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Current Pharmaceutical Design

Volume 27, 46 Issues, 2021
ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)
This journal supports open access

Aims & Scope

Current Pharmaceutical Design publishes timely in-depth reviews/mini reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field.

Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

Current Pharmaceutical Design

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Volume 27

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Number 46









Research Article





Review Article (Mini-Review)

Vanillic Acid and Non-Alcoholic Fatty Liver Disease: A Focus on AMPK in Adipose and Liver Tissues

, 27(46): 4686 - 4692

Sepideh Shekari, Fatemeh Khonsha, Mohammad Rahmati-Yamchi, Hamid R. Nejabati* and Ali Mota*


DOI: 10.2174/1381612827666210701145438


Review Article (Mini-Review)

Dermoprotective Effects of Saffron: A Mini Review

, 27(46): 4693 - 4698

Hamid Rigi, Leila Mohtashami, Maryam Asnaashari, Seyed A. Emami and Zahra Tayarani-Najaran*


DOI: 10.2174/1381612827666210920150855


General Review Article

OIP5-AS1: A Fascinating Long Noncoding RNA in Carcinoma

, 27(46): 4699 - 4706

Juanjuan Zhong, Jinlan Chen, Bei Wang, Zixian Zhou, Yujie Shen, Yibo Gong, Fangshun Tan and Chengfu Yuan*


DOI: 10.2174/1381612827666210927105558


Articles Ahead of Print

BDZs, Designer BDZs and Z-drugs: Pharmacology and Misuse Insights


Simona Zaami, Silvia Graziano, Roberta Tittarelli, Renata Beck and Enrico Marinelli*


DOI: 10.2174/1381612827666210917145636
View Abstract View on PubMed



The Potential Therapeutic Value of Renin-Angiotensin System Inhibitors in the Treatment of Colorectal Cancer


Ehsan Tabatabai*, Majid Khazaei, Mohammad Reza Parizadeh, Mohammad Nouri, Seyed Mahdi Hassanian, Gordon A Ferns, Mohammad Rahmati and Amir Avan


DOI: 10.2174/1381612827666211011113308
View Abstract View on PubMed




The Impact of Traditional Chinese Medicine on Mitophagy in Disease Models


Li-Ping Yu, Ting-Ting Shi, Yan-Qin Li, Jian-Kang Mu, Ya-Qin Yang, Wei-Xi Li, Jie Yu* and Xing-Xin Yang*


DOI: 10.2174/1381612827666211006150410
View Abstract View on PubMed


Therapeutic Potential of Galectin-1 and Galectin-3 in Autoimmune Diseases


Yi-Sheng He, Yu-Qian Hu, Kun Xiang, Yue Chen, Ya-Ting Feng, Kang-Jia Yin, Ji-Xiang Huang, Jie Wang, Zheng-Dong Wu, Gui-Hong Wang* and Hai-Feng Pan*


DOI: 10.2174/1381612827666210927164935
View Abstract View on PubMed




Ryanodine Receptor as Insecticide Target


Arthur Samurkas, Li Yao, Hadiatullah Hadiatullah*, Ruifang Ma, Yunxun Xie, Rajamanikandan Sundarraj, Han Zuilhof and Zhiguang Yuchi*


DOI: 10.2174/1381612827666210902150224
View Abstract View on PubMed


Abstracts Ahead of Print




Fourth generation of synthetic cannabinoid receptor agonists: A review on the latest insights


Sara Malaca, Francesco Paolo Busardò*, Giulio Nittari, Ascanio Sirignano and Giovanna Ricci


DOI: 10.2174/1381612827666211115170521
View Abstract


Development of nanomedicines and nano-similars: recent advances in regulatory landscape


Rishi Paliwal*, Pramod Kumar, Akash Chaurasiya, Rameshroo Kenwat, Sumeet Katke and Shivani Rai Paliwal


DOI: 10.2174/1381612827666211115170001
View Abstract




Prospective for diagnosis and treatment of diabetic retinopathy


Faiza Idris Himasa, Manmohan Singhal, Abhijeet Ojha and Bhavna Kumar*


DOI: 10.2174/1381612827666211115154907
View Abstract




Published Contents

Editor's Choice





Outer Membrane Vesicles of Bordetella pertussis Encapsulated into Sodium Alginate Nanoparticles as Novel Vaccine Delivery System

, 2021; 27(42): 4341 - 4354

Abbas Rami, Fatemeh Kazemi-Lomedasht, Ali Mirjalili, Mojtaba Noofeli, Fereshteh Shahcheraghi* and Naser M. Dounighi*


DOI: 10.2174/1381612827666210907154715



Anticholinergic Exposure in Elderly Complex Chronic Patients: A Cross-Sectional Study

, 2021; 27(40): 4186 - 4194

Ángela Tristancho-Pérez, Ángela Villalba-Moreno, María D. Santos-Rubio, María D. López-Malo, Bernardo Santos-Ramos and Susana Sánchez-Fidalgo*


DOI: 10.2174/1381612827666210830164054






Hypertension in Pregnancy: Unanswered Questions

, 2021; 27(36): 3795 - 3803

Vasilios Papademetriou *, Konstantinos Stavropoulos , Dimitrios Patoulias, Christodoulos Papadopoulos, Kerpiniotis Georgios, Maria Toumpourleka and Alexandros Sachinidis


DOI: 10.2174/1381612827666210830091652



Open Access Articles


The Efficacy and Safety of Topical Tranexamic Acid for Spinal Surgery

, 2021; 27(44): 4496 - 4503

Tai Guo, Wenxia Xuan, Haoyu Feng, Junjie Wang and Xun Ma*




The Intracellular Mechanism of Berberine-Induced Inhibition of CYP3A4 Activity

, 2021; 27(40): 4179 - 4185

Pan-Feng Feng, Long-Xun Zhu, Jing Jie, Peng-Xiang Yang and Xia Chen*




The Pathogenic Subpopulation of Th17 Cells in Obesity

, 2021; 27(37): 3924 - 3938

Natalia Todosenko, Maria Vulf*, Kristina Yurova, Daria Skuratovskaia, Olga Khaziakhmatova, Natalia Gazatova, Olga Melashchenko, Olga Urazova and Larisa Litvinova





Exosome Limitations in the Treatment of Inflammatory Diseases

, 2021; 27(28): 3105 - 3121

Daria Skuratovskaia*, Maria Vulf, Olga Khaziakhmatova, Vladimir Malashchenko, Aleksandra Komar, Egor Shunkin, Natalia Gazatova and Larisa Litvinova




Marine Bioactive Peptides in Supplements and Functional Foods - A Commercial Perspective

, 2021; 27(11): 1353 - 1364

Ragnhild Dragøy Whitaker*, Themis Altintzoglou, Kjersti Lian and Estefania Noriega Fernandez




Anti-malarial Drugs are Not Created Equal for SARS-CoV-2 Treatment: A Computational Analysis Evidence

, 2021; 27(10): 1323 - 1329

Simone Ronsisvalle, Federica Panarello, Rosaria Di Mauro, Renato Bernardini, Giovanni Li Volti* and Giuseppina Cantarella









Design, Synthesis and Antitumor Activity of Novel Dispiro[oxindole-cyclohexanone]- pyrrolidines

, 2021; 27: 1 - 10 (E-Pub Ahead of Print)

Magy Gouda, Majed Bawzeer, Lamees Hegazy, Mohamed Azab, Mohamed Elagawany, Mostafa Rateb, Mohammed Yaseen and Bahaa Elgendy*




Treatment of Anderson-Fabry Disease

, 2020; 26(40): 5089 - 5099

Irene Simonetta*, Antonino Tuttolomondo, Mario Daidone, Salvatore Miceli and Antonio Pinto





Most Cited Articles

General Review Article

Long non-coding RNAs as epigenetic regulators in cancer

, 2019; 25(33): 3563-3577.

Asma Vafadar, Zahra Shabaninejad, Ahmad Movahedpour, Soheila Mohammadi, Sima Fathullahzadeh, Hamid R. Mirzaei, Afshin Namdar, Amir Savardashtaki* and Hamed Mirzaei*


DOI: 10.2174/1381612825666190830161528


Review Article

Pollution, toxicity and carcinogenicity of organic dyes and their catalytic bio-remediation

, 2019; 25(34): 3645-3663.

Muhammad Ismail, Kalsoom Akhtar, M.I. Khan, Tahseen Kamal, Murad A. Khan, Abdullah M. Asiri, Jongchul Seo and Sher B. Khan*


DOI: 10.2174/1381612825666191021142026


Review Article

Synthesis of silver nanoparticles and their biomedical applications a comprehensive review

, 2019; 25(24): 2650-2660.

Rajasree Shanmuganathan, Indira Karuppusamy, Muthupandian Saravanan, Harshiny Muthukumar, Kumar Ponnuchamy, Vijayan Sri Ramkumar and Arivalagan Pugazhendhi*


DOI: 10.2174/1381612825666190708185506


Review Article

Cholinesterase inhibitors for Alzheimer's disease: Multitargeting strategy based on anti-Alzheimer's drugs repositioning

, 2019; 25(33): 3519-3535.

Md. Tanvir Kabir, Md. Sahab Uddin*, Mst. Marium Begum, Shanmugam Thangapandiyan, Md. Sohanur Rahman, Lotfi Aleya, Bijo Mathew, Muniruddin Ahmed, George E. Barreto and Ghulam Md. Ashraf


DOI: 10.2174/1381612825666191008103141


Review Article

NMDA receptor antagonists: Repositioning of memantine as a multitargeting agent for Alzheimer's therapy

, 2019; 25(33): 3506-3518.

Md. Tanvir Kabir, Mohammad A. Sufian, Md. Sahab Uddin*, Mst. Marium Begum, Shammi Akhter, Ariful Islam, Bijo Mathew, Md. Siddiqul Islam, Md. Shah Amran and Ghulam Md. Ashraf*


DOI: 10.2174/1381612825666191011102444


Review Article

Alginate nanoparticles for drug delivery and targeting

, 2019; 25(11): 1312-1334.

Patricia Severino, Classius F. da Silva, Luciana N. Andrade, Daniele de Lima Oliveira, Joana Campos and Eliana B. Souto*


DOI: 10.2174/1381612825666190425163424


Review Article

Emerging potential of naturally occurring autophagy modulators against neurodegeneration

, 2020; 26(7): 772-779.

Md. Ataur Rahman*, Md Rezanur Rahman, Toyfiquz Zaman, Md. Sahab Uddin, Rokibul Islam, Mohamed M. Abdel-Daim and Hyewhon Rhim*


DOI: 10.2174/1381612826666200107142541




Review Article

Composition and potential health benefits of pomegranate: A review

, 2019; 25(16): 1817-1827.

Vesna Vučić*, Milkica Grabež, Armen Trchounian and Aleksandra Arsić


DOI: 10.2174/1381612825666190708183941


Review Article

Metal/metal oxide nanoparticles: Toxicity, applications, and future prospects

, 2019; 25(37): 4013-4029.

Ratiram G. Chaudhary*, Ganesh S. Bhusari, Ashish D. Tiple, Alok R. Rai, Subhash R. Somkuvar, Ajay K. Potbhare, Trimurti L. Lambat, Prashant P. Ingle and Ahmed A. Abdala*


DOI: 10.2174/1381612825666191111091326


General Review Article

Ethnobotany, phytochemistry and traditional uses of curcuma spp. and pharmacological profile of two important species (C. longa and C. zedoaria): A Review

, 2019; 25(8): 871-935.

Zahra Ayati, Mahin Ramezani , Mohammad Sadegh Amiri, Ali Tafazoli Moghadam, Hoda Rahimi, Aref Abdollahzade, Amirhossein Sahebkar * and Seyed Ahmad Emami *


DOI: 10.2174/1381612825666190402163940



Review Article

Extracellular vesicles as drug delivery systems - Methods of production and potential therapeutic applications

, 2019; 25(2): 132-154.

Magdalena Surman, Anna Drożdż, Ewa Stępień and Małgorzata Przybyło*


DOI: 10.2174/1381612825666190306153318




Most Accessed Articles

Exosome Limitations in the Treatment of Inflammatory Diseases

, 2021; 27(28): 3105-3121.

Daria Skuratovskaia*, Maria Vulf, Olga Khaziakhmatova, Vladimir Malashchenko, Aleksandra Komar, Egor Shunkin, Natalia Gazatova and Larisa Litvinova


DOI: 10.2174/1381612826666201210120444



The Pathogenic Subpopulation of Th17 Cells in Obesity

, 2021; 27(37): 3924-3938.

Natalia Todosenko, Maria Vulf*, Kristina Yurova, Daria Skuratovskaia, Olga Khaziakhmatova, Natalia Gazatova, Olga Melashchenko, Olga Urazova and Larisa Litvinova


DOI: 10.2174/1381612826666210101154913


Lipid Disorders in Pregnancy

, 2021; 27(36): 3804-3807.

Anastasios Liberis*, Stamatis Petousis and Panagiotis Tsikouras


DOI: 10.2174/1381612827666210421103245


Polycystic Ovary Syndrome: A Contemporary Clinical Approach

, 2021; 27(36): 3812-3820.

Jelica Bjekić-Macut*, Tamara Vukašin, Zelija Velija-Ašimi, Azra Bureković, Marija Zdravković, Zoran Andrić, Marija Branković, Slobodanka Crevar-Marinović, Tatjana Madić, Olivera Stanojlović, Danijela V. Milutinović, Sarantis Livadas and George Mastorakos


DOI: 10.2174/1381612827666210119104721


CA125: An Increasingly Promising Biomarker of Heart Failure

, 2021; 27(37): 3871-3880.

Chunqi Pan, Mengyun Zhou, Ying Jian, Yuanyuan Zeng, Mingwei Wang* and Feng Chen*


DOI: 10.2174/1381612827666210118122521


Harnessing the Potential of Long Non-coding RNAs to Manage Metabolic Diseases

, 2021; 27(35): 3668-3685.

Khushdeep Bandesh , Daisy Masih , Nirjhar Bhattacharyya and Dwaipayan Bharadwaj *


DOI: 10.2174/1381612827666210315145254



Clinical Review of COVID-19; Pathogenesis, Diagnosis, and Management

, 2021; 27(41): 4232-4244.

Hussien Ahmed H. Abdelgawad*, Ahmed Sayed, Malak Munir, Mostafa H. Elberry, Ibrahim M. Sayed, Md. Amjad Kamal, Ahmed Negida, Mahmoud A. Ebada and Eshak I. Bahbah*


DOI: 10.2174/1381612826666201222162509


Highlights on Medical Treatment of Uterine Fibroids

, 2021; 27(36): 3821-3832.

Stefano Angioni, Maurizio N. D’Alterio and Angelos Daniilidis*


DOI: 10.2174/1381612826666210101152820



Recent Updates on Current and Upcoming Biomarkers for Cardiovascular Diseases

, 2021; 27(37): 3881-3900.

Ashif Iqubal, Aamir Khan, Adeeba laeeq, Kabil Malhotra, Mohd. A. Ansari and Syed E. Haque*


DOI: 10.2174/1381612827666210224143047


Therapeutic Management of COVID-19 Patients: Clinical Manifestation and Limitations

, 2021; 27(41): 4223-4231.

Urooj Fatima, Syed Saif A. Rizvi, Neha Raina, Saher Fatima, Safikur Rahman, Md. Amjad Kamal and Md. Imtaiyaz Hassan*


DOI: 10.2174/1381612826666201125112719


Silybin B and Cianidanol Inhibit Mpro and Spike Protein of SARS-CoV-2: Evidence from in silico Molecular Docking Studies

, 2021; 27(32): 3476-3489.

Rashi Srivastava, Shubham Tripathi, Sreepoorna Unni, Arif Hussain, Shafiul Haque, Nandita Dasgupta, Vineeta Singh* and Bhartendu N. Mishra*


DOI: 10.2174/1381612826666201210122726


Nutrition and NSCLC; Should We Administer Food Supplements?

, 2021; 27(34): 3602-3608.

Paul Zarogoulidis*, Christoforos Kosmidis, Isaak Kesisoglou, Kosmas Tsakiridis, Wolfgang Hohenforst-Schmidt, Haidong Huang, Κonstantinos Romanidis, Anastasios Vagionas and Konstantinos Sapalidis


DOI: 10.2174/1381612827999210111193133




Editor-in-Chief

graphic
Alessandro Antonelli
(12,288 citations)
Department of Clinical and Experimental Medicine
Laboratory of Primary Human Cells
University of Pisa
Pisa
(Italy)
Biography
View Full Editorial Board

Executive Editor

graphic
Atta-ur-Rahman, FRS
(32052 citations)
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
(UK)
Biography

Nobel Laureates on Editorial Board

graphic
Andrew V. Schally
(USA)

COPE Compliant

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Journal History

Current Pharmaceutical Design was introduced in 1995. Prof. Alessandro Antonelli serves as the Editor-in-Chief of the journal.

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