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Combinatorial Chemistry & High Throughput Screening

Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 24, 10 Issues, 2021
ISSN: 1875-5402 (Online)
ISSN: 1386-2073 (Print)
This journal supports open access

Aims & Scope

Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal:

  • Target identification and validation
  • Assay design, development, miniaturization and comparison
  • High throughput/high content/in silico screening and associated technologies
  • Label-free detection technologies and applications
  • Stem cell technologies
  • Biomarkers
  • ADMET/PK/PD methodologies and screening
  • Probe discovery and development, hit to lead optimization
  • Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries)
  • Chemical library design and chemical diversity
  • Chemo/bio-informatics, data mining
  • Compound management
  • Pharmacognosy
  • Natural Products Research (Chemistry, Biology and Pharmacology of Natural Products)
  • Natural Product Analytical Studies
  • Bipharmaceutical studies of Natural products
  • Drug repurposing
  • Data management and statistical analysis
  • Laboratory automation, robotics, microfluidics, signal detection technologies
  • Current & Future Institutional Research Profile
  • Technology transfer, legal and licensing issues
  • Patents

In these respective subject areas, Combinatorial Chemistry & High Throughput Screening is intended to function as the most comprehensive and up-to-date medium available. The journal should be of value to individuals engaged in the process of drug discovery and development, in the settings of industry, academia or government.

Combinatorial Chemistry & High Throughput Screening

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Volume 24

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Number 10





Review Article

Carbon Nano Tubes: Novel Drug Delivery System in Amelioration of Alzheimer’s Disease

, 24(10): 1528 - 1543

Jayanti Mishra, Bhumika Kumar, Mukesh Pandey, Faheem H. Pottoo, Faizana Fayaz, Firdos Alam Khan and Pravat K. Sahoo*


DOI: 10.2174/1386207323999200918112538


Review Article

Envisioning the Future of Nanomedicines in Management and Treatment of Neurological Disorders

, 24(10): 1544 - 1556

Shobhit Kumar*, Priyanka Singh, Shrestha Sharma, Faheem H. Pottoo, Javed Ali and Sanjula Baboota


DOI: 10.2174/1386207323666201217151132


Research Article

A Potential MRI Agent and an Anticancer Drug Encapsulated within CPMV Virus-Like Particles

, 24(10): 1557 - 1571

Alaa A.A. Aljabali*, Lorca Alzoubi, Yassmen Hamzat, Alaa Alqudah, Mohammad A. Obeid, Mazhar S. Al Zoubi, Raed M. Ennab, Walhan Alshaer, Khaled Albatayneh, Bahaa Al-Trad, Dana A. Alqudah, Dinesh Kumar Chellappan, Gaurav Gupta, Murtaza M. Tambuwala, Dua Kamal and David J. Evans


DOI: 10.2174/1386207323666200914110012




Review Article

Herbal Medicine: Clinical Perspective and Regulatory Status

, 24(10): 1573 - 1582

Md. Abul Barkat*, Anjali Goyal, Harshita A. Barkat, Mohammad Salauddin, Faheem H. Pottoo and Esra T. Anwer


DOI: 10.2174/1386207323999201110192942


Review Article

Nutraceuticals for Sleep Disorders

, 24(10): 1583 - 1592

Ruhi Ali*, Sana Tariq, Ozaifa Kareem, Faizana Fayaz, Tahira Aziz, Meenu, Faheem Hyder Pottoo and Nadeem Siddiqui


DOI: 10.2174/1386207324666210121111446


Research Article



Combinatorial Chemistry & High Throughput Screening, Volume 25 (2022) - Number 1


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

In Vitro Antifungal Screening of Argentine Native or Naturalized Plants against the Phytopathogen Monilinia fructicola


María Inés Stegmayer, Laura Noemí Fernández, Norma Hortensia Álvarez, Gisela Marisol Seimandi, Andrea Guadalupe Reutemann and Marcos Gabriel Derita*


DOI: 10.2174/1386207324666210121113648
View Abstract View on PubMed






Berberine in the Treatment of Neurodegenerative Diseases and Nanotechnology Enabled Targeted Delivery


Roohi Mohi-ud-din*, Reyaz Hassan Mir, Taha Umair Wani, Abdul Jalil Shah, Nazia Banday and Faheem Hyder Pottoo*


DOI: 10.2174/1386207324666210804122539
View Abstract View on PubMed





FABP1 Gene Variant is Associated with Risk of Metabolic Syndrome


Reza Zare-Feyzabadi, Majid Mozaffari*, Majid Ghayour-Mobarhan* and Mohsen Valizadeh


DOI: 10.2174/1386207324666210603114434
View Abstract View on PubMed


Abstracts Ahead of Print


MiR-4295 Promotes the Malignant Progression of Gastric Cancer via Targeting PTEN


Xiaoyan Yang, Jing Yang, Yunlian Tang, Zhizhong Xie, Yang Zhang, Xiaoyong Lei* and Runliang Gan*


DOI: 10.2174/1386207325666211110095307
View Abstract






Synthesis and Antinociceptive activity of Newly Modified Amine analogs of Phencyclidine in Mice


Maryam Shokrollahi, Marjaneh Samadizadeh, Mohsen Khalili, Seyed Ali Sobhanian and Abbas Ahmadi*


DOI: 10.2174/1386207325666211005155128
View Abstract



Amalgamation and Scrutinizing of Leucine Derivatives Schiff bases Complexes as Antimicrobial Agent


Muhammad Pervaiz*, Ikram Ahmad, Zohaib Saeed, Muhammad Sagir, Umer Younas, Muhammad Bilal Tahir*, Awais Ahmad, Ayoub Rashid, Quratulain Syed and Ahmad Adnan


DOI: 10.2174/1386207325666210927092623
View Abstract



Published Contents

Editor's Choice

A Potential MRI Agent and an Anticancer Drug Encapsulated within CPMV Virus-Like Particles

, 2021; 24(10): 1557 - 1571

Alaa A.A. Aljabali*, Lorca Alzoubi, Yassmen Hamzat, Alaa Alqudah, Mohammad A. Obeid, Mazhar S. Al Zoubi, Raed M. Ennab, Walhan Alshaer, Khaled Albatayneh, Bahaa Al-Trad, Dana A. Alqudah, Dinesh Kumar Chellappan, Gaurav Gupta, Murtaza M. Tambuwala, Dua Kamal and David J. Evans


DOI: 10.2174/1386207323666200914110012








Cervical Cancer Diagnosis: Insights into Biochemical Biomarkers and Imaging Techniques

, 2021; 24(5): 605 - 623

Fatemeh Tavakoli, Sara Sadat Khatami, Fatemeh Momeni, Javid Azadbakht* and Faezeh Ghasemi*


DOI: 10.2174/1386207323666200901101955






Open Access Articles


3 CpG Methylation Biomarkers for the Diagnosis of Polycystic Ovary Syndrome (PCOS) in Blood Samples

, 2022; 25: 1 - 10 (E-Pub Ahead of Print)

Linling Xie, Xiaotao Jiang, Yi Chen, Cihui Huang, Yanfen Chen, Guantong Liu, Wenxi Sun, Lei Zeng* and Ruling Lu*




Preliminary Study of microRNAs Allele-specific Targeting in Allergic Rhinitis Patients from Central China

, 2022; 25: 1 - 11 (E-Pub Ahead of Print)

Yu-Qin Deng, Song Li, Zheng-Yan Liang*, Fen Li, Si-Lu Wen and Ze-Zhang Tao*




Identification of Key Molecules in Recurrent Miscarriage Based on Bioinformatics Analysis

, 2022; 25: 1 - 11 (E-Pub Ahead of Print)

Haiwang Wu, Yan Ning , Qingying Yu, Songping Luo* and Jie Gao*







Exploring miRNA-related Molecular Targets of Erchen Decoction Against Lipid Metabolism Disorder using A Network Pharmacologic Approach

, 2021; 24: 1 - 12 (E-Pub Ahead of Print)

Shanshan Ding, Qiliang Chen, Yiqing Huang, Xiaomei Li, Yujuan Chai, Candong Li and Tetsuya Asakawa*




GCSF as a Potential Molecular Target for Overall Survival of Hepatocellular Carcinoma

, 2021; 24: 1 - 19 (E-Pub Ahead of Print)

Heng Cao, Peng Guo, Xiaohui Wu, Jiankun Li, Chenlong Ge and Shunxiang Wang*




3-T MRI in Patients who Received Anterior Cervical Discectomy and Fusion Surgery with MAVRIC SL IR Sequence: A Feasibility Study

, 2021; 24: 1 - 7 (E-Pub Ahead of Print)

Renjie Yang, Changsheng Liu, Liang Li, Liang Chen, Weiyin Vivian Liu and Yunfei Zha*




FEN1 Status and Its Correlation with Clinicopathologic Characteristic in Colorectal Cancer

, 2021; 24: 1 - 7 (E-Pub Ahead of Print)

Yundi Guo*, Zixuan Du *, Yuanshuai Zhou, Haijun Sun, Rui Liang, Min-Xuan Sun, Zaixiang Tang and Song-Bai Liu






RNA Sequencing Reveals the Wound Repair Mechanism of Cuyuxunxi Prescription in Surgical Patients with Anal Fistulas

, 2021; 24: 1 - 11 (E-Pub Ahead of Print)

Yin Qu, Zhijun Zhang, Yafeng Lu, De Zheng and Wei Yang*




The Relationship Between the Severity of Coronary Artery Disease and Erythrocyte Morphology Parameters Measured by New-Generation Hematology Analyzer

, 2021; 24: 1 - 6 (E-Pub Ahead of Print)

Ibrahin Halil Yasak , Mustafa Begenc Tascanov, Ataman Gönel* and Eyyup Sabri Seyhanli





Most Cited Articles


Research Article

Drug target group prediction with multiple drug networks

, 2020; 23(4): 274-284.

Jingang Che, Lei Chen*, Zi-Han Guo, Shuaiqun Wang and Aorigele


DOI: 10.2174/1386207322666190702103927



Review Article

Progress in molecularly imprinted polymers for biomedical applications

, 2019; 22(2): 78-88.

Jane Ru Choi*, Kar Wey Yong*, Jean Yu Choi and Alistair C. Cowie


DOI: 10.2174/1386207322666190325115526


Research Article

Identification of the active constituents and significant pathways of guizhi-shaoyao-zhimu decoction for the treatment of diabetes mellitus based on molecular docking and network pharmacology

, 2019; 22(9): 584-598.

Qing Zhang, Ruolan Li, Wei Peng, Mengmeng Zhang, Jia Liu, Shujun Wei, Jiaolong Wang, Chunjie Wu, Yongxiang Gao* and Xufeng Pu*


DOI: 10.2174/1386207322666191022101613




General Research Article

Lead finding from selected flavonoids with antiviral (Sars-cov-2) potentials against covid-19: An in-silico evaluation

, 2021; 24(6): 879-890.

Uma Sankar Gorla*, Koteswara Rao, Uma Sankar Kulandaivelu, Rajasekhar Reddy Alavala and Siva Prasad Panda


DOI: 10.2174/1386207323999200818162706


General Research Article

Discovery of potent sars-cov-2 inhibitors from approved antiviral drugs via docking and virtual screening

, 2021; 24(3): 441-454.

Samir Chtita *, Assia Belhassan, Adnane Aouidate, Salah Belaidi, Mohammed Bouachrine and Tahar Lakhlifi


DOI: 10.2174/1386207323999200730205447





Research Article

Green route for the removal of pb from aquatic environment

, 2020; 23(7): 587-598.

Ahmed Refaat*, Hanan Elhaes, Nabila S. Ammar, Hanan S. Ibrahim and Medhat Ibrahim


DOI: 10.2174/1386207323666200127123349





Most Accessed Articles


Phyto-chlorophyllin Prevents Food Additive Induced Genotoxicity and Mitochondrial Dysfunction via Cytochrome c Mediated Pathway in Mice Model

, 2021; 24(10): 1618-1627.

Asmita Samadder*, Sudatta Dey, Priyanka Sow, Ruchira Das, Sisir Nandi, Jayeeta Das*, Banani Bhattacharjee, Arnob Chakrovorty, Maharaj Biswas and Pradeepta Guptaroy


DOI: 10.2174/1386207323666201230093510


Nutraceuticals for Sleep Disorders

, 2021; 24(10): 1583-1592.

Ruhi Ali*, Sana Tariq, Ozaifa Kareem, Faizana Fayaz, Tahira Aziz, Meenu, Faheem Hyder Pottoo and Nadeem Siddiqui


DOI: 10.2174/1386207324666210121111446


Herbal Medicine: Clinical Perspective and Regulatory Status

, 2021; 24(10): 1573-1582.

Md. Abul Barkat*, Anjali Goyal, Harshita A. Barkat, Mohammad Salauddin, Faheem H. Pottoo and Esra T. Anwer


DOI: 10.2174/1386207323999201110192942




A Potential MRI Agent and an Anticancer Drug Encapsulated within CPMV Virus-Like Particles

, 2021; 24(10): 1557-1571.

Alaa A.A. Aljabali*, Lorca Alzoubi, Yassmen Hamzat, Alaa Alqudah, Mohammad A. Obeid, Mazhar S. Al Zoubi, Raed M. Ennab, Walhan Alshaer, Khaled Albatayneh, Bahaa Al-Trad, Dana A. Alqudah, Dinesh Kumar Chellappan, Gaurav Gupta, Murtaza M. Tambuwala, Dua Kamal and David J. Evans


DOI: 10.2174/1386207323666200914110012


Identification of an MiRNA-mRNA Regulatory Network in Colorectal Cancer

, 2021; 24(10): 1736-1745.

Ming-fu Cui, Yuan-yu Wu, Ming-yan Chen, Yang Zhao, Song-yun Han, Rui-jie Wang, Haiyan Zhang* and Xue-dong Fang*


DOI: 10.2174/1386207323666201110154142




Molecular Mechanisms of Thymoquinone as Anticancer Agent

, 2021; 24(10): 1644-1653.

Fatma Alhmied, Ali Alammar, Bayan Alsultan, Muruj Alshehri and Faheem Hyder Pottoo*


DOI: 10.2174/1386207323999201027225305


Carbon Nano Tubes: Novel Drug Delivery System in Amelioration of Alzheimer’s Disease

, 2021; 24(10): 1528-1543.

Jayanti Mishra, Bhumika Kumar, Mukesh Pandey, Faheem H. Pottoo, Faizana Fayaz, Firdos Alam Khan and Pravat K. Sahoo*


DOI: 10.2174/1386207323999200918112538


Envisioning the Future of Nanomedicines in Management and Treatment of Neurological Disorders

, 2021; 24(10): 1544-1556.

Shobhit Kumar*, Priyanka Singh, Shrestha Sharma, Faheem H. Pottoo, Javed Ali and Sanjula Baboota


DOI: 10.2174/1386207323666201217151132






Editor-in-Chief

graphic
Gerald H. Lushington
LiS Consulting
Lawrence, KS
(USA)
Biography
View Full Editorial Board

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Journal History

Combinatorial Chemistry & High Throughput Screening Journal was launched in 1998. Dr. Gerald H. Lushington serves as the Editor-in-Chief of the journal.

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