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Combinatorial Chemistry & High Throughput Screening

Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 25, 14 Issues, 2022
ISSN: 1875-5402 (Online)
ISSN: 1386-2073 (Print)
This journal supports open access

Aims & Scope

Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal:

  • Target identification and validation
  • Assay design, development, miniaturization and comparison
  • High throughput/high content/in silico screening and associated technologies
  • Label-free detection technologies and applications
  • Stem cell technologies
  • Biomarkers
  • ADMET/PK/PD methodologies and screening
  • Probe discovery and development, hit to lead optimization
  • Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries)
  • Chemical library design and chemical diversity
  • Chemo/bio-informatics, data mining
  • Compound management
  • Pharmacognosy
  • Natural Products Research (Chemistry, Biology and Pharmacology of Natural Products)
  • Natural Product Analytical Studies
  • Bipharmaceutical studies of Natural products
  • Drug repurposing
  • Data management and statistical analysis
  • Laboratory automation, robotics, microfluidics, signal detection technologies
  • Current & Future Institutional Research Profile
  • Technology transfer, legal and licensing issues
  • Patents

In these respective subject areas, Combinatorial Chemistry & High Throughput Screening is intended to function as the most comprehensive and up-to-date medium available. The journal should be of value to individuals engaged in the process of drug discovery and development, in the settings of industry, academia or government.

Combinatorial Chemistry & High Throughput Screening


Volume 25


Number 7

Research Article

Free Convective Flow of Hamilton-Crosser Model Gold-water Nanofluid Through a Channel with Permeable Moving Walls

, 25(7): 1103 - 1114

Pradyumna Kumar Pattnaik, Munawwar Ali Abbas, Satyaranjan Mishra, Sami Ullah Khan and Muhammad Mubashir Bhatti*

DOI: 10.2174/1386207324666210813112323

Review Article (Mini-Review)

Pouteria sapota (Red Mamey Fruit): Chemistry and Biological Activity of Carotenoids

, 25(7): 1134 - 1147

Johant Lakey-Beitia, Velmarini Vasquez, Randy Mojica-Flores, Arelys L. Fuentes C., Enrique Murillo, Muralidhar L. Hegde and K.S. Rao*

DOI: 10.2174/1386207324666210301093711

Articles Ahead of Print

Abstracts Ahead of Print

RNA seq and ceRNA network analysis in the rat model of chronic kidney disease

Hepeng Xu, Zhen He, Mengjuan Zhang, Wenping Zhou, Chang Xu, Ming He, Zheng Wang and Xiangting Wang*

DOI: 10.2174/1386207325666220516145502
View Abstract

Accounting Conformational Dynamics into Structural Modeling Reflected by Cryo-EM with Deep Learning

Qiushi Ye, Yizhen Zhao, Xuhua Li, Yimin Zhao, Xinyue Fu, Shengli Zhang, Zhiwei Yang* and Lei Zhang

DOI: 10.2174/1386207325666220514143909
View Abstract

Published Contents

Editor's Choice

A Potential MRI Agent and an Anticancer Drug Encapsulated within CPMV Virus-Like Particles

, 2021; 24(10): 1557 - 1571

Alaa A.A. Aljabali*, Lorca Alzoubi, Yassmen Hamzat, Alaa Alqudah, Mohammad A. Obeid, Mazhar S. Al Zoubi, Raed M. Ennab, Walhan Alshaer, Khaled Albatayneh, Bahaa Al-Trad, Dana A. Alqudah, Dinesh Kumar Chellappan, Gaurav Gupta, Murtaza M. Tambuwala, Dua Kamal and David J. Evans

DOI: 10.2174/1386207323666200914110012

Cervical Cancer Diagnosis: Insights into Biochemical Biomarkers and Imaging Techniques

, 2021; 24(5): 605 - 623

Fatemeh Tavakoli, Sara Sadat Khatami, Fatemeh Momeni, Javid Azadbakht* and Faezeh Ghasemi*

DOI: 10.2174/1386207323666200901101955

Open Access Articles

Elucidation of the Mechanisms and Molecular Targets of Qishen Yiqi Formula for the Treatment of Pulmonary Arterial Hypertension using a Bioinformatics/Network Topology-based Strategy

, 2021; 24(5): 701 - 715

Peiliang Wu, Xiaona Xie, Mayun Chen, Junwei Sun, Luqiong Cai, Jinqiu Wei, Lin Yang, Xiaoying Huang* and Liangxing Wang*

Network Pharmacology-based Investigation of the Underlying Mechanism of Panax notoginseng Treatment of Diabetic Retinopathy

, 2020; 23(4): 334 - 344

Chunli Piao*, Zheyu Sun, De Jin, Han Wang, Xuemin Wu, Naiwen Zhang, Fengmei Lian* and Xiaolin Tong*

Transcriptome Analysis of FEN1 Knockdown HEK293T Cell Strain Reveals Alteration in Nucleic Acid Metabolism, Virus Infection, Cell Morphogenesis and Cancer Development

, 2019; 22(6): 379 - 386

Song-Bai Liu*, Xiu-Qin Qiu, Wei-Qiang Guo, Jin-Li Li, Qian Su, Jia-Hui Du, He-Juan Hu, Xiao-Xiao Wang, Yao-Hua Song, Xiao Lou* and Xiang-Bin Xu*

Effect of the Phragmitis Rhizoma Aqueous Extract on the Pharmacokinetics of Docetaxel in Rats

, 2019; 22(5): 326 - 332

Sarah Shin, No Soo Kim, Young Ah Kim, Hea Ry Oh and Ok-Sun Bang*

High Throughput Screening of Esterases, Lipases and Phospholipases in Mutant and Metagenomic Libraries: A Review

, 2016; 19(8): 605 - 615

Carlina Peña-García, Mónica Martínez-Martínez, Dolores Reyes-Duarte* and Manuel Ferrer*

Identification of Protein Palmitoylation Inhibitors from a Scaffold Ranking Library

, 2016; 19(4): 262 - 274

Laura D. Hamel, Brian J. Lenhart, David A. Mitchell, Radleigh G. Santos, Marc A. Giulianotti and Robert J. Deschenes*

Most Cited Articles

Research Article

Drug target group prediction with multiple drug networks

, 2020; 23(4): 274-284.

Jingang Che, Lei Chen*, Zi-Han Guo, Shuaiqun Wang and Aorigele

DOI: 10.2174/1386207322666190702103927

Review Article

Progress in molecularly imprinted polymers for biomedical applications

, 2019; 22(2): 78-88.

Jane Ru Choi*, Kar Wey Yong*, Jean Yu Choi and Alistair C. Cowie

DOI: 10.2174/1386207322666190325115526

Research Article

Identification of the active constituents and significant pathways of guizhi-shaoyao-zhimu decoction for the treatment of diabetes mellitus based on molecular docking and network pharmacology

, 2019; 22(9): 584-598.

Qing Zhang, Ruolan Li, Wei Peng, Mengmeng Zhang, Jia Liu, Shujun Wei, Jiaolong Wang, Chunjie Wu, Yongxiang Gao* and Xufeng Pu*

DOI: 10.2174/1386207322666191022101613

General Research Article

Lead finding from selected flavonoids with antiviral (Sars-cov-2) potentials against covid-19: An in-silico evaluation

, 2021; 24(6): 879-890.

Uma Sankar Gorla*, Koteswara Rao, Uma Sankar Kulandaivelu, Rajasekhar Reddy Alavala and Siva Prasad Panda

DOI: 10.2174/1386207323999200818162706

General Research Article

Discovery of potent sars-cov-2 inhibitors from approved antiviral drugs via docking and virtual screening

, 2021; 24(3): 441-454.

Samir Chtita *, Assia Belhassan, Adnane Aouidate, Salah Belaidi, Mohammed Bouachrine and Tahar Lakhlifi

DOI: 10.2174/1386207323999200730205447

Research Article

Green route for the removal of pb from aquatic environment

, 2020; 23(7): 587-598.

Ahmed Refaat*, Hanan Elhaes, Nabila S. Ammar, Hanan S. Ibrahim and Medhat Ibrahim

DOI: 10.2174/1386207323666200127123349

Most Accessed Articles

Lead Finding from Selected Flavonoids with Antiviral (SARS-CoV-2) Potentials Against COVID-19: An In-silico Evaluation

, 2021; 24(6): 879-890.

Gorla, Uma Sankar; Rao, Gsn Koteswara; Kulandaivelu, Uma Sankar; Alavala, Rajasekhar Reddy; Panda, Siva Prasad

DOI: 10.2174/1386207323999200818162706

Discovery of Potent SARS-CoV-2 Inhibitors from Approved Antiviral Drugs via Docking and Virtual Screening

, 2021; 24(3): 441-454.

Chtita, Samir; Belhassan, Assia; Aouidate, Adnane; Belaidi, Salah; Bouachrine, Mohammed; Lakhlifi, Tahar

DOI: 10.2174/1386207323999200730205447

Diagnosis of Alzheimer's Disease Based on Deeply-Fused Nets

, 2021; 24(6): 781-789.

Chen, Chang Zu; Wu, Qi; Li, Zuo Yong; Xiao, Lei; Hu, Zhong Yi

DOI: 10.2174/1386207323666200825092649

Molecular Mechanisms of Thymoquinone as Anticancer Agent

, 2021; 24(10): 1573-1582.

Alhmied, Fatma; Alammar, Ali; Alsultan, Bayan; Alshehri, Muruj; Pottoo, Faheem Hyder

DOI: 10.2174/1386207323999201110192942

Herbal Medicine: Clinical Perspective & Regulatory Status

, 2021; 24(1): 139-147.

Barkat, Md Abul; Goyal, Anjali; Barkat, Harshita A.; Salauddin, Mohammad; Pottoo, Faheem H.; Anwer, Esra T.

DOI: 10.2174/1386207323666200712145041

Curcumin-containing Silver Nanoparticles Prevent Carbon Tetrachlo-ride-induced Hepatotoxicity in Mice

, 2021; 24(7): 1055-1068.

Ebaid, Hossam; Habila, Mohamed; Hassan, Iftekhar; Al-Tamimi, Jameel; Omar, Mohamed S.; Rady, Ahmed; Alhazza, Ibrahim M.

DOI: 10.2174/1386207323999200824115536

Potential Leads from Liquorice Against SARS-CoV-2 Main Protease using Molecular Docking Simulation Studies

, 2021; 24(2): 195-212.

Sinha, Saurabh K.; Prasad, Satyendra K.; Islam, Md Ataul; Chaudhary, Sushil K.; Singh, Shashikant; Shakya, Anshul

DOI: 10.2174/1386207323666200605150024

A Systems Biology Approach for miRNA-mRNA Expression Patterns Analysis in Rheumatoid Arthritis

, 2021; 24(2): 294-305.

Tavasolian, Fataneh; Hosseini, Ahmad Zavaran; Soudi, Sara; Naderi, Mahmood; Sahebkar, Amirhossein

DOI: 10.2174/1386207323666200806164635


Gerald H. Lushington
LiS Consulting
Lawrence, KS
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Journal History

Combinatorial Chemistry & High Throughput Screening Journal was launched in 1998. Dr. Gerald H. Lushington serves as the Editor-in-Chief of the journal.



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