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Current Medicinal Chemistry

Volume 29, 42 Issues, 2022
ISSN: 1875-533X (Online)
ISSN: 0929-8673 (Print)
This journal supports open access

Aims & Scope

Current Medicinal Chemistry covers all the latest and outstanding developments in the field of medicinal chemistry. It also includes topics related to quantitative structure-function relationships, drug absorption, drug distribution, drug metabolism, new and emerging drug targets, pharmacogenomics, drug discovery toxicology, high-throughput screening, combinatorial chemistry, structural characterization and organic syntheses of naturally occurring compounds, as well as chemical and analytical techniques used in rational drug design. Each issue incorporates a series of timely in-depth/mini-reviews and guest-edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents.

Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be informed and up-to-date with the latest and most important developments relevant to their field.

Current Medicinal Chemistry

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Volume 29

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Number 3




Editorial




Review Article

Use of Exogenous Enzymes in Human Therapy: Approved Drugs and Potential Applications

, 29(3): 411 - 452

Patrizia Cioni, Edi Gabellieri, Barbara Campanini, Stefano Bettati and Samanta Raboni*


DOI: 10.2174/0929867328666210713094722


Review Article

Gene Therapy as the New Frontier for Sickle Cell Disease

, 29(3): 453 - 466

Himanshu Garg, Kristina J. Tatiossian, Karsten Peppel, Gregory J. Kato and Eva Herzog*


DOI: 10.2174/0929867328666210527092456




Review Article

Pulmonary Surfactant: A Unique Biomaterial with Life-saving Therapeutic Applications

, 29(3): 526 - 590

Barbara Pioselli*, Fabrizio Salomone, Giuseppe Mazzola, Davide Amidani, Elisa Sgarbi, Francesco Amadei, Xabi Murgia, Silvia Catinella, Gino Villetti, Daniele De Luca, Virgilio Carnielli and Maurizio Civelli


DOI: 10.2174/0929867328666210825110421


Articles Ahead of Print

PCSK9 as a New Player in Cancer: New Opportunity or Red Herring?


Aldo Bonaventura*, Alessandra Vecchié, Massimiliano Ruscica, Francesco Grossi and Francesco Dentali


DOI: 10.2174/0929867328666211115122324
View Abstract View on PubMed


An Updated Review on the Therapeutic, Diagnostic, and Prognostic Value of Long Non-Coding RNAs in Gastric Cancer


Alemeh Mohammadzadeh, Narges Dastmalchi, Bashdar Mahmud Hussen, Mahdi Abdoli Shadbad and Reza Safaralizadeh*


DOI: 10.2174/0929867328666211115121019
View Abstract View on PubMed


Recent Trends in Rationally Designed Molecules as Kinase Inhibitors


Parteek Prasher, Mousmee Sharma, Yinghan Chan, Sachin Kumar Singh, Krishnan Anand, Harish Dureja, Niraj Kumar Jha, Gaurav Gupta, Flavia Zacconi, Dinesh K. Chellappan and Kamal Dua*


DOI: 10.2174/0929867328666211111161811
View Abstract View on PubMed




Mutual Effects of Free and Nanoencapsulated Phenolic Compounds on Human Microbiota


Carina Cassini, Pedro Henrique Zatti, Valéria Weiss Angeli, Catia Santos Branco* and Mirian Salvador


DOI: 10.2174/0929867328666211101095131
View Abstract View on PubMed




A Comprehensive Review on Pyranoindole-containing Agents


Alessia Catalano*, Domenico Iacopetta, Jessica Ceramella, Carmela Saturnino and Maria Stefania Sinicropi


DOI: 10.2174/0929867328666211206111058
View Abstract View on PubMed



Abstracts Ahead of Print

Ιmmunity, Vascular Aging, and Stroke


Anna-Maria Louka*, Dimitrios Sagris and George Ntaios


DOI: 10.2174/0929867329666220103101700
View Abstract


Biofilm formation as valuable target to fight severe chronic infections


Camilla Pecoraro*, Daniela Carbone*, Deng Dongmei, Stella Maria Cascioferro, Patrizia Diana and Elisa Giovannetti*


DOI: 10.2174/0929867329666220103095551
View Abstract




Epigenetic Modulators as Treatment Alternative to Diverse Types of Cancer


Jorseth Rodelo Gutiérrez, Arturo René Mendoza Salgadoa, Marcio De Ávila Arias, Homero San- Juan- Vergara, Wendy Rosales Rada and Carlos Mario Meléndez Gómez*


DOI: 10.2174/0929867329666211228111036
View Abstract


The significant role of nutraceutical compounds in ulcerative colitis treatment


Azzurra Chiara De Maio, Giovanna Basile, Domenico Iacopetta, Alessia Catalano*, Jessica Ceramella, Danilo Cafaro, Carmela Saturnino and Maria Stefania Sinicropi


DOI: 10.2174/0929867329666211227121321
View Abstract




Nanoparticles mediated target-specific drug delivery in prostate cancer: In-depth review


Tarun Kumar Upadhyay*, Mohammed Irfan Ali, Fahad Khan, Harsh Goel, Manas Mathur, Keshav Goyal, Sarmad Moin, Pratibha Pandey, Pranay Tanwar, Amit Baran Sharangi, Saloni Dinesh Chandra Gautam, Jhanvi Kiran Kapdi, Kruti Indravadan Patel, Meghna Vipulbhai Patel, Amisha M Parmar and Mohammad Amjad Kamal


DOI: 10.2174/0929867329666211221112312
View Abstract


Effect of epicatechin on skeletal muscle


Hermann Zbinden-Foncea *, Mauricio Castro-Sepulveda , Jocelyn Fuentes and Hernan Speisky


DOI: 10.2174/0929867329666211217100020
View Abstract


Published Contents

Open Access Articles

Dual Targeting Strategies on Histone Deacetylase 6 (HDAC6) and Heat Shock Protein 90 (Hsp90)

, 2022; 29: 1 - 29 (E-Pub Ahead of Print)

Davide Bonanni, Andrea Citarella, Davide Moi, Luca Pinzi, Elisa Bergamini and Giulio Rastelli*






Deep Learning in the Quest for Compound Nomination for Fighting COVID-19

, 2021; 28(28): 5699 - 5732

Maria Mernea, Eliza C. Martin, Andrei-José Petrescu* and Speranta Avram*





Polyisoprenylated Cysteinyl Amide Inhibitors: A Novel Approach to Controlling Cancers with Hyperactive Growth Signaling

, 2021; 28(18): 3476 - 3489

Nazarius S. Lamango*, Augustine T. Nkembo, Elizabeth Ntantie and Nada Tawfeeq





Role of Alpha-Fetoprotein in Hepatocellular Carcinoma Drug Resistance

, 2021; 28(6): 1126 - 1142

Wei Li, Kun Liu, Yi Chen, Mingyue Zhu* and Mengsen Li*





Tumor in 3D: In Vitro Complex Cellular Models to Improve Nanodrugs Cancer Therapy

, 2020; 27(42): 7234 - 7255

Soraia Fernandes*, Marco Cassani, Stefania Pagliari, Petr Filipensky, Francesca Cavalieri and Giancarlo Forte*





Osteoporosis: Current and Emerging Therapies Targeted to Immunological Checkpoints

, 2020; 27(37): 6356 - 6372

Massimo De Martinis, Maria Maddalena Sirufo and Lia Ginaldi*








Most Cited Articles


Review Article

Role of ox-LDL and LOX-1 in atherogenesis

, 2019; 26(9): 1693-1700.

Ajoe John Kattoor, Sri Harsha Kanuri and Jawahar L. Mehta*


DOI: 10.2174/0929867325666180508100950


Review Article

Targeting cxcl12/cxcr4 axis in tumor immunotherapy

, 2019; 26(17): 3026-3041.

Weiqiang Zhou, Shanchun Guo*, Mingli Liu, Matthew E. Burow and Guangdi Wang*


DOI: 10.2174/0929867324666170830111531



Review Article

Immune checkpoint inhibitors: Basics and challenges

, 2019; 26(17): 3009-3025.

Bin Li*, Ho Lam Chan and Pingping Chen*


DOI: 10.2174/0929867324666170804143706


Review Article

Plant-derived products as antibacterial and antifungal agents in human health care

, 2019; 26(29): 5501-5541.

Ladislav Kokoska*, Pavel Kloucek , Olga Leuner* and Pavel Novy


DOI: 10.2174/0929867325666180831144344


Review Article

Cyclooxygenase-2 inhibitors as a therapeutic target in inflammatory diseases

, 2019; 26(18): 3225-3241.

Miguel D. Ferrer, Carla Busquets-Cortés, Xavier Capó, Silvia Tejada, Josep A. Tur, Antoni Pons and Antoni Sureda*


DOI: 10.2174/0929867325666180514112124


Review Article

Role of autophagy in Parkinson’s disease

, 2019; 26(20): 3702-3718.

Silvia Cerri and Fabio Blandini*


DOI: 10.2174/0929867325666180226094351


General Review Article

Metal–organic framework (MoF)-based nanomaterials for biomedical applications

, 2019; 26(18): 3341-3369.

Zhidong Luo, Shuran Fan, Chuying Gu, Weicong Liu, Jinxiang Chen, Baohong Li* and Jianqiang Liu*


DOI: 10.2174/0929867325666180214123500


General Review Article

Homocysteine and hyperhomocysteinaemia

, 2019; 26(16): 2948-2961.

Bozidarka L. Zaric*, Milan Obradovic, Vladan Bajic , Mohamed A. Haidara , Milos Jovanovic and Esma R. Isenovic*


DOI: 10.2174/0929867325666180313105949


Review Article

Metal-organic framework (Mof)-based drug delivery

, 2020; 27(35): 5949-5969.

Jian Cao, Xuejiao Li and Hongqi Tian*


DOI: 10.2174/0929867326666190618152518


Review Article

Applications of cellulose-based materials in sustained drug delivery systems

, 2019; 26(14): 2485-2501.

Bo Sun, Min Zhang, Jing Shen, Zhibin He, Pedram Fatehi* and Yonghao Ni


DOI: 10.2174/0929867324666170705143308


General Review Article

Aptamer-based targeted drug delivery systems: Current potential and challenges

, 2020; 27(13): 2189-2219.

Fen He, Nachuan Wen, Daipeng Xiao, Jianhua Yan, Hongjie Xiong, Shundong Cai, Zhenbao Liu* and Yanfei Liu*


DOI: 10.2174/0929867325666181008142831



Review Article

Medical applications of collagen and collagen-based materials

, 2019; 26(3): 506-516.

Anatoly B. Shekhter, Alexey L. Fayzullin*, Marina N. Vukolova, Tatyana G. Rudenko, Varvara D. Osipycheva and Petr F. Litvitsky


DOI: 10.2174/0929867325666171205170339



Most Accessed Articles


Nanomedical Applications of Amphiphilic Dendrimeric Micelles

, 2021; 28(38): 7937-7960.

Guillermo Leobardo Rodríguez-Acosta, Carlos Hernández-Montalbán, María Fernanda Sabrina Vega-Razo, Irving Osiel Castillo-Rodríguez and Marcos Martínez-García*


DOI: 10.2174/0929867328666210329125601




Lipid-Lowering Therapies for Atherosclerosis: Statins, Fibrates, Ezetimibe and PCSK9 Monoclonal Antibodies

, 2021; 28(36): 7427-7445.

Adel Hajj Ali, Nour Younis, Rola Abdallah, Farah Shaer, Ali Dakroub, Mohammed Akli Ayoub, Rabah Iratni, Hadi Mohamad Yassine, Kazem Zibara, Alexander Orekhov, Ahmed Fawzy El-Yazbi and Ali H. Eid *


DOI: 10.2174/0929867328666210222092628


Design and Synthesis of Quinolizidine Derivatives as Influenza Virus and HIV-1 Inhibitors

, 2021; 28(24): 4995-5003.

Zhao Dang, Lei Zhu, Lan Xie, Kuo-Hsiung Lee, Faisal Malik, Zhijun Li, Li Huang* and Chin-Ho Chen*


DOI: 10.2174/0929867328666201229121802



MicroRNAs as Biomarkers in Hypertrophic Cardiomyopathy: Current State of the Art

, 2021; 28(36): 7400-7412.

Andreas Angelopoulos, Evangelos Oikonomou*, Georgia Vogiatzi, Alexios Antonopoulos, Sotirios Tsalamandris, Christos Georgakopoulos, Paraskevi Papanikolaou, George Lazaros, Georgios Charalambous, Gerasimos Siasos, Charalambos Vlachopoulos and Dimitris Tousoulis


DOI: 10.2174/0929867328666210405122703


The Therapeutic use of the Zonulin Inhibitor AT-1001 (Larazotide) for a Variety of Acute and Chronic Inflammatory Diseases

, 2021; 28(28): 5788-5807.

Jacopo Troisi*, Giorgia Venutolo, Concetta Terracciano, Matteo Delli Carri, Simone Di Micco, Annamaria Landolfi and Alessio Fasano


DOI: 10.2174/0929867328666210104110053


Machine Learning Approaches in Parkinson’s Disease

, 2021; 28(32): 6548-6568.

Annamaria Landolfi*, Carlo Ricciardi, Leandro Donisi, Giuseppe Cesarelli, Jacopo Troisi, Carmine Vitale, Paolo Barone and Marianna Amboni


DOI: 10.2174/0929867328999210111211420


Viral Envelope Membrane: A Special Entry Pathway and a Promising Drug Target

, 2021; 28(34): 6957-6976.

Nastasja Palombi, Annalaura Brai, Martina Gerace, Salvatore Di Maria, Francesco Orofino and Federico Corelli*


DOI: 10.2174/0929867328666210218182203








Editor-in-Chief

graphic
Atta-ur-Rahman, FRS
(32052 citations)
Kings College
University of Cambridge
Cambridge
(UK)
Biography
View Full Editorial Board

Nobel Laureates on Editorial Board

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Prof. John Gurdon
(UK)

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Prof. Jean-Marie Lehn
(France)

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Prof. Ferid Murad
(USA)

COPE Compliant

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Journal History

Current Medicinal Chemistry was introduced in 1994 with the assistance of Dr. Atta-ur-Rahman, who is the current Editor-in-Chief serving since 1994.

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