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Current Drug Metabolism

Volume 22, 14 Issues, 2021
ISSN: 1875-5453 (Online)
ISSN: 1389-2002 (Print)
This journal supports open access

Aims & Scope

Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism, pharmacokinetics, and drug disposition. The journal serves as an international forum for the publication of full-length/mini review, research articles and guest edited issues in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the most important developments. The journal covers the following general topic areas: pharmaceutics, pharmacokinetics, toxicology, and most importantly drug metabolism.

More specifically, in vitro and in vivo drug metabolism of phase I and phase II enzymes or metabolic pathways; drug-drug interactions and enzyme kinetics; pharmacokinetics, pharmacokinetic-pharmacodynamic modeling, and toxicokinetics; interspecies differences in metabolism or pharmacokinetics, species scaling and extrapolations; drug transporters; target organ toxicity and interindividual variability in drug exposure-response; extrahepatic metabolism; bioactivation, reactive metabolites, and developments for the identification of drug metabolites. Preclinical and clinical reviews describing the drug metabolism and pharmacokinetics of marketed drugs or drug classes.

Current Drug Metabolism

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Volume 22

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Number 3



Biography   Open Access





Review Article

Advances in Understanding the Metabolites and Metabolomics of Polygonum multiflorum Thunb: A Mini-review

, 22(3): 165 - 172

Jian-Bo Yang, Hui-Yu Gao, Yun-Fei Song, Yue Liu, Qi Wang, Ying Wang, Shuang-Cheng Ma*, Xian-Long Cheng and Feng Wei*


DOI: 10.2174/1389200221666201201091345






Systematic Review Article

Topical Capsaicin for the Treatment of Neuropathic Pain

, 22(3): 198 - 207

Adiba Sultana, Rajeev K. Singla, Xuefei He, Yan Sun, Md. Shahin Alam and Bairong Shen*


DOI: 10.2174/1389200221999201116143701




General Research Article



Articles Ahead of Print

Evaluation of Dermorphin Metabolism Using Zebrafish Water Tank Model and Human Liver Microsomes


Juliana de L. Castro*, Henrique M. G. Pereira, Valéria P. de Sousa and Maria Elvira P. Martucci


DOI: 10.2174/1389200222666210216095753
View Abstract View on PubMed








Comparison of the Inhibitory Effects of Clotrimazole and Ketoconazole Against Human Carboxylesterase 2


Tingting Zhao, Dalong Wang, Zhao Shan, Jing Chen, Tongyi Dou, Guangbo Ge, Changyuan Wang, Qiang Meng, Huijun Sun, Kexin Liu and Jingjing Wu*


DOI: 10.2174/1389200222666210210115509
View Abstract View on PubMed



Recent Patents, Regulatory Issues, and Toxicity of Nanoparticles in Neuronal Disorders


Abdul Muheem, Mohammed Asadullah Jahangir, Chandra Prakash Jaiswal, Mohammed Jafar, Mohammad Zaki Ahmad, Javed Ahmad and Musarrat Husain Warsi*


DOI: 10.2174/1389200221999201210213036
View Abstract View on PubMed


Abstracts Ahead of Print




Role of Natural Products in the Treatment of Obesity: Nanotechnological perspectives


Kashish Kapoor, Reecha Madaan*, Suresh Kumar, Rajni Bala and Raman Preet Walia


DOI: 10.2174/1389200222666210324150738
View Abstract


Absorption, Metabolism, Distribution, and Excretion of Letermovir


Karsten Menzel*, Prajakti Kothare, Jacqueline B. McCrea, Xiaoyan Chu and Dirk Kropeit


DOI: 10.2174/1389200222666210223112826
View Abstract


Design and Evaluation of Ornidazole Sustained release Dental Inserts


Sunchu Harika*, Y. Shravan Kumar*, Y. Madhusudhan Rao, Pavani Sriram and Uma Shankar


DOI: 10.2174/1389200222666210222152940
View Abstract





Emerging Promise of Nanoparticle-Based Treatment for Parkinson’s Disease


Md. Marufur Rahman Moni, Mst. Marium Begum, Md. Sahab Uddin* and Ghulam Md Ashraf*


DOI: 10.2174/1389200222666210202110129
View Abstract


Published Contents

Editor's Choice

Topical Capsaicin for the Treatment of Neuropathic Pain

, 2021; 22(3): 198 - 207

Adiba Sultana, Rajeev K. Singla, Xuefei He, Yan Sun, Md. Shahin Alam and Bairong Shen*


DOI: 10.2174/1389200221999201116143701





Current Treatment Options for HCC: From Pharmacokinetics to Efficacy and Adverse Events in Liver Cirrhosis

, 2020; 21(11): 866 - 884

Giovanni Galati*, Antonio Fabio Massimo Vainieri*, Claudia Angela Maria Fulgenzi, Stefano Di Donato, Marianna Silletta, Paolo Gallo, Angelo Onorato, Umberto Vespasiani-Gentilucci and Antonio Picardi


DOI: 10.2174/1389200221999200918141239




Polymeric Nanoparticles for Brain Drug Delivery - A Review

, 2020; 21(9): 649 - 660

Subashini Raman, Syed Mahmood*, Ayah R. Hilles, Md Noushad Javed, Motia Azmana and Khater Ahmed Saeed Al-Japairai


DOI: 10.2174/1389200221666200508074348






Exosome-based Tumor Therapy: Opportunities and Challenges

, 2020; 21(5): 339 - 351

Chunmei Li, Xiaoming Hou, Peng Zhang, Juan Li, Xiaoguang Liu, Yuping Wang, Quanlin Guan and Yongning Zhou*


DOI: 10.2174/1389200221666200515103354



Open Access Articles


Dysregulation of lncRNA and circRNA Expression in Mouse Testes after Exposure to Triptolide

, 2019; 20(8): 665 - 673

Suping Xiong, Yanting Li, Yang Xiang, Na Peng, Chunmiao Shen, Yanqiu Cai, Dandan Song, Peng Zhang, Xiaolong Wang, Xuihui Zeng and Xiaoning Zhang*




Influence of the OATP Polymorphism on the Population Pharmacokinetics of Methotrexate in Chinese Patients

, 2019; 20(7): 592 - 600

Zhiqi Wang, Nan Zhang, Chaoyang Chen, Shuqing Chen, Junyu Xu, Ying Zhou, Xia Zhao* and Yimin Cui*




Decreased Disposition of Anticancer Drugs Predominantly Eliminated via the Liver in Patients with Renal Failure

, 2019; 20(5): 361 - 376

Ken-ichi Fujita *, Natsumi Matsumoto, Hiroo Ishida, Yutaro Kubota, Shinichi Iwai, Motoko Shibanuma and Yukio Kato




Effects of CYP2C8 and SLCO1B1 Genetic Polymorphisms on Repaglinide Pharmacokinetics: A Systematic Review and Meta-Analysis

, 2019; 20(4): 266 - 274

Shuang Zhou, Qian Xiang, Guangyan Mu, Lingyue Ma, Shuqing Chen, Qiufen Xie, Zhuo Zhang and Yimin Cui*






Survey of Drug Oxidation Activities in Hepatic and Intestinal Microsomes of Individual Common Marmosets, a New Nonhuman Primate Animal Model

, 2019; 20(2): 103 - 113

Shotaro Uehara, Toru Oshio, Kazuyuki Nakanishi, Etsuko Tomioka, Miyu Suzuki, Takashi Inoue, Yasuhiro Uno, Erika Sasaki and Hiroshi Yamazaki*





Thiazide Therapy in Chronic Kidney Disease: Renal and Extra Renal Targets

, 2018; 19(12): 1012 - 1020

Negiin Pourafshar*, Saeed Alshahrani, Ashkan Karimi and Manoocher Soleimani*




Models of Drug Induced Liver Injury (DILI) – Current Issues and Future Perspectives

, 2018; 19(10): 830 - 838

Lucija Kuna, Ivana Bozic, Tomislav Kizivat, Kristina Bojanic, Margareta Mrso, Edgar Kralj, Robert Smolic, George Y. Wu and Martina Smolic*






Digestive Enzyme Supplementation in Gastrointestinal Diseases

, 2016; 17(2): 187 - 193

Gianluca Ianiro, Silvia Pecere, Valentina Giorgio, Antonio Gasbarrini and Giovanni Cammarota




Role of Drug Metabolism in the Cytotoxicity and Clinical Efficacy of Anthracyclines

, 2015; 16(6): 412 - 426

Derek W. Edwardson, Rashmi Narendrula, Simon Chewchuk, Kyle Mispel-Beyer, Jonathan P.J. Mapletoft and Amadeo M. Parissenti





Most Cited Articles

Review Article

Decoding novel mechanisms and emerging therapeutic strategies in breast cancer resistance

, 2020; 21(3): 199-210.

Sadat Shafi, Sana Khan, Farazul Hoda, Faizana Fayaz, Archu Singh, Mohammad Ahmed Khan*, Ruhi Ali, Faheem Hyder Pottoo, Sana Tariq and Abul Kalam Najmi


DOI: 10.2174/1389200221666200303124946


Research Article

Dietary baicalin zinc supplementation alleviates oxidative stress and enhances nutrition absorption in deoxynivalenol challenged pigs

, 2020; 21(8): 614-625.

Andong Zha, Zhijuan Cui, Ming Qi, Simeng Liao, Lixin Chen, Peng Liao* and Bie Tan*


DOI: 10.2174/1389200221666200302124102


Review Article

The current state of potential therapeutic modalities for glioblastoma multiforme: A clinical review

, 2020; 21(8): 564-578.

Elmira Mohtashami, Negar Shafaei-Bajestani, Hamid Mollazadeh, Seyed Hadi Mousavi, Mohammad Jalili-Nik, Amirhossein Sahebkar* and Amir R. Afshari*


DOI: 10.2174/1389200221666200714101038



Review Article

Stem cells in tumour microenvironment aid in prolonged survival rate of cancer cells and developed drug resistance: major challenge in osteosarcoma treatment

, 2020; 21(1): 44-52.

Bhaskar Birru, ChandraSai Potla Durthi*, Santhosh Kacham, Madhuri Pola, Satish Babu Rajulapati, Sreenivasa Rao Parcha and Mohammad Amjad Kamal


DOI: 10.2174/1389200221666200214120226


Research Article

Modulation of the drug resistance by platonia insignis mart. Extract, ethyl acetate fraction and morelloflavone/volkensiflavone (biflavonoids) in staphylococcus aureus strains overexpressing efflux pump genes

, 2021; 22(2): 114-122.

Andressa K.F. e Silva, Antonielly C. dos Reis, Emanuelly E.A. Pinheiro, Jonas N. de Sousa, Felipe A. de Alcântara Oliveira, Arkellau K.S. Moura, José de Sousa L. Neto, Antonia M. das Graças L. Citó, José P. Siqueira-Júnior, Glenn W. Kaatz and Humberto M. Barreto*


DOI: 10.2174/1389200221666200523155617


Review Article

Nanostructured lipid carriers (NLCs): Nose-to-brain delivery and theranostic application

, 2020; 21(14): 1136-1143.

Javed Ahmad*, Md. Rizwanullah, Saima Amin, Musarrat Husain Warsi, Mohammad Zaki Ahmad and Md. Abul Barkat


DOI: 10.2174/1389200221666200719003304


Review Article

Research progress of herbal medicines on drug metabolizing enzymes: Consideration based on toxicology

, 2020; 21(12): 913-927.

Shuting Wang, Wanfang Li, Jianbo Yang, Zengyan Yang, Cuiping Yang* and Hongtao Jin*


DOI: 10.2174/1389200221999200819144204


Review Article (Mini-Review)

Exosome-based tumor therapy: Opportunities and challenges

, 2020; 21(5): 339-351.

Chunmei Li, Xiaoming Hou, Peng Zhang, Juan Li, Xiaoguang Liu, Yuping Wang, Quanlin Guan and Yongning Zhou*


DOI: 10.2174/1389200221666200515103354


Review Article

Chemical metabolism of xenobiotics by gut microbiota

, 2020; 21(4): 260-269.

Radislav Nakov* and Tsvetelina Velikova


DOI: 10.2174/1389200221666200303113830


Review Article

Prognostic role of hedgehog-gli1 signaling pathway in aggressive and metastatic breast cancers

, 2020; 21(1): 33-43.

Prasuja Rokkam, Shailender Gugalavath, Deepak Kakara Gift Kumar, Rahul Kumar Vempati and Rama Rao Malla*


DOI: 10.2174/1389200221666200122120625


Review Article

Versatile and valuable utilization of amidohydrolase l-glutaminase in pharma and food industries: A review

, 2020; 21(1): 11-24.

Chandrasai Potla Durthi*, Madhuri Pola, Satish Babu Rajulapati*, Anand Kishore Kola and Mohammad Amjad Kamal


DOI: 10.2174/1574884715666200116110542


Review Article

Talin: A potential drug target for cancer therapy

, 2020; 21(1): 25-32.

Rama Rao Malla and Rahul Kumar Vempati *


DOI: 10.2174/1389200221666200214114018


Review Article (Mini-Review)

Natural compounds as source of aldose reductase (Ar) inhibitors for the treatment of diabetic complications: A mini review

, 2020; 21(14): 1091-1116.

Ajmer Singh Grewal, Komal Thapa, Neha Kanojia, Neelam Sharma and Sukhbir Singh*


DOI: 10.2174/1389200221666201016124125




Most Accessed Articles


Toward Greater Insights on Applications of Modeling and Simulation in Pregnancy

, 2020; 21(9): 722-741.

Ling Song, Cheng Cui, Ying Zhou, Zhongqi Dong, Zhiheng Yu, Yifan Xu, Tianyan Zhou, Khaled Abduljalil, Hongcan Han, Li Li, Jinbo Yang, Yangyu Zhao*, Haiyan Li and Dongyang Liu*


DOI: 10.2174/1389200221666200907143941





Stem Cells in Tumour Microenvironment Aid in Prolonged Survival Rate of Cancer Cells and Developed Drug Resistance: Major Challenge in Osteosarcoma Treatment

, 2020; 21(1): 44-52.

Bhaskar Birru, ChandraSai Potla Durthi*, Santhosh Kacham, Madhuri Pola, Satish Babu Rajulapati, Sreenivasa Rao Parcha and Mohammad Amjad Kamal


DOI: 10.2174/1389200221666200214120226


A Review: Effects of Macrolides on CYP450 Enzymes

, 2020; 21(12): 928-937.

Liyun Zhang, Xiaoqing Xu, Sara Badawy, Awais Ihsan, Zhenli Liu, Changqing Xie, Xu Wang* and Yanfei Tao*


DOI: 10.2174/1389200221666200817113920


Advances in Understanding the Metabolites and Metabolomics of Polygonum multiflorum Thunb: A Mini-review

, 2021; 22(3): 165-172.

Jian-Bo Yang, Hui-Yu Gao, Yun-Fei Song, Yue Liu, Qi Wang, Ying Wang, Shuang-Cheng Ma*, Xian-Long Cheng and Feng Wei*


DOI: 10.2174/1389200221666201201091345



Metabolism and Distribution of Novel Tumor Targeting Drugs In Vivo

, 2020; 21(13): 996-1008.

Mengli Wang, Qiuzheng Du, Lihua Zuo, Peng Xue, Chao Lan* and Zhi Sun*


DOI: 10.2174/1389200221666201112110638




Metabolism of Direct-acting Antiviral Agents (DAAs) in Hepatitis C Therapy: A Review of the Literature

, 2021; 22(2): 89-98.

Ivana Mikolasevic*, Tajana F. Kanizaj, Dorotea Bozic, Petra Puz, Sanja S. Shapeski, Zeljko Puljiz, Delfa Radic-Kristo, Milos Lalovac, Maja Mijic, Bozena Delija, Toni Juric, Ivan Bogadi and Lucija Virovic-Jukic


DOI: 10.2174/1389200221999201214224126






Editor-in-Chief

graphic
Ming Hu
University of Houston
College of Pharmacy
Houston, TX
(USA)
Biography
View Full Editorial Board

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Journal History

Current Drug Metabolism was launched in 2000. Dr. Ming Hu serves as the Editor-in-Chief of the journal.

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