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Current Pharmaceutical Design

Volume 25, 46 Issues, 2019
ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)
This journal supports open access

Aims & Scope

Current Pharmaceutical Design publishes timely in-depth/mini reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field.

Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

Current Pharmaceutical Design

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Volume 24

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Number 45



Perspective   Open Access



Editorial   Open Access



Review Article



Review Article

Bioengineered in vitro Vascular Models for Applications in Interventional Radiology

, 24(45): 5367 - 5374

Xiaoyun Li*, Seyed M. Moosavi-Basri, Rahul Sheth, Xiaoying Wang* and Yu S. Zhang*


DOI: 10.2174/1381612824666180416114325


Review Article



Review Article

Lung on a Chip for Drug Screening and Design

, 24(45): 5386 - 5396

Ahmet Akif Kızılkurtlu, Tuğçe Polat, Gül Banu Aydın and Ali Akpek*


DOI: 10.2174/1381612825666190208122204


Review Article

The Application of Microfluidic Techniques on Tissue Engineering in Orthopaedics

, 24(45): 5397 - 5406

Lingtian Wang, Dajun Jiang, Qiyang Wang, Qing Wang, Haoran Hu and Weitao Jia*


DOI: 10.2174/1381612825666190301142833


Review Article



Articles Ahead of Print

Hyperuricemia and Cardiovascular Disease


Shuangshuang Zhang, Yong Wang, Jinsong Cheng, Ning Huangfu, Ruochi Zhao, Zhenyu Xu, Fuxing Zhang, Wenyuan Zheng and Dandan Zhang*


View Abstract View on PubMed



Laponite-based Nanomaterials for Biomedical Applications: A Review


Sabya Sachi Das, Neelam, Kashif Hussain, Sima Singh*, Afzal Hussain, Abdul Faruk and Tebyetekerwa Mike


View Abstract View on PubMed



Human Placental Vascular Reactivity in Health and Disease: Implications for the Treatment of Pre-eclampsia


Emilie Hitzerd*, Michelle Broekhuizen, Rugina I. Neuman, Katrina M. Mirabito Colafella, Daphne Merkus, Sam Schoenmakers, Sinno H.P. Simons, Irwin K.M. Reiss and A. H. Jan Danser


View Abstract View on PubMed


10-Phenyltriazoyl Artemisinin is a Novel P-glycoprotein Inhibitor that Suppresses the Overexpression and Function of P-glycoprotein


Dong-Hwan Lee*, Md. Hasanuzzaman*, Daeho Kwon, Hye-Young Choi, So Myoung Kim, Dong Jin Kim, Dong Ju Kang, Tae-Ho Hwang, Hyung-Hoi Kim, Ho Jung Shin, Jae-Gook Shin, Sangtae Oh, Seokjoon Lee and So Won Kim


View Abstract View on PubMed


Design, Synthesis, Pharmacological Evaluation and Vascular Effects of Delphinidin Analogues


Samuel Legeay*, Kiên Trấn, Yannick Abatuci, Hélène Justiniano, Claire Lugnier, Olivier Duval, Jean-Jacques Helesbeux and Sébastien Faure


View Abstract View on PubMed



Future Anti-aldosterone Agents


Kyriakos Dimitriadis*, Constantinos Tsioufis, Panayotis Iliakis, Alexandros Kasiakogias, Ioannis Andrikou, Ioannis Leontsinis, Dimitrios Konstantinidis and Dimitrios Tousoulis


View Abstract View on PubMed


Boosting the Limited Use of Mineralocorticoid Receptor Antagonists Through New Agents for Hyperkalemia


Vasilios G. Athyros*, Alexandros G. Sachinidis, Ioanna Zografou, Elisavet Simoulidou, Alexia Piperidou, Nikiforos Stavropoulos and Asterios Karagiannis


View Abstract View on PubMed


Abstracts Ahead of Print

An update on use of alginate in additive biofabrication techniques


Amoljit Singh Gill, Parneet Kaur Deol and Indu Pal Kaur*


View Abstract


Macroalgal Polysacharrides in Biomimetic Nanodelivery Systems


Nikola Geskovski, Simona Dimchevska Sazdovska and Katerina Goracinova*


View Abstract



Preventive role of Resveratrol against inflammatory cytokines and related diseases


Tanzir Rafe, Parvez Ahmed Shawon, Liyad Salem, Nafij Imtiyaj Chowdhury, Farjana Kabir, Shah Mehedi Bin Zahur, Rowshon Akther, Humaira Binte Noor, Md Mohabbulla Mohib and Md. Abu Taher Sagor*


View Abstract


Synthetic optimization of ellipticine and antitumor activity of novel hexacyclic derivatives of ellipticine


Jingjing Lin, Mei Tang, Ru Zhao, Qianqian Du, Longying Shen, Guohua Du, Yafen Zhang, Yan Li* and Xiandao Pan*


View Abstract


Inhibitors of DNA methylation and histone deacetylation as epigenetically active drugs for anticancer therapy


Veronika A. Myasoedova, Vasily N. Sukhorukov, Andrey V. Grechko, Dongwei Zhang, Elena B. Romanenko, Varvara A. Orekhova and Alexander N. Orekhov*


View Abstract



Design of Sphingosine Kinases Inhibitors: Challenges and Recent Developments


Elisa Magli, Angela Corvino, Ferdinando Fiorino, Francesco Frecentese, Elisa Perissutti, Irene Saccone, Vincenzo Santagada, Giuseppe Caliendo* and Beatrice Severino


View Abstract


Ethnobotany, phytochemistry and traditional uses of Curcuma spp. and pharmacological profile of two important species (C. longa and C. zedoaria): a review


Zahra Ayati, Mahin Ramezani , Mohammad Sadegh Amiri, Ali Tafazoli Moghadam, Hoda Rahimi, Aref Abdollahzade, Seyed Ahmad Emami * and Amirhossein Sahebkar *


View Abstract


Depression and treatment with effective herbs


Zohre Fathinezhad, Robert D.E Sewell, Zahra Lorigooini and Mahmoud Rafieian-Kopaei*


View Abstract


Editor's Choice



Advanced Approaches of Bioactive Peptide Molecules and Protein Drug Delivery Systems

, 2018; 24(43): 5147 - 5163

Nagarani Thotakura, Lokesh Kaushik, Vipin Kumar, Simran Preet and Penke Vijaya Babu*


DOI: 10.2174/1381612825666190206211458



Role of Polymers in 3D Printing Technology for Drug Delivery - An Overview

, 2018; 24(42): 4979 - 4990

Ankit Jain, Kuldeep K. Bansal*, Ankita Tiwari, Ari Rosling and Jessica M. Rosenholm*


DOI: 10.2174/1381612825666181226160040





The Role of TGF-β Signaling Regulatory MicroRNAs in the Pathogenesis of Colorectal Cancer

, 2018; 24(39): 4611 - 4618

Reyhaneh Moradi-Marjaneh, Majid Khazaei, Gordon A. Ferns and Seyed H. Aghaee-Bakhtiari*


DOI: 10.2174/1381612825666190110150705



Rivaroxaban versus Clopidogrel for Peripheral Artery Disease: A Clinico-Economic Approach of the COMPASS Trial

, 2018; 24(38): 4516 - 4517

Diamantis I. Tsilimigras, Demetrios Moris*, Georgios Karaolanis, Stavros K. Kakkos, Konstantinos Filis and Fragiska Sigala


DOI: 10.2174/1381612825666190101100832



Circulating Exosomes as Potential Biomarkers in Cardiovascular Disease

, 2018; 24(37): 4436 - 4444

Seyed Mostafa Parizadeh, Reza Jafarzadeh-Esfehani, Maryam Ghandehari, Seyed Mohammad Reza Parizadeh, Seyed Mahdi Hassanian, Majid Rezayi, Majid Ghayour-Mobarhan, Gordon A. Ferns and Amir Avan*


DOI: 10.2174/1381612825666181219162655



Potential of Natural-Based Anticancer Compounds for P-Glycoprotein Inhibition

, 2018; 24(36): 4334 - 4354

Jelena Dinić, Ana Podolski-Renić, Marko Jeremić and Milica Pešić*


DOI: 10.2174/1381612825666190112164211



Open Access Articles


Small Molecules as PD-1/PD-L1 Pathway Modulators for Cancer Immunotherapy

, 2018; 24(41): 4911 - 4920

Peifu Jiao, Qiaohong Geng*, Peng Jin, Gaoxing Su, Houyun Teng, Jinlong Dong and Bing Yan*





Novel Data on the Prevalence, Identification, Scouting, and Treatment of Familial Hypercholesterolaemia

, 2018; 24(31): 3597 - 3598

Michael Doumas, Konstantinos Imprialos, Konstantinos Stavropoulos and Vasilios G. Athyros





Modified LDL Particles Activate Inflammatory Pathways in Monocyte-derived Macrophages: Transcriptome Analysis

, 2018; 24(26): 3143 - 3151

Alexander N. Orekhov*, Yumiko Oishi , Nikita G. Nikiforov, Andrey V. Zhelankin, Larisa Dubrovsky, Igor A. Sobenin, Alexander Kel, Daria Stelmashenko, Vsevolod J. Makeev, Kathy Foxx, Xueting Jin, Howard S. Kruth and Michael Bukrinsky




Novel Technologies for Dipeptide Drugs Design and their Implantation

, 2018; 24(26): 3020 - 3027

Tatiana A. Gudasheva*, Rita U. Ostrovskaya and Sergey B. Seredenin




Next-generation Metabolomics in the Development of New Antidepressants: Using Albiflorin as an Example

, 2018; 24(22): 2530 - 2540

Jian Han, Yonghong Xia, Lejun Lin, Zuoguang Zhang, Hui Tian and Kefeng Li*





Defense Mechanisms Against Acid Exposure by Dental Enamel Formation, Saliva and Pancreatic Juice Production

, 2018; 24(18): 2012 - 2022

Robert Racz, Akos Nagy, Zoltan Rakonczay , Erika Katalin Dunavari, Gabor Gerber and Gabor Varga*




Peptide Mediated Brain Delivery of Nano- and Submicroparticles: A Synergistic Approach

, 2018; 24(13): 1366 - 1376

Mark McCully, Macarena Sanchez-Navarro , Meritxell Teixido* and Ernest Giralt*




Development of Peptide Vaccines in Dengue

, 2018; 24(11): 1157 - 1173

Kavita Reginald, Yanqi Chan, Magdalena Plebanski and Chit Laa Poh*





Virtual Screening and Statistical Analysis in the Design of New Caffeine Analogues Molecules with Potential Epithelial Anticancer Activity

, 2018; 24(5): 576 - 594

Josivan da Silva Costa*, Karina da Silva Lopes Costa, Josiane Viana Cruz, Ryan da Silva Ramos, Luciane Barros Silva, Davi Do Socorro Barros Brasil, Carlos Henrique Tomich de Paula da Silva, Cleydson Breno Rodrigues dos Santos and Williams Jorge da Cruz Macedo






Most Cited Articles

Autism: Pathophysiology and Promising Herbal Remedies

, 2016; 22(3): 277-285.

Mahmoud Bahmani, Amir Sarrafchi, Hedayatollah Shirzad and Mahmoud Rafieian-Kopaei


DOI: 10.2174/1381612822666151112151529


Air Pollution Exposure and Blood Pressure: An Updated Review of the Literature

, 2016; 22(1): 28-51.

Paolo Giorgini, Paolo Di Giosia, Davide Grassi, Melvyn Rubenfire, Robert D. Brook and Claudio Ferri


DOI: 10.2174/1381612822666151109111712



Circulating microRNAs in Hepatocellular Carcinoma: Potential Diagnostic and Prognostic Biomarkers

, 2016; 22(34): 5257-5269.

Hamid Reza Mirzaei, Amirhossein Sahebkar, Mohsen Mohammadi, Reza Yari, Hossein Salehi, Mohammad Hasan Jafari, Afshin Namdar, Ehsan Khabazian, Mahmoud Reza Jaafari and Hamed Mirzaei


DOI: 10.2174/1381612822666160303110838


The potential for circulating microRNAs in the diagnosis of myocardial infarction: a novel approach to disease diagnosis and treatment

, 2016; 22(3): 397-403.

Sharareh Gholamin, Alireza Pasdar, Mohammad Sadegh Khorrami, Hamed Mirzaei, Hamid Reza Mirzaei, Rasoul Salehi, Gordon A. Ferns, Majid Ghayour-Mobarhan and Amir Avan


DOI: 10.2174/1381612822666151112151924


Computer Aided Drug Design: Success and Limitations

, 2016; 22(5): 572-581.

Mohammad Hassan Baig, Khurshid Ahmad, Sudeep Roy, Jalaluddin Mohammad Ashraf, Mohd Adil, Mohammad Haris Siddiqui, Saif Khan, Mohammad Amjad Kamal, Ivo Provazník and Inho Choi


DOI: 10.2174/1381612822666151125000550


Herba Epimedii: An Ancient Chinese Herbal Medicine in the Prevention and Treatment of Osteoporosis

, 2016; 22(3): 328-349.

Lili Wang, Yu Li, Yubo Guo, Rufeng Ma, Min Fu, Jianzhao Niu, Sihua Gao and Dongwei Zhang


DOI: 10.2174/1381612822666151112145907


From Fangs to Pharmacology: The Future of Snakebite Envenoming Therapy

, 2016; 22(34): 5270-5293.

Andreas H. Laustsen, Mikael Engmark, Christina Milbo, Jónas Johannesen, Bruno Lomonte, José María Gutiérrez and Brian Lohse


DOI: 10.2174/1381612822666160623073438




Most Accessed Articles

Advances in Binding Free Energies Calculations: QM/MM-Based Free Energy Perturbation Method for Drug Design

, 2013; 19(26): 4674-4686.

R.S. Rathore, M. Sumakanth, M. Siva Reddy, P. Reddanna, Allam Appa Rao, Mark D. Erion and M.R. Reddy


DOI: 10.2174/1381612811319260002


Reversal of Novel Anticoagulants in Emergent Surgery and Trauma: A Comprehensive Review and Proposed Management Algorithm

, 2018; 24(38): 4540-4553.

Leonidas Palaiodimos*, Jeremy Miles, Damianos G. Kokkinidis, Christos Barkolias, Anil K. Jonnalagadda, Dimitrios Papaconstantinou, Maximos Frountzas, Evangelos P. Misiakos and Dimitrios Schizas


DOI: 10.2174/1381612825666181226150629


Recent Advances in Cancer Therapy: An Overview

, 2010; 16(1): 3-10.

A. Urruticoechea, R. Alemany, J. Balart, A. Villanueva, F. Vinals and G. Capella


DOI: 10.2174/138161210789941847



Computer-aided Drug Design and Drug Pharmacokinetic Prediction: A Mini-review

, 2018; 24(26): 3014-3019.

Jamshid Tabeshpour, Amirhossein Sahebkar*, Mohammad Reza Zirak, Majid Zeinali, Mahmoud Hashemzaei, Sajed Rakhshani and Saleh Rakhshani*


DOI: 10.2174/1381612824666180903123423


Where is the Clinical Breakthrough of Heme Oxygenase-1 / Carbon Monoxide Therapeutics?

, 2018; 24(20): 2264-2282.

Christopher P. Hopper, Lorenz Meinel, Christoph Steiger* and Leo E. Otterbein*


DOI: 10.2174/1381612824666180723161811


The Landscape of Protein Tyrosine Phosphatase (Shp2) and Cancer

, 2018; 24(32): 3767-3777.

Ashfaq Ur Rehman, Mueed Ur Rahman, Muhammad T. Khan, Shah Saud, Hao Liu, Dong Song, Pinky Sultana, Abdul Wadood and Hai-Feng Chen*


DOI: 10.2174/1381612824666181106100837



Association of SLCO1B1 Polymorphisms and Atorvastatin Safety and Efficacy: A Meta-analysis

, 2018; 24(34): 4044-4050.

Yaming Du, Sizheng Wang, Zhangyong Chen, Shusen Sun, Zhigang Zhao* and Xingang Li*


DOI: 10.2174/1381612825666181219163534



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