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Current Alzheimer Research

Volume 18, 14 Issues, 2021
ISSN: 1875-5828 (Online)
ISSN: 1567-2050 (Print)
This journal supports open access

Aims & Scope

Current Alzheimer Research publishes peer-reviewed frontier review, research, drug clinical trial studies and letter articles on all areas of Alzheimer’s disease. This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer’s disease. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, molecular, and animal models. The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer’s disease. Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer's disease with other dementia and neurodegenerative disorders. Book reviews, meeting reports and letters-to-the-editor are also published. The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer’s disease. Current Alzheimer Research provides a comprehensive 'bird's-eye view' of the current state of Alzheimer's research for neuroscientists, clinicians, health science planners, granting, caregivers and families of this devastating disease.

Current Alzheimer Research

,

Volume 18

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Number 6



Review Article   Open Access

The Janus-like Association between Proton Pump Inhibitors and Dementia

, 18(6): 453 - 469

Anna Papazoglou, Muhammad I. Arshaad, Christina Henseler, Johanna Daubner, Karl Broich, Britta Haenisch and Marco Weiergräber*


DOI: 10.2174/1567205018666210929144740




Research Article

Determinants of Cognitive Trajectories in Normal Aging: A Longitudinal PET-MRI Study in a Community-based Cohort

, 18(6): 482 - 491

François R. Herrmann, Marie-Louise Montandon, Valentina Garibotto, Cristelle Rodriguez, Sven Haller and Panteleimon Giannakopoulos*


DOI: 10.2174/1567205018666210930111806






Research Article







Current Alzheimer Research, Volume 18 (2021) - Number 8


This issue is in progress but contains articles that are final and fully citable.

Current Alzheimer Research, Volume 18 (2021) - Number 7


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print


Connectivity and Patterns of Regional Cerebral Blood Flow, Cerebral Glucose Uptake, and Aβ-Amyloid Deposition in Alzheimer's Disease (Early and Late-Onset) Compared to Normal Ageing


Falasco Germán*, Damian Andres, Urrutia Leandro, Niell Nicolás, Lago Graciela, Bérgamo Yanina, Chrem Patricio, Quagliata Adriana, Bentancourt Cecilia, Calandri Ismael, Cordero Ismael, Magdalena Ponce de León, Contreras Valeria, Viviana Feuerstein, Dansilio Sergio, Allegri Ricard, Engler Henry and Vazquez Silvia


DOI: 10.2174/1567205018666211116095035
View Abstract View on PubMed



Microglia and its Genetics in Alzheimer's Disease


Xinyan Liang , Haijian Wu, Mark Colt , Xinying Guo, Brock Pluimer , Jianxiong Zeng, Shupeng Dong and Zhen Zhao


DOI: 10.2174/1567205018666211105140732
View Abstract


Palmitoylated Prolactin-releasing Peptide Reduced Aβ Plaques and Microgliosis in the Cerebellum: APP/PS1 Mice Study


Anna Mengr, Lucie Hrubá, Aneta Exnerová, Martina Holubová, Andrea Popelová, Blanka Železná, Jaroslav Kuneš and Lenka Maletínská*


DOI: 10.2174/1567205018666210922110652
View Abstract View on PubMed


Abstracts Ahead of Print

Classification of Patients with Alzheimer’s Disease and Dementia with Lewy Bodies using Resting EEG Selected Features at Sensor and Source Levels: A proof-of-concept study


Rodrigo San-Martin, Francisco J. Fraga*, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Flavio Nobili , Dario Arnaldi , Fabrizia D'Antonio, Carlo De Lena, Bahar Güntekin , Lutfu Hanoğlu , John Paul Taylor, Ian McKeith, Fabrizio Stocchi, Raffaele Ferri, Marco Onofrj, Susanna Lopez , Laura Bonanni and Claudio Babiloni


DOI: 10.2174/1567205018666211027143944
View Abstract


The Transition of Mild Cognitive Impairment Over Time: An AV45- and FDG-PET Study of Reversion and Conversion Phenomena


Amir Ashraf-Ganjouei, Kamyar Moradi*, Shahriar Faghani, AmirHussein Abdolalizadeh, Mohammadreza Khomeijani-Farahani and Farzad Fatehi


DOI: 10.2174/1567205018666211124110710
View Abstract


In vitro Aggregation Ability of Five Commercially Available Aβ42 Peptides


Zhaoji Lv, Xi Du, Zhongsheng Chen, Fengjuan Liu, Rong Zhang, Li Ma, Shengliang Ye, Peng Jiang, Zongkui Wang, Haijun Cao* and Changqing Li*


DOI: 10.2174/1567205018666211124105844
View Abstract




Unfolded p53 as a marker of oxidative stress in Mild Cognitive Impairment, Alzheimer’s and Parkinson’s disease


Sara García*, Olaya Amor-Gutiérrez, María Palomares-Albarrán, Celia Toyos-Rodríguez, Fernando Cuetos, Carmen Martínez, Agustín Costa-García, Maria Teresa Fernández-Sánchez, Alfredo de la Escosura-Muñiz and Antonello Novelli


DOI: 10.2174/1567205018666211117101216
View Abstract



Diabetes/Dementia in Sub-saharian Africa and Nigerian Women in the Eye of Storm


Efosa K. Oghagbon*, José Prieto-Pino, Faeren Dogoh, Monday Ogiator and Lydia Giménez-Llort*


DOI: 10.2174/1567205018666211116093747
View Abstract



Functional Roles of Neuronal Nitric Oxide Synthase in Neurodegenerative Diseases and Mood Disorders


Chi Him Poon, Ka Chun Tsui, Sze Chun Chau, Pit Shan Chong, Sylvia Wing Yan Lui, Luca Aquili, Kah Hui Wong and Lee Wei Lim*


DOI: 10.2174/1567205018666211022164025
View Abstract


Published Contents

Editor's Choice


The Janus-like Association between Proton Pump Inhibitors and Dementia

, 2021; 18(6): 453 - 469

Anna Papazoglou, Muhammad I. Arshaad, Christina Henseler, Johanna Daubner, Karl Broich, Britta Haenisch and Marco Weiergräber*


DOI: 10.2174/1567205018666210929144740




Accelerated Epigenetic Aging in Peripheral Blood does not Predict Dementia Risk

, 2021; 18(5): 443 - 451

P.D. Fransquet, P. Lacaze, R. Saffery, R.C. Shah, R. Vryer, A. Murray, R.L. Woods and J. Ryan*


DOI: 10.2174/1567205018666210823100721



High Fat Diet Aggravates AD-Related Pathogenic Processes in APP/PS1 Mice

, 2021; 18(4): 310 - 325

Xiaokang Gong, Zheng Liang, Wei Liu, Yang Zhao, Youhua Yang, Mengjuan Wu, Jinting Shang, Yifan Xiao, Yong Mei, Qiqi Su, Binlian Sun, Jian Bao* and Xiji Shu*


DOI: 10.2174/1567205018666210628100812



123I-Ioflupane SPECT and 18F-FDG PET Combined Use in the Characterization of Movement and Cognitive Associated Disorders in Neurodegenerative Diseases

, 2021; 18(3): 196 - 207

Susanna Nuvoli*, Giovanna Tanda, Maria L. Stazza, Barbara Palumbo, Viviana Frantellizzi, Giuseppe De Vincentis, Angela Spanu and Giuseppe Madeddu


DOI: 10.2174/1567205018666210608112302




Cerebrospinal Fluid Inflammatory Markers in Alzheimer’s Disease: Influence of Comorbidities

, 2021; 18(2): 157 - 170

Ying Wang, Ceren Emre, Helena Gyllenhammar-Schill, Karin Fjellman, Helga Eyjolfsdottir, Maria Eriksdotter, Marianne Schultzberg and Erik Hjorth*


DOI: 10.2174/1567205018666210330162207



Retinal Changes in Transgenic Mouse Models of Alzheimer’s Disease

, 2021; 18(2): 89 - 102

Li Guo*, Nivedita Ravindran, Ehtesham Shamsher, Daniel Hill and M. Francesca Cordeiro


DOI: 10.2174/1567205018666210414113634



Clinical Application of the Vestibular Stimulation Effect on Balance Disorders with Dementia

, 2021; 18(1): 1 - 7

Kiyotaka Nakamagoe*, Shiori Yamada, Rio Kawakami, Takami Maeno, Tadachika Koganezawa and Akira Tamaoka


DOI: 10.2174/1567205018666210324105642



Open Access Articles


The Janus-like Association between Proton Pump Inhibitors and Dementia

, 2021; 18(6): 453 - 469

Anna Papazoglou, Muhammad I. Arshaad, Christina Henseler, Johanna Daubner, Karl Broich, Britta Haenisch and Marco Weiergräber*





Pregabalin Treatment does not Affect Amyloid Pathology in 5XFAD Mice

, 2021; 18(4): 283 - 297

Katherine R. Sadleir*, Jelena Popovoic, Wei Zhu, Cory T. Reidel, Ha Do, Richard B. Silverman and Robert Vassar




Clinical Phenotype and Mutation Spectrum of Alzheimer’s Disease with Causative Genetic Mutation in a Chinese Cohort

, 2021; 18(3): 265 - 272

Chenhui Mao, Jie Li, Liling Dong, Xinying Huang, Dan Lei, Jie Wang, Shanshan Chu, Caiyan Liu, Bin Peng, Gustavo C. Román, Liying Cui and Jing Gao*





Cerebrospinal Fluid Inflammatory Markers in Alzheimer’s Disease: Influence of Comorbidities

, 2021; 18(2): 157 - 170

Ying Wang, Ceren Emre, Helena Gyllenhammar-Schill, Karin Fjellman, Helga Eyjolfsdottir, Maria Eriksdotter, Marianne Schultzberg and Erik Hjorth*





Statins, Risk of Death and Ischemic Stroke in Patients with Dementia: A Registry-Based Observational Cohort Study

, 2020; 17(10): 881 - 892

Bojana Petek*, Hong Xu, Marta Villa-Lopez, Bengt Winblad, Milica G. Kramberger, Maria Eriksdotter and Sara Garcia-Ptacek*




Cerebrospinal Fluid and Blood CX3CL1 as a Potential Biomarker in Early Diagnosis and Prognosis of Dementia

, 2020; 17(8): 709 - 721

Agnieszka Kulczyńska-Przybik*, Agnieszka Słowik, Piotr Mroczko, Bartłomiej Borawski, Magdalena Groblewska, Renata Borawska and Barbara Mroczko




Presenilin 1 and APP Gene Mutations in Early-Onset AD Families from a Southeast Region of China

, 2020; 17(6): 540 - 546

Jiajia Zhou, Yi Chen, Fanxia Meng, Kan Zhang, Xiaoyan Liu and Guoping Peng*




The Parietal Atrophy Score on Brain Magnetic Resonance Imaging is a Reliable Visual Scale

, 2020; 17(6): 534 - 539

David Silhan, Ales Bartos*, Jana Mrzilkova, Olga Pashkovska, Ibrahim Ibrahim and Jaroslav Tintera





Mechanisms of Anticholinesterase Interference with Tau Aggregation Inhibitor Activity in a Tau-Transgenic Mouse Model

, 2020; 17(3): 285 - 296

Gernot Riedel , Jochen Klein , Grazyna Niewiadomska, Constantin Kondak , Karima Schwab , Dilyara Lauer , Mandy Magbagbeolu , Marta Steczkowska, Maciej Zadrozny , Malgorzata Wydrych , Anna Cranston , Valeria Melis, Renato X. Santos , Franz Theuring , Charles R. Harrington and Claude M. Wischik*




Dangerous Liaisons: Tau Interaction with Muscarinic Receptors

, 2020; 17(3): 224 - 237

Adrianna Wysocka, Ewelina Palasz, Marta Steczkowska and Grazyna Niewiadomska*





Most Cited Articles






Review Article

Mitigating Alzheimer’s disease with natural polyphenols: A review

, 2019; 16(6): 529-543.

Roger Gaudreault* and Normand Mousseau*


DOI: 10.2174/1567205016666190315093520


Review Article

Learning from the past: A review of clinical trials targeting amyloid, tau and neuroinflammation in Alzheimer’s disease

, 2020; 17(2): 112-125.

Kelly Ceyzériat, Thomas Zilli, Philippe Millet, Giovanni B. Frisoni, Valentina Garibotto and Benjamin B. Tournier*


DOI: 10.2174/1567205017666200304085513


Research Article

Resveratrol rescues tau-induced cognitive deficits and neuropathology in a mouse model of tauopathy

, 2019; 16(8): 710-722.

Xiao-Ying Sun, Quan-Xiu Dong, Jie Zhu, Xun Sun, Li-Fan Zhang, Mandy Qiu, Xiao-Lin Yu* and Rui-Tian Liu*


DOI: 10.2174/1567205016666190801153751


Review Article

Neuroinflammation in alzheimer’s disease: Microglia, molecular participants and therapeutic choices

, 2019; 16(7): 659-674.

Haijun Wang, Yin Shen, Haoyu Chuang, Chengdi Chiu, Youfan Ye and Lei Zhao*


DOI: 10.2174/1567205016666190503151648



Systemic Review Article

Midlife modifiable risk factors for dementia: A systematic review and meta-analysis of 34 prospective cohort studies

, 2019; 16(14): 1254-1268.

Xiao-Ying Li , Min Zhang*, Wei Xu, Jie-Qiong Li, Xi-Peng Cao , Jin-Tai Yu * and Lan Tan*


DOI: 10.2174/1567205017666200103111253


Systematic Review Article

Physical activity as a moderator of alzheimer pathology: A systematic review of observational studies

, 2019; 16(4): 362-378.

Kristian Steen Frederiksen*, Le Gjerum, Gunhild Waldemar and Steen Gregers Hasselbalch


DOI: 10.2174/1567205016666190315095151


Research Article

The temporal relationship between pain intensity and pain interference and incident dementia

, 2019; 16(2): 109-115.

Ali Ezzati*, Cuiling Wang, Mindy J. Katz, Carol A. Derby, Andrea R. Zammit, Molly E. Zimmerman, Jelena M. Pavlovic, Martin J. Sliwinski and Richard B. Lipton


DOI: 10.2174/1567205016666181212162424


Research Article

A pilot study of exenatide actions in alzheimer’s disease

, 2019; 16(8): 741-752.

Roger J. Mullins, Maja Mustapic, Chee W. Chia, Olga Carlson, Seema Gulyani, Joyce Tran, Yazhou Li, Mark P. Mattson, Susan Resnick, Josephine M. Egan, Nigel H. Greig and Dimitrios Kapogiannis*


DOI: 10.2174/1567205016666190913155950


Systematic Review Article

Depression in dementia or dementia in depression? Systematic review of studies and hypotheses

, 2020; 17(1): 16-28.

Agnieszka Brzezińska, Julius Bourke, Rayito Rivera-Hernández, Magda Tsolaki, Joanna Wożniak and Jakub Każmierski*


DOI: 10.2174/1567205017666200217104114



Most Accessed Articles


Accelerated Epigenetic Aging in Peripheral Blood does not Predict Dementia Risk

, 2021; 18(5): 443-451.

P.D. Fransquet, P. Lacaze, R. Saffery, R.C. Shah, R. Vryer, A. Murray, R.L. Woods and J. Ryan*


DOI: 10.2174/1567205018666210823100721



Risk Factors for Alzheimer’s Disease: An Epidemiological Study

, 2021; 18(5): 372-379.

Jana Janoutová*, Martina Kovalová, Ondřej Machaczka, Petr Ambroz, Anna Zatloukalová, Kateřina Němček and Vladimír Janout


DOI: 10.2174/1567205018666210820124135


Cerebral Microbleeds and White Matter Hyperintensities are Associated with Cognitive Decline in an Asian Memory Clinic Study

, 2021; 18(5): 399-413.

Bibek Gyanwali, Benedict Lui, Chuen S. Tan, Eddie J.Y. Chong, Henri Vrooman, Christopher Chen and Saima Hilal*


DOI: 10.2174/1567205018666210820125543


Neutrophil Granule Proteins Inhibit Amyloid Beta Aggregation and Neurotoxicity

, 2021; 18(5): 414-427.

Anne Kasus-Jacobi*, Jennifer L. Washburn, Craig A. Land and Heloise Anne Pereira


DOI: 10.2174/1567205018666210823095044


Effect of High Cholesterol Regulation of LRP1 and RAGE on Aβ Transport Across the Blood-Brain Barrier in Alzheimer’s Disease

, 2021; 18(5): 428-442.

Rui Zhou, Li-li Chen, Hai Yang, Ling Li, Juan Liu, Le Chen, Wen-Juan Hong, Cong-guo Wang, Jing-Jing Ma, Jie Huang, Xin-Fu Zhou, Dong Liu and Hua-Dong Zhou*


DOI: 10.2174/1567205018666210906092940


Robust Discovery of Mild Cognitive Impairment Subtypes and Their Risk of Alzheimer's Disease Conversion Using Unsupervised Machine Learning and Gaussian Mixture Modeling

, 2021; 18(7): 595-606.

Fahimeh Nezhadmoghadam*, Antonio Martinez-Torteya, Victor Treviño, Emmanuel Martínez, Alejandro Santos, Jose Tamez-Peña and Alzheimer’s Disease Neuroimaging Initiative


DOI: 10.2174/1567205018666210831145825



Clinical Phenotype and Mutation Spectrum of Alzheimer’s Disease with Causative Genetic Mutation in a Chinese Cohort

, 2021; 18(3): 265-272.

Chenhui Mao, Jie Li, Liling Dong, Xinying Huang, Dan Lei, Jie Wang, Shanshan Chu, Caiyan Liu, Bin Peng, Gustavo C. Román, Liying Cui and Jing Gao*


DOI: 10.2174/1567205018666210608120339


Association of the MAOB rs1799836 Single Nucleotide Polymorphism and APOE ɛ4 Allele in Alzheimer’s Disease

, 2021; 18(7): 585-594.

Mirjana B. Leko, Matea N. Perković, Gordana N. Erjavec, Nataša Klepac, Dubravka Š. Štrac, Fran Borovečki, Nela Pivac, Patrick R. Hof and Goran Šimić*


DOI: 10.2174/1567205018666210917162843



Association of Dietary Habits with Mild Cognitive Impairment among Elderly in Rural Area of North China

, 2021; 18(3): 256-264.

Huilian Duan, Changqing Sun, Yun Zhu, Qian Liu, Yue Du, Hongyan Lin, Mengdi Jin, Jingzhu Fu, Fei Ma, Wen Li, Huan Liu, Jing Yan, Yongjie Chen, Guangshun Wang and Guowei Huang*


DOI: 10.2174/1567205018666210617152205


Parkinson’s Symptoms and Caregiver Affiliate Stigma: A Multinational Study

, 2021; 18(3): 222-231.

Richard S. Henry, Paul B. Perrin*, Sarah K. Lageman, Teresita Villaseñor, Annahir N. Cariello, Mickeal Pugh, Erin R. Smith, Monica Arroyo, Alejandra Zarate, Judith Avila and Jose A. Soto-Escageda


DOI: 10.2174/1567205018666210608100917


Reading Fluency in Spanish Patients with Alzheimer’s Disease

, 2021; 18(3): 243-255.

María del Carmen Pérez-Sánchez, María González-Nosti*, Fernando Cuetos, Carmen Martínez and Marta Álvarez-Cañizo


DOI: 10.2174/1567205018666210608102012




Editor-in-Chief

graphic
Debomoy K. Lahiri
(16607 citations)
Department of Psychiatry
Indiana University School of Medicine
Indianapolis, IN
(United States)
Biography
View Full Editorial Board

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Journal History

Current Alzheimer Research was introduced in 2004 with the assistance of Dr. Debomoy K. Lahiri, who is the current Editor-in-Chief serving since 2004.
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