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Current Drug Metabolism

Volume 21, 14 Issues, 2020
ISSN: 1875-5453 (Online)
ISSN: 1389-2002 (Print)
This journal supports open access

In the current pandemic scenario, publication process of all articles related to Coronavirus will be expedited, for timely publication of much needed research

Aims & Scope

Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism, pharmacokinetics, and drug disposition. The journal serves as an international forum for the publication of full-length/mini review, research articles and guest edited issues in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the most important developments. The journal covers the following general topic areas: pharmaceutics, pharmacokinetics, toxicology, and most importantly drug metabolism.

More specifically, in vitro and in vivo drug metabolism of phase I and phase II enzymes or metabolic pathways; drug-drug interactions and enzyme kinetics; pharmacokinetics, pharmacokinetic-pharmacodynamic modeling, and toxicokinetics; interspecies differences in metabolism or pharmacokinetics, species scaling and extrapolations; drug transporters; target organ toxicity and interindividual variability in drug exposure-response; extrahepatic metabolism; bioactivation, reactive metabolites, and developments for the identification of drug metabolites. Preclinical and clinical reviews describing the drug metabolism and pharmacokinetics of marketed drugs or drug classes.

Current Drug Metabolism

,

Volume 21

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Number 6



Biography   Open Access



Perspective



Review Article (Mini-Review)



Review Article

Preclinical Evidence for the Pharmacological Actions of Glycyrrhizic Acid: A Comprehensive Review

, 21(6): 436 - 465

Muneeb U. Rehman*, Adil Farooq, Rayeesa Ali, Sana Bashir, Nazirah Bashir, Samia Majeed, Syed Taifa, Sheikh Bilal Ahmad, Azher Arafah, Aga Syed Sameer*, Rehan Khan, Wajhul Qamar, Saiema Rasool and Anas Ahmad


DOI: 10.2174/1389200221666200620204914


Research Article



Research Article

Effect of Green Tea and (-)-Epigallocatechin Gallate on the Pharmacokinetics of Rosuvastatin

, 21(6): 471 - 478

Shenjia Huang, Qingqing Xu, Linsheng Liu, Yicong Bian, Shichao Zhang, Chenrong Huang* and Liyan Miao*


DOI: 10.2174/1389200221666200514133355


Current Drug Metabolism, Volume 21 (2020) - Number 8


This issue is in progress but contains articles that are final and fully citable.

Current Drug Metabolism, Volume 21 (2020) - Number 7


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print


The genetic polymorphism of CYP3A4 rs2242480 is associated with sirolimus trough concentrations among adult renal transplant recipients


Lolita Lolita*, Ming Zheng*, Xiang Zhang*, Zhijian Han, Jun Tao, Shuang Fei, Zijie Wang, Miao Guo, Haiwei Yang, Xiaobing Ju, Ruoyun Tan, Ji-Fu Wei and Min Gu


DOI: 10.2174/1389200221999201027203401
View Abstract


Analysis of the Potential Association of Drug-Metabolizing Enzymes CYP2C9*3 and CYP2C19*3 Gene Variations With Type 2 Diabetes: A Case-Control Study


Imadeldin Elfaki*, Rashid Mir, Faisel M. Abu-Duhier, Chandan K. Jha, Adel I. Al-Alawy, Abdullatif Taha Babakr and Salem Abd El-Hadi Habib


DOI: 10.2174/1389200221999201027200931
View Abstract


A randomized study on the bioequivalence of desloratadine in Chinese healthy subjects and the association of different metabolic phenotypes with UGT2B10 and CYP2C8 genotypes


Suping Niu, Yan Li, Wenliang Dong, Lin Xia, Tiantian Shen, Jiaxue Wang, Qian Wang, Tan Zhang, Minjie Zhang, Gang Liu, Danjie Guo* and Yi Fang*


DOI: 10.2174/1389200221999201027143903
View Abstract








Abstracts Ahead of Print

There are currently no Abstracts Ahead of Print available for this journal.

Published Contents

Editor's Choice


Exosome-based Tumor Therapy: Opportunities and Challenges

, 2020; 21(5): 339 - 351

Chunmei Li, Xiaoming Hou, Peng Zhang, Juan Li, Xiaoguang Liu, Yuping Wang, Quanlin Guan and Yongning Zhou*


DOI: 10.2174/1389200221666200515103354




Human Papillomavirus Induced Cervical and Oropharyngeal Cancers: From Mechanisms to Potential Immuno-therapeutic Strategies

, 2020; 21(3): 167 - 177

Mohd. Saeed*, Syed Mohd Faisal, Firoz Akhtar, Saheem Ahmad, Mousa M. Alreshidi, Mohd. Adnan Kausar, Shadab Kazmi, Amir Saeed, Mohd. Adnan and Ghulam Md Ashraf*


DOI: 10.2174/1389200221666200421121228



Has the Time Come to Employ Population and Individual Bioequivalence for the Evaluation of Generics?

, 2020; 21(2): 112 - 125

Francis Micheal*, Mohanlal Sayana, Rajendra Prasad and Balamurali Musuvathi Motilal


DOI: 10.2174/1389200221666200401105119




Effect of Environmental Exposure and Pharmacogenomics on Drug Metabolism

, 2019; 20(14): 1103 - 1113

Basu Dev Banerjee*, Ranjeet Kumar, Krishna Latha Thamineni, Harendra Shah, Gaurav Kumar Thakur and Tusha Sharma


DOI: 10.2174/1389200221666200110153304



Therapeutic Study of Phytochemicals Against Cancer and Alzheimer’s Disease Management

, 2019; 20(13): 1006 - 1013

Syed Sayeed Ahmad, Tayyaba Waheed, Sayed Rozeen, Sufia Mahmood and Mohammad Amjad Kamal*


DOI: 10.2174/1389200221666200103092719



A Retrospective Look at Anti-EGFR Agents in Pancreatic Cancer Therapy

, 2019; 20(12): 958 - 966

Henu K. Verma, Praveen K. Kampalli, Saikrishna Lakkakula, Gayathri Chalikonda, Lakkakula V.K.S. Bhaskar* and Smaranika Pattnaik*


DOI: 10.2174/1389200220666191122104955




Open Access Articles

Dysregulation of lncRNA and circRNA Expression in Mouse Testes after Exposure to Triptolide

, 2019; 20(8): 665 - 673

Suping Xiong, Yanting Li, Yang Xiang, Na Peng, Chunmiao Shen, Yanqiu Cai, Dandan Song, Peng Zhang, Xiaolong Wang, Xuihui Zeng and Xiaoning Zhang*




Influence of the OATP Polymorphism on the Population Pharmacokinetics of Methotrexate in Chinese Patients

, 2019; 20(7): 592 - 600

Zhiqi Wang, Nan Zhang, Chaoyang Chen, Shuqing Chen, Junyu Xu, Ying Zhou, Xia Zhao* and Yimin Cui*




Decreased Disposition of Anticancer Drugs Predominantly Eliminated via the Liver in Patients with Renal Failure

, 2019; 20(5): 361 - 376

Ken-ichi Fujita *, Natsumi Matsumoto, Hiroo Ishida, Yutaro Kubota, Shinichi Iwai, Motoko Shibanuma and Yukio Kato




Effects of CYP2C8 and SLCO1B1 Genetic Polymorphisms on Repaglinide Pharmacokinetics: A Systematic Review and Meta-Analysis

, 2019; 20(4): 266 - 274

Shuang Zhou, Qian Xiang, Guangyan Mu, Lingyue Ma, Shuqing Chen, Qiufen Xie, Zhuo Zhang and Yimin Cui*






Survey of Drug Oxidation Activities in Hepatic and Intestinal Microsomes of Individual Common Marmosets, a New Nonhuman Primate Animal Model

, 2019; 20(2): 103 - 113

Shotaro Uehara, Toru Oshio, Kazuyuki Nakanishi, Etsuko Tomioka, Miyu Suzuki, Takashi Inoue, Yasuhiro Uno, Erika Sasaki and Hiroshi Yamazaki*





Thiazide Therapy in Chronic Kidney Disease: Renal and Extra Renal Targets

, 2018; 19(12): 1012 - 1020

Negiin Pourafshar*, Saeed Alshahrani, Ashkan Karimi and Manoocher Soleimani*




Models of Drug Induced Liver Injury (DILI) – Current Issues and Future Perspectives

, 2018; 19(10): 830 - 838

Lucija Kuna, Ivana Bozic, Tomislav Kizivat, Kristina Bojanic, Margareta Mrso, Edgar Kralj, Robert Smolic, George Y. Wu and Martina Smolic*






Digestive Enzyme Supplementation in Gastrointestinal Diseases

, 2016; 17(2): 187 - 193

Gianluca Ianiro, Silvia Pecere, Valentina Giorgio, Antonio Gasbarrini and Giovanni Cammarota




Role of Drug Metabolism in the Cytotoxicity and Clinical Efficacy of Anthracyclines

, 2015; 16(6): 412 - 426

Derek W. Edwardson, Rashmi Narendrula, Simon Chewchuk, Kyle Mispel-Beyer, Jonathan P.J. Mapletoft and Amadeo M. Parissenti




Preclinical Pharmacokinetics, Pharmacodynamics and Safety of Sucroferric Oxyhydroxide

, 2014; 15(10): 953 - 965

Mario Cozzolino, Felix Funk, Viatcheslav Rakov, Olivier Phan and Isaac Teitelbaum





Most Cited Articles

Review Article

Recent advances in machine learning methods for predicting heat shock proteins

, 2019; 20(3): 224-228.

Wei Chen*, Pengmian Feng, Tao Liu and Dianchuan Jin


DOI: 10.2174/1389200219666181031105916


Review Article

Survey of machine learning techniques in drug discovery

, 2019; 20(3): 185-193.

Natalie Stephenson, Emily Shane, Jessica Chase, Jason Rowland, David Ries, Nicola Justice, Jie Zhang, Leong Chan and Renzhi Cao*


DOI: 10.2174/1389200219666180820112457




Review Article

Magnetic nanoparticles: Current trends and future aspects in diagnostics and nanomedicine

, 2019; 20(6): 457-472.

Naga Veera Srikanth Vallabani, Sanjay Singh* and Ajay Singh Karakoti*


DOI: 10.2174/1389200220666181122124458



Review Article

Survey of machine learning techniques for prediction of the isoform specificity of cytochrome P450 substrates

, 2019; 20(3): 229-235.

Yi Xiong, Yanhua Qiao, Daisuke Kihara, Hui-Yuan Zhang, Xiaolei Zhu* and Dong-Qing Wei*


DOI: 10.2174/1389200219666181019094526


General Review Article

Advanced glycation end products (AGEs), glutathione and breast cancer: Factors, mechanism and therapeutic interventions

, 2019; 20(1): 65-71.

Anil K. Sharma, Var R. Sharma, Girish K. Gupta, Ghulam Md. Ashraf and Mohammad A. Kamal*


DOI: 10.2174/1389200219666180912104342


Review Article

Recent advances in the machine learning-based drug-target interaction prediction

, 2019; 20(3): 194-202.

Wen Zhang*, Weiran Lin, Ding Zhang, Siman Wang, Jingwen Shi and Yanqing Niu


DOI: 10.2174/1389200219666180821094047


Review Article

Iron oxide nanoparticles for breast cancer theranostics

, 2019; 20(6): 446-456.

Md. Salman Shakil, Md. Ashraful Hasan* and Satya Ranjan Sarker*


DOI: 10.2174/1389200220666181122105043


Review Article

Herb-drug interactions and hepatotoxicity

, 2019; 20(4): 275-282.

Mohammad K. Parvez* and Vikas Rishi


DOI: 10.2174/1389200220666190325141422


Review Article

Curcumin-a novel therapeutic agent in the prevention of colorectal cancer

, 2019; 20(12): 977-987.

Manoj K. Gupta, Ramakrishna Vadde and Vemula Sarojamma*


DOI: 10.2174/1389200220666191007153238


Review Article

Drug-drug interactions of P-gp substrates unrelated to CYP metabolism

, 2019; 20(2): 124-129.

Yumiko Akamine, Norio Yasui-Furukori and Tsukasa Uno*


DOI: 10.2174/1389200219666181003142036


Review Article

Cancer nanotechnology: A new revolution for cancer diagnosis and therapy

, 2019; 20(6): 416-429.

Vivek K Chaturvedi, Anshuman Singh, Vinay K. Singh and Mohan P. Singh*


DOI: 10.2174/1389200219666180918111528




Most Accessed Articles

Stem Cells in Tumour Microenvironment Aid in Prolonged Survival Rate of Cancer Cells and Developed Drug Resistance: Major Challenge in Osteosarcoma Treatment

, 2020; 21(1): 44-52.

Bhaskar Birru, ChandraSai Potla Durthi*, Santhosh Kacham, Madhuri Pola, Satish Babu Rajulapati, Sreenivasa Rao Parcha and Mohammad Amjad Kamal


DOI: 10.2174/1389200221666200214120226



Metabolic Pathways of T-2 Toxin

, 2008; 9(1): 77-82.

Kamil Kuca, Vlastimil Dohnal, Alena Jezkova and Daniel Jun


DOI: 10.2174/138920008783331176


Essential Oils: Extraction Techniques, Pharmaceutical And Therapeutic Potential - A Review

, 2018; 19(13): 1100-1110.

Zarith Asyikin Abdul Aziz, Akil Ahmad, Siti Hamidah Mohd Setapar*, Alptug Karakucuk, Muhammad Mohsin Azim, David Lokhat, Mohd. Rafatullah, Magdah Ganash, Mohammad A. Kamal and Ghulam Md Ashraf*


DOI: 10.2174/1389200219666180723144850



Clinical Pharmacokinetics of Propranolol Hydrochloride: A Review

, 2020; 21(2): 89-105.

Muhammad Nasir Kalam , Muhammad Fawad Rasool , Asim Ur Rehman and Naveed Ahmed *


DOI: 10.2174/1389200221666200414094644


Further Considerations Towards an Effective and Efficient Oncology Drug Discovery DMPK Strategy

, 2020; 21(2): 145-162.

Beth Williamson , Nicola Colclough, Adrian John Fretland, Barry Christopher Jones, Rhys Dafydd Owen Jones and Dermot Francis McGinnity *


DOI: 10.2174/1389200221666200312104837



Pharmacokinetic and Pharmacodynamic Properties of Anti-VEGF Drugs After Intravitreal Injection

, 2015; 16(7): 572-584.

Francesco Semeraro, Francesco Morescalchi, Sarah Duse, Elena Gambicorti, Anna Cancarini and Ciro Costagliola


DOI: 10.2174/1389200216666151001120831



Editor-in-Chief

Ming Hu
University of Houston College of Pharmacy
Houston, TX
(USA)
Biography
View Full Editorial Board

COPE Compliant

Journal History

Current Drug Metabolism was launched in 2000. Dr. Michael Sinz serves as the Editor-in-Chief of the journal.
Scopus CiteScore Metrics: 2.75

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