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Current Alzheimer Research

Volume 19, 14 Issues, 2022
ISSN: 1875-5828 (Online)
ISSN: 1567-2050 (Print)
This journal supports open access

Aims & Scope

Current Alzheimer Research publishes peer-reviewed frontier review, research, drug clinical trial studies and letter articles on all areas of Alzheimer’s disease. This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer’s disease. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, molecular, and animal models. The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer’s disease. Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer's disease with other dementia and neurodegenerative disorders. Book reviews, meeting reports and letters-to-the-editor are also published. The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer’s disease. Current Alzheimer Research provides a comprehensive 'bird's-eye view' of the current state of Alzheimer's research for neuroscientists, clinicians, health science planners, granting, caregivers and families of this devastating disease.

Current Alzheimer Research

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Volume 19

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Number 2



Research Article

Discrepancy Between Cognitive Test and Brain Imaging Results in Alzheimer’s Disease Associated with Diabetes

, 19(2): 95 - 103

Haruo Hanyu*, Yumi Koyama, Haruka Horita, Toshinori Aoki, Tomohiko Sato, Hidekazu Kanetaka, Soichiro Shimizu and Kentaro Hirao


DOI: 10.2174/1567205019666220228152655


Review Article

The Impact of Uremic Toxins on Alzheimer's Disease

, 19(2): 104 - 118

Yuqi Zheng, Bin Ji, Sijun Chen, Rong Zhou* and Ruiqing Ni*


DOI: 10.2174/1567205019666220120113305





Review Article

Diabetes/Dementia in Sub-Saharian Africa and Nigerian Women in the Eye of Storm

, 19(2): 161 - 170

Efosa K. Oghagbon*, José Prieto-Pino, Faeren Dogoh, Monday Ogiator and Lydia Giménez-Llort*


DOI: 10.2174/1567205018666211116093747


Clinical Trial

Sixteen Weeks of Aerobic Exercise does not Alter Resting-state Connectivity of the Precuneus in Patients with Alzheimer's Disease

, 19(2): 171 - 177

Christian Sandøe Musaeus*, Louise Baruël Johansen, Steen Hasselbalch, Nina Beyer, Peter Høgh, Hartwig Roman Siebner and Kristian Steen Frederiksen


DOI: 10.2174/1567205019666220304091241


Articles Ahead of Print


Co-Treatment with the Herbal Medicine SIP3 and Donepezil Improves Memory and Depression in the Mouse Model of Alzheimer’s Disease


Quan Feng Liu, Hoon Choi, Taekwon Son, Young-Mi Kim, Suganya Kanmani, Young-Won Chin, Seung-Nam Kim, Kwang Ki Kim, Kyu-Won Kim and Byung-Soo Koo*


DOI: 10.2174/1567205019666220413082130
View Abstract View on PubMed


Effects of Supplementation with Probiotics in Experimental Models of Alzheimer's Disease: A Systematic Review of Animal Experiments


Francisca Idalina Neta, Francisco Emílio Simplício de Souza, André Lima Batista, Francisco Irochima Pinheiro, Ricardo Ney Cobucci and Fausto Pierdoná Guzen*


DOI: 10.2174/1567205019666220318092003
View Abstract View on PubMed


Polymorphism Rs2421943 of the Insulin-Degrading Enzyme Gene and the Risk of Late-Onset Alzheimer’s Disease


Omar Šerý*, Tomáš Zeman, Alice Hálová, Vladimír Janout, Jana Janoutová, Jan Lochman and Vladimir J. Balcar


DOI: 10.2174/1567205019666220302120950
View Abstract View on PubMed


Dysexecutive Alzheimer’s Disease with Lewy Body Disease Co-Pathology


Ryan P. Coburn, Hugo Botha, Jonathan Graff-Radford, R. Ross Reichard, David T. Jones and Vijay K Ramanan*


DOI: 10.2174/1567205019666220308152219
View Abstract View on PubMed


Abstracts Ahead of Print



Poloxamer-188 Exacerbates Brain Amyloidosis, Presynaptic Dystrophies, and Pathogenic Microglial Activation in 5XFAD Mice.


Antonio Di Meco, Shahrnaz Kemal, Jelena Popovic, Sidhanth Chandra, Katherine R Sadleir and Robert Vassar*


DOI: 10.2174/1567205019666220509143823
View Abstract


The Effect of Gut Microbe Dysbiosis on the Pathogenesis of Alzheimer's Disease (AD) and related conditions


Mohamed H. Nafady, Zeinab S. Sayed, Dalia A. Abdelkawy, Mostafa E. Shebl, Reem A. Elsayed, Ghulam Md Ashraf, Asma Perveen, Mohamed S. Attia and Eshak I. Bahbah*


DOI: 10.2174/1567205019666220419101205
View Abstract


Alzheimer’s Disease-Related Psychosis: An Overview of Clinical Manifestations, Pathogenesis, and Current Treatment


Amira Yasmine Benmelouka, Yassamine Ouerdane, Oumaima Outani, Yusra Talal Alnasser, Badrah S. Alghamdi, Asma Perveen, Ghulam Md Ashraf* and Mahmoud Ahmed Ebada*


DOI: 10.2174/1567205019666220418151914
View Abstract


Temporal speech parameters detect mild cognitive impairment in different languages: validation and comparison of the Speech-GAP Test® in English and Hungarian


János Kálmán*, Davangere P. Devanand, Gábor Gosztolya, Réka Balogh, Nóra Imre, László Tóth, Ildikó Hoffmann, Ildikó Kovács, Veronika Vincze and Magdolna Pákáski


DOI: 10.2174/1567205019666220418155130
View Abstract




Oculomotor abnormalities during reading in offspring of late-onset Alzheimer’s disease


Gerardo Fernández*, Ana Paula González, Carolina Abulafia, Leticia Fiorentini, Osvaldo Agamennoni and Salvador M. Guinjoan


DOI: 10.2174/1567205019666220413075840
View Abstract


Blood Biomarkers Predict Future Cognitive Decline after Military-Related Traumatic Brain Injury


Sara. M. Lippa*, Jessica Gill, Tracey A. Brickell, Vivian A. Guedes, Louis M. French and Rael T. Lange


DOI: 10.2174/1567205019666220330144432
View Abstract


Published Contents

Editor's Choice



Unfolded p53 as a Marker of Oxidative Stress in Mild Cognitive Impairment, Alzheimer’s and Parkinson’s Disease

, 2021; 18(9): 695 - 700

Sara García*, Olaya Amor-Gutiérrez, María Palomares-Albarrán, Celia Toyos-Rodríguez, Fernando Cuetos, Carmen Martínez, Agustín Costa-García, Maria Teresa Fernández-Sánchez, Alfredo de la Escosura-Muñiz and Antonello Novelli


DOI: 10.2174/1567205018666211117101216



Palmitoylated Prolactin-releasing Peptide Reduced Aβ Plaques and Microgliosis in the Cerebellum: APP/PS1 Mice Study

, 2021; 18(8): 607 - 622

Anna Mengr, Lucie Hrubá, Aneta Exnerová, Martina Holubová, Andrea Popelová, Blanka Železná, Jaroslav Kuneš and Lenka Maletínská*


DOI: 10.2174/1567205018666210922110652



A Novel Probiotic Formula, BIOCG, Protects Against Alzheimer’s-Related Cognitive Deficits via Regulation of Dendritic Spine Dynamics

, 2021; 18(7): 558 - 572

Miao Sun*, Wenchenyang Bao, Chengyu Huang, Ziyue Xia, Changliang Zhang, Guangxian Wang, Runxin Wang, Jiangyu Li, Shaun Roux, Qian Li, Dongmei Zou, Kai Ma* and Xiaofeng Bao*


DOI: 10.2174/1567205018666211022091110




The Janus-like Association between Proton Pump Inhibitors and Dementia

, 2021; 18(6): 453 - 469

Anna Papazoglou, Muhammad I. Arshaad, Christina Henseler, Johanna Daubner, Karl Broich, Britta Haenisch and Marco Weiergräber*


DOI: 10.2174/1567205018666210929144740




Accelerated Epigenetic Aging in Peripheral Blood does not Predict Dementia Risk

, 2021; 18(5): 443 - 451

P.D. Fransquet, P. Lacaze, R. Saffery, R.C. Shah, R. Vryer, A. Murray, R.L. Woods and J. Ryan*


DOI: 10.2174/1567205018666210823100721



High Fat Diet Aggravates AD-Related Pathogenic Processes in APP/PS1 Mice

, 2021; 18(4): 310 - 325

Xiaokang Gong, Zheng Liang, Wei Liu, Yang Zhao, Youhua Yang, Mengjuan Wu, Jinting Shang, Yifan Xiao, Yong Mei, Qiqi Su, Binlian Sun, Jian Bao* and Xiji Shu*


DOI: 10.2174/1567205018666210628100812



Open Access Articles


Random-Forest-Algorithm-Based Applications of the Basic Characteristics and Serum and Imaging Biomarkers to Diagnose Mild Cognitive Impairment

, 2022; 19(1): 76 - 83

Juan Yang, Haijing Sui, Ronghong Jiao, Min Zhang, Xiaohui Zhao, Lingling Wang, Wenping Deng and Xueyuan Liu*




Inflammation in the CNS: Understanding Various Aspects of the Pathogenesis of Alzheimer's Disease

, 2022; 19(1): 16 - 31

Julia Doroszkiewicz*, Piotr Mroczko and Agnieszka Kulczyńska-Przybik*





Mitochondrially-Targeted Therapeutic Strategies for Alzheimer’s Disease

, 2021; 18(10): 753 - 771

Isaac G. Onyango*, James P. Bennett and Gorazd B. Stokin




Heterogeneity of Tau Deposition and Microvascular Involvement in MCI and AD

, 2021; 18(9): 711 - 720

Annie G. Bryant, Mary K. Manhard, David H. Salat, Bruce R. Rosen, Bradley T. Hyman, Keith A. Johnson, Susie Huang, Rachel E. Bennett and Yi-Fen Yen*




Microglia and its Genetics in Alzheimer's Disease

, 2021; 18(9): 676 - 688

Xinyan Liang , Haijian Wu, Mark Colt , Xinying Guo, Brock Pluimer , Jianxiong Zeng, Shupeng Dong and Zhen Zhao*






The Janus-like Association between Proton Pump Inhibitors and Dementia

, 2021; 18(6): 453 - 469

Anna Papazoglou, Muhammad I. Arshaad, Christina Henseler, Johanna Daubner, Karl Broich, Britta Haenisch and Marco Weiergräber*





Pregabalin Treatment does not Affect Amyloid Pathology in 5XFAD Mice

, 2021; 18(4): 283 - 297

Katherine R. Sadleir*, Jelena Popovoic, Wei Zhu, Cory T. Reidel, Ha Do, Richard B. Silverman and Robert Vassar




Real-world Utilisation of the Rivastigmine Transdermal Patches Accompanying the Use of Risk Minimisation Tools in Patients with Dementia

, 2021; 18(4): 273 - 282

Fritjof Reinhardt, Nikolaos Scarmeas, Rajesh Karan, Uday K. Veldandi, Sunil Modali*, Krishna Duvvuri and Rashid K. Pathan




Clinical Phenotype and Mutation Spectrum of Alzheimer’s Disease with Causative Genetic Mutation in a Chinese Cohort

, 2021; 18(3): 265 - 272

Chenhui Mao, Jie Li, Liling Dong, Xinying Huang, Dan Lei, Jie Wang, Shanshan Chu, Caiyan Liu, Bin Peng, Gustavo C. Román, Liying Cui and Jing Gao*






Most Cited Articles






Review Article

Mitigating Alzheimer’s disease with natural polyphenols: A review

, 2019; 16(6): 529-543.

Roger Gaudreault* and Normand Mousseau*


DOI: 10.2174/1567205016666190315093520


Review Article

Learning from the past: A review of clinical trials targeting amyloid, tau and neuroinflammation in Alzheimer’s disease

, 2020; 17(2): 112-125.

Kelly Ceyzériat, Thomas Zilli, Philippe Millet, Giovanni B. Frisoni, Valentina Garibotto and Benjamin B. Tournier*


DOI: 10.2174/1567205017666200304085513


Research Article

Resveratrol rescues tau-induced cognitive deficits and neuropathology in a mouse model of tauopathy

, 2019; 16(8): 710-722.

Xiao-Ying Sun, Quan-Xiu Dong, Jie Zhu, Xun Sun, Li-Fan Zhang, Mandy Qiu, Xiao-Lin Yu* and Rui-Tian Liu*


DOI: 10.2174/1567205016666190801153751


Review Article

Neuroinflammation in alzheimer’s disease: Microglia, molecular participants and therapeutic choices

, 2019; 16(7): 659-674.

Haijun Wang, Yin Shen, Haoyu Chuang, Chengdi Chiu, Youfan Ye and Lei Zhao*


DOI: 10.2174/1567205016666190503151648



Systemic Review Article

Midlife modifiable risk factors for dementia: A systematic review and meta-analysis of 34 prospective cohort studies

, 2019; 16(14): 1254-1268.

Xiao-Ying Li , Min Zhang*, Wei Xu, Jie-Qiong Li, Xi-Peng Cao , Jin-Tai Yu * and Lan Tan*


DOI: 10.2174/1567205017666200103111253


Research Article

The temporal relationship between pain intensity and pain interference and incident dementia

, 2019; 16(2): 109-115.

Ali Ezzati*, Cuiling Wang, Mindy J. Katz, Carol A. Derby, Andrea R. Zammit, Molly E. Zimmerman, Jelena M. Pavlovic, Martin J. Sliwinski and Richard B. Lipton


DOI: 10.2174/1567205016666181212162424


Systematic Review Article

Physical activity as a moderator of alzheimer pathology: A systematic review of observational studies

, 2019; 16(4): 362-378.

Kristian Steen Frederiksen*, Le Gjerum, Gunhild Waldemar and Steen Gregers Hasselbalch


DOI: 10.2174/1567205016666190315095151


Research Article

A pilot study of exenatide actions in alzheimer’s disease

, 2019; 16(8): 741-752.

Roger J. Mullins, Maja Mustapic, Chee W. Chia, Olga Carlson, Seema Gulyani, Joyce Tran, Yazhou Li, Mark P. Mattson, Susan Resnick, Josephine M. Egan, Nigel H. Greig and Dimitrios Kapogiannis*


DOI: 10.2174/1567205016666190913155950


Review Article

Pharmacological interventions to attenuate Alzheimer’s disease progression: The story so far

, 2019; 16(3): 261-277.

Firas H. Bazzari*, Dalaal M. Abdallah and Hanan S. El-Abhar


DOI: 10.2174/1567205016666190301111120



Most Accessed Articles

Accelerated Epigenetic Aging in Peripheral Blood does not Predict Dementia Risk

, 2021; 18(5): 443-451.

P.D. Fransquet, P. Lacaze, R. Saffery, R.C. Shah, R. Vryer, A. Murray, R.L. Woods and J. Ryan*


DOI: 10.2174/1567205018666210823100721



Risk Factors for Alzheimer’s Disease: An Epidemiological Study

, 2021; 18(5): 372-379.

Jana Janoutová*, Martina Kovalová, Ondřej Machaczka, Petr Ambroz, Anna Zatloukalová, Kateřina Němček and Vladimír Janout


DOI: 10.2174/1567205018666210820124135



Cerebral Microbleeds and White Matter Hyperintensities are Associated with Cognitive Decline in an Asian Memory Clinic Study

, 2021; 18(5): 399-413.

Bibek Gyanwali, Benedict Lui, Chuen S. Tan, Eddie J.Y. Chong, Henri Vrooman, Christopher Chen and Saima Hilal*


DOI: 10.2174/1567205018666210820125543


Neutrophil Granule Proteins Inhibit Amyloid Beta Aggregation and Neurotoxicity

, 2021; 18(5): 414-427.

Anne Kasus-Jacobi*, Jennifer L. Washburn, Craig A. Land and Heloise Anne Pereira


DOI: 10.2174/1567205018666210823095044


Effect of High Cholesterol Regulation of LRP1 and RAGE on Aβ Transport Across the Blood-Brain Barrier in Alzheimer’s Disease

, 2021; 18(5): 428-442.

Rui Zhou, Li-li Chen, Hai Yang, Ling Li, Juan Liu, Le Chen, Wen-Juan Hong, Cong-guo Wang, Jing-Jing Ma, Jie Huang, Xin-Fu Zhou, Dong Liu and Hua-Dong Zhou*


DOI: 10.2174/1567205018666210906092940


Robust Discovery of Mild Cognitive Impairment Subtypes and Their Risk of Alzheimer's Disease Conversion Using Unsupervised Machine Learning and Gaussian Mixture Modeling

, 2021; 18(7): 595-606.

Fahimeh Nezhadmoghadam*, Antonio Martinez-Torteya, Victor Treviño, Emmanuel Martínez, Alejandro Santos, Jose Tamez-Peña and Alzheimer’s Disease Neuroimaging Initiative


DOI: 10.2174/1567205018666210831145825


Microglia and its Genetics in Alzheimer's Disease

, 2021; 18(9): 676-688.

Xinyan Liang , Haijian Wu, Mark Colt , Xinying Guo, Brock Pluimer , Jianxiong Zeng, Shupeng Dong and Zhen Zhao*


DOI: 10.2174/1567205018666211105140732


Palmitoylated Prolactin-releasing Peptide Reduced Aβ Plaques and Microgliosis in the Cerebellum: APP/PS1 Mice Study

, 2021; 18(8): 607-622.

Anna Mengr, Lucie Hrubá, Aneta Exnerová, Martina Holubová, Andrea Popelová, Blanka Železná, Jaroslav Kuneš and Lenka Maletínská*


DOI: 10.2174/1567205018666210922110652


Association of the MAOB rs1799836 Single Nucleotide Polymorphism and APOE ε4 Allele in Alzheimer’s Disease

, 2021; 18(7): 585-594.

Mirjana B. Leko, Matea N. Perković, Gordana N. Erjavec, Nataša Klepac, Dubravka Š. Štrac, Fran Borovečki, Nela Pivac, Patrick R. Hof and Goran Šimić*


DOI: 10.2174/1567205018666210917162843


A Novel Probiotic Formula, BIOCG, Protects Against Alzheimer’s-Related Cognitive Deficits via Regulation of Dendritic Spine Dynamics

, 2021; 18(7): 558-572.

Miao Sun*, Wenchenyang Bao, Chengyu Huang, Ziyue Xia, Changliang Zhang, Guangxian Wang, Runxin Wang, Jiangyu Li, Shaun Roux, Qian Li, Dongmei Zou, Kai Ma* and Xiaofeng Bao*


DOI: 10.2174/1567205018666211022091110


Non-Ceruloplasmin Copper as a Stratification Biomarker of Alzheimer’s Disease Patients: How to Measure and Use It

, 2021; 18(7): 533-545.

Rosanna Squitti*, Mariacarla Ventriglia, Alberto Granzotto, Stefano L. Sensi and Mauro Ciro A. Rongioletti


DOI: 10.2174/1567205018666211022085755






Editor-in-Chief

graphic
Debomoy K. Lahiri
(16607 citations)
Department of Psychiatry
Indiana University School of Medicine
Indianapolis, IN
(United States)
Biography
View Full Editorial Board

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Journal History

Current Alzheimer Research was introduced in 2004 with the assistance of Dr. Debomoy K. Lahiri, who is the current Editor-in-Chief serving since 2004.
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