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Current Gene Therapy

Volume 21, 5 Issues, 2021
ISSN: 1566-5232 (Print)
ISSN: 1875-5631 (Online)
This journal supports open access

Aims & Scope

Current Gene Therapy is a bi-monthly peer-reviewed journal aimed at academic and industrial scientists with an interest in major topics concerning basic research and clinical applications of gene and cell therapy of diseases. Cell therapy manuscripts can also include application in diseases when cells have been genetically modified. Current Gene Therapy publishes full-length/mini reviews and original research on the latest developments in gene transfer and gene expression analysis, vector development, cellular genetic engineering, animal models and human clinical applications of gene and cell therapy for the treatment of diseases.

Current Gene Therapy publishes reviews and original research containing experimental data on gene and cell therapy. The journal also includes manuscripts on technological advances, ethical and regulatory considerations of gene and cell therapy. Reviews should provide the reader with a comprehensive assessment of any area of experimental biology applied to molecular medicine that is not only of significance within a particular field of gene therapy and cell therapy but also of interest to investigators in other fields. Authors are encouraged to provide their own assessment and vision for future advances. Reviews are also welcome on late breaking discoveries on which substantial literature has not yet been amassed. Such reviews provide a forum for sharply focused topics of recent experimental investigations in gene therapy primarily to make these results accessible to both clinical and basic researchers. Manuscripts containing experimental data should be original data, not previously published.

Current Gene Therapy

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Volume 21

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Number 4















General Review Article





Articles Ahead of Print

Recent Progress of Machine Learning in Gene Therapy


Cassandra Hunt, Sandra Montgomery, Joshua William Berkenpas, Noel Sigafoos, John Christian Oakley, Jacob Espinosa, Nicola Justice, Kiyomi Kishaba, Kyle Hippe, Dong Si, Jie Hou, Hui Ding and Renzhi Cao*


DOI: 10.2174/1566523221666210622164133
View Abstract View on PubMed




Current Designs of Polymeric Platforms Towards the Delivery of Nucleic Acids Inside the Cells with Focus on Polyethylenimine


Fernando A. de Oliveira, Lindomar J. C. Albuquerque, Gwendoline Delecourt, Véronique Bennevault, Philippe Guégan and Fernando C. Giacomelli*


DOI: 10.2174/1566523221666210705130238
View Abstract View on PubMed






In Situ Gene Therapy


Hallana Souza Santos, Luiza Rodrigues, Luisa Natalia Pimentel Vera, Edina Poletto, Eduardo Filippi-Chiela, Lia Franciê Ribeiro dos Santos Bruschi, Roselena Schuh and Guilherme Baldo*


DOI: 10.2174/1566523221666210504103323
View Abstract View on PubMed


Gene Therapy in the Anterior Eye Segment


Cynthia Amador, Ruchi Shah, Sean Ghiam, Andrei A. Kramerov and Alexander V. Ljubimov*


DOI: 10.2174/1566523221666210423084233
View Abstract View on PubMed


Abstracts Ahead of Print


New hope for intervertebral disc degeneration: bone marrow mesenchymal stem cells and exosomes derived from bone marrow mesenchymal stem cell transplantation


Xiao-Bo Zhang, Xiang-Yi Chen, Jin Qi, Hai-Yu Zhou*, Xiao-Bing Zhao, Yi-Cun Hu, Rui-Hao Zhang, De-Chen Yu, Xi-Dan Gao, Ke-Ping Wang and Lin Ma


DOI: 10.2174/1566523221666211012092855
View Abstract



CRISPR Systems Suitable for Single AAV Vector Delivery


Marta Stevanovic*, Elena Piotter, Michelle McClements and Robert MacLaren


DOI: 10.2174/1566523221666211006120355
View Abstract




Treatment of GM2 Gangliosidosis in Adult Sandhoff Mice using an Intravenous Self-Complementary Hexosaminidase Vector


Karlaina JL. Osmon*, Patrick Thompson, Evan Woodley, Subha Karumuthil-Melethil, Cliff Heindel, John G. Keimel, William F. Kaemmerer, Steven J. Gray and Jagdeep S. Walia


DOI: 10.2174/1566523221666210916153051
View Abstract





Published Contents

Editor's Choice

Recent Advances in CRISPR/Cas9 Directed Base Editing

, 2021; 21(4): 327 - 337

Nan Liu, Lifang Zhou, Junyan Qu and Shaohua Yao*


DOI: 10.2174/1566523221666210322090638



Potential Non-coding RNAs from Microorganisms and their Therapeutic Use in the Treatment of Different Human Cancers

, 2021; 21(3): 207 - 215

Raju Biswas, Dipanjana Ghosh, Bhramar Dutta, Urmi Halder, Prittam Goswami and Rajib Bandopadhyay*


DOI: 10.2174/1566523220999201230204814




Challenges of Gene Therapy for Neurodegenerative Disorders

, 2021; 21(1): 3 - 10

Md. Sahab Uddin*, Zeeshan Ahmad Khan, Dewan Md. Sumsuzzman, Asma Perveen and Ghulam Md. Ashraf*


DOI: 10.2174/1566523220999201105150442






Gene Therapy for Hemophilia A: Where We Stand

, 2020; 20(2): 142 - 151

Miaojin Zhou, Zhiqing Hu, Chunhua Zhang, Lingqian Wu, Zhuo Li* and Desheng Liang*


DOI: 10.2174/1566523220666200806110849




Nano-enhanced Optical Gene Delivery to Retinal Degenerated Mice

, 2019; 19(5): 318 - 329

Subrata Batabyal, Sivakumar Gajjeraman, Sulagna Bhattacharya, Weldon Wright and Samarendra Mohanty*


DOI: 10.2174/1566523219666191017114044



Open Access Articles

Cytoplasmic Trafficking of Nanoparticles Delivers Plasmid DNA for Macrophage Gene-editing

, 2021; 21(4): 349 - 360

So Yoon Lee, Javier Fierro, An M. Tran , Daewoo Hong, Jamil Espinal and Huanyu Dou *





Gene Therapy in the Anterior Eye Segment

, 2021; 21: 1 - 28 (E-Pub Ahead of Print)

Cynthia Amador, Ruchi Shah, Sean Ghiam, Andrei A. Kramerov and Alexander V. Ljubimov*




Predicting LncRNA-Disease Association Based on Generative Adversarial Network

, 2021; 21: 1 - 8 (E-Pub Ahead of Print)

Biao Du, Lin Tang, Lin Liu* and Wei Zhou*




Feasibility of Mesenchymal Stem Cell Therapy for COVID-19: A Mini Review

, 2020; 20(4): 285 - 288

Jingwen Li, Xinyi Wang, Na Li , Ying Jiang, Heqing Huang*, Tao Wang, Zhicheng Lin and Nian Xiong*




Hemophilia Gene Therapy: New Development from Bench to Bed Side

, 2019; 19(4): 264 - 273

Xiao-Lu Guo, Tsai-Hua Chung, Yue Qin, Jie Zheng, Huyong Zheng, Liyuan Sheng, Tung Wynn and Lung-Ji Chang*




A Recurrent Rare SOX9 Variant (M469V) is Associated with Congenital Vertebral Malformations

, 2019; 19(4): 242 - 247

Nan Wu, Lianlei Wang, Jianhua Hu*, Sen Zhao, Bowen Liu, Yaqi Li, Huakang Du, Yuanqiang Zhang, Xiaoxin Li, Zihui Yan, Shengru Wang, Yipeng Wang, Jianguo Zhang, Zhihong Wu, DISCO (Deciphering Disorders Involving Scoliosis & Comorbidities) study group and Guixing Qiu




Reduction of Autophagic Accumulation in Pompe Disease Mouse Model Following Gene Therapy

, 2019; 19(3): 197 - 207

Angela L. McCall*, Sylvia G. Stankov, Gabrielle Cowen, Denise Cloutier, Zizhao Zhang, Lin Yang, Nathalie Clement, Darin J. Falk and Barry J. Byrne*




Three Cases of Leber’s Hereditary Optic Neuropathy with Rapid Increase in Visual Acuity After Gene Therapy

, 2019; 19(2): 134 - 138

Yong Zhang, Jia-jia Yuan, Hong-li Liu, Zhen Tian, Si-wei Liu and Bin Li*





Functional Improvement of Chimeric Antigen Receptor Through Intrinsic Interleukin-15Rα Signaling

, 2019; 19(1): 40 - 53

Sushmita Nair, Jing-Bo Wang, Shih-Ting Tsao, Yuchen Liu, Wei Zhu, William B. Slayton, Jan S. Moreb, Lujia Dong and Lung-Ji Chang*





Clinical Observation of Patients with Leber’s Hereditary Optic Neuropathy Before Gene Therapy

, 2018; 18(6): 386 - 392

Jiajia Yuan, Yong Zhang, Hongli Liu, Zhen Tian, Xin Li, Yichen Zheng, Qin Gao, Lin Song, Xiao Xiao, Jian Sun, Zhitao Wang and Bin Li*




Clinical-Grade Oncolytic Adenovirus Purification Using Polysorbate 20 as an Alternative for Cell Lysis

, 2018; 18(6): 366 - 374

Mafalda G. Moleirinho, Sara Rosa, Manuel J.T. Carrondo*, Ricardo J.S. Silva, Åsa Hagner-McWhirter, Gustaf Ahlén, Mats Lundgren, Paula M. Alves and Cristina Peixoto




Emerging Therapeutic Approaches for Diamond Blackfan Anemia

, 2018; 18(6): 327 - 335

Anna Aspesi*, Chiara Borsotti and Antonia Follenzi*





Most Cited Articles


General Review Article

The therapeutic potential and role of miRNA, IncRNA, and circRNA in osteoarthritis

, 2019; 19(4): 255-263.

Yuangang Wu, Xiaoxi Lu, Bin Shen and Yi Zeng*


DOI: 10.2174/1566523219666190716092203


Review Article

The emerging role of stem cells in regenerative dentistry

, 2020; 20(4): 259-268.

Paolo Capparè*, Giulia Tetè, Maria Teresa Sberna and Paola Panina-Bordignon*


DOI: 10.2174/1566523220999200818115803


Review Article

Current rna-based therapeutics in clinical trials

, 2019; 19(3): 172-196.

Ling-Yan Zhou, Zhou Qin, Yang-Hui Zhu, Zhi-Yao He* and Ting Xu*


DOI: 10.2174/1566523219666190719100526


Research Article

Functional improvement of chimeric antigen receptor through intrinsic interleukin-15Rα signaling

, 2019; 19(1): 40-53.

Sushmita Nair, Jing-Bo Wang, Shih-Ting Tsao, Yuchen Liu, Wei Zhu, William B. Slayton, Jan S. Moreb, Lujia Dong and Lung-Ji Chang*


DOI: 10.2174/1566523218666181116093857


Review Article

The relationship between ferroptosis and tumors: A novel landscape for therapeutic approach

, 2019; 19(2): 117-124.

Xiaojun Xia, Xiaoping Fan*, Mingyi Zhao* and Ping Zhu*


DOI: 10.2174/1566523219666190628152137


General Review Article

Circular RNAs serve as novel biomarkers and therapeutic targets in cancers

, 2019; 19(2): 125-133.

Shuai Fang, Jinchang Pan, Chengwei Zhou, Hui Tian, Jinxian He, Weiyu Shen, Xiaofeng Jin, Xiaodan Meng, Nan Jiang and Zhaohui Gong*


DOI: 10.2174/1566523218666181109142756


Research Article

Mirna-146a improves immunomodulatory effects of msc-derived exosomes in rheumatoid arthritis

, 2020; 20(4): 297-312.

Fataneh Tavasolian, Ahmad Zavaran Hosseini*, Sara Soudi and Mahmood Naderi


DOI: 10.2174/1566523220666200916120708




Research Article

Effect of tumor suppressor miR-34a loaded on ZSM-5 nanozeolite in hepatocellular carcinoma: In vitro and in vivo approach

, 2019; 19(5): 342-354.

Zeinab Salah*, Eman M. Abd El Azeem, Hanan F. Youssef , Amira M. Gamal-Eldeen*, Abdel R. Farrag, Emad El-Meliegy, Bangly Soliman and Mahmoud Elhefnawi*


DOI: 10.2174/1566523219666191108103739


Research Article

A mendelian randomization study on infant length and type 2 diabetes mellitus risk

, 2019; 19(4): 224-231.

He Zhuang, Ying Zhang, Shuo Yang, Liang Cheng* and Shu-Lin Liu*


DOI: 10.2174/1566523219666190925115535



Review Article

Exosomes: Structure, biogenesis, types and application in diagnosis and gene and drug delivery

, 2020; 20(3): 195-206.

Shriya Agarwal, Vinayak Agarwal, Mugdha Agarwal and Manisha Singh*


DOI: 10.2174/1566523220999200731011702


Review Article

Gene therapy, a novel therapeutic tool for neurological disorders: Current progress, challenges and future prospective

, 2020; 20(3): 184-194.

Ashif Iqubal, Mohammad Kashif Iqubal, Aamir Khan, Javed Ali, Sanjula Baboota and Syed Ehtaishamul Haque*


DOI: 10.2174/1566523220999200716111502



Most Accessed Articles

Efficacy of Gene Therapy to Restore Cognition in Alzheimer’s Disease: A Systematic Review

, 2021; 21(3): 246-257.

Desyrre V. Tedeschi, Anderson F da Cunha, Márcia R. Cominetti and Renata Valle Pedroso*


DOI: 10.2174/1566523221666210120091146




Hutchinson-Gilford Progeria Syndrome: An Overview of the Molecular Mechanism, Pathophysiology and Therapeutic Approach

, 2021; 21(3): 216-229.

Md. Mominur Rahman, Kazi Sayma Ferdous, Muniruddin Ahmed, Mohammad Touhidul Islam, Md. Robin Khan, Asma Perveen, Ghulam Md. Ashraf and Md. Sahab Uddin*


DOI: 10.2174/1566523221666210303100805


Potential Non-coding RNAs from Microorganisms and their Therapeutic Use in the Treatment of Different Human Cancers

, 2021; 21(3): 207-215.

Raju Biswas, Dipanjana Ghosh, Bhramar Dutta, Urmi Halder, Prittam Goswami and Rajib Bandopadhyay*


DOI: 10.2174/1566523220999201230204814





NF1, Neurofibromin and Gene Therapy: Prospects of Next-Generation Therapy

, 2020; 20(2): 100-108.

Xi-Wei Cui, Jie-Yi Ren, Yi-Hui Gu, Qing-Feng Li* and Zhi-Chao Wang*


DOI: 10.2174/1566523220666200806111451


CRISPR/Cas9 Technology as a Modern Genetic Manipulation Tool for Recapitulating of Neurodegenerative Disorders in Large Animal Models

, 2021; 21(2): 130-148.

Mahdi Barazesh, Shiva Mohammadi*, Yadollah Bahrami*, Pooneh Mokarram, Mohammad Hossein Morowvat, Massoud Saidijam, Morteza Karimipoor, Soudabeh Kavousipour, Amir Reza Vosoughi and Korosh Khanaki


DOI: 10.2174/1566523220666201214115024





The Dramatic Role of IFN Family in Aberrant Inflammatory Osteolysis

, 2021; 21(2): 112-129.

Zihan Deng, Wenhui Hu, Hongbo Ai, Yueqi Chen* and Shiwu Dong*


DOI: 10.2174/1566523220666201127114845


ZEB2 Knock-down Induces Apoptosis in Human Myeloid Leukemia HL-60 Cells

, 2021; 21(2): 149-159.

Masoumeh Fardi*, Ali Mohammadi, Behzad Baradaran and Sahar Safaee


DOI: 10.2174/1566523221999210120210017




Editor-in-Chief

graphic
Liang Cheng
College of Bioinformatics, Science and Technology
Harbin Medical University
Harbin, Heilongjiang
(China)
Biography
View Full Editorial Board

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Journal History

Current Gene Therapy Journal was launched in 2001. Dr. Ignacio Anegon was the founding editor of the journal.
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Probing Intracellular Regulation



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