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Current Drug Targets

Volume 20, 16 Issues, 2019
ISSN: 1873-5592 (Online)
ISSN: 1389-4501 (Print)
This journal supports open access

Ranking and Category

  • 131st of 267 in

    Pharmacology & Pharmacy

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Aims & Scope

Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes.

Current Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of drug targets. The journal also accepts for publication full-length/mini review articles and drug clinical trial studies.

As the discovery, identification, characterization and validation of novel human drug targets for drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.

Current Drug Targets

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Volume 20

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Number 16



Review Article



Review Article

Aptamers in Drug Design: An Emerging Weapon to Fight a Losing Battle

, 20(16): 1624 - 1635

Jobin Jose, Aaron Mathew Thomas, Darewin Mendonsa, Mohammad M. Al-Sanea, Md. Sahab Uddin, Della Grace Thomas Parambi, R Narayana Charyulu and Bijo Mathew*


DOI: 10.2174/1389450120666190729121747


Review Article

Potential Drug Targets Against Hepatitis B Virus Based on Both Virus and Host Factors

, 20(16): 1636 - 1651

Bing-Yi Zhang, Dan-Ping Chai, Yi-Hang Wu*, Li-Peng Qiu, Yong-Yong Zhang, Zi-Hong Ye and Xiao-Ping Yu


DOI: 10.2174/1389450120666190729115646


Review Article



Systemic Review Article



Review Article (Mini-Review)



Review Article (Mini-Review)   Open Access



Acknowledgement   Open Access



Articles Ahead of Print



Understanding the Pharmaceutical Aspects of Dendrimers for the Delivery of Anticancer Drugs


Sunil Kumar Dubey, Shubham Salunkhe, Mukta Agrawal, Maithili Kali, Gautam Singhvi, Sanjay Tiwari, Swarnlata Saraf, Shailendra Saraf and Amit Alexander*


DOI: 10.2174/1389450120666191031092259
View Abstract View on PubMed



Exploring the Clinical Impact of Predictive Biomarkers in Serous Ovarian Carcinomas


Cécile Le Page*, Jacqueline Chung, Kurosh Rahimi, Martin Kobel, Diane Provencher and Anne-Marie Mes-Masson


DOI: 10.2174/1389450120666191016143836
View Abstract View on PubMed




Combining Radiotherapy with Immunocheckpoint Inhibitors or CAR-T in Renal Cell Carcinoma


Matteo Santoni, Daniel YC Heng, Gaetano Aurilio, Andrea Iozzelli, Lucilla Servi, Andrea Fabiani, Massimo Giannini, Roberta Mazzucchelli, Alessia Cimadamore, Marina Scarpelli, Mohamed S. Zaghloul, Nicola Battelli and Rodolfo Montironi*


DOI: 10.2174/1389450120666191017113051
View Abstract View on PubMed




Abstracts Ahead of Print


The therapeutic potential of quercetin in Parkinson’s disease: Insights into its molecular and cellular regulation


Omid Reza Tamtaji, Tooba Hadinezhad, Maryam Fallah, Arash Rezaei Shahmirzadi, Mohsen Taghizadeh, Mohammad Behnam and Zatollah Asemi*


DOI: 10.2174/1389450120666191112155654
View Abstract


Free Fatty Acid Receptors as new potential target in Colorectal Cancer


Adrian Bartoszek, Jakub Fichna*, Aleksandra Tarasiuk, Agata Binienda, Adam Fabisiak, Julia B. Krajewska, Paula Mosińska, Karolina Niewinna and Maciej Salaga


DOI: 10.2174/1389450120666191112141901
View Abstract



Published Contents

Editor's Choice

Aptamers in Drug Design: An Emerging Weapon to Fight a Losing Battle

, 2019; 20(16): 1624 - 1635

Jobin Jose, Aaron Mathew Thomas, Darewin Mendonsa, Mohammad M. Al-Sanea, Md. Sahab Uddin, Della Grace Thomas Parambi, R Narayana Charyulu and Bijo Mathew*


DOI: 10.2174/1389450120666190729121747




Anti-TNF and Postoperative Complications in Abdominal Crohn's Disease Surgery

, 2019; 20(13): 1339 - 1348

Takayuki Yamamoto*, Fabio Vieira Teixeira, Rogerio Saad-Hossne, Paulo Gustavo Kotze and Silvio Danese


DOI: 10.2174/1389450120666190404144048





The Use of Naltrexone in Dermatology. Current Evidence and Future Directions

, 2019; 20(10): 1058 - 1067

Mariusz Sikora*, Adriana Rakowska, Małgorzata Olszewska and Lidia Rudnicka


DOI: 10.2174/1389450120666190318121122





Targeting Water in the Brain: Role of Aquaporin-4 in Ischemic Brain Edema

, 2019; 20(7): 748 - 755

Muyassar Mamtilahun, Guanghui Tang, Zhijun Zhang, Yongting Wang, Yaohui Tang* and Guo-Yuan Yang*


DOI: 10.2174/1389450120666190214115309



Estrogen Receptor Alpha and its Ubiquitination in Breast Cancer Cells

, 2019; 20(6): 690 - 704

Angeles C. Tecalco-Cruz*, Josué O. Ramírez-Jarquín and Eduardo Cruz-Ramos


DOI: 10.2174/1389450119666181015114041



Open Access Articles

Recognition of Plasminogen Activator Inhibitor Type 1 as the Primary Regulator of Fibrinolysis

, 2019; 20(16): 1695 - 1701

Tetsumei Urano*, Yuko Suzuki, Takayuki Iwaki, Hideto Sano, Naoki Honkura and Francis J. Castellino




Current Understanding of Group A Streptococcal Biofilms

, 2019; 20(9): 982 - 993

Heema K.N. Vyas, Emma-Jayne Proctor, Jason McArthur, Jody Gorman and Martina Sanderson-Smith*








Opportunities of Bacterial Cellulose to Treat Epithelial Tissues

, 2019; 20(8): 808 - 822

Irene Anton-Sales, Uwe Beekmann, Anna Laromaine*, Anna Roig* and Dana Kralisch





Blood Eosinophils as Biomarkers to Drive Treatment Choices in Asthma and COPD

, 2018; 19(16): 1882 - 1896

Konstantinos Kostikas, Caterina Brindicci and Francesco Patalano*




Current Status and Perspectives on Pharmacologic Therapy for Abdominal Aortic Aneurysm

, 2018; 19(11): 1265 - 1275

Koichi Yoshimura*, Noriyasu Morikage, Shizuka Nishino-Fujimoto, Akira Furutani, Bungo Shirasawa and Kimikazu Hamano





TXNIP in Metabolic Regulation: Physiological Role and Therapeutic Outlook

, 2017; 18(9): 1095 - 1103

Naif Mohammad Alhawiti, Saeed Al Mahri, Mohammad Azhar Aziz, Shuja Shafi Malik and Sameer Mohammad*






Structural and Functional Aspects of Class A Carbapenemases

, 2016; 17(9): 1006 - 1028

Thierry Naas, Laurent Dortet and Bogdan I. Iorga





Most Cited Articles

Review Article

Cytochrome P450 structure, function and clinical significance: A review

, 2018; 19(1): 38-54.

Palrasu Manikandan and Siddavaram Nagini*


DOI: 10.2174/1389450118666170125144557


Review Article

Cyclin-dependent kinase 2 in cellular senescence and cancer. A structural and functional review

, 2019; 20(7): 716-726.

Priscylla Andrade Volkart, Gabriela Bitencourt-Ferreira, André Arigony Souto* and Walter Filgueira de Azevedo *


DOI: 10.2174/1389450120666181204165344



Review Article

Recent advances in protein tyrosine phosphatase 1b targeted drug discovery for Type II diabetes and obesity

, 1 April 2018; 19(5): 551-575.

Neelesh Maheshwari, Chandrabose Karthikeyan, Piyush Trivedi and N.S. Hari Narayana Moorthy*


DOI: 10.2174/1389450118666170222143739


Review Article

Flavonoids and its neuroprotective effects on brain ischemia and neurodegenerative diseases

, 2018; 19(14): 1710-1720.

Manish Putteeraj, Wei Ling Lim, Seong Lin Teoh and Mohamad Fairuz Yahaya*


DOI: 10.2174/1389450119666180326125252



Review Article

Nanoparticles in cancer treatment: Opportunities and obstacles

, 2018; 19(14): 1696-1709.

Rajendra Awasthi*, Ariane Roseblade, Philip Michael Hansbro, Michael John Rathbone, Kamal Dua and Mary Bebawy*


DOI: 10.2174/1389450119666180326122831


Review Article

Stimuli-responsive smart liposomes in cancer targeting

, 1 March 2018; 19(3): 259-270.

Ankit Jain and Sanjay K. Jain*


DOI: 10.2174/1389450117666160208144143


Review Article

GRP78 influences chemoresistance and prognosis in cancer

, 2018; 19(6): 701-708.

Jenifer B. Gifford and Reginald Hill*


DOI: 10.2174/1389450118666170615100918


Review Article

Antitumor activity of polysaccharides: An overview

, 2018; 19(1): 89-96.

Ling Chen and Gangliang Huang*


DOI: 10.2174/1389450118666170704143018


Review Article

Insights into the targeting potential of thymoquinone for therapeutic intervention against triple-negative breast cancer

, 2018; 19(1): 70-80.

Md Abul Barkat, Harshita, Javed Ahmad, Mohammad Ahmed Khan*, Sarwar Beg* and Farhan Jalees Ahmad*


DOI: 10.2174/1389450118666170612095959


Review Article

CDK9 as an appealing target for therapeutic interventions

, 2019; 20(4): 453-464.

Shirin Eyvazi, Mohammad Saeid Hejazi, Homan Kahroba, Mozghan Abasi, Reza Eghdam Zamiri and Vahideh Tarhriz*


DOI: 10.2174/1389450119666181026152221


Review Article

Blood eosinophils as biomarkers to drive treatment choices in asthma and COPD

, 2018; 19(16): 1882-1896.

Konstantinos Kostikas, Caterina Brindicci and Francesco Patalano*


DOI: 10.2174/1389450119666180212120012


Review Article

Metformin, a new era for an old drug in the treatment of immune mediated disease?

, 2018; 19(8): 945-959.

Mark Schuiveling, Nadia Vazirpanah, Timothy R.D.J. Radstake, Maili Zimmermann* and Jasper C.A. Broen*


DOI: 10.2174/1389450118666170613081730


Review Article

Current status and perspectives on pharmacologic therapy for abdominal aortic aneurysm

, 2018; 19(11): 1265-1275.

Koichi Yoshimura*, Noriyasu Morikage, Shizuka Nishino-Fujimoto, Akira Furutani, Bungo Shirasawa and Kimikazu Hamano


DOI: 10.2174/1389450119666171227223331



Most Accessed Articles




Loss of the Tumor Suppressor HACE1 Contributes to Cancer Progression

, 2019; 20(10): 1018-1028.

Jun-Chen Li, Xing Chang, Yang Chen, Xin-Zhe Li, Xiang-Lian Zhang, Shi-Ming Yang, Chang-Jiang Hu* and Hao Zhang*


DOI: 10.2174/1389450120666190227184654


Age-related Macular Degeneration: Current Knowledge of Zinc Metalloproteinases Involvement

, 2019; 20(9): 903-918.

Francesca Liva, Doretta Cuffaro, Elisa Nuti, Susanna Nencetti, Elisabetta Orlandini, Giovanni Vozzi and Armando Rossello*


DOI: 10.2174/1389450120666190122114857


Photopolymerizable Resins for 3D-Printing Solid-Cured Tissue Engineered Implants

, 2019; 20(8): 823-838.

Antonio J. Guerra, Hernan Lara-Padilla, Matthew L. Becker, Ciro A. Rodriguez and David Dean*


DOI: 10.2174/1389450120666190114122815





Significance and Mechanisms of P-glycoprotein in Central Nervous System Diseases

, 2019; 20(11): 1141-1155.

Liangliang Huang, Binbin Li, Xiang Li, Ge Liu, Rui Liu, Jia Guo, Baohui Xu, Yunman Li* and Weirong Fang*


DOI: 10.2174/1389450120666190308144448




Editor-in-Chief

Francis J. Castellino
(14643 citations)
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
USA

View Full Editorial Board

Journal History

Current Drug Targets Journal was launched in 2000. Dr. Francis J. Castellino serves as the Editor-in-Chief of the journal.
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Scopus CiteScore Metrics: 1.91

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