Vulf*, Kristina Yurova, Daria Skuratovskaia, Olga Khaziakhmatova, Natalia Gazatova, Olga Melashchenko, Olga Urazova and Larisa Litvinova*


DOI: 10.2174/1381612826666210101154913
View Abstract View on PubMed



Abstracts Ahead of Print

Chronic inflammation and cancer: The role of endothelial dysfunction and vascular inflammation


Lara J. Bou Malhab, Maha M. Saber-Ayad, Ranyah Al-Hakm, Vidhya A Nair, Panagiotis Paliogiannis*, Gianfranco Pintus and Wael M. Abdel-Rahman*


DOI: 10.2174/1381612827666210303143442
View Abstract


Sex differences in clinical outcomes of patients with stable coronary artery disease after percutaneous coronary intervention


Emmanuel P. Vardas, Evangelos Oikonomou, Gerasimos Siasos, Panagiotis Theofilis, Polychronis Dilaveris, Angelos Papanikolaou and Dimitris Tousoulis*


DOI: 10.2174/1381612827666210303142901
View Abstract


The effects of PDE inhibitors on multiple sclerosis: a review of in vitro and in vivo models


Alexandra Ainatzoglou, Eleni Stamoula, Ioannis Dardalas, Spyridon Siafis and Georgios Papazisis*


DOI: 10.2174/1381612827666210303142356
View Abstract


Diabetes and COVID-19; a review of possible mechanisms


Reyhaneh Moradi-Marjaneh, Fereshteh Asgharzadeh, Elnaz Khordad and Mahdi Moradi Marjaneh*


DOI: 10.2174/1381612827666210303141846
View Abstract


Recent advances in diagnostic and therapeutic approaches for breast cancer: A comprehensive review


Fatima Noor, Ayesha Noor, Ali Raza Ishaq, Iqra Farzeen, Muhammad Hamzah Saleem, Kanwal Ghaffar, Muhammad Farhan Aslam, Sidra Aslam* and Jen‐Tsung Chen*


DOI: 10.2174/1381612827666210303141416
View Abstract



Identification of butyrylcholinesterase and monoamine oxidase B targeted ligands and their putative application in Alzheimer’s treatment: A computational strategy


Nasimudeen R Jabir, Md Tabish Rehman, Shams Tabrez*, Raed F. Alserihi, Mohamed F AlAjmi, Mohd Shahnawaz Khan, Fohad Mabood Husain and Bakrudeen Ali Ahmed*


DOI: 10.2174/1381612827666210226123240
View Abstract



Recent updates on current and upcoming biomarkers for cardiovascular diseases


Ashif Iqubal, Aamir Khan, Adeeba laeeq, Kabil Malhotra, Mohd. Asif Ansari and Syed Ehtaishamul Haque*


DOI: 10.2174/1381612827666210224143047
View Abstract


COVID-19: Epidemiology, Pathology, Diagnosis, Treatment, and Impact


Saimon Shahriar, Md. Sohel Rana, Md. Sabbir Hossain, Ariful Karim, Tasneem Nayla Mredula, Nadia Nourin, Md. Sahab Uddin* and Md. Shah Amran*


DOI: 10.2174/1381612827666210224142446
View Abstract


Published Contents

Editor's Choice


Exploring Potential of Alkaloidal Phytochemicals Targeting Neuroinflammatory Signaling of Alzheimer's Disease

, 2021; 27(3): 357 - 366

Md. Sahab Uddin*, Md. Tanvir Kabir, Abdullah Al Mamun, Tapan Behl, Rasha A. Mansouri, Akram Ahmed Aloqbi, Asma Perveen, Abdul Hafeez and Ghulam Md Ashraf*


DOI: 10.2174/1381612826666200531151004



Do Mitochondrial DNA Mutations Play a Key Role in the Chronification of Sterile Inflammation? Special Focus on Atherosclerosis

, 2021; 27(2): 276 - 292

Alexander N. Orekhov*, Elena V. Gerasimova, Vasily N. Sukhorukov, Anastasia V. Poznyak* and Nikita G. Nikiforov


DOI: 10.2174/1381612826666201012164330



Repurposing Drugs for the Management of Patients with Confirmed Coronavirus Disease 2019 (COVID-19)

, 2021; 27(1): 115 - 126

Evellyn Claudia Wietzikoski Lovato, Lorena Neris Barboza, Samantha Wietzikoski, Amanda Nascimento Vasques de Souza, Pablo Alvarez Auth, Arquimedes Gasparotto Junior and Francislaine Aparecida dos Reis Lívero*


DOI: 10.2174/1381612826666200707121636



Targeting Cancer using Curcumin Encapsulated Vesicular Drug Delivery Systems

, 2021; 27(1): 2 - 14

Joel Hardwick, Jack Taylor, Meenu Mehta, Saurabh Satija, Keshav R. Paudel, Philip M. Hansbro, Dinesh K. Chellappan, Mary Bebawy* and Kamal Dua*


DOI: 10.2174/1381612826666200728151610



Therapeutic Options for Mucopolysaccharidosis II (Hunter Disease)

, 2020; 26(40): 5100 - 5109

Francyne Kubaski, Filippo Vairo, Guilherme Baldo, Fabiano de Oliveira Poswar, Amauri Dalla Corte and Roberto Giugliani*


DOI: 10.2174/1381612826666200724161504




Catechins as Model Bioactive Compounds for Biomedical Applications

, 2020; 26(33): 4032 - 4047

Adriana N. dos Santos, Tatiana R. de L. Nascimento, Brenna L. C. Gondim, Marilia M. A. C. Velo, Renaly I. de A. Rêgo, José R. do C. Neto, Juliana R. Machado, Marcos V. da Silva, Helvia W. C. de Araújo, Maria G. Fonseca and Lúcio R. C. Castellano*


DOI: 10.2174/1381612826666200603124418




Precision Medicine Approach in Prostate Cancer

, 2020; 26(31): 3783 - 3798

Majid Assadi, Narges Jokar, Mojtaba Ghasemi, Iraj Nabipour, Ali Gholamrezanezhad and Hojjat Ahmadzadehfar*


DOI: 10.2174/1381612826666200218104921



Open Access Articles


The Pathogenic Subpopulation of Th17 Cells in Obesity

, 2021; 27: 1 - 15 (E-Pub Ahead of Print)

Natalia Todosenko, Maria Vulf*, Kristina Yurova, Daria Skuratovskaia, Olga Khaziakhmatova, Natalia Gazatova, Olga Melashchenko, Olga Urazova and Larisa Litvinova*




Treatment of Anderson-Fabry Disease

, 2020; 26(40): 5089 - 5099

Irene Simonetta*, Antonino Tuttolomondo, Mario Daidone, Salvatore Miceli and Antonio Pinto




Nanostructured Lipid Carriers as Potential Drug Delivery Systems for Skin Disorders

, 2020; 26(36): 4569 - 4579

Tejashree Waghule, Vamshi Krishna Rapalli, Srividya Gorantla, Ranendra Narayan Saha, Sunil Kumar Dubey, Anu Puri and Gautam Singhvi*




A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats

, 2020; 26(31): 3884 - 3894

Branka Petković*, Srđan Kesić, Slavica Ristić, Željko Pavković, Jelena Podgorac, Gordana Stojadinović and Vesna Pešić





γ-Aminobutyric Acid and Derivatives Reduce the Incidence of Acute Pain after Herpes Zoster - A Systematic Review and Meta-analysis

, 2020; 26(25): 3026 - 3038

Wuttapon Sadaeng, Katalin Márta, Péter Mátrai, Péter Hegyi, Barbara Tóth, Balázs Németh, László M. Czumbel, Thanyaporn Sang-Ngoen, Zoltán Gyöngyi, Gábor Varga*, Péter Révész, István Szanyi, Kázmér Karádi and Gábor Gerber




Effects of Chlorine Dioxide on Oral Hygiene - A Systematic Review and Meta-analysis

, 2020; 26(25): 3015 - 3025

Beáta Kerémi, Katalin Márta, Kornélia Farkas, László M. Czumbel, Barbara Tóth, Zsolt Szakács, Dezső Csupor, József Czimmer, Zoltán Rumbus, Péter Révész, Adrienn Németh, Gábor Gerber, Péter Hegyi and Gábor Varga*




Artemia species: An Important Tool to Screen General Toxicity Samples

, 2020; 26(24): 2892 - 2908

Epole Ntungwe N, Eva M. Domínguez-Martín, Amilcar Roberto, Joana Tavares, Vera M. S. Isca, Paula Pereira, Maria-João Cebola and Patrícia Rijo*




Vaccinium myrtillus L. Fruits as a Novel Source of Phenolic Compounds with Health Benefits and Industrial Applications - A Review

, 2020; 26(16): 1917 - 1928

Tânia C. S. P. Pires , Cristina Caleja , Celestino Santos-Buelga , Lillian Barros* and Isabel C.F.R. Ferreira*






Circulating MicroRNAs and Blood-Brain-Barrier Function in Breast Cancer Metastasis

, 2020; 26(13): 1417 - 1427

Carolin J. Curtaz, Constanze Schmitt, Kinga G. Blecharz-Lang, Norbert Roewer, Achim Wöckel and Malgorzata Burek*




A Chronological Review of Potential Disease-Modifying Therapeutic Strategies for Alzheimer's Disease

, 2020; 26(12): 1286 - 1299

Miren Ettcheto, Oriol Busquets, Triana Espinosa-Jiménez, Ester Verdaguer , Carme Auladell and Antoni Camins*






Most Cited Articles

Review Article

Emerging potential of naturally occurring autophagy modulators against neurodegeneration

, 2020; 26(7): 772-779.

Md. Ataur Rahman*, Md Rezanur Rahman, Toyfiquz Zaman, Md. Sahab Uddin, Rokibul Islam, Mohamed M. Abdel-Daim and Hyewhon Rhim*


DOI: 10.2174/1381612826666200107142541


Review Article

Exploring the multifunctional neuroprotective promise of rasagiline derivatives for multi-dysfunctional Alzheimer’s disease

, 2020; 26(37): 4690-4698.

Md. Sahab Uddin*, Md. Tanvir Kabir, Md. Habibur Rahman, Md. Abdul Alim, Md. Motiar Rahman, Anurag Khatkar, Abdullah Al Mamun, Abdur Rauf, Bijo Mathew and Ghulam Md. Ashraf


DOI: 10.2174/1381612826666200406075044


Review Article

Polymer-lipid hybrid nanoparticles: A next-generation nanocarrier for targeted treatment of solid tumors

, 2020; 26(11): 1206-1215.

Md. Rizwanullah, Meraj Alam, Harshita, Showkat R. Mir, Mohd. M.A. Rizvi and Saima Amin*


DOI: 10.2174/1381612826666200116150426


Review Article

Current nanoparticle approaches in nose to brain drug delivery and anticancer therapy-a review

, 2020; 26(11): 1128-1137.

Mohammad A. Ansari, Ill-Min Chung, Govindasamy Rajakumar, Mohammad A. Alzohairy, Mohammad N. Alomary, Muthu Thiruvengadam*, Faheem H. Pottoo and Niyaz Ahmad


DOI: 10.2174/1381612826666200116153912


Review Article

Lipid-based nanosystem as intelligent carriers for versatile drug delivery applications

, 2020; 26(11): 1167-1180.

Harshita, Md. Abul Barkat, Sabya S. Das, Faheem H. Pottoo, Sarwar Beg and Ziyaur Rahman*


DOI: 10.2174/1381612826666200206094529


Review Article

Nanomedicines in diagnosis and treatment of cancer: An update

, 2020; 26(11): 1216-1231.

Nafis Haider, Sana Fatima, Murtada Tahar, Md. Rizwanullah, Jamia Firdous, Rafeeque Ahmad , Faizan Mazhar and Mohammad A. Khan*


DOI: 10.2174/1381612826666200318170716


Review Article

Liposomes: Novel drug delivery approach for targeting Parkinson’s disease

, 2020; 26(37): 4721-4737.

Bhumika Kumar, Mukesh Pandey, Faheem H. Pottoo, Faizana Fayaz, Anjali Sharma and P.K. Sahoo*


DOI: 10.2174/1381612826666200128145124


Review Article

Surface-engineered cancer nanomedicine: Rational design and recent progress

, 2020; 26(11): 1181-1190.

Javed Ahmad*, Ameeduzzafar, Mohammad Z. Ahmad and Habban Akhter


DOI: 10.2174/1381612826666200214110645


Review Article

Applications of nanocarriers as drug delivery vehicles for active phytoconstituents

, 2020; 26(36): 4580-4590.

Phui Qi Ng, Laura Soon Cheau Ling, Jestin Chellian, Thiagarajan Madheswaran, Jithendra Panneerselvam, Anil Philip Kunnath, Gaurav Gupta, Saurabh Satija, Meenu Mehta, Philip Michael Hansbro, Trudi Collet, Kamal Dua* and Dinesh Kumar Chellappan*


DOI: 10.2174/1381612826666200610111013


Review Article

Inflammatory bowel diseases: The role of gut microbiota

, 2020; 26(25): 2951-2961.

Cristiana De Musis, Lucia Granata, Marcello Dallio, Agnese Miranda, Antonietta G. Gravina and Marco Romano*


DOI: 10.2174/1381612826666200420144128


Review Article

Vaccinium myrtillus l. Fruits as a novel source of phenolic compounds with health benefits and industrial applications-a review

, 2020; 26(16): 1917-1928.

Tânia C. S. P. Pires , Cristina Caleja , Celestino Santos-Buelga , Lillian Barros* and Isabel C.F.R. Ferreira*


DOI: 10.2174/1381612826666200317132507


Review Article

Recent nano-based therapeutic intervention of bioactive sesquiterpenes: Prospects in cancer therapeutics

, 2020; 26(11): 1138-1144.

Mohammad A. Ansari*, Khan F. Badrealam, Asrar Alam, Saba Tufail, Gulshan Khalique, Mohammad J. Equbal*, Mohammad A. Alzohairy, Ahmad Almatroudi, Mohammad N. Alomary and Faheem H. Pottoo


DOI: 10.2174/1381612826666200116151522


Review Article (Mini-Review)

New insights about regulatory T cells distribution and function with exercise: The role of immunometabolism

, 2020; 26(9): 979-990.

Gilson P. Dorneles*, Aline A.Z. dos Passos, Pedro R.T. Romão and Alessandra Peres*


DOI: 10.2174/1381612826666200305125210


Review Article

Type 1 diabetes and physical exercise: Moving (forward) as an adjuvant therapy

, 2020; 26(9): 946-957.

Othmar Moser*, Max L. Eckstein, Daniel J. West, Nandu Goswami, Harald Sourij and Peter Hofmann


DOI: 10.2174/1381612826666200108113002


Review Article (Mini-Review)

EPO and EPO-receptor system as potential actionable mechanism for the protection of brain and heart in refractory epilepsy and SUDEP

, 2020; 26(12): 1356-1364.

Jerónimo Auzmendi , María B. Puchulu, Julio C. G. Rodríguez , Ana M. Balaszczuk , Alberto Lazarowski and Amalia Merelli *


DOI: 10.2174/1381612826666200219095548



Most Accessed Articles

Novel Phytochemical Constituents and their Potential to Manage Diabetes

, 2021; 27(6): 775-788.

Shaik Ibrahim Khalivulla*, Arifullah Mohammed* and Kokkanti Mallikarjuna


DOI: 10.2174/1381612826666201222154159


Epidemiology of Non-alcoholic Fatty Liver Disease in North America

, 2020; 26(10): 993-997.

Tamoore Arshad, Pegah Golabi, Linda Henry and Zobair M. Younossi*


DOI: 10.2174/1381612826666200303114934



Heart Failure in Diabetes Mellitus: An Updated Review

, 2020; 26(46): 5933-5952.

Catrin Sohrabi, Bunny Saberwal, Wei-Yao Lim, Dimitris Tousoulis, Syed Ahsan and Nikolaos Papageorgiou*


DOI: 10.2174/1381612826666201118091659


Medicinal Plants and Bioactive Compounds for Diabetes Management: Important Advances in Drug Discovery

, 2021; 27(6): 763-774.

Kondeti Ramudu Shanmugam*, Bhasha Shanmugam, Ganjikunta Venkata Subbaiah, Sahukari Ravi and Kesireddy Sathyavelu Reddy


DOI: 10.2174/1381612826666200928160357


Novel Antidiabetic Agents: Cardiovascular and Safety Outcomes

, 2020; 26(46): 5911-5932.

Gerasimos Siasos*, Evanthia Bletsa, Panagiota K. Stampouloglou, Stavroula A. Paschou, Evangelos Oikonomou, Vasiliki Tsigkou, Alexios S. Antonopoulos, Manolis Vavuranakis and Dimitrios Tousoulis


DOI: 10.2174/1381612826666201109110107



Beneficiary and Adverse Effects of Phytoestrogens: A Potential Constituent of Plant-Based Diet

, 2021; 27(6): 802-815.

V. Sridevi, P. Naveen, Venkat Shashank Karnam, P. Ramachandra Reddy* and Arifullah Mohammed*


DOI: 10.2174/1381612826999200917154747


Focus on MicroRNAs as Biomarker in Pediatric Diseases

, 2021; 27(6): 826-832.

Giuseppe Lassandro, Loredana Ciaccia, Anna Amoruso, Valentina Palladino, Viviana Valeria Palmieri and Paola Giordano*


DOI: 10.2174/1381612826666201021125512



Role of Molecular Hydrogen in Skin Diseases and its Impact in Beauty

, 2021; 27(5): 737-746.

Johny Bajgai, Kyu-Jae Lee*, Md. Habibur Rahman, Ailyn Fadriquela and Cheol-Su Kim


DOI: 10.2174/1381612826666200925124235


Regulation of Electrolyte Permeability by Herbal Monomers in Edematous Disorders

, 2021; 27(6): 833-839.

Yong Cui, Yapeng Hou, Honglei Zhang, Yanhong Liu, Kejun Mao, Hongguang Nie and Yan Ding*


DOI: 10.2174/1381612826666200917144655







Editor-in-Chief

graphic
Alessandro Antonelli
(12,288 citations)
Laboratory of Primary Human Cells
University of Pisa
Pisa
(Italy)
Biography
View Full Editorial Board

Executive Editor

graphic
Atta-ur-Rahman, FRS
(32052 citations)
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
(UK)
Biography

Nobel Laureate on Editorial Board

graphic
Andrew V. Schally
(USA)

Journal History

Current Pharmaceutical Design was introduced in 1995 with the assistance of Dr. William A. Banks.

Related Journals

Related eBooks

eBooks Catalog