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How to Fluorescently Label the Potassium Channel: A Case in hERG


Xiaomeng Zhang, Beilei Wang, Zhenzhen Liu, Yubin Zhou and Lupei Du*


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Management of Peripheral Neuropathy Induced by Chemotherapy


Maayan Fradkin*, Ron Batash*, Shiran Elamleh*, Ronen Debi , Pamela Schaffer , Moshe Schaffer and Noam Asna


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Therapeutic Targeting of the Soluble Guanylate Cyclase


Garyfallia I Makrynitsa, Aikaterini A Zompra, Aikaterini I Argyriou, Georgios A Spyroulias and Stavros Topouzis*


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Small Molecules Targeting Mutant P53: A Promising Approach for Cancer Treatment


Elizabeth A. Lopes, Sara Gomes, Lucília Saraiva and Maria Santos*


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Nano-biofilm Arrays as a Novel Universal Platform for Microscale Microbial Culture and High-Throughput Downstream Applications


Anand Srinivasan , Anand K. Ramasubramanian and José L. Lopez-Ribot*


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The Mycobacterial HBHA Protein: A Promising Biomarker for Tuberculosis


Flavio De Maio, Flavia Squeglia, Delia Goletti and Giovanni Delogu*


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Ionic Liquids for Topical Delivery in Cancer


Ana Rita Dias, João Costa-Rodrigues, Cátia Teixeira, Paula Gomes, Cristina Prudêncio* and Ricardo Ferraz


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Autophagy Modulators and Neuroinflammation


Kyoung Sang Cho, Jang Ho Lee, Jeiwon Cho, Guang-Ho Cha* and Gyun Jee Song*


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Proteomic and Glycomic Markers to Differentiate Lung Adenocarcinoma from COPD


Miklos Szabo, Laszlo Hajba, Renáta Kun, András Guttman* and Eszter Csánky


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Perioperative Heart-Brain Axis Protection in Obese Surgical Patients: The Nutrigenomic Approach


Jacopo Agrimi, Carlotta Baroni, Ekene Anakor and Vincenzo Lionetti*


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Goniothalamin-Related Styryl Lactones. Isolation, Synthesis, Biological Activity and Mode of Action


Ronaldo Aloise Pilli*, Ian de Toledo, Matheus Andrade Meirelles and Thiago Augusto Grigolo


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Nanoparticle-plasma Membrane Interactions: Thermodynamics, Toxicity and Cellular Response


A. G. Rodríguez-Hernández , R. Vazquez-Duhalt and A. Huerta-Saquero *


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Healthy Diet and Reduction of Chronic Disease Risks of Night Shift Workers


Giovanni M. Ferri*, Domenica Cavone, Graziana Intranuovo and Linda Macinagrossa


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Graphene and Graphene Oxide Applications for SERS Sensing and Imaging


Anna Jablonska, Alekdandra Jaworska, Mateusz Kasztelan , Sylwia Berbec and Barbara Palys *


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Targeting Kinetoplastid and Apicomplexan Thymidylate Biosynthesis as an Antiprotozoal Strategy


Maria Valente, Antonio E. Vidal and Dolores Gonzalez Pacanowska*


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Anesthetic-induced Myocardial Conditioning: Molecular Fundamentals and Scope


Jose Luis Guerrero Orriach*, Juan Jose Escalona Belmonte , Marta Ramirez-Aliaga, Alicia Ramirez-Fernandez , Aida Raigon-Ponferrada , Manuel Rubio-Navarro and Jose Cruz-Manas


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Chitosan-based Polymer Matrix for Pharmaceutical Excipients and Drug Delivery


Md. Iqbal Hassan Khan , Xingye An, Lei Dai , Hailong Li, Avik Khan and Yonghao Ni*


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The Role of Mitochondria in Systemic Lupus Erythematosus: A Glimpse of Various Pathogenetic Mechanisms


Shi-kun Yang, Hao-ran Zhang, Shu-peng Shi, Ying-qiu Zhu, Na Song, Qing Dai, Wei Zhang, Ming Gui and Hao Zhang*


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The Role of TRP Channels in Allergic Inflammation and its Clinical Relevance


Woo Kyung Kim* and Joo Hyun Nam


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Nanocarriers: A Successful Tool to Increase Solubility, Stability and Optimise Bioefficacy of Natural Constituents


Anna Rita Bilia*, Vieri Piazzini, Laura Risaliti, Giulia Vanti, Marta Casamonti, Meng Wang and Maria Camilla Bergonzi


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Sugars and Sweeteners: Structure, Properties and In Silico Modeling


Dusanka Janezic, Lorentz Jantschi* and Sorana D. Bolboaca


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Development of Health Products from Natural Sources


Francesca Sansone, Teresa Mencherini, Patrizia Picerno, Maria Rosaria Lauro, Michele Cerrato and Rita Patrizia Aquino*


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Agronomic Cultivation, Chemical Composition, Functional Activities and Applications of Pereskia Species – A Mini Review


Vinicius B.V. Maciel, Cristiana M.P. Yoshida and Francisco Goycoolea*


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A Systematic Review on Anti-diabetic Properties of Chalcones


Sonia Rocha, Daniela Ribeiro, Eduarda Fernandes* and Marisa Freitas*


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Recent Advances and Challenges of the Drugs Acting on Monoamine Transporters


Weiwei Xue*, Tingting Fu, Guoxun Zheng, Gao Tu, Yang Zhang, Fengyuan Yang, Lin Tao, Lixia Yao and Feng Zhu*


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Complex Signaling Networks Controlling Dynamic Molecular Changes in Pseudomonas aeruginosa Biofilm


Grzegorz Gula, Agata Dorotkiewicz-Jach, Kamila Korzekwa, Miguel Angel Valvano and Zuzanna Drulis-Kawa*


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An Update on the Neurochemistry of Essential Tremor


Félix Javier Jiménez-Jiménez *, Hortensia Alonso-Navarro, Elena García-Martín and José A.G. Agúndez


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The ERM Complex: A New Player Involved in Diabetes-induced Vascular Leakage


Olga Simo-Servat, Cristina Hernández and Rafael Simó*


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Biopolymer Substrates in Buccal Drug Delivery: Current Status and Future Trend


Bo Sun, Weijun Wang, Zhibin He, Min Zhang, Fangong Kong and Mohini Sain*


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Targeting Nodal and Cripto-1: Perspectives Inside Dual Potential Theranostic Cancer Biomarkers


Annamaria Sandomenico* and Menotti Ruvo


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Trends in Diagnosis for Active Tuberculosis Using Nanomaterials


Le Mihn Tu Phan, Lemma Teshome Tufa, Hwa-Jung Kim, Jaebeom Lee and Tae Jung Park*


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Sam Domains in Multiple Diseases


Marian Vincenzi, Flavia Anna Mercurio and Marilisa Leone*


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Stimuli-responsive Drug Delivery Nanocarriers in the Treatment of Breast Cancer


Joao A. Oshiro-Junior , Renata Carolina Alves, Gilmar Hanck-Silva , Mariana R. Sato, Camila Rodero, Josimar O. Eloy* and Marlus Chorilli*


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Pyridine and Pyrimidine Derivatives as Privileged Scaffolds in Biologically Active Agents


Maria Assunta Chiacchio , Daniela Iannazzo , Roberto Romeo, Salvatore V. Giofrè and Laura Legnani*


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A Review of Drug Repositioning Based Chemical-induced Cell Line Expression Data


Fei Wang, Xiujuan Lei and Fang-Xiang Wu*


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Structural and Molecular Tear Film Changes in Glaucoma


Rodolfo Mastropasqua*, Luca Agnifili and Leonardo Mastropasqua


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Manipulation of the Immune System for Cancer Defeat: A Focus on the T Cell Inhibitory Checkpoint Molecules


Paolo D’Arrigo, Martina Tufano, Anna Rea, Vincenza Vigorito, Nunzia Novizio, Salvatore Russo, Maria Fiammetta Romano and Simona Romano*


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Development of Pin1 Inhibitors and their Potential as Therapeutic Agents


Yusuke Nakatsu, Yasuka Matsunaga, Koji Ueda, Takeshi Yamamotoya, Yuki Inoue, Masa-ki Inoue, Yu Mizuno, Akifumi Kushiyama, Hiraku Ono, Midori Fujishiro, Hisanaka Ito, Takayoshi Okabe and Tomoichiro Asano*


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Pharmacological Management of Chronic Obstructive Lung Disease (COPD). Evidence from a Real-World Perspective


Aliaksei Kisialiou, Giulia Prinzi, Palma Lamonaca, Vittorio Cardaci, Massimo Fini, Stefano Bonassi and Patrizia Russo *


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Peripheral Immunity, Immunoaging and Neuroinflammation in Parkinson’s Disease


Kustrimovic Natasa, Marino Franca and Marco Cosentino*


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Therapeutic Approaches for the Management of Sleep Disorders in Geriatric Population


Mireille Salas-Crisostomo, Pablo Torterolo , André Barciela Veras, Nuno Barbosa Rocha, Sérgio Machado and Eric Murillo-Rodríguez§*


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Bacterial Lipoprotein Biosynthetic Pathway as a Potential Target for Structure-based Design of Antibacterial Agents


Jie Xia*, Bo Feng, Gang Wen, Wenjie Xue, Guixing Ma, Hongmin Zhang and Song Wu*


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Aptamer-Based Targeted Drug Delivery Systems: Current Potential and Challenges


Fen He, Nachuan Wen, Daipeng Xiao, Jianhua Yan, Hongjie Xiong, Shundong Cai, Zhenbao Liu* and Yanfei Liu*


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Antimicrobial Capacity of Plant Polyphenols against Gram-positive Bacteria: A Comprehensive Review


Francisco Javier Alvarez-Martinez, Enrique Barrajon-Catalan*, Jose Antonio Encinar, Juan Carlos Rodriguez-Diaz and Vicente Micol


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An Overview of Antiretroviral Agents for Treating HIV Infection in Paediatric Population


Rita Melo, Agostinho Lemos, António J. Preto, Beatriz Bueschell, Pedro Matos-Filipe, Carlos Barreto, José G. Almeida, Rúben D.M. Silva, João D. G. Correia and Irina Moreira*


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The Close Interplay of Nitro-Oxidative Stress, Advanced Glycation end Products and Inflammation in Inflammatory Bowel Diseases


Fabiana Andrea Moura, Marília Oliveira Fonseca Goulart*, Amylly Sanuelly da Paz Martins and Samara Bonfim Gomes Campos


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Prognostic Impact of Tissue Inhibitor of Metalloproteinase-1 in Non- Small Cell Lung Cancer: Systematic Review and Meta-Analysis


Gurudeeban Selvaraj*, Satyavani Kaliamurthi, Shuhuang Lin, Keren Gu and Dong-Qing Wei


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Can We Extrapolate Data from One Immune-Mediated Inflammatory Disease to Another One?


Fernando Magro*, Rosa Coelho and Armando Peixoto


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Tumor Vasculature Targeted TNFα Therapy: Reversion of Microenvironment Anergy and Enhancement of the Anti-tumor Efficiency


Enrica Balza, Barbara Carnemolla, Paola Orecchia, Anna Rubartelli, Alessandro Poggi and Lorenzo Mortara*


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Metabolomics of Exhaled Breath Condensate by Nuclear Magnetic Resonance Spectroscopy and Mass Spectrometry: A Methodological Approach


Mauro Maniscalco*, Adele Cutignano, Debora Paris, Dominique J. Melck, Antonio Molino, Salvatore Fuschillo and Andrea Motta*


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Cubilin, the Intrinsic Factor-vitamin B12 Receptor in Development and Disease


Renata Kozyraki * and Olivier Cases


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The Thiol-polyamine Metabolism of Trypanosoma cruzi: Molecular Targets and Drug Repurposing Strategies


Alan Talevi, Carolina Carrillo and Marcelo A Comini*


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Hydrogel-clay Nanocomposites as Carriers for Controlled Release


Raluca Ianchis, Claudia Ninciuleanu*, Ioana Catalina Gifu, Elvira Alexandrescu, Cristina Lavinia Nistor, Sabina Georgiana Nitu and Cristian Petcu


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Recent Progress in Histone Deacetylase Inhibitors as Anticancer Agents


Loredana Cappellacci*, Diego R. Perinelli, Filippo Maggi, Mario Grifantini and Riccardo Petrelli*


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The Glycogen Synthase Kinase-3 in the Regulation of Ion Channels and Cellular Carriers


Mentor Sopjani, Lulzim Millaku, Dashnor Nebija, Merita Emini, Miribane Dermaku-Sopjani* and Arleta Rifati-Nixha


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Electronic Noses in Medical Diagnostics


Wojciech Wojnowski*, Tomasz Dymerski, Jacek Gębicki and Jacek Namieśnik


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Phenylboronic Acid-polymers for Biomedical Applications


Ji Hyun Ryu, Gyeong Jin Lee, Yu-Ru V Shih, Tae-il Kim* and Shyni Varghese*


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Cordycepin in Anticancer Research: Molecular Mechanism of Therapeutic Effects


Md. Asaduzzaman Khan* and Mousumi Tania


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Omega-3 Polyunsaturated Fatty Acid Derived Lipid Mediators and their Application in Drug Discovery


Curtis W. Pazderka, Brian Oliver, Michael Murray and Tristan Rawling*


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The Current Status and Perspectives of Delivery Strategy for Boronbased Drugs


Zhu Yinghuai*, Xinglong Lin, Hongming Xie, Jianlin Li, Narayan S. Hosmane and Yingjun Zhang


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Streptococcal Collagen-like Protein 1 Binds Wound Fibronectin: Implications in Pathogen Targeting


Dudley H McNitt, Livingston Van De Water, Daniela Marasco, Rita Berisio and Slawomir Lukomski*


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Plant-Derived Products as Antibacterial and Antifungal Agents in Human Health Care


Ladislav Kokoska*, Pavel Kloucek , Olga Leuner and Pavel Novy


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Advances in Docking


Vladimir B Sulimov*, Danil C Kutov and Alexey V Sulimov


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Exosome-like Nanovectors for Drug Delivery in Cancer


Noemi Arrighetti, Claudia Corbo, Michael Evangelopoulos, Anna Pasto, Valentina Zuco and Ennio Tasciotti*


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T-type Calcium Channels in Health and Disease


Dan Wang, Lotten Ragnarsson and Richard J. Lewis*


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Ocular Ciliopathies: Genetic and Mechanistic Insights into Developing Therapies


Mahesh Shivanna, Manisha Anand, Subhabrata Chakrabarti and Hemant Khanna*


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Lithium – Pharmacological and Toxicological Aspects: The Current State of the Art


Branislava Medić*, Marko Stojanović, Bojan Štimec, Nevena Divac, Katarina Savić Vujović, Radan Stojanović, Mirjana Čolović, Danijela Z. Krstić and Milica Prostran


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Novel Diagnostic Biomarkers of Prostate Cancer: An Update


Umberto Anceschi*, Gabriele Tuderti, Franco Lugnani, Pier Mario Biava, Gianni Malossini, Lorenzo Luciani, Tommaso Cai, Davide Marsiliani, Alessio Filianoti, Daniele Mattevi, Manuela Costantini, Leonardo Misuraca and Giuseppe Simone


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Lipids as Biomarkers of Cancer and Bacterial Infections


Gerald Larrouy-Maumus *


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Carbohydrates: Potential Sweet Tools Against Cancer


Oscar Lopez*, Antonio Franconetti and Jose G. Fernandez-Bolanos


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Migraine: Genetic Variants and Clinical Phenotypes


Innocenzo Rainero*, Alessandro Vacca, Flora Govone, Annalisa Gai, Lorenzo Pinessi and Elisa Rubino


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Structural and Biological Overview of Boron-containing Amino Acids in the Medicinal Chemistry Field


Antonio Abad Garcia, Alexey Rayevski, Erik Andrade-Jorge and Jose G. Trujillo-Ferrara*


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The Healing Effects of Spices in Chronic Diseases


Danka Bukvicki*, Davide Gottardi, Sahdeo Prasad, Miroslav Novakovic, Petar Marin and Amit Kumar Tyagi


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Circulating Biomarkers for Tumor Angiogenesis: Where Are We?


Virginia Di Paolo, Marta Colletti, Valentina Ferruzzi, Ida Russo, Angela Galardi, Iside Alessi , Giuseppe Maria Milano and Angela Di Giannatale*


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Xanthine Derivatives as Agents Affecting Non-dopaminergic Neuroprotection in Parkinson`s Disease


Alexandra Kasabova-Angelova, Diana Tzankova, Javor Mitkov, Maya Georgieva, Virginia Tzankova, Alexander Zlatkov and Magdalena Kondeva-Burdina*


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Silver Nanomaterials in Contemporary Molecular Physiology Research


Igor Pantic*, David Sarenac, Mila Cetkovic, Milan Milisavljevic, Rastko Rakocevic and Sandor Kasas


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Hybrid Compounds & Oxidative Stress Induced Apoptosis in Cancer Therapy


Aysegul Hanikoglu, Hakan Ozben, Ferhat Hanikoglu and Tomris Ozben*


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Methodological Aspects of Phytosterol Measurements in Biological Samples


Helena Gylling*, Piia Simonen, Leena Kaipiainen and Ingmar Wester


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Therapeutic Macromolecular Iron Chelators


Upendra Bulbake, Alka Singh, Avi Domb* and Wahid Khan


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The Neurokinins: Peptidomimetic Ligand Design and Therapeutic Applications


Charlene Gadais and Steven Ballet*


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Non-Steroidal Androgen Receptor Antagonists and Prostate Cancer: A Survey on Chemical Structures Binding this Fast-Mutating Target


Claudia Ferroni* and Greta Varchi*


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The Role of Adipokines in the Establishment and Progression of Head and Neck Neoplasms


Theodora Tzanavari, Jason Tasoulas*, Chrysoula Vakaki , Chrysovalantou Mihailidou , Gerasimos Tsourouflis and Stamatios Theocharis


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Antimicrobial Peptides: Amphibian Host Defense Peptides


Jiri Patocka, Eugenie Nepovimova , Blanka Klimova, Qinghua Wu and Kamil Kuca*


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Quercetin and its Natural Sources in Wound Healing Management


Nicoletta Polera , Mariateresa Badolato , Filomena Perri , Gabriele Carullo and Francesca Aiello*


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A Walk in Nature. Sesquiterpene Lactones as Multi-Target Agents Involved in Inflammatory Pathways


Adriana Coricello, James David Adams*, Eric Lien, Christopher Nguyen, Filomena Perri, Travis J. Williams and Francesca Aiello


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Recent Drug-Repurposing-Driven Advances in the Discovery of Novel Antibiotics


Ananda Kumar Konreddy, Grandhe Usha Rani, Kyeong Lee and Yongseok Choi*


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Pharmacological Management of Chronic Obstructive Lung Disease (COPD). Focus on Mutations


Patrizia Russo, Filippo Lococco, Aliaksei Kisialiou*, Giulia Prinzi, Palma Lamonaca, Vittorio Cardaci and Massimo Fini


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Latest Updates in Dengue Fever Therapeutics: Natural, Marine and Synthetic Drugs


Samira Hosseini*, Rodrigo B. Munoz-Soto, Jacqueline Oliva-Ramirez, Patricia Vazquez-Villegas, Nasrin Aghamohammadi, Aida Rodriguez-Garcia and Sergio O. Martinez-Chapa


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Could Flavonoids Compete with Synthetic Azoles in Diminishing Candida albicans Infections? A Comparative Review Based on In Vitro Studies


Marija Smiljkovic*, Marina Kostic, Dejan Stojkovic, Jasmina Glamoclija and Marina Sokovic


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Synthetic Peptide Libraries. From Random Mixtures to In Vivo Testing


Annamaria Sandomenico, Andrea Caporale, Nunzianna Doti, Simon Cross, Gabriele Cruciani, Angela Chambery, Sandro De Falco and Menotti Ruvo*


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Cancer-associated Cachexia, Reactive Oxygen Species, and Nutrition Therapy


Geir Bjorklund*, Maryam Dadar , Jan Aaseth , Salvatore Chirumbolo and Joeri J. Pen


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Impact of Natural Dietary Agents on Multiple Myeloma Prevention and Treatment: Molecular Insights and Potential for Clinical Translation


Lavinia Raimondi, Angela De Luca, Gianluca Giavaresi, Agnese Barone, Pierosandro Tagliaferri, Pierfrancesco Tassone and Nicola Amodio*


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Rational Drug Design Approach of Receptor Tyrosine Kinase Type III Inhibitors


Eunae Kim* and Cheolhee Kim


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Dual Inhibitors as a New Challenge for Cancer Multidrug Resistance Treatment


Tijana Stankovic, Jelena Dinic, Ana Podolski-Renic, Loana Musso, Sonja Stojkovic Buric, Sabrina Dallavalle* and Milica Pesic


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Signal Transducer and Activator of Transcription Protein 3 (STAT3): An Update on its Direct Inhibitors as Promising Anticancer Agents


Arianna Gelain , Matteo Mori , Fiorella Meneghetti and Stefania Villa*


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Focusing on the Influenza Virus Polymerase Complex: Recent Progress in Drug Discovery and Assay Development


Jiantao Zhang, Yanmei Hu, Rami Ghassan Musharrafieh, Hang Yin and Jun Wang*


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Porous Inorganic and Hybrid Systems for Drug Delivery: Future Promise in Combatting Drug Resistance and Translation to Botanical Applications


Junling Guo, Bruno D. Mattos, Blaise L. Tardy, Vanessa M. Moody, Gao Xiao, Hirotaka Ejima, Jiwei Cui, Kang Liang and Joseph Jacob Richardson*


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Mitochondria-Targeting Anticancer Metal Complexes


Andrea Erxleben*


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The Mechanisms Behind the Biological Activity of Flavonoids


Ana M. Gonzalez-Paramas, Begona Ayuda-Duran, Sofia Martinez, Susana Gonzalez-Manzano and Celestino Santos-Buelga*


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Pharmacokinetic and Pharmacogenetic Markers of Irinotecan Toxicity


Roberta Zilles Hahn, Marina Venzon Antunes, Simone Gasparin Verza , Magda Susana Perassolo, Edna Sayuri Suyenaga , Gilberto Schwartsmann and Rafael Linden *


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Energy Metabolism Impairment in Migraine


Sabina Cevoli*, Valentina Favoni and Pietro Cortelli


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Advances in the Tyrosinase Inhibitors from Plant Source


Marco Bonesi, Jianbo Xiao, Rosa Tundis*, Francesca Aiello, Vincenzo Sicari and Monica R. Loizzo


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The Role of Matrix Gla Protein (MGP) in Vascular Calcification


Geir Bjorklund*, Erik Svanberg, Maryam Dadar, David J. Card, Salvatore Chirumbolo, Dominic J. Harrington and Jan Aaseth


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State of the Art on Carbonic Anhydrase Modulators for Biomedical Purposes


Murat Bozdag, Abdulmalik Saleh Alfawaz Altamimi, Daniela Vullo, Claudiu T. Supuran and Fabrizio Carta*


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Promising Alternative Therapeutics for Oral Candidiasis


Celia Fortuna Rodrigues, Maria Elisa Rodrigues and Mariana Contente Rangel Henriques*


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Inhibitors of Serine/Threonine Protein Phosphatases: Biochemical and Structural Studies Provide Insight for Further Development


Mark R Swingle and Richard Eric Honkanen*


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Sitosterolemia: Diagnosis, Metabolic and Hematological Abnormalities, Cardiovascular Disease and Management


Jose Maria Bastida*, Maria Luisa Giros, Rocio Benito, Kamila Janusz, Jesus Maria Hernandez-Rivas and Jose Ramon Gonzalez-Porras


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Ionic Liquid-Like Pharmaceutical Ingredients and Applications of Ionic Liquids in Medicinal Chemistry: Development, Status and Prospects


Jie Tang , Hang Song , Xueting Feng , Alula Yohannes and Shun Yao*


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Genome Wide Approaches to Identify Protein-DNA Interactions


Tao Ma, Zhenqing Ye and Liguo Wang*


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Phytosterols and Inflammation


Gemma Vilahur, Soumaya Ben-Aicha, Elisa Diaz, Lina Badimon and Teresa Padro*


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Biological Consequences of Dysfunctional HDL


Angela Pirillo , Alberico Luigi Catapano* and Giuseppe Danilo Norata


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The Impact of Phytosterols on the Healthy and Diseased Brain


Tess Dierckx, Jeroen F.J. Bogie and Jerome A Hendriks*


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An Overview of the Loading Efficacy of Cationic Lipids with Milk Proteins: A Potential Application for Lipid Delivery


P. Chanphai, Philippe Bourassa and Heidar -Ali Tajmir-Riahi*


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Influence of Oxidative Stress on Catalytic and Non-glycolytic Functions of Glyceraldehyde-3-phosphate Dehydrogenase


Vladimir I. Muronetz*, Aleksandra K. Melnikova, Luciano Saso and Elena V. Schmalhausen


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The Role of Diet-Related Short-Chain Fatty Acids in Colorectal Cancer Metabolism and Survival: Prevention and Therapeutic Implications


Sara Daniela Gomes, Claudia Suellen Oliveira, Joao Azevedo-Silva, Marta Casanova, Judite Barreto, Helena Pereira, Susana Chaves, Ligia Rodrigues, Margarida Casal, Manuela Corte-Real, Fatima Baltazar and Ana Preto*


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Circulating Biomarkers in Migraine. New Opportunities for Precision Medicine


Patrizia Ferroni*, Piero Barbanti, Antonella Spila, Federica Fratangeli, Cinzia Aurilia, Luisa Fofi, Gabriella Egeo and Fiorella Guadagni


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Epigenetic Metalloenzymes


Christophe Blanquart, Camille Linot, Pierre-Francois Cartron, Daniela Tomaselli, Antonello Mai and Philippe Bertrand*


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Flavonoids and Reduction of Cardiovascular Disease (CVD) in Chronic Obstructive Pulmonary Disease (COPD)


Patrizia Russo*, Giulia Prinzi, Palma Lamonaca, Vittorio Cardaci and Massimo Fini


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DNA Topoisomerases of Leishmania Parasites; Druggable Targets for Drug Discovery


Rosa M Reguera, Ehab Kotb Elmahallawy, Carlos Garcia-Estrada, Ruben Carbajo-Andres and Rafael Balana-Fouce *


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A Systematic Review on Donepezil-based Derivatives as Potential Cholinesterase Inhibitors for Alzheimer’s Disease


Jan Korabecny , Katarina Spilovska, Eva Mezeiova , Ondrej Benek , Radomir Juza , Daniel Kaping and Ondrej Soukup*


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Chronic Low Back Pain: Current Pharmacotherapeutic Therapies and a New Biological Approach


Karel Pavelka*, Hana Jarosova, Olga Sleglova, Radka Svobodova, Martina Votavova, Leonello Milani, Zdenek Prochazka, Lucie Kotlarova, Pavel Kostiuk, Jiri Sliva and Alberto Marco Meroni


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Advances in the Treatment of Explicit Water Molecules in Docking and Binding Free Energy Calculations


Xiao Hu, Irene Maffucci and Alessandro Contini*


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Genetically Engineered Elastin-based Biomaterials for Biomedical Applications


Mercedes Santos , Sofia Serrano-Ducar , Juan Gonzalez-Valdivieso , Reinaldo Vallejo, Alessandra Girotti , Purificacion Cuadrado and Francisco Javier Arias*


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Advances and Application of DNA-functionalized Nanoparticles


Xun Zhang *, Fei Wang, Jin-Liang Sheng and Min-Xuan Sun


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Medicinal Chemistry of Potassium Channel Modulators: An Update of Recent Progress (2011-2017)


Vivek K. Vyas*, Palak Parikh , Jonali Ramani and Manjunath Ghate


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Drugs for Targeted Therapies of Alzheimer’s Disease


Chit Tam*, Jack Ho Wong*, Tzi Bun Ng*, Stephen Kwok Wing Tsui and Tao Zuo


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Liver Radioembolization: An Analysis of Parameters that Influence the Catheter-Based Particle-Delivery via CFD


Jorge Aramburu*, Raul Anton, Alejandro Rivas, Juan Carlos Ramos, Bruno Sangro and Jose Ignacio Bilbao


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Natural Alkaloids Intervening the Insulin Pathway: New Hopes for Anti-Diabetic Agents?


Maria-Ioanna Christodoulou*, Job Tchoumtchoua , Alexios-Leandros Skaltsounis , Andreas Scorilas and Maria Halabalaki


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Targeted Therapies for Autosomal Dominant Polycystic Kidney Disease


Cherie Stayner*, Darby G Brooke, Michael Bates and Michael R. Eccles


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Gene Silencing Strategies in Cancer Therapy: An Update for Drug Resistance


Sanaz Naghizadeh, Behzad Mansoori, Ali Mohammadi, Ebrahim Sakhinia and Behzad Baradaran*


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Insights on melatonin as an active pharmacological molecule in cancer prevention: what’s new?


Geir Bjorklund*, Samiul Alam Rajib , Nadia Saffoon, Joeri J. Pen and Salvatore Chirumbolo


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Research Progress on Brucellosis


Yuming Deng, Xinyue Liu, Kaifang Duan and Qisheng Peng*


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Honey: An Effective Regenerative Medicine Product in Wound Management


Simona Martinotti*, Marcela Bucekova , Juraj Majtan and Elia Ranzato


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Current and Future Prospects of Nitro-compounds as Drugs for Trypanosomiasis and Leishmaniasis


Alan H. Fairlamb* and Stephen Patterson


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Zinc Dependent Histone Deacetylase Inhibitors in Cancer Therapeutics: Recent Update


Faria Sultana, Kesari Lakshmi Manasa, Siddiq Pasha Shaik, Srinivasa Reddy Bonam and Ahmed Kamal*


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A Chemical Approach to Overcome Tyrosine Kinase Inhibitors Resistance: Learning from Chronic Myeloid Leukemia


Enrico Zanforlin, Giuseppe Zagotto* and Giovanni Ribaudo


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The LDL-Receptor and its Molecular Properties: From Theory to Novel Biochemical and Pharmacological Approaches in Reducing LDL-cholesterol


Dimitrios Petroglou, Ilias Kanellos, Christos Savopoulos , Georgia Kaiafa*, Anastasios Chrysochoou , Panagiotis Skantzis , Stylianos Daios , Apostolos I. Hatzitolios and Georgios Giannoglou


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Phytosterols in Cancer: From Molecular Mechanisms to Preventive and Therapeutic Potentials


Francisco Blanco-Vaca, Lidia Cedo and Josep Julve*


View Abstract View on PubMed



SGLT-2 inhibitors in Diabetic Kidney Disease: What Lies Behind their Renoprotective Properties?


Panagiotis I. Georgianos , Maria Divani , Theodoros Eleftheriadis, Peter R. Mertens and Vassilios Liakopoulos*


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Recent Advances on Glioblastoma Multiforme and Nano-drug Carriers: A Review


Wang Liao, Shengnuo Fan, Yuqiu Zheng, Shaowei Liao , Ying Xiong, Yi Li and Jun Liu *


View Abstract View on PubMed


The Therapeutic Impact of New Migraine Discoveries


Laszlo Vecsei*, Melinda Lukacs, Janos Tajti, Ferenc Fulop, Jozsef Toldi and Lars Edvinsson


View Abstract View on PubMed


Contribution of Spinal Cord Oligodendrocytes to Neuroinflammatory Diseases and Pain


Sergio M. Borghi , Victor Fattori , Miriam S. N. Hohmann and Waldiceu A. Verri*


View Abstract View on PubMed


Aporphines and Alzheimer’s Disease: Towards a Medical Approach Facing the Future


Seyed Mohammad Nabavi, Eugenio Uriarte, Luca Rastrelli and Eduardo Sobarzo-Sanchez*


View Abstract View on PubMed


Neurodegenerative Process Linking the Eye and the Brain


Raffaele Mancino, Massimo Cesareo, Alessio Martucci, Emiliano Di Carlo, Elena Ciuffoletti, Luigi Antonio Morrone, Carlo Nucci*, Clarissa Giannini and Francesco Garaci


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Neoadjuvant Therapy is Essential for Resectable Pancreatic Cancer


Jin-Zhi Xu, Wen-Quan Wang, Shi-Rong Zhang, Hua-Xiang Xu, Chun-Tao Wu, Zi-Hao Qi, He-Li Gao, Shuo Li, Quan-Xing Ni, Xian-Jun Yu and Liang Liu*


View Abstract View on PubMed


Polypharmacology in the Treatment of Chagas Disease


Elena Aguilera, Guzman Alvarez, Hugo Cerecetto and Mercedes Gonzalez *


View Abstract View on PubMed


Diverse Targeted Approaches to Battle Multidrug Resistance in Cancer


Nagula Shankaraiah*, Shalini Nekkanti , Ojaswitha Ommi and P. S. Soukya Lakshmi


View Abstract View on PubMed


The Design of New HIV-IN Tethered Bifunctional Inhibitors Using Multiple Microdomain Targeted Docking


Mihai Ciubotaru*, Mihaela Georgiana Musat, Marius Surleac, Elena Ionita , Andrei Jose Petrescu, Edgars Abele and Ramona Abele


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Tacrine-Natural-Product Hybrids for Alzheimer’s Disease Therapy


Maria Jesus Oset-Gasque* and Jose Marco-Contelles


View Abstract View on PubMed


Targeting AMPK in Diabetes and Diabetic Complications: Energy Homeostasis, Autophagy and Mitochondrial Health


Y. V. Madhavi , Nikhil Gaikwad , Veera Ganesh Yerra , Anil Kumar Kalvala , Srinivas Nanduri and Ashutosh Kumar*


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Glycosides from Medicinal Plants as Potential Anticancer Agents: Emerging Trends Towards Future Drugs


Haroon Khan, Mina Saeedi, Seyed Mohammad Nabavi, Mohammad S. Mubarak and Anupam Bishayee*


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Metabolic Remodeling Induced by Adipocytes: A New Achille Heels in Invasive Breast Cancer?


Camille Attane*, Delphine Milhas, Andrew J. Hoy and Catherine Muller


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Clinical and Pharmacologic Features of Monoclonal Antibodies and Checkpoint Blockade Therapy in Multiple Myeloma


Mattia D’Agostino, Giulia Gazzera , Giusy Cetani , Sara Bringhen, Mario Boccadoro and Francesca Gay*


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Cyclooxygenase-2 Inhibitors as a Therapeutic Target in Inflammatory Diseases


Miguel D. Ferrer, Carla Busquests-Cortes, Xavier Capo, Silvia Tejada, Josep A. Tur, Antoni Pons and Antoni Sureda*


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Role of Ox-LDL and LOX-1 in Atherogenesis


Ajoe John Kattoor, Sri Harsha Kanuri and Jawahar L. Mehta*


View Abstract View on PubMed


Freely Accessible Chemical Database Resources of Compounds for In Silico Drug Discovery


JingFang Yang, Di Wang, Chenyang Jia, Mengyao Wang , GeFei Hao and GuangFu Yang*


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Electronegative LDL: An Active Player in Atherogenesis or a By- Product of Atherosclerosis?


Andrea Rivas-Urbina, Anna Rull, Jordi Ordonez-Llanos and Jose Luis Sanchez-Quesada*


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Pigments from Filamentous Ascomycetes for Combination Therapy


Robert Hromadka, Zdenek Kejík , Milan Jakubek, Robert Kaplanek, Viera Sandrikova , Marian Urban , Pavel Martasek and Vladimir Kral*


View Abstract View on PubMed


ADAM Metalloproteinases as Potential Drug Targets


Caterina Camodeca, Doretta Cuffaro, Elisa Nuti* and Armando Rossello


View Abstract View on PubMed


Impact of Dysfunctional Protein Catabolism on Macrophage Cholesterol Handling


Takuro Miyazaki* and Akira Miyazaki


View Abstract View on PubMed



NAChR α4β2 Subtype and their Relation with Nicotine Addiction, Cognition, Depression and Hyperactivity Disorder


Manuela M. Laikowski , Favero Reisdorfer and Sidnei Moura*


View Abstract View on PubMed


Mechanism and Inhibition of Matrix Metalloproteinases


Linda Cerofolini, Marco Fragai* and Claudio Luchinat


View Abstract View on PubMed


Biomarkers Determining Prognosis of Atrial Fibrillation Ablation


Dimitris Tsiachris*, George Giannopoulos, Charis Kossyvakis, Spyridon Deftereos, Constantinos Tsioufis, Gerasimos Siasos, Evangelos Oikonomou, Konstantinos Gatzoulis, Dimitris Tousoulis and Christodoulos Stefanadis


View Abstract View on PubMed



Modified and Dysfunctional Lipoproteins in Atherosclerosis: Effectors or Biomarkers?


Alexander N Orekhov* and Igor A. Sobenin


View Abstract View on PubMed


Dysfunctional HDL as a Therapeutic Target for Atherosclerosis Prevention


Alice Ossoli, Chiara Pavanello, Eleonora Giorgio, Laura Calabresi and Monica Gomaraschi*


View Abstract View on PubMed


HDL Dysfunction Caused by Mutations in apoA-I and Other Genes that are Critical for HDL Biogenesis and Remodeling


Angeliki Chroni and Dimitris Kardassis*


View Abstract View on PubMed


In Silico Chemogenomics Drug Repositioning Strategies for Neglected Tropical Diseases


Carolina Horta Andrade*, Bruno Junior Neves, Cleber Camilo Melo-Filho, Juliana Rodrigues, Diego Cabral Silva, Rodolpho Campos Braga and Pedro Vitor Lemos Cravo


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Flavonoids and Platelet-Derived Thrombotic Disorders


Jose J Lopez, Mohammed El haouari, Isaac Jardin, Nieves Alonso, Sergio Regodon, Raquel Diez Bello, Pedro Cosme Redondo and Juan A Rosado*


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ABC Transporters in Extrahepatic Tissues: Pharmacological Regulation in Heart and Intestine


Silvina Villanueva, Wei Zhang, Felipe Zecchinati, Aldo Mottino and Mary Vore*


View Abstract View on PubMed


Linking Antimicrobial Potential of Natural Products Derived from Aquatic Organisms and Microbes Involved in Alzheimer’s Disease - A Review


Dejan Stojkovic*, Marina Kostic, Marija Smiljkovic, Milena Aleksic, Perica Vasiljevic, Milos Nikolic and Marina Sokovic


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The Significance of Oxidized Low-Density Lipoprotein in Body Fluids as a Marker Related to Diseased Conditions


Hiroyuki Itabe*, Rina Kato, Naoko Sasabe, Takashi Obama and Matsuo Yamamoto


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Antimicrobial and Structural Properties of Metal Ions Complexes with Thiosemicarbazide Motif and Related Heterocyclic Compounds


Ewelina Namiecinska, Marta Sobiesiak, Magdalena Malecka, Piotr Guga, Barbara Rozalska and Elzbieta Budzisz*


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Organic Fluorescent Dye-based Nanomaterials: Advances in the Rational Design for Imaging and Sensing Applications


Denis Svechkarev and Aaron M. Mohs*


View Abstract View on PubMed


Neuropharmacological Properties of the Essential Oil of Bergamot for the Clinical Management of Pain-Related BPSDs


Damiana Scuteri, Laura Rombola, Laura Tridico, Hirokazu Mizoguchi, Chizuko Watanabe, Tsukasa Sakurada, Shinobu Sakurada, Maria TIziana Corasaniti, Giacinto Bagetta and Luigi Antonio Morrone*


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Environmental Training and Synaptic Functions in Young and Old Brain: A Presynaptic Perspective


Tommaso Bonfiglio , Matteo Vergassola , Guendalina Olivero and Anna Pittaluga*


View Abstract View on PubMed



Functional Neuroimaging Biomarkers in Migraine: Diagnostic, Prognostic and Therapeutic Implications


Antonio Russo*, Marcello Silvestro, Alessandro Tessitore and Gioacchino Tedeschi


View Abstract View on PubMed


An Update on JAK Inhibitors


Francesca Musumeci*, Chiara Greco, Ilaria Giacchello, Anna Lucia Fallacara, Munjed M. Ibrahim , Giancarlo Grossi, Chiara Brullo and Silvia Schenone


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Metal Ion Complexes with Pyrazoles, Aziridines and Diaziridines – Synthesis and Biological Activity


Katarzyna Malinowska, Ingo-Peter Lorenz, Beata Sadowska and Paulina Mucha*


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The Role of (Modified) Lipoproteins in Vascular Function: A Duet Between Monocytes and the Endothelium


Johan G. Schnitzler, Geesje M. Dallinga-Thie and Jeffrey Kroon*


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Potential Roles for G-Quadruplexes in Mitochondria


Micol Falabella, Rafael J. Fernandez, Brad Johnson and Brett A. Kaufman*


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Modulation of Hepatic MRP3/ABCC3 by Xenobiotics and Pathophysiological Conditions: Role in Drug Pharmacokinetics


Carolina I. Ghanem and Jose E. Manautou*


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Homocysteine and Hyperhomocysteinaemia


Bozidarka L. Zaric, Milan Obradovic, Vladan Bajic , Mohamed A. Haidara , Milos Jovanovic and Esma R. Isenovic*


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Recent Progress in the Development of Fluorometric Chemosensors to Detect Enzymatic Activity


Tingwen Wei , Fang Wang, Zhijie Zhang , Jiang Qiang, Jing Lv , Tiantian Chen, Jia Li and Xiaoqiang Chen*


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Mapping of Protein-Protein Interactions: Web-Based Resources for Revealing Interactomes


Branislava Gemovic, Neven Sumonja, Radoslav Davidovic, Vladimir Perovic and Nevena Veljkovic*


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DNA Double Strand Breaks Repair Inhibitors: Relevance as Potential New Anticancer Therapeutics


Paulina Kopa , Anna Macieja, Grzegorz Galita, Zbigniew J. Witczak* and Tomasz Poplawski


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MUC1 Story: Great Expectations, Disappointments and the Renaissance


Mikhail A. Rubtsov *, Marina S. Syrkina and Yegor S. Vassetzky


View Abstract View on PubMed


Acyclovir in the Treatment of Herpes Viruses – A Review


Katarzyna Klysik, Aneta Pietraszek, Anna Karewicz and Maria Nowakowska*


View Abstract View on PubMed


Current Trends and Future Directions of Fluoroquinolones


Hamada H. H. Mohammed , Gamal El-Din A.A. Abuo-Rahma*, Samar H. Abbas and El-Shimaa M. N. Abdelhafez


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Recent Advances in the Use of Metallic Nanoparticles with Antitumoral Action - Review


Patricia Bento da Silva, Rachel Temperani Amaral Machado , Andressa Maria Pironi, Renata Carolina Alves, Patricia Rocha de Araujo, Amanda Cutrim Dragalzew, Ingrid Dalberto and Marlus Chorilli*


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Metal–Organic Framework (MOF)-based Nanomaterials for Biomedical Applications


Zhidong Luo , Shuran Fan , Chuying Gu , Weicong Liu , Baohong Li and Jianqiang Liu*


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Advances in the Development of Anticancer HSP-based Vaccines


Alexey V. Baldin, Andrey A. Zamyatnin, Alexandr V. Bazhin, Wan-Hai Xu and Lyudmila V. Savvateeva*


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Ganglioside GM3 and Its Role in Cancer


Changping Zheng , Marco Terreni , Matthieu Sollogoub and Yongmin Zhang*


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DNA Double Strand Break Repair - Related Synthetic Lethality


Monika Toma, Tomasz Skorski and Tomasz Sliwinski*


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The Role of Selenium in Oxidative Stress and in Nonthyroidal Illness Syndrome (NTIS): An Overview


Andrea Silvestrini*, Alvaro Mordente, Giuseppe Martino, Carmine Bruno, Edoardo Vergani, Elisabetta Meucci and Antonio Mancini


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Role of ABC Transporters in Veterinary Medicine: Pharmaco- Toxicological Implications


Guillermo Virkel, Mariana Ballent, Carlos Lanusse and Adrian Lifschitz*


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Inhibitors of ER Aminopeptidase 1 and 2: From Design to Clinical Application


Dimitris Georgiadis, Anastasia Mpakali, Despoina Koumantou and Efstratios Stratikos*


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The Use of Immunotherapy to Treat Metastatic Breast Cancer


Andrea Nicolini*, Vivian Barak, Piermario Biava, Paola Ferrari, Giuseppe Rossi and Angelo Carpi


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Novel Therapeutic Approaches in Rheumatoid Arthritis: Role of Janus Kinases Inhibitors


Felice Rivellese, Antonio Lobasso, Letizia Barbieri, Bianca Liccardo, Amato De Paulis and Francesca Wanda Rossi*


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New Drugs, Therapeutic Strategies, and Future Direction for the Treatment of Pulmonary Arterial Hypertension


Valentina Mercurio*, Anna Bianco, Giacomo Campi, Alessandra Cuomo, Nermin Diab, Angela Mancini, Paolo Parrella, Mario Petretta, Paul Hassoun and Domenico Bonaduce


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ABC Transporters: Regulation and Association with Multidrug Resistance in Hepatocellular Carcinoma and Colorectal Carcinoma


María Paula Ceballos, Juan Pablo Rigalli, Lucila Ines Cere, Mariana Semeniuk, Viviana Alicia Catania and Maria Laura Ruiz*


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MRP4/ABCC4 As a New Therapeutic Target: Meta-Analysis to Determine cAMP Binding Sites as a Tool for Drug Design


Agustín Yaneff*, Ana Sahores, Natalia Gomez, Alejandro Carozzo, Carina Shayo and Carlos Davio


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Surfing the Blood Coagulation Cascade: Insight into the Vital Factor Xa


Nicolas E. Nunez-Navarro, Fabian M. Santana, Loreto P. Parra and Flavia C. Zacconi*


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Looking for New Antifungal Drugs from Flavonoids: Impact of the Genetic Diversity of Candida albicans on the in-vitro Response


Maria Rosa Felice, Letterio Giuffre, Lamya El Aamri, Majida Hafidi, Giuseppe Criseo, Orazio Romeo* and Fabio Scordino


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Recent Advances in Peptide-Based Approaches for Cancer Treatment


Anne C. Conibear, Alanca Schmid, Meder Kamalov, Christian F.W. Becker and Claudia Bello*


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Stimuli-responsive Carriers for Controlled Intracellular Drug Release


Yan Sheng*, Jiaming Hu, Junfeng Shi and Ly James Lee


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Olfactory Loss and Dysfunction in Ciliopathies: Molecular Mechanisms and Potential Therapies


Cedric R. Uytingco*, Warren W. Green and Jeffrey R. Martens


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Breaking the DNA Damage Response via Serine/Threonine Kinase Inhibitors to Improve Cancer Treatment


Wioletta Rozpedek, Dariusz Pytel, Alicja Nowak-Zdunczyk , Dawid Lewko , Radoslaw Wojtczak , John Alan Diehl* and Ireneusz Majsterek


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Novel Biological Therapies in Severe Asthma: Targeting the Right Trait


Gilda Varricchi*, Giancarlo Marone, Giuseppe Spadaro, Michele Russo, Francescopaolo Granata, Arturo Genovese and Gianni Marone


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Unfolding Cardiac Amyloidosis –From Pathophysiology to Cure


Klemens Ablasser, Nicolas Verheyen, Theresa Glantschnig, Giulio Agnetti and Peter P Rainer*


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Fine-tuning of microRNAs in Type 2 Diabetes Mellitus


Juan A. Rosado, Raquel Diez-Bello, Gines Maria Salido and I. Jardin*


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New Insights into Adipokines as Potential Biomarkers for Type-2 Diabetes Mellitus


Marta Olivera-Santa Catalina, Pedro C. Redondo, Carlos Cantonero , Maria P. Granados, Jose Sanchez-Collado, Letizia Albarran and Jose Javier Lopez*


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Use of Antibiotic Loaded Biomaterials for the Management of Bone Prosthesis Infections: Rationale and Limits


Matilde Tschon, Maria Sartori*, Deyanira Contartese, Gianluca Giavaresi, Nicolo Nicoli Aldini and Milena Fini


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γ-AApeptides as a New Strategy for Therapeutic Development


Alekhya Nimmagadda, Yan Shi and Jianfeng Cai*


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Dynamic Localization of Hepatocellular Transporters: Role in Biliary Excretion and Impairment in Cholestasis


Marcelo Gabriel Roma*, Ismael R. Barosso, Gisel S. Miszczuk, Fernando A. Crocenzi and Enrique J. Sanchez Pozzi


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Trends and Prospects of Plant Proteases in Therapeutics


Anastasia V. Balakireva, Natalia V. Kuznetsova, Anastasia I. Petushkova, Lyudmila Savvateeva and Andrey A. Zamyatnin *


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Plant-Made Antibodies: Properties and Therapeutic Applications


Tatiana V. Komarova, Ekaterina V Sheshukova and Yuri L Dorokhov*


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Sunitinib in the Treatment of Thyroid Cancer


Silvia Martina Ferrari, Marco Centanni, Camilla Virili, Mario Miccoli , Paola Ferrari, Ilaria Ruffilli , Francesca Ragusa, Alessandro Antonelli* and Poupak Fallahi


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Medical Applications of Collagen and Collagen-Based Materials


Anatoly Borisovich Shekhter, Alexey Leonidovich Fayzullin*, Marina Nikolaevna Vukolova, Tatyana Georgiyevna Rudenko, Varvara Dmitriyevna Osipycheva and Petr Francevich Litvitsky


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Metallodrugs in Targeted Cancer Therapeutics. Aiming at Chemoresistance- related Patterns and Immunosuppressive Tumor Networks


Athanasios Salifoglou*, Savvas Petanidis and Efrosini Kioseoglou


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G4-Interacting DNA Helicases and Polymerases: Potential Therapeutic Targets


Katrina N. Estep*, Thomas J . Butler, Jun Ding and Robert M. Brosh


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Biodegradable Black Phosphorus-based Nanomaterials in Biomedicine: Theranostic Applications


Zhen Wang, Zhiming Liu, Chengkang Su, Biwen Yang, Xixi Fei, Yi Li, Yuqing Hou, Henan Zhao, Yanxian Guo, Zhengfei Zhuang*, Huiqing Zhong and Zhouyi Guo*


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Potential Triazole-based Molecules for the Treatment of Neglected Diseases


Susimaire Pedersoli Mantoani, Peterson de Andrade, Talita Perez Cantuaria Chierrito, Andreza Silva Figueredo and Ivone Carvalho*


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High-Throughput Screening Strategies for the Development of Anti- Virulence Inhibitors Against Staphylococcus aureus


Xiaodan Cai, Weihao Zheng and Zigang Li*


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Recent Advances and Challenges in Steroid Metabolomics for Biomarker Discovery


Alicja Kotlowska* and Piotr Szefer


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New Molecular Targets and Strategies for Antimalarial Discovery


Anna Caroline Aguiar, Lorena R. F. de Sousa, Celia R. S. Garcia, Glaucius Oliva and Rafael V. C. Guido*


View Abstract View on PubMed


Inflammatory Biomarkers in Atrial Fibrillation


Effimia Zacharia, Nikolaos Papageorgiou*, Adam Ioannou, Gerasimos Siasos, Manolis Vavuranakis, George Latsios, Charalampos Vlachopoulos, Konstantinos Toutouzas, Spyridon Deftereos, Rui Providência and Dimitris Tousoulis


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Biomarkers of Atrial Fibrillation in Hypertension


Costas Tsioufis*, Dimitrios Konstantinidis, Elias Nikolakopoulos, Evi Vemou, Theodoros Kalos, Georgios Georgiopoulos, Nikos Vogiatzakis, Aristos Ifantis, Konstantinos Konstantinou, V. Gennimata and Dimitris Tousoulis


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Privileged Structures in the Design of Potential Drug Candidates for Neglected Diseases


Ana Cristina Lima Leite*, José Wanderlan Pontes Espíndola, Marcos Veríssimo de Oliveira Cardoso and Gevanio Bezerra de Oliveira Filho


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Modern Approach to Medical Diagnostics - the Use of Separation Techniques in Microorganisms Detection


Agnieszka Chylewska*, Malgorzata Ogryzek and Mariusz Makowski


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Hyphenated Mass Spectrometry Techniques in the Diagnosis of Amyloidosis


Marta Spodzieja, Sylwia Rodziewicz-Motowidło and Aneta Szymanska*


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Collagenolytic Enzymes and their Applications in Biomedicine


Anatoly Borisovich Shekhter*, Anastasia V. Balakireva, Natalia V. Kuznetsova, Marina N. Vukolova, Petr F. Litvitsky and Andrey A. Zamyatnin


View Abstract View on PubMed


Metabolomics and Heart Diseases: From Basic to Clinical Approach


Ignasi Barba*, Mireia Andres and D Garcia Dorado


View Abstract View on PubMed


Metabolomic Heterogeneity of Urogenital Tract Cancers Analyzed by Complementary Chromatographic Techniques Coupled with Mass Spectrometry


Arlette Yumba Mpanga, Wiktoria Struck-Lewicka, Renata Bujak, Marcin Markuszewski, Marek Roslan, Roman Kaliszan and Michał Jan Markuszewski*


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Virome and Inflammasomes, a Finely Tuned Balance with Important Consequences for the Host Health


Giulia Freer, Fabrizio Maggi and Mauro Pistello*


View Abstract View on PubMed



Platelet Oxidative Stress and its Relationship with Cardiovascular Diseases in Type 2 Diabetes Mellitus Patients


Mohammed El Haouari*


View Abstract View on PubMed



Smart Organic-Inorganic Nanogels for Activatable Theranostics


Fangyuan Li, Zeyu Liang and Daishun Ling*


View Abstract View on PubMed



Protective Effects of the Caffeine Against Neurodegenerative Diseases


Ester Tellone*, Antonio Galtieri, Annamaria Russo and Silvana Ficarra


View Abstract View on PubMed


Rutin as Neuroprotective Agent: From Bench to Bedside


Barbara Budzynska, Caterina Faggio, Marta Kruk-Slomka, Dunja Samec, Seyed Fazel Nabavi, Antoni Sureda, Kasi Pandima Devi and Seyed Mohammad Nabavi*


View Abstract View on PubMed


Allosteric Targeting of Aurora A Kinase Using Small Molecules: A Step Forward Towards Next Generation Medicines


Resmi C Panicker, Anthony G. Coyne and Rajavel Srinivasan*


View Abstract View on PubMed



Biomarkers of Atrial Fibrillation in Metabolic Syndrome


Christos Georgakopoulos, Charalambos Vlachopoulos*, Georgios Lazaros and Dimitris Tousoulis


View Abstract View on PubMed



Improving Metabolic Control Through Functional Foods


John G. Jones* and Joao C.P. Silva


View Abstract View on PubMed


Effects of Isolated Isoflavones Intake on Health


Antonella Smeriglio*, Antonella Calderaro, Marcella Denaro, Giuseppina Laganà and Ersilia Bellocco


View Abstract View on PubMed


Current Progress of Lipid Analysis in Metabolic Diseases by Mass Spectrometry Methods


Adriana Mika*, Tomasz Sledzinski and Piotr Stepnowski


View Abstract View on PubMed



Structure-based Approaches Targeting Parasite Cysteine Proteases


Rafael Pinto Vieira, Viviane Corrêa Santos and Rafaela Salgado Ferreira*


View Abstract View on PubMed


Ag+ Complexes as Potential Therapeutic Agents in Medicine and Pharmacy


Aleksandra Hecel, Paulina Kolkowska, Karolina Krzywoszynska, Agnieszka Szebesczyk, Magdalena Rowinska-Zyrek and Henryk Kozlowski*


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Enzyme-Instructed Self-assembly in Biological Milieu for Theranostics Purpose


Zhentao Huang, Qingxin Yao, Simin Wei, Jiali Chen and Yuan Gao*


View Abstract View on PubMed



Protozoan Parasites Glycosylphosphatidylinositol Anchors: Structures, Functions and Trends for Drug Discovery


Ana Luísa Malaco Morotti, Maristela Braga Martins-Teixeira and Ivone Carvalho*


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Fighting Type-2 Diabetes: Present and Future Perspectives


Cai-Guo Yu , Ying Fu, Yuan Fang , Ning Zhang, Rong-Xin Sun , Dong Zhao, Ying-Mei Feng and Bao-Yu Zhang*


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Nutraceuticals and "Repurposed" Drugs of Phytochemical Origin in Prevention and Interception of Chronic Degenerative Disease and Cancer


Adriana Albini, Barbara Bassani, Denisa Baci, Katiuscia Dallaglio, Matteo Gallazzi, Paola Corradino, Antonino Bruno and Douglas Noonan*


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Untargeted Metabolomics Provides Insight into the Mechanisms Underlying Resistant Hypertension


Renata Bujak, Arlette Yumba-Mpanga, Wiktoria Struck-Lewicka, Marta Kordalewska, Katarzyna Polonis, Małgorzata Patejko, Monika Mironiuk, Anna Szyndle, Marzena Chrostowska, Michał Hoffmann, Ryszard T. Smoleński, Roman Kaliszan, Krzysztof Narkiewicz and Michał J. Markuszewski*


View Abstract View on PubMed


Amino Acid Degrading Enzymes and their Application in Cancer Therapy


Vadim S Pokrovsky*, Olga E Chepikova, Denis Zh Davydov, Andrey A Zamyatnin, Alexander N Lukashev and Elena V Lukasheva


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Bacterial Protein Mimetic of Peptide Hormone as a New Class of Protein- based Drugs


S. O. Fetissov*, Romain Legrand and Nicolas Lucas


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Stem Cell Differentiation Stage Factors and their Role in Triggering Symmetry Breaking Processes during Cancer Development: A Quantum Field Theory Model for Reprogramming Cancer Cells to Healthy Phenotypes


Pier Mario Biava*, Fabio Burigana, Roberto Germano, Philip Kurian, Claudio Verzegnassi and Giuseppe Vitiello


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Antibody Fragments as Potential Biopharmaceuticals for Cancer Therapy: Success and Limitations


Roman V Kholodenko*, Daniel V. Kalinovsky, Igor I Doronin, Eugene D Ponomarev and Irina V Kholodenko


View Abstract View on PubMed


Histone Deacetylase Inhibitors in Tumor Immunotherapy


Li-Ming Zhao* and Jie-Huan Zhang


View Abstract View on PubMed


Biomarkers in Atrial Fibrillation and Heart Failure


Evangelos Oikonomou*, Theodoros Zografos, Georgios-Angelos Papamikroulis, Gerasimos Siasos , Georgia Vogiatzi , Panagiotis Theofilis, Alexandros Briasoulis, Spyridon Papaioannou, Manolis Vavuranakis, Vasiliki Gennimata and Dimitris Tousoulis


View Abstract View on PubMed


MicroRNAs in Atrial Fibrillation


Alexandros Briasoulis*, Shikha Sharma, Tesfaye Telila, Sagar Mallikethi-Reddy, Nikolaos Papageorgiou, Evangelos Oikonomou and Dimitris Tousoulis


View Abstract View on PubMed


Atrial Fibrillation: Biomarkers Determining Prognosis


Savas Mazaris, Gerasimos Siasos*, Evangelos Oikonomou, Vicky Tsigkou, Manolis Vavuranakis, Eleni Kokkou, Marina Zaromitidou, Georgios-Angelos Papamikroulis, Athanasios G Papavassiliou, Spyridon Papaioannou, Nikolaos Papageorgiou, George Latsios, Christodoulos Stefanadis and Dimitris Tousoulis


View Abstract View on PubMed


Transient Production of Recombinant Pharmaceutical Proteins in Plants: Evolution and Perspectives


Lilya Kopertekh* and Joachim Schiemann


View Abstract View on PubMed



Immune Modulation of Asian Folk Herbal Medicines and Related Chemical Components for Cancer Management


Manee Patanaponpibul and Qiao-Hong Chen*


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The Role of Dietary Approach in Irritable Bowel Syndrome


Piero Portincasa*, Antony Lembo, Ornella De Bari, Domenica M. Di Palo, Anna Maggio, Ilaria Cataldo and Giuseppe Calamita


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Effects of Diets on Adipose Tissue


Silvia Ezquerro, Amaia Rodríguez, Piero Portincasa and Gema Frühbeck*


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Rational Drug Design of Antineoplastic Agents Using 3D-QSAR, Cheminformatic, and Virtual Screening Approaches


Jelica Vucicevic, Katarina Nikolic* and John B O Mitchell


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Applications of Cellulose-based Materials in Sustained Drug Delivery Systems


Bo Sun, Min Zhang, Jing Shen, Zhibin He, Pedram Fatehi* and Yonghao Ni


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Exploiting Cancer Metal Metabolism using Anti-Cancer Metal- Binding Agents


Angelica M Merlot*, Danuta S Kalinowski, Zaklina Kovacevic, Patric J Jansson, Sumit Sahni, Michael L Huang, Darius L Lane, Hiu Lok and Des R Richardson


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The Panomics Approach in Neurodegenerative Disorders


Balazs Szatmari, Peter Balicza, Gyorgy Nemeth and Judit Mária Molnár*


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Impact of Diabetes on Cardiac and Vascular Disease: Role of Calcium Signaling


Tarik Smani*, Isabel Gallardo-Castillo, Javier Ávila-Médina, Manuel F. Jimenez-Navarro, Antonio Ordoñez and Abdelkrim Hmadcha


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Targeting CXCL12/CXCR4 Axis in Tumor Immunotherapy


Weiqiang Zhou, Shanchun Guo, Mingli Liu, Matthew E. Burow and Guangdi Wang*


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Biomarkers Associated with Atrial Fibrosis and Remodeling


Polychronis Dilaveris, Christos-Konstantinos Antoniou, Panagiota Manolakou, Eleftherios Tsiamis, Konstantinos Gatzoulis and Dimitris Tousoulis*


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Redox State in Atrial Fibrillation Pathogenesis and Relevant Therapeutic Approaches


Alexios S. Antonopoulos*, Athina Goliopoulou, Evangelos Oikonomou, Sotiris Tsalamandris, Georgios-Angelos Papamikroulis, George Lazaros, Eleftherios Tsiamis, George Latsios, Stella Brili, Spyridon Papaioannou, Vasiliki Gennimata and Dimitris Tousoulis


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The Role of Diet in Patients with Metabolic Syndrome


Paloma Almeda-Valdes, Roberto J. Herrera-Mercadillo, Carlos A. Aguilar-Salinas, Misael Uribe and Nahum Méndez-Sánchez*


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Short-term Dietary Interventions for the Management of Nonalcoholic Fatty Liver


Caroline S. Stokes*, Frank Lammert and Marcin Krawczyk


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Weighing the Impact of Diet and Lifestyle on Female Reproductive Function


Gabriella Garruti*, Raffaella De Palo and Maria De Angelisc


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Post Cardiovascular Surgery Atrial Fibrillation. Biomarkers Determining Prognosis


Olivia Manfrini, Edina Cenko, Beatrice Ricci and Raffaele Bugiardini*


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Nutrition as a Health Determinant in Elderly Patients


Tecla Mastronuzzi and Ignazio Grattagliano*


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Modulation of Aquaporins by Dietary Patterns and Plant Bioactive Compounds


Ilaria Cataldo, Anna Maggio , Patrizia Gena, Ornella de bari, Grazia Tamma , Piero Portincasa and Giuseppe Calamita*


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Green Synthesized Nanomaterials as Theranostic Platforms for Cancer Treatment: Principles, Challenges and the Road Ahead


Pala Rajasekharreddy, Chao Huang, Siddhardha Busi, Jobina Rajkumari, Ming-Hong Tai and Gang Liu


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Anti-fatigue Effects of Active Ingredients from Traditional Chinese Medicine: A Review


Si-Si Zhou and Jian-Guo Jiang *


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Immune Checkpoint Inhibitors: Basics and Challenges


Bin Li*, Ho Lam Chan and Pingping Chen


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Biomarkers in Aortic Valve Stenosis and their Clinical Significance in Transcatheter Aortic Valve Implantation


Konstantinos Toutouzas*, Konstantinos Stathogiannis, George Latsios, Andreas Synetos, Maria Drakopoulou, Vicky Penesopoulou, Archontoula Michelongona, Eleftherios Tsiamis and Dimitris Tousoulis


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Biomarkers Associated with Bleeding Risk in the Setting of Atrial Fibrillation


Skevos Sideris*, Stefanos Archontakis, George Latsios, George Lazaros, Konstantinos Toutouzas, Eleftherios Tsiamis, Manolis Vavuranakis, Charalampos Vlachopoulos, Konstantinos Gatzoulis, Konstantinos Tsioufis and Dimitris Tousoulis


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Biomarkers Associated with Stroke Risk in Atrial Fibrillation


Adam Ioannou, Nikolaos Papageorgiou*, Debbie Falconer, Onkar Rehal, Emma Sewart, Effimia Zacharia, Konstantinos Toutouzas, Charalampos Vlachopoulos, Gerasimos Siasos, Constantinos Tsioufis and Dimitris Tousoulis


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Impact of Red Wine Consumption on Cardiovascular Health


Luca Liberale, Aldo Bonaventura, Fabrizio Montecucco*, Franco Dallegri and Federico Carbone


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Na+,K+-ATPase as a Target for Treatment of Tissue Fibrosis


Sergei N. Orlov, Jenifer La, Larisa V. Smolyaninova and Nickolai O. Dulin*


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Update on the Molecular Mechanisms Underlying the Effect of Cholecystokinin and Cholecystokinin-1 Receptor on the Formation of Cholesterol Gallstones


Helen H. Wang, Piero Portincasa and David Q.-H. Wang*


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Therapeutic Proteins for Treatment of Corneal Epithelial Defects


Evgeni Yu. Zernii, Viktoriia E. Baksheeva, Elena V. Yani, Pavel P. Philippov and Ivan I. Senin*


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Fatty Acids and Effects on In Vitro and In Vivo Models of Liver Steatosis


Laura Vergani*


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The Role of Diet in the Pathogenesis of Cholesterol Gallstones


Agostino Di Ciaula, Gabriella Garruti, Gema Frühbeck, Maria De Angelis, Ornella De Bari, David Q.-H. Wang, Frank Lammert and Piero Portincasa*


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Food and Gastroesophageal Reflux Disease


Teodora Surdea-Blaga, Dana E. Negrutiu, Mariana Palage and Dan L. Dumitrascu*


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Dietary Polyphenols and Mitochondrial Function: Role in Health and Disease


José Teixeira, Daniel Chavarria, Fernanda Borges, Lech Wojtczak, Mariusz R. Wieckowsk, Anieszka Karkucińska-Wieckowska and Paulo J. Oliveira*


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Diet After Cholecystectomy


Donato F. Altomare*, Maria T. Rotelli and Nicola Palasciano


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The Food-Gut Human Axis: The Effects of Diet on Gut Microbiota and Metabolome


Maria De Angelis*, Gabriella Garruti, Fabio Minervini, Leonilde Bonfrate, Piero Portincasa and Marco Gobbetti


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Diet and Cardiovascular Disease: Effects of Foods and Nutrients in Classical and Emerging Cardiovascular Risk Factors


Lina Badimon*, Patricia Chagas and Gemma Chiva-Blanch


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Biosimilars for the Management of Inflammatory Bowel Diseases: Economic Considerations


Laszlo Gulacsi, Marta Pentek, Fanni Rencz, Valentin Brodszky, Petra Baji, Zsuzsanna Vegh, Krisztina B Gecse, Silvio Danese, Laurent Peyrin- Biroulet and Peter L. Lakatos*


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Lactate Dehydrogenase Inhibition: Biochemical Relevance and Therapeutical Potential


Giuseppina Laganà, Davide Barreca, Antonella Calderaro and Ersilia Bellocco


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Efficacy, Safety and Immunogenicity of Biosimilars in Inflammatory Bowel Diseases: A Systematic Review


Laura Martelli and Laurent Peyrin-Biroulet


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