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Current Medicinal Chemistry

Volume 26, 42 Issues, 2019
ISSN: 1875-533X (Online)
ISSN: 0929-8673 (Print)
This journal supports open access

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  • 91st of 298 in

    Biochemistry & Molecular Biology

  • 12th of 61 in

    Chemistry, Medicinal

  • 55th of 267 in

    Pharmacology & Pharmacy

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Articles Ahead of Print






Protein Microarrays: Valuable Tools for Ocular Diseases Research


María Garranzo-Asensio, Ana Montero-Calle, Guillermo Solís-Fernández, Rodrigo Barderas and Ana Guzman-Aranguez*


DOI: 10.2174/0929867326666190627131300
View Abstract View on PubMed


Autoimmune Hepatitis and Stellate Cells; an Insight into the Role of Autophagy


Shahram Golbabapour, Kamran Bagheri-Lankarani, Saeid Ghavami and Bita Geramizadeh*


DOI: 10.2174/0929867326666190402120231
View Abstract View on PubMed



Chitosan-based Polymer Matrix for Pharmaceutical Excipients and Drug Delivery


Md. Iqbal Hassan Khan , Xingye An, Lei Dai , Hailong Li, Avik Khan and Yonghao Ni*


DOI: 10.2174/0929867325666180927100817
View Abstract View on PubMed




Microbiota, Immune System and Autism Spectrum Disorders. An Integrative Model towards Novel Treatment Options


Barbara Carpita, Donatella Marazziti*, Lionella Palego, Gino Giannaccini, Laura Betti and Liliana Dell'Osso


DOI: 10.2174/0929867326666190328151539
View Abstract






Differential Characteristics of HMGB2 Versus HMGB1 and their Perspectives in Ovary and Prostate Cancer


María Cámara-Quílez, Aida Barreiro-Alonso, Esther Rodríguez-Bemonte, María Quindós-Varela, Esperanza Cerdán and Mónica Lamas-Maceiras*


DOI: 10.2174/0929867326666190123120338
View Abstract View on PubMed










Targeting Neuropathic Pain: Pathobiology, Current Treatment and Peptidomimetics as a New Therapeutic Opportunity


Maria Cristina Caroleo, Antonella Brizzi*, Maria De Rosa, Ankur Pandey, Luca Gallelli, Mariateresa Badolato, Gabriele Carullo and Erika Cione


DOI: 10.2174/0929867326666190530121133
View Abstract View on PubMed








Obesity and Cardioprotection


Saveria Femminò, Pasquale Pagliaro and Claudia Penna*


DOI: 10.2174/0929867326666190325094453
View Abstract View on PubMed





Development of Topical Nanocarriers for Skin Cancer Treatment Using Quality by Design Approach


Erzsebet Csanyi*, Mónika Bakonyi, Anita Kovács, Mária Budai-Szűcs, Ildikó Csóka and Szilvia Berkó


DOI: 10.2174/0929867325666181116143713
View Abstract View on PubMed


Anthocyanins As Modulators of Cell Redox-Dependent Pathways in Non-Communicable Diseases


Antonio Speciale, Antonella Saija, Romina Bashllari, Maria Sofia Molonia, Claudia Muscara, Cristina Occhiuto, Francesco Cimino* and Mariateresa Cristani


DOI: 10.2174/0929867325666181112093336
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Turning Fear of Boron Toxicity into Boron-containing Drug Design


Marvin Antonio Soriano-Ursúa *, Eunice Dalet Farfán-García and Simonetta Geninatti-Crich


DOI: 10.2174/0929867326666190327154954
View Abstract View on PubMed


Targeting Tumour Metastasis: The Emerging Role of Nanotechnology


Sarah Visentin, Mirela Sedić, Sandra Kraljević Pavelić and Krešimir Pavelić*


DOI: 10.2174/0929867326666181220095343
View Abstract View on PubMed


Linseed Essential Oil – Source of Lipids as Active Ingredients for Pharmaceuticals and Nutraceuticals


Joana Campos , Patricia Severino, Classius Ferreira, A Zielinska, Antonello Santini, Selma Souto and Eliana B. Souto*


DOI: 10.2174/0929867325666181031105603
View Abstract View on PubMed



B7-H3 Immune Checkpoint Protein in Human Cancer


Karine Flem-Karlsen, Oystein Fodstad and Caroline E. Nunes-Xavier*


DOI: 10.2174/0929867326666190517115515
View Abstract View on PubMed


Tear Film, Conjunctival and Corneal Modifications Induced by Glaucoma Treatment


Gloria Roberti*, Lucia Tanga, Gianluca Manni, Ivano Riva, Alice Chandra Verticchio, Francesca Berardo, Carmela Carnevale and Francesco Oddone


DOI: 10.2174/0929867326666190517111823
View Abstract View on PubMed



Reversine: A Synthetic Purine with a Dual Activity as a Cell Dedifferentiating Agent and a Selective Anticancer Drug


Marco Piccoli, Andrea Ghiroldi, Michelle M. Monasky, Federica Cirillo, Giuseppe Ciconte, Carlo Pappone and Luigi Anastasia*


DOI: 10.2174/0929867326666190103120725
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Structure and Function of L,D- and D,D-transpeptidase Family Enzymes from Mycobacterium tuberculosis


Gideon F. Tolufashe, Victor T. Sabe, Colins U. Ibeji, Thandokuhle Ntombela, Thavendran Govender, Glenn E. M. Maguire, Hendrik G. Kruger, Gyanu Lamichhane and Bahareh Honarparvar*


DOI: 10.2174/0929867326666181203150231
View Abstract View on PubMed



Immunoliposomes in Acute Myeloid Leukaemia Therapy. An Overview of Possible Targets and Obstacles


Aditi Singh, Nikolai Norevik Myklebust, Sarah Marie Vie Furevik, Ragnhild Haugse and Lars Herfindal*


DOI: 10.2174/0929867326666190517114450
View Abstract View on PubMed


Quaternized Chitosan Nanoparticles in Vaccine Applications


Shuang Yu , Shengnan Hao, Beini Sun , Dongying Zhao , Xingye Yan and Kai Zhao*


DOI: 10.2174/0929867326666190227192527
View Abstract View on PubMed



Metabolic Reprogramming of Cancer by Chemicals that Target Glutaminase Isoenzymes


José M. Matés*, José A. Campos-Sandoval, Juan de los Santos-Jiménez, Juan A. Segura, Francisco J. Alonso and Javier Márquez


DOI: 10.2174/0929867326666190416165004
View Abstract View on PubMed


Tear Inflammatory Molecules in Contact Lens Wearers: A Literature Review


Alberto López-dela Rosa, María J González-García, Margarita Calonge* and Amalia Enríquez-de-Salamanca


DOI: 10.2174/0929867326666190409152921
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Recent Advances of Chitosan and Its Derivatives in Biomedical Applications


Fei Ding, Jiawei Fu, Chuang Tao, Yanhua Yu, Xianran He, Yangguang Gao and Yongmin Zhang*


DOI: 10.2174/0929867326666190405151538
View Abstract View on PubMed



Therapeutic applications of Peptides Against Zika Virus: A Review


Preeti Karwal, Ishwar Dutt Vats, Niharika Sinha, Anchal Singhal, Teena Sehgal and Pratibha Kumari*


DOI: 10.2174/0929867326666190111115132
View Abstract View on PubMed


Obesity and Body Composition in Man and Woman: Associated Diseases and the New Role of Gut Microbiota


Ennio Avolio*, Paola Gualtieri , Lorenzo Romano, Claudio Pecorella, Simona Ferraro, Laura Di Renzo and Antonino De Lorenzo


DOI: 10.2174/0929867326666190326113607
View Abstract View on PubMed


Novel Vaccine Candidates against Tuberculosis


Zhihao Li, Changping Zheng, Marco Terreni, Lisa Tanzi, Matthieu Sollogoub and Yongmin Zhang*


DOI: 10.2174/0929867326666181126112124
View Abstract View on PubMed





Recent Progress in the Development of Fluorometric Chemosensors to Detect Enzymatic Activity


Tingwen Wei , Fang Wang, Zhijie Zhang , Jiang Qiang, Jing Lv , Tiantian Chen, Jia Li and Xiaoqiang Chen*


DOI: 10.2174/0929867325666180214105552
View Abstract View on PubMed


Mapping of Protein-Protein Interactions: Web-Based Resources for Revealing Interactomes


Branislava Gemovic, Neven Sumonja, Radoslav Davidovic, Vladimir Perovic and Nevena Veljkovic*


DOI: 10.2174/0929867325666180214113704
View Abstract View on PubMed


Therapeutic Targeting of the Soluble Guanylate Cyclase


Garyfallia I Makrynitsa, Aikaterini A Zompra, Aikaterini I Argyriou, Georgios A Spyroulias and Stavros Topouzis*


DOI: 10.2174/0929867326666190108095851
View Abstract View on PubMed


State of the Art on Carbonic Anhydrase Modulators for Biomedical Purposes


Murat Bozdag, Abdulmalik Saleh Alfawaz Altamimi, Daniela Vullo, Claudiu T. Supuran and Fabrizio Carta*


DOI: 10.2174/0929867325666180622120625
View Abstract View on PubMed



Novel Therapeutic Approaches in Rheumatoid Arthritis: Role of Janus Kinases Inhibitors


Felice Rivellese, Antonio Lobasso, Letizia Barbieri, Bianca Liccardo, Amato De Paulis and Francesca Wanda Rossi*


DOI: 10.2174/0929867325666180209145243
View Abstract View on PubMed




Dietary Polyphenols and Mitochondrial Function: Role in Health and Disease


José Teixeira, Daniel Chavarria, Fernanda Borges, Lech Wojtczak, Mariusz R. Wieckowsk, Anieszka Karkucińska-Wieckowska and Paulo J. Oliveira*


DOI: 10.2174/0929867324666170529101810
View Abstract View on PubMed


Neurodegenerative Process Linking the Eye and the Brain


Raffaele Mancino, Massimo Cesareo, Alessio Martucci, Emiliano Di Carlo, Elena Ciuffoletti, Luigi Antonio Morrone, Carlo Nucci*, Clarissa Giannini and Francesco Garaci


DOI: 10.2174/0929867325666180307114332
View Abstract View on PubMed


Neuropharmacological Properties of the Essential Oil of Bergamot for the Clinical Management of Pain-Related BPSDs


Damiana Scuteri, Laura Rombola, Laura Tridico, Hirokazu Mizoguchi, Chizuko Watanabe, Tsukasa Sakurada, Shinobu Sakurada, Maria TIziana Corasaniti, Giacinto Bagetta and Luigi Antonio Morrone*


DOI: 10.2174/0929867325666180307115546
View Abstract View on PubMed


New Drugs, Therapeutic Strategies, and Future Direction for the Treatment of Pulmonary Arterial Hypertension


Valentina Mercurio*, Anna Bianco, Giacomo Campi, Alessandra Cuomo, Nermin Diab, Angela Mancini, Paolo Parrella, Mario Petretta, Paul Hassoun and Domenico Bonaduce


DOI: 10.2174/0929867325666180201095743
View Abstract View on PubMed


Fine-tuning of microRNAs in Type 2 Diabetes Mellitus


Juan A. Rosado, Raquel Diez-Bello, Gines Maria Salido and I. Jardin*


DOI: 10.2174/0929867325666171205163944
View Abstract View on PubMed









ADAM Metalloproteinases as Potential Drug Targets


Caterina Camodeca, Doretta Cuffaro, Elisa Nuti* and Armando Rossello


DOI: 10.2174/0929867325666180326164104
View Abstract View on PubMed





Impact of Diabetes on Cardiac and Vascular Disease: Role of Calcium Signaling


Tarik Smani*, Isabel Gallardo-Castillo, Javier Ávila-Médina, Manuel F. Jimenez-Navarro, Antonio Ordoñez and Abdelkrim Hmadcha


DOI: 10.2174/0929867324666170523140925
View Abstract View on PubMed





Privileged Structures in the Design of Potential Drug Candidates for Neglected Diseases


Ana Cristina Lima Leite*, José Wanderlan Pontes Espíndola, Marcos Veríssimo de Oliveira Cardoso and Gevanio Bezerra de Oliveira Filho


DOI: 10.2174/0929867324666171023163752
View Abstract View on PubMed


New Molecular Targets and Strategies for Antimalarial Discovery


Anna Caroline Aguiar, Lorena R. F. de Sousa, Celia R. S. Garcia, Glaucius Oliva and Rafael V. C. Guido*


DOI: 10.2174/0929867324666170830103003
View Abstract View on PubMed



Structure-based Approaches Targeting Parasite Cysteine Proteases


Rafael Pinto Vieira, Viviane Corrêa Santos and Rafaela Salgado Ferreira*


DOI: 10.2174/0929867324666170810165302
View Abstract View on PubMed





Potential Triazole-based Molecules for the Treatment of Neglected Diseases


Susimaire Pedersoli Mantoani, Peterson de Andrade, Talita Perez Cantuaria Chierrito, Andreza Silva Figueredo and Ivone Carvalho*


DOI: 10.2174/0929867324666170727103901
View Abstract View on PubMed




Unfolding Cardiac Amyloidosis –From Pathophysiology to Cure


Klemens Ablasser, Nicolas Verheyen, Theresa Glantschnig, Giulio Agnetti and Peter P Rainer*


DOI: 10.2174/0929867325666180104153338
View Abstract View on PubMed


The Design of New HIV-IN Tethered Bifunctional Inhibitors Using Multiple Microdomain Targeted Docking


Mihai Ciubotaru*, Mihaela Georgiana Musat, Marius Surleac, Elena Ionita , Andrei Jose Petrescu, Edgars Abele and Ramona Abele


DOI: 10.2174/0929867325666180406114405
View Abstract View on PubMed



Epigenetic Metalloenzymes


Christophe Blanquart, Camille Linot, Pierre-Francois Cartron, Daniela Tomaselli, Antonello Mai and Philippe Bertrand*


DOI: 10.2174/0929867325666180706105903
View Abstract View on PubMed



Cyclooxygenase-2 Inhibitors as a Therapeutic Target in Inflammatory Diseases


Miguel D. Ferrer, Carla Busquests-Cortes, Xavier Capo, Silvia Tejada, Josep A. Tur, Antoni Pons and Antoni Sureda*


DOI: 10.2174/0929867325666180514112124
View Abstract View on PubMed


In Silico Chemogenomics Drug Repositioning Strategies for Neglected Tropical Diseases


Carolina Horta Andrade*, Bruno Junior Neves, Cleber Camilo Melo-Filho, Juliana Rodrigues, Diego Cabral Silva, Rodolpho Campos Braga and Pedro Vitor Lemos Cravo


DOI: 10.2174/0929867325666180309114824
View Abstract View on PubMed


Can Antidiabetic Drugs Improve Male Reproductive (Dys)Function Associated with Diabetes?


Renata Santos Tavares, Sara Escada-Rebelo, Maria Ines Sousa, Andreia Silva, Joao Ramalho-Santos and Sandra Amaral*


DOI: 10.2174/0929867325666181101111404
View Abstract View on PubMed



New Insights into Adipokines as Potential Biomarkers for Type-2 Diabetes Mellitus


Marta Olivera-Santa Catalina, Pedro C. Redondo, Carlos Cantonero , Maria P. Granados, Jose Sanchez-Collado, Letizia Albarran and Jose Javier Lopez*


DOI: 10.2174/0929867325666171205162248
View Abstract View on PubMed


A Walk in Nature. Sesquiterpene Lactones as Multi-Target Agents Involved in Inflammatory Pathways


Adriana Coricello, James David Adams*, Eric Lien, Christopher Nguyen, Filomena Perri, Travis J. Williams and Francesca Aiello


DOI: 10.2174/0929867325666180719111123
View Abstract View on PubMed


Targeting n-3 Polyunsaturated Fatty Acids in Non-alcoholic Fatty Liver Disease


Rodrigo Valenzuela*, Macarena Ortiz, María Catalina Hernández-Rodas, Francisca Echeverría and Luis A. Videla


DOI: 10.2174/0929867326666190410121716
View Abstract View on PubMed



Mechanistic Insights of Chemicals and Drugs as Risk Factors for Systemic Lupus Erythematosus


Qingjun Pan*, Yun Guo*, Linjie Guo*, Shuzhen Liao, Chunfei Zhao, Sijie Wang and Hua-feng Liu


DOI: 10.2174/0929867326666190404140658
View Abstract View on PubMed



Management of Peripheral Neuropathy Induced by Chemotherapy


Maayan Fradkin*, Ron Batash*, Shiran Elmaleh*, Ronen Debi , Pamela Schaffer , Moshe Schaffer and Noam Asna


DOI: 10.2174/0929867326666190107163756
View Abstract View on PubMed




From Recognition to Reaction Mechanism: An Overview on the Interactions between HIV-1 Protease and its Natural Targets


Monsurat M. Lawal, Zainab K. Sanusi, Thavendran Govender, Glenn E. M. Maguire, Bahareh Honarparvar and Hendrik G. Kruger*


DOI: 10.2174/0929867325666181113122900
View Abstract View on PubMed


Structural Basis of Drug Recognition by Human Serum Albumin


Loris Leboffe, Alessandra di Masi*, Fabio Polticelli, Viviana Trezza and Paolo Ascenzi


DOI: 10.2174/0929867326666190320105316
View Abstract View on PubMed



Anesthetic-induced Myocardial Conditioning: Molecular Fundamentals and Scope


Jose Luis Guerrero Orriach*, Juan Jose Escalona Belmonte , Marta Ramirez-Aliaga, Alicia Ramirez-Fernandez , Aida Raigon-Ponferrada , Manuel Rubio-Navarro and Jose Cruz-Manas


DOI: 10.2174/0929867325666180926161427
View Abstract View on PubMed


Targeting the Ribosome Biogenesis Key Molecule Fibrillarin to Avoid Chemoresistance


Btissame El Hassouni, Dzjemma Sarkisjan, J. Chris Vos, Elisa Giovannetti and Godefridus J Peters*


DOI: 10.2174/0929867326666181203133332
View Abstract View on PubMed



Therapeutic Prospects in Preeclampsia – A Mini-Review


Nidhi Sharon Das, Shaikali Thameem Dheen, Eng-Ang Ling, Boon Huat Bay and Dinesh Kumar Srinivasan*


DOI: 10.2174/0929867326666190228115423
View Abstract View on PubMed


B7-H3-targeted Radioimmunotherapy of Human Cancer


Benjamin B. Kasten, Soldano Ferrone, Kurt R. Zinn and Donald J. Buchsbaum*


DOI: 10.2174/0929867326666190228120908
View Abstract View on PubMed





Metabolomic Biomarkers in Gynecology: A Treasure Path or a False Path?


Igor Govorov , Stanislav Sitkin , Tatyana Pervunina , Alexey Moskvin , Denis Baranenko and Eduard Komlichenko


DOI: 10.2174/0929867326666190104124245
View Abstract View on PubMed




Onion-Like Carbon Nanostructures: An Overview of Bio-Applications


Diana M. Bobrowska, Piotr Olejnika, Luis Echegoyen and Marta E. Plonska-Brzezinska*


DOI: 10.2174/0929867325666181101105535
View Abstract View on PubMed





Obesity Therapy: How and Why?


S. Paccosi, B. Cresci, L. Pala, C. M. Rotella and A. Parenti*


DOI: 10.2174/0929867326666190124121725
View Abstract View on PubMed


Exosome-like Nanoparticles: A New Type of Nanocarrier


Mário Fernandes, Ivo Lopes, José Teixeira, Cláudia Botelho and Andreia C. Gomes*


DOI: 10.2174/0929867326666190129142604
View Abstract View on PubMed



Inhibitors of ER Aminopeptidase 1 and 2: From Design to Clinical Application


Dimitris Georgiadis, Anastasia Mpakali, Despoina Koumantou and Efstratios Stratikos*


DOI: 10.2174/0929867325666180214111849
View Abstract View on PubMed




The Glycogen Synthase Kinase-3 in the Regulation of Ion Channels and Cellular Carriers


Mentor Sopjani, Lulzim Millaku, Dashnor Nebija, Merita Emini, Arleta Rifati-Nixha and Miribane Dermaku-Sopjani*


DOI: 10.2174/0929867325666181009122452
View Abstract View on PubMed


Oxidative Status in Multiple Sclerosis and Off-Targets of Antioxidants: The Case of Edaravone


Cristina Agresti, Rosella Mechelli, Stefania Olla, Caterina Veroni, Cecilia Eleuteri, Giovanni Ristori and Marco Salvetti*


DOI: 10.2174/0929867326666190124122752
View Abstract View on PubMed


Editorial: Novel Therapeutic Strategies for the Treatment of Chronic Diseases


Gianluca Testa, Fabiana Passaro, Aldo Cinquegrana, Melania Palma, Pasquale Abete and Carlo Gabriele Tocchetti*


DOI: 10.2174/0929867325666190128121918



Endothelium as a Therapeutic Target in Diabetes Mellitus: From Basic Mechanisms to Clinical Practice


Anastasios Tentolouris, Ioanna Eleftheriadou, Evangelia Tzeravini, Dimitrios Tsilingiris, Stavroula A. Paschou, Gerasimos Siasos and Nikolaos Tentolouris*


DOI: 10.2174/0929867326666190119154152
View Abstract View on PubMed






Ionic Liquids for Topical Delivery in Cancer


Ana Rita Dias, João Costa-Rodrigues, Cátia Teixeira, Paula Gomes, Cristina Prudêncio* and Ricardo Ferraz


DOI: 10.2174/0929867325666181026110227
View Abstract View on PubMed



Autophagy Modulators and Neuroinflammation


Kyoung Sang Cho, Jang Ho Lee, Jeiwon Cho, Guang-Ho Cha* and Gyun Jee Song*


DOI: 10.2174/0929867325666181031144605
View Abstract View on PubMed











Graphene and Graphene Oxide Applications for SERS Sensing and Imaging


Anna Jablonska, Alekdandra Jaworska, Mateusz Kasztelan , Sylwia Berbec and Barbara Palys *


DOI: 10.2174/0929867325666181004152247
View Abstract View on PubMed




The Role of Mitochondria in Systemic Lupus Erythematosus: A Glimpse of Various Pathogenetic Mechanisms


Shi-kun Yang, Hao-ran Zhang, Shu-peng Shi, Ying-qiu Zhu, Na Song, Qing Dai, Wei Zhang, Ming Gui and Hao Zhang*


DOI: 10.2174/0929867326666181126165139
View Abstract View on PubMed



Nanocarriers: A Successful Tool to Increase Solubility, Stability and Optimise Bioefficacy of Natural Constituents


Anna Rita Bilia*, Vieri Piazzini, Laura Risaliti, Giulia Vanti, Marta Casamonti, Meng Wang and Maria Camilla Bergonzi


DOI: 10.2174/0929867325666181101110050
View Abstract View on PubMed



Development of Health Products from Natural Sources


Francesca Sansone, Teresa Mencherini, Patrizia Picerno, Maria Rosaria Lauro, Michele Cerrato and Rita Patrizia Aquino*


DOI: 10.2174/0929867325666180926152139
View Abstract View on PubMed






Recent Advances and Challenges of the Drugs Acting on Monoamine Transporters


Weiwei Xue*, Tingting Fu, Guoxun Zheng, Gao Tu, Yang Zhang, Fengyuan Yang, Lin Tao, Lixia Yao and Feng Zhu*


DOI: 10.2174/0929867325666181009123218
View Abstract View on PubMed



An Update on the Neurochemistry of Essential Tremor


Félix Javier Jiménez-Jiménez *, Hortensia Alonso-Navarro, Elena García-Martín and José A.G. Agúndez


DOI: 10.2174/0929867325666181112094330
View Abstract View on PubMed





Sam Domains in Multiple Diseases


Marian Vincenzi, Flavia Anna Mercurio and Marilisa Leone*


DOI: 10.2174/0929867325666181009114445
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Stimuli-responsive Drug Delivery Nanocarriers in the Treatment of Breast Cancer


Joao A. Oshiro-Junior , Renata Carolina Alves, Gilmar Hanck-Silva , Mariana R. Sato, Camila Rodero, Josimar O. Eloy* and Marlus Chorilli*


DOI: 10.2174/0929867325666181009120610
View Abstract View on PubMed


Pyridine and Pyrimidine Derivatives as Privileged Scaffolds in Biologically Active Agents


Maria Assunta Chiacchio , Daniela Iannazzo , Roberto Romeo, Salvatore V. Giofrè and Laura Legnani*


DOI: 10.2174/0929867325666180904125400
View Abstract View on PubMed





Manipulation of the Immune System for Cancer Defeat: A Focus on the T Cell Inhibitory Checkpoint Molecules


Paolo D’Arrigo, Martina Tufano, Anna Rea, Vincenza Vigorito, Nunzia Novizio, Salvatore Russo, Maria Fiammetta Romano and Simona Romano*


DOI: 10.2174/0929867325666181106114421
View Abstract View on PubMed


Development of Pin1 Inhibitors and their Potential as Therapeutic Agents


Yusuke Nakatsu, Yasuka Matsunaga, Koji Ueda, Takeshi Yamamotoya, Yuki Inoue, Masa-ki Inoue, Yu Mizuno, Akifumi Kushiyama, Hiraku Ono, Midori Fujishiro, Hisanaka Ito, Takayoshi Okabe and Tomoichiro Asano*


DOI: 10.2174/0929867325666181105120911
View Abstract View on PubMed


Therapeutic Approaches for the Management of Sleep Disorders in Geriatric Population


Mireille Salas-Crisostomo, Pablo Torterolo , André Barciela Veras, Nuno Barbosa Rocha, Sérgio Machado and Eric Murillo-Rodríguez§*


DOI: 10.2174/0929867325666180904113115
View Abstract View on PubMed




Aptamer-Based Targeted Drug Delivery Systems: Current Potential and Challenges


Fen He, Nachuan Wen, Daipeng Xiao, Jianhua Yan, Hongjie Xiong, Shundong Cai, Zhenbao Liu* and Yanfei Liu*


DOI: 10.2174/0929867325666181008142831
View Abstract View on PubMed


Antimicrobial Capacity of Plant Polyphenols against Gram-positive Bacteria: A Comprehensive Review


Francisco Javier Alvarez-Martinez, Enrique Barrajon-Catalan*, Jose Antonio Encinar, Juan Carlos Rodriguez-Diaz and Vicente Micol


DOI: 10.2174/0929867325666181008115650
View Abstract View on PubMed


An Overview of Antiretroviral Agents for Treating HIV Infection in Paediatric Population


Rita Melo, Agostinho Lemos, António J. Preto, Beatriz Bueschell, Pedro Matos-Filipe, Carlos Barreto, José G. Almeida, Rúben D.M. Silva, João D. G. Correia and Irina Moreira*


DOI: 10.2174/0929867325666180904123549
View Abstract View on PubMed


The Close Interplay of Nitro-Oxidative Stress, Advanced Glycation end Products and Inflammation in Inflammatory Bowel Diseases


Fabiana Andrea Moura, Marília Oliveira Fonseca Goulart*, Amylly Sanuelly da Paz Martins and Samara Bonfim Gomes Campos


DOI: 10.2174/0929867325666180904115633
View Abstract View on PubMed





Metabolomics of Exhaled Breath Condensate by Nuclear Magnetic Resonance Spectroscopy and Mass Spectrometry: A Methodological Approach


Mauro Maniscalco*, Adele Cutignano, Debora Paris, Dominique J. Melck, Antonio Molino, Salvatore Fuschillo and Andrea Motta*


DOI: 10.2174/0929867325666181008122749
View Abstract View on PubMed





Hydrogel-clay Nanocomposites as Carriers for Controlled Release


Raluca Ianchis, Claudia Ninciuleanu*, Ioana Catalina Gifu, Elvira Alexandrescu, Cristina Lavinia Nistor, Sabina Georgiana Nitu and Cristian Petcu


DOI: 10.2174/0929867325666180831151055
View Abstract View on PubMed


Recent Progress in Histone Deacetylase Inhibitors as Anticancer Agents


Loredana Cappellacci*, Diego R. Perinelli, Filippo Maggi, Mario Grifantini and Riccardo Petrelli*


DOI: 10.2174/0929867325666181016163110
View Abstract View on PubMed


Phenylboronic Acid-polymers for Biomedical Applications


Ji Hyun Ryu, Gyeong Jin Lee, Yu-Ru V Shih, Tae-il Kim* and Shyni Varghese*


DOI: 10.2174/0929867325666181008144436
View Abstract View on PubMed





The Current Status and Perspectives of Delivery Strategy for Boronbased Drugs


Zhu Yinghuai*, Xinglong Lin, Hongming Xie, Jianlin Li, Narayan S. Hosmane and Yingjun Zhang


DOI: 10.2174/0929867325666180904105212
View Abstract View on PubMed




Advances in Docking


Vladimir B Sulimov*, Danil C Kutov and Alexey V Sulimov


DOI: 10.2174/0929867325666180904115000
View Abstract View on PubMed


Exosome-like Nanovectors for Drug Delivery in Cancer


Noemi Arrighetti, Claudia Corbo, Michael Evangelopoulos, Anna Pasto, Valentina Zuco and Ennio Tasciotti*


DOI: 10.2174/0929867325666180831150259
View Abstract View on PubMed




Lithium – Pharmacological and Toxicological Aspects: The Current State of the Art


Branislava Medić*, Marko Stojanović, Bojan Štimec, Nevena Divac, Katarina Savić Vujović, Radan Stojanović, Mirjana Čolović, Danijela Z. Krstić and Milica Prostran


DOI: 10.2174/0929867325666180904124733
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Migraine: Genetic Variants and Clinical Phenotypes


Innocenzo Rainero*, Alessandro Vacca, Flora Govone, Annalisa Gai, Lorenzo Pinessi and Elisa Rubino


DOI: 10.2174/0929867325666180719120215
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The Healing Effects of Spices in Chronic Diseases


Danka Bukvicki*, Davide Gottardi, Sahdeo Prasad, Miroslav Novakovic, Petar Marin and Amit Kumar Tyagi


DOI: 10.2174/0929867325666180831145800
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Circulating Biomarkers for Tumor Angiogenesis: Where Are We?


Virginia Di Paolo, Marta Colletti, Valentina Ferruzzi, Ida Russo, Angela Galardi, Iside Alessi , Giuseppe Maria Milano and Angela Di Giannatale*


DOI: 10.2174/0929867325666180821151409
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Xanthine Derivatives as Agents Affecting Non-dopaminergic Neuroprotection in Parkinson`s Disease


Alexandra Kasabova-Angelova, Diana Tzankova, Javor Mitkov, Maya Georgieva, Virginia Tzankova, Alexander Zlatkov and Magdalena Kondeva-Burdina*


DOI: 10.2174/0929867325666180821153316
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Silver Nanomaterials in Contemporary Molecular Physiology Research


Igor Pantic*, David Sarenac, Mila Cetkovic, Milan Milisavljevic, Rastko Rakocevic and Sandor Kasas


DOI: 10.2174/0929867325666180719110432
View Abstract View on PubMed







The Role of Adipokines in the Establishment and Progression of Head and Neck Neoplasms


Theodora Tzanavari, Jason Tasoulas*, Chrysoula Vakaki , Chrysovalantou Mihailidou , Gerasimos Tsourouflis and Stamatios Theocharis


DOI: 10.2174/0929867325666180713154505
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Antimicrobial Peptides: Amphibian Host Defense Peptides


Jiri Patocka, Eugenie Nepovimova , Blanka Klimova, Qinghua Wu and Kamil Kuca*


DOI: 10.2174/0929867325666180713125314
View Abstract View on PubMed



Quercetin and its Natural Sources in Wound Healing Management


Nicoletta Polera , Mariateresa Badolato , Filomena Perri , Gabriele Carullo and Francesca Aiello*


DOI: 10.2174/0929867325666180713150626
View Abstract View on PubMed




Latest Updates in Dengue Fever Therapeutics: Natural, Marine and Synthetic Drugs


Samira Hosseini*, Rodrigo B. Munoz-Soto, Jacqueline Oliva-Ramirez, Patricia Vazquez-Villegas, Nasrin Aghamohammadi, Aida Rodriguez-Garcia and Sergio O. Martinez-Chapa


DOI: 10.2174/0929867325666180629124709
View Abstract View on PubMed



Synthetic Peptide Libraries. From Random Mixtures to In Vivo Testing


Annamaria Sandomenico, Andrea Caporale, Nunzianna Doti, Simon Cross, Gabriele Cruciani, Angela Chambery, Sandro De Falco and Menotti Ruvo*


DOI: 10.2174/0929867325666180716110833
View Abstract View on PubMed


Cancer-associated Cachexia, Reactive Oxygen Species, and Nutrition Therapy


Geir Bjorklund*, Maryam Dadar , Jan Aaseth , Salvatore Chirumbolo and Joeri J. Pen


DOI: 10.2174/0929867325666180629123817
View Abstract View on PubMed


Impact of Natural Dietary Agents on Multiple Myeloma Prevention and Treatment: Molecular Insights and Potential for Clinical Translation


Lavinia Raimondi, Angela De Luca, Gianluca Giavaresi, Agnese Barone, Pierosandro Tagliaferri, Pierfrancesco Tassone and Nicola Amodio*


DOI: 10.2174/0929867325666180629153141
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Dual Inhibitors as a New Challenge for Cancer Multidrug Resistance Treatment


Tijana Stankovic, Jelena Dinic, Ana Podolski-Renic, Loana Musso, Sonja Stojkovic Buric, Sabrina Dallavalle* and Milica Pesic


DOI: 10.2174/0929867325666180607094856
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Porous Inorganic and Hybrid Systems for Drug Delivery: Future Promise in Combatting Drug Resistance and Translation to Botanical Applications


Junling Guo, Bruno D. Mattos, Blaise L. Tardy, Vanessa M. Moody, Gao Xiao, Hirotaka Ejima, Jiwei Cui, Kang Liang and Joseph Jacob Richardson*


DOI: 10.2174/0929867325666180706111909
View Abstract View on PubMed



The Mechanisms Behind the Biological Activity of Flavonoids


Ana M. Gonzalez-Paramas, Begona Ayuda-Duran, Sofia Martinez, Susana Gonzalez-Manzano and Celestino Santos-Buelga*


DOI: 10.2174/0929867325666180706104829
View Abstract View on PubMed





Advances in the Tyrosinase Inhibitors from Plant Source


Marco Bonesi, Jianbo Xiao, Rosa Tundis*, Francesca Aiello, Vincenzo Sicari and Monica R. Loizzo


DOI: 10.2174/0929867325666180522091311
View Abstract View on PubMed


The Role of Matrix Gla Protein (MGP) in Vascular Calcification


Geir Bjorklund*, Erik Svanberg, Maryam Dadar, David J. Card, Salvatore Chirumbolo, Dominic J. Harrington and Jan Aaseth


DOI: 10.2174/0929867325666180716104159
View Abstract View on PubMed



Promising Alternative Therapeutics for Oral Candidiasis


Celia Fortuna Rodrigues, Maria Elisa Rodrigues and Mariana Contente Rangel Henriques*


DOI: 10.2174/0929867325666180601102333
View Abstract View on PubMed



Sitosterolemia: Diagnosis, Metabolic and Hematological Abnormalities, Cardiovascular Disease and Management


Jose Maria Bastida*, Maria Luisa Giros, Rocio Benito, Kamila Janusz, Jesus Maria Hernandez-Rivas and Jose Ramon Gonzalez-Porras


DOI: 10.2174/0929867325666180705145900
View Abstract View on PubMed






Phytosterols and Inflammation


Gemma Vilahur, Soumaya Ben-Aicha, Elisa Diaz, Lina Badimon and Teresa Padro*


DOI: 10.2174/0929867325666180622151438
View Abstract View on PubMed








The Role of Diet-Related Short-Chain Fatty Acids in Colorectal Cancer Metabolism and Survival: Prevention and Therapeutic Implications


Sara Daniela Gomes, Claudia Suellen Oliveira, Joao Azevedo-Silva, Marta Casanova, Judite Barreto, Helena Pereira, Susana Chaves, Ligia Rodrigues, Margarida Casal, Manuela Corte-Real, Fatima Baltazar and Ana Preto*


DOI: 10.2174/0929867325666180530102050
View Abstract View on PubMed


Circulating Biomarkers in Migraine. New Opportunities for Precision Medicine


Patrizia Ferroni*, Piero Barbanti, Antonella Spila, Federica Fratangeli, Cinzia Aurilia, Luisa Fofi, Gabriella Egeo and Fiorella Guadagni


DOI: 10.2174/0929867325666180622122938
View Abstract View on PubMed




DNA Topoisomerases of Leishmania Parasites; Druggable Targets for Drug Discovery


Rosa M Reguera, Ehab Kotb Elmahallawy, Carlos Garcia-Estrada, Ruben Carbajo-Andres and Rafael Balana-Fouce *


DOI: 10.2174/0929867325666180518074959
View Abstract View on PubMed


A Systematic Review on Donepezil-based Derivatives as Potential Cholinesterase Inhibitors for Alzheimer’s Disease


Jan Korabecny , Katarina Spilovska, Eva Mezeiova , Ondrej Benek , Radomir Juza , Daniel Kaping and Ondrej Soukup*


DOI: 10.2174/0929867325666180517094023
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Genetically Engineered Elastin-based Biomaterials for Biomedical Applications


Mercedes Santos , Sofia Serrano-Ducar , Juan Gonzalez-Valdivieso , Reinaldo Vallejo, Alessandra Girotti , Purificacion Cuadrado and Francisco Javier Arias*


DOI: 10.2174/0929867325666180508094637
View Abstract View on PubMed







Natural Alkaloids Intervening the Insulin Pathway: New Hopes for Anti-Diabetic Agents?


Maria-Ioanna Christodoulou*, Job Tchoumtchoua , Alexios-Leandros Skaltsounis , Andreas Scorilas and Maria Halabalaki


DOI: 10.2174/0929867325666180430152618
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Gene Silencing Strategies in Cancer Therapy: An Update for Drug Resistance


Sanaz Naghizadeh, Behzad Mansoori, Ali Mohammadi, Ebrahim Sakhinia and Behzad Baradaran*


DOI: 10.2174/0929867325666180403141554
View Abstract View on PubMed



Research Progress on Brucellosis


Yuming Deng, Xinyue Liu, Kaifang Duan and Qisheng Peng*


DOI: 10.2174/0929867325666180510125009
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Zinc Dependent Histone Deacetylase Inhibitors in Cancer Therapeutics: Recent Update


Faria Sultana, Kesari Lakshmi Manasa, Siddiq Pasha Shaik, Srinivasa Reddy Bonam and Ahmed Kamal*


DOI: 10.2174/0929867325666180530094120
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The LDL-Receptor and its Molecular Properties: From Theory to Novel Biochemical and Pharmacological Approaches in Reducing LDL-cholesterol


Dimitrios Petroglou, Ilias Kanellos, Christos Savopoulos , Georgia Kaiafa*, Anastasios Chrysochoou , Panagiotis Skantzis , Stylianos Daios , Apostolos I. Hatzitolios and Georgios Giannoglou


DOI: 10.2174/0929867325666180604114819
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SGLT-2 inhibitors in Diabetic Kidney Disease: What Lies Behind their Renoprotective Properties?


Panagiotis I. Georgianos , Maria Divani , Theodoros Eleftheriadis, Peter R. Mertens and Vassilios Liakopoulos*


DOI: 10.2174/0929867325666180524114033
View Abstract View on PubMed


Recent Advances on Glioblastoma Multiforme and Nano-drug Carriers: A Review


Wang Liao, Shengnuo Fan, Yuqiu Zheng, Shaowei Liao , Ying Xiong, Yi Li and Jun Liu *


DOI: 10.2174/0929867325666180514113136
View Abstract View on PubMed


The Therapeutic Impact of New Migraine Discoveries


Laszlo Vecsei*, Melinda Lukacs, Janos Tajti, Ferenc Fulop, Jozsef Toldi and Lars Edvinsson


DOI: 10.2174/0929867325666180530114534
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Neoadjuvant Therapy is Essential for Resectable Pancreatic Cancer


Jin-Zhi Xu, Wen-Quan Wang, Shi-Rong Zhang, Hua-Xiang Xu, Chun-Tao Wu, Zi-Hao Qi, He-Li Gao, Shuo Li, Quan-Xing Ni, Xian-Jun Yu and Liang Liu*


DOI: 10.2174/0929867325666180413101722
View Abstract View on PubMed


Polypharmacology in the Treatment of Chagas Disease


Elena Aguilera, Guzman Alvarez, Hugo Cerecetto and Mercedes Gonzalez *


DOI: 10.2174/0929867325666180410101728
View Abstract View on PubMed


Diverse Targeted Approaches to Battle Multidrug Resistance in Cancer


Nagula Shankaraiah*, Shalini Nekkanti , Ojaswitha Ommi and P. S. Soukya Lakshmi


DOI: 10.2174/0929867325666180410110729
View Abstract View on PubMed



Targeting AMPK in Diabetes and Diabetic Complications: Energy Homeostasis, Autophagy and Mitochondrial Health


Y. V. Madhavi , Nikhil Gaikwad , Veera Ganesh Yerra , Anil Kumar Kalvala , Srinivas Nanduri and Ashutosh Kumar*


DOI: 10.2174/0929867325666180406120051
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Pigments from Filamentous Ascomycetes for Combination Therapy


Robert Hromadka, Zdenek Kejík , Milan Jakubek, Robert Kaplanek, Viera Sandrikova , Marian Urban , Pavel Martasek and Vladimir Kral*


DOI: 10.2174/0929867325666180330091933
View Abstract View on PubMed



Flavonoids and Platelet-Derived Thrombotic Disorders


Jose J Lopez, Mohammed El haouari, Isaac Jardin, Nieves Alonso, Sergio Regodon, Raquel Diez Bello, Pedro Cosme Redondo and Juan A Rosado*


DOI: 10.2174/0929867325666180417170218
View Abstract View on PubMed







Potential Roles for G-Quadruplexes in Mitochondria


Micol Falabella, Rafael J. Fernandez, Brad Johnson and Brett A. Kaufman*


DOI: 10.2174/0929867325666180228165527
View Abstract View on PubMed



Homocysteine and Hyperhomocysteinaemia


Bozidarka L. Zaric, Milan Obradovic, Vladan Bajic , Mohamed A. Haidara , Milos Jovanovic and Esma R. Isenovic*


DOI: 10.2174/0929867325666180313105949
View Abstract View on PubMed


Acyclovir in the Treatment of Herpes Viruses – A Review


Katarzyna Klysik, Aneta Pietraszek, Anna Karewicz and Maria Nowakowska*


DOI: 10.2174/0929867325666180309105519
View Abstract View on PubMed


Current Trends and Future Directions of Fluoroquinolones


Hamada H. H. Mohammed , Gamal El-Din A.A. Abuo-Rahma*, Samar H. Abbas and El-Shimaa M. N. Abdelhafez


DOI: 10.2174/0929867325666180214122944
View Abstract View on PubMed


Metal–Organic Framework (MOF)-based Nanomaterials for Biomedical Applications


Zhidong Luo , Shuran Fan , Chuying Gu , Weicong Liu , Baohong Li and Jianqiang Liu*


DOI: 10.2174/0929867325666180214123500
View Abstract View on PubMed



Ganglioside GM3 and Its Role in Cancer


Changping Zheng , Marco Terreni , Matthieu Sollogoub and Yongmin Zhang*


DOI: 10.2174/0929867325666180129100619
View Abstract View on PubMed


The Role of Selenium in Oxidative Stress and in Nonthyroidal Illness Syndrome (NTIS): An Overview


Andrea Silvestrini*, Alvaro Mordente, Giuseppe Martino, Carmine Bruno, Edoardo Vergani, Elisabetta Meucci and Antonio Mancini


DOI: 10.2174/0929867325666180201111159
View Abstract View on PubMed



Surfing the Blood Coagulation Cascade: Insight into the Vital Factor Xa


Nicolas E. Nunez-Navarro, Fabian M. Santana, Loreto P. Parra and Flavia C. Zacconi*


DOI: 10.2174/0929867325666180125165340
View Abstract View on PubMed


Looking for New Antifungal Drugs from Flavonoids: Impact of the Genetic Diversity of Candida albicans on the in-vitro Response


Maria Rosa Felice, Letterio Giuffre, Lamya El Aamri, Majida Hafidi, Giuseppe Criseo, Orazio Romeo* and Fabio Scordino


DOI: 10.2174/0929867325666171226102700
View Abstract View on PubMed


Recent Advances in Peptide-Based Approaches for Cancer Treatment


Anne C. Conibear, Alanca Schmid, Meder Kamalov, Christian F.W. Becker and Claudia Bello*


DOI: 10.2174/0929867325666171123204851
View Abstract View on PubMed



Novel Biological Therapies in Severe Asthma: Targeting the Right Trait


Gilda Varricchi*, Giancarlo Marone, Giuseppe Spadaro, Michele Russo, Francescopaolo Granata, Arturo Genovese and Gianni Marone


DOI: 10.2174/0929867325666180110094542
View Abstract View on PubMed



Use of Antibiotic Loaded Biomaterials for the Management of Bone Prosthesis Infections: Rationale and Limits


Matilde Tschon, Maria Sartori*, Deyanira Contartese, Gianluca Giavaresi, Nicolo Nicoli Aldini and Milena Fini


DOI: 10.2174/0929867325666171129220031
View Abstract View on PubMed





Rutin as Neuroprotective Agent: From Bench to Bedside


Barbara Budzynska, Caterina Faggio, Marta Kruk-Slomka, Dunja Samec, Seyed Fazel Nabavi, Antoni Sureda, Kasi Pandima Devi and Seyed Mohammad Nabavi*


DOI: 10.2174/0929867324666171003114154
View Abstract View on PubMed




Effects of Isolated Isoflavones Intake on Health


Antonella Smeriglio*, Antonella Calderaro, Marcella Denaro, Giuseppina Laganà and Ersilia Bellocco


DOI: 10.2174/0929867324666171006143047
View Abstract View on PubMed


The Role of Dietary Approach in Irritable Bowel Syndrome


Piero Portincasa*, Antony Lembo, Ornella De Bari, Domenica M. Di Palo, Anna Maggio, Ilaria Cataldo and Giuseppe Calamita


DOI: 10.2174/0929867324666170428102451
View Abstract View on PubMed


Effects of Diets on Adipose Tissue


Silvia Ezquerro, Amaia Rodríguez, Piero Portincasa and Gema Frühbeck*


DOI: 10.2174/0929867324666170518102340
View Abstract View on PubMed



Targeting CXCL12/CXCR4 Axis in Tumor Immunotherapy


Weiqiang Zhou, Shanchun Guo, Mingli Liu, Matthew E. Burow and Guangdi Wang*


DOI: 10.2174/0929867324666170830111531
View Abstract View on PubMed



The Role of Diet in Patients with Metabolic Syndrome


Paloma Almeda-Valdes, Roberto J. Herrera-Mercadillo, Carlos A. Aguilar-Salinas, Misael Uribe and Nahum Méndez-Sánchez*


DOI: 10.2174/0929867324666170518095316
View Abstract View on PubMed



Modulation of Aquaporins by Dietary Patterns and Plant Bioactive Compounds


Ilaria Cataldo, Anna Maggio , Patrizia Gena, Ornella de bari, Grazia Tamma , Piero Portincasa and Giuseppe Calamita*


DOI: 10.2174/0929867324666170523123010
View Abstract View on PubMed



Impact of Red Wine Consumption on Cardiovascular Health


Luca Liberale, Aldo Bonaventura, Fabrizio Montecucco*, Franco Dallegri and Federico Carbone


DOI: 10.2174/0929867324666170518100606
View Abstract View on PubMed



The Role of Diet in the Pathogenesis of Cholesterol Gallstones


Agostino Di Ciaula, Gabriella Garruti, Gema Frühbeck, Maria De Angelis, Ornella De Bari, David Q.-H. Wang, Frank Lammert and Piero Portincasa*


DOI: 10.2174/0929867324666170530080636
View Abstract View on PubMed


Food and Gastroesophageal Reflux Disease


Teodora Surdea-Blaga, Dana E. Negrutiu, Mariana Palage and Dan L. Dumitrascu*


DOI: 10.2174/0929867324666170515123807
View Abstract View on PubMed


Diet After Cholecystectomy


Donato F. Altomare*, Maria T. Rotelli and Nicola Palasciano


DOI: 10.2174/0929867324666170518100053
View Abstract View on PubMed


The Food-Gut Human Axis: The Effects of Diet on Gut Microbiota and Metabolome


Maria De Angelis*, Gabriella Garruti, Fabio Minervini, Leonilde Bonfrate, Piero Portincasa and Marco Gobbetti


DOI: 10.2174/0929867324666170428103848
View Abstract View on PubMed





Editor-in-Chief

Atta-ur-Rahman, FRS
(25732 citations)
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK

Biography View Full Editorial Board

Journal History

Current Medicinal Chemistry was introduced in 1994 with the assistance of Dr. Atta-ur-Rahman, who is the current Editor-in-Chief serving since 1994.
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Scopus CiteScore Metrics: 1.72

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