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Current Molecular Pharmacology

Volume 15, 7 Issues, 2022
ISSN: 1874-4702 (Online)
ISSN: 1874-4672 (Print)
This journal supports open access

Aims & Scope

Current Molecular Pharmacology aims to publish the latest developments in cellular and molecular pharmacology with a major emphasis on the mechanism of action of novel drugs under development, innovative pharmacological technologies, cell signaling, transduction pathway analysis, genomics, proteomics, and metabonomics applications to drug action. An additional focus will be the way in which normal biological function is illuminated by knowledge of the action of drugs at the cellular and molecular level. The journal publishes full-length/mini reviews, original research articles and thematic issues on molecular pharmacology.

Current Molecular Pharmacology is an essential journal for every scientist who is involved in drug design and discovery, target identification, target validation, preclinical and clinical development of drugs therapeutically useful in human disease.

Current Molecular Pharmacology

,

Volume 15

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Number 6



Mini-Review Article

Polysaccharides to Combat Viruses (COVID-19) and Microbes: New updates

, 15(6): 803 - 814

Manaf AlMatar*, Essam A. Makky, Aizi Nor Mazila Ramli, Nesibe Ebru Kafkas and Fatih Köksal


DOI: 10.2174/1874467215666220112150332


Mini-Review Article

BAPST. A Combo of Common Use Drugs as Metabolic Therapy for Cancer: A Theoretical Proposal

, 15(6): 815 - 831

Adriana Romo-Perez, Guadalupe Dominguez-Gomez, Alma Chavez-Blanco, Lucia Taja-Chayeb, Aurora Gonzalez-Fierro, Elisa Garcia-Martinez, Jose Correa-Basurto and Alfonso Duenas-Gonzalez*


DOI: 10.2174/1874467214666211006123728


Review Article




Research Article

Dapagliflozin Protects H9c2 Cells Against Injury Induced by Lipopolysaccharide via Suppression of CX3CL1/CX3CR1 Axis and NF-κB Activity

, 15(6): 862 - 869

Yousef Faridvand, Maryam Nemati, Elham Zamani-Gharehchamani, Hamid Reza Nejabati, Arezoo Rezaie Nezhad Zamani, Samira Nozari, Nasser Safaie, Mohammad Nouri and Ahmadreza Jodati*


DOI: 10.2174/1874467214666211008142347


Research Article

Effect of Edaravone on MicroRNA Expression in Exosomes after Hepatic Ischemia-reperfusion Injury

, 15(6): 870 - 882

Yanxia Fei, Jiali Shao, Ge Huang, Lijuan Wang, Shuangfa Zou, Huiping Sun, Chumei Zheng and Jinfeng Yang*


DOI: 10.2174/1874467214666211130162152


Research Article

Cytotoxic and Antitumoral Activity of N-(9H-purin-6-yl) Benzamide Derivatives and Related Water-soluble Prodrugs

, 15(6): 883 - 894

Emeline Cros-Perrial, Steve Saulnier, Muhammad Zawwad Raza, Rémi Charmelot, David Egron, Charles Dumontet, Laurent Chaloin, Suzanne Peyrottes and Lars Petter Jordheim*


DOI: 10.2174/1874467214666211014164406


Current Molecular Pharmacology, Volume 15 (2022) - Number 7


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print



Nf-κb: A Target for Synchronizing the Functioning Nervous Tissue Progenitors of Different Types in Alzheimer's Disease


Gleb Nikolaevich Zyuz’kov*, Larisa Arkad` evna Miroshnichenko, Alexander Vasil `evich Chayikovskyi and Larisa Yur`evna Kotlovskaya


DOI: 10.2174/1874467215666220601144727
View Abstract View on PubMed


Targeting Signaling Pathway by Curcumin in Osteosarcoma


Parnia Rahnamay Farnood*, Romina Danesh Pazhooh, Zatollah Asemi* and Bahman Yousefi


DOI: 10.2174/1874467215666220408104341
View Abstract View on PubMed






Endoplasmic Reticulum Stress and Renin-Angiotensin System Crosstalk in Endothelial Dysfunction


Himanshu Sankrityayan, Pooja Dhileepkumar Rao, Vishwadeep Shelke, Yogesh A. Kulkarni, Shrikant R. Mulay and Anil Bhanudas Gaikwad*


DOI: 10.2174/1874467215666220301113833
View Abstract View on PubMed



Abstracts Ahead of Print

Probing the ubiquitination-mediated function of Epithelial Sodium Channel in A549 cells


Waheed Shabbir, Keun-Hang Susan Yang, Afzal M. Dogar, Dmytro Isaev and Murat Oz*


DOI: 10.2174/1874467215666220726112002
View Abstract



The therapeutic activities of metformin: Focus on the Nrf2 signaling pathway and oxidative stress amelioration


Mohammad Yassin Zamanian, Lydia Giménez-Llort, Marjan Nikbakhtzadeh, Zahra Kamiab, Mahsa Heidari and Gholamreza Bazmandegan*


DOI: 10.2174/1874467215666220620143655
View Abstract


Nephrotic Syndrome and Renin Angiotensin System: pathophysiological role and therapeutic potential


Alessandra Aguiar dos Anjos, Isadora Tucci de Paiva, Giovanna Letícia Simões Lima, Roberta da Silva Filha, Brunna Pinto e Fróes, Sérgio Veloso Brant Pinheiro and Ana Cristina Simões e Silva*


DOI: 10.2174/1874467215666220616152312
View Abstract


Resveratrol in cancer treatment with a focus on breast cancer


Hamed Kowsari, Amirhossein Davoodvandi, Fatemeh Dashti, Seyed Mohamad Ali Mirazimi, Zahra Razaghi Bahabadi, Michael Aschner, Amirhossein Sahebkar, Hamid Reza Gilasi*, Michael R Hamblin* and Hamed Mirzaei*


DOI: 10.2174/1874467215666220616145216
View Abstract




Evaluation of the Relationship Between Aromatase/Sirtuin1 Interaction and miRNA Expression in Human Neuroblastoma Cells


Yasemin Kartal, Unal Metin Tokat, Pelin Kelicen-Ugur, Serkan Yılmaz, Sevilay Karahan and Murat Timur Budak*


DOI: 10.2174/1874467215666220510112118
View Abstract



Effect of Curcumin on Head and Neck Squamous Cell Carcinoma Cell Line HN5


Elaheh Dalir Abdolahinia, Shahin Ahmadian, Sepideh Bohlouli, Faezeh Jafarmadar Gharehbagh, Negar Ghorbani Jahandizi, Sepideh Zununi Vahed, Yalda Rahbar Saadat, Amirala Aghbali, Simin Sharifi*, Solmaz Maleki Dizaj, Khalaf F Alsharif and Haroon Khan*


DOI: 10.2174/1874467215666220414143441
View Abstract


Published Contents

Editor's Choice


Polyphenols as Potential Therapeutics for Pain and Inflammation in Spinal Cord Injury

, 2021; 14(5): 714 - 730

Ashif Iqubal, Musheer Ahmed, Mohammad K. Iqubal, Faheem H. Pottoo* and Syed E. Haque*


DOI: 10.2174/1874467213666201223111743



Statins Attenuate Fibrotic Manifestations of Cardiac Tissue Damage

, 2021; 14(5): 782 - 797

Armita M. Gorabi, Nasim Kiaie, Vanessa Bianconi, Matteo Pirro, Tannaz Jamialahmadi and Amirhossein Sahebkar*


DOI: 10.2174/1874467214666210210123206





Recent Advances in Herbal Nanomedicines for Cancer Treatment

, 2021; 14(3): 292 - 305

Deepak Pradhan, Prativa Biswasroy, Amita Sahu, Dipak K. Sahu, Goutam Ghosh and Goutam Rath*


DOI: 10.2174/1874467213666200525010624



Hypoxia-Inducible Factor (HIF): Fuel for Cancer Progression

, 2021; 14(3): 321 - 332

Saurabh Satija*, Harpreet Kaur, Murtaza M. Tambuwala, Prabal Sharma, Manish Vyas, Navneet Khurana, Neha Sharma, Hamid A. Bakshi, Nitin B. Charbe, Flavia C. Zacconi, Alaa A. Aljabali, Srinivas Nammi, Harish Dureja, Thakur G. Singh, Gaurav Gupta, Daljeet S. Dhanjal, Kamal Dua, Dinesh K. Chellappan* and Meenu Mehta*


DOI: 10.2174/1874467214666210120154929




TRPC3-Based Protein Signaling Complex as a Therapeutic Target of Myocardial Atrophy

, 2021; 14(2): 123 - 131

Kazuhiro Nishiyama, Tomohiro Tanaka, Akiyuki Nishimura and Motohiro Nishida*


DOI: 10.2174/1874467213666200407090121



Molecular Mechanisms Involved in the Progression and Protection of Osteoarthritis

, 2021; 14(2): 165 - 169

Yoshifumi Takahata*, Tomohiko Murakami, Kenji Hata and Riko Nishimura


DOI: 10.2174/1874467213666200417122933



Open Access Articles

Lactoferrin Suppresses Decreased Locomotor Activities by Improving Dopamine and Serotonin Release in the Amygdala of Ovariectomized Rats

, 2021; 14(2): 245 - 252

Nobuo Izumo*, Ishibashi Yukiko, Nobuharu Kagaya, Megumi Furukawa, Rina Iwasaki, Akihide Sumino, Kohsuke Hayamizu, Makoto Nakano, Tatsuo Hoshino, Haruna Kurono, Yasuo Watanabe and Takayuki Manabe*





Nuezhenide Exerts Anti-Inflammatory Activity through the NF-κB Pathway

, 2021; 14(1): 101 - 111

Qin-Qin Wang, Shan Han, Xin-Xing Li, Renyikun Yuan, Youqiong Zhuo, Xinxin Chen, Chenwei Zhang, Yangling Chen, Hongwei Gao*, Li-Chun Zhao* and Shilin Yang




Anticancer Mechanism of Lobaplatin as Monotherapy and in Combination with Paclitaxel in Human Gastric Cancer

, 2018; 11(4): 316 - 325

Suhang Hua, Xiangyu Kong, Binbin Chen, Wenxin Zhuang, Qian Sun, Wei Yang, Wenzhi Liu* and Yongxing Zhang*





Decoding Corticotropin-Releasing Factor Receptor Type 1 Crystal Structures

, 2017; 10(4): 334 - 344

Andrew S. Dore, Andrea Bortolato, Kaspar Hollenstein, Robert K.Y. Cheng, Randy J. Read and Fiona H. Marshall*





Pharmacology of L-type Calcium Channels: Novel Drugs for Old Targets?

, 2015; 8(2): 110 - 122

Jorg Striessnig, Nadine J. Ortner and Alexandra Pinggera





Most Cited Articles

Review Article

Mitochondria-targeted drugs

, 2019; 12(3): 202-214.

Roman A. Zinovkin* and Andrey A. Zamyatnin*


DOI: 10.2174/1874467212666181127151059


Review Article

NADPH oxidase as a target for modulation of radiation response; implications to carcinogenesis and radiotherapy

, 2019; 12(1): 50-60.

Keywan Mortezaee, Nasser Hashemi Goradel, Peyman Amini, Dheyauldeen Shabeeb, Ahmed Eleojo Musa, Masoud Najafi* and Bagher Farhood*


DOI: 10.2174/1874467211666181010154709


Review Article

New insights in cannabinoid receptor structure and signaling

, 2019; 12(3): 239-248.

Lingyan Ye, Zheng Cao, Weiwei Wang and Naiming Zhou*


DOI: 10.2174/1874467212666190215112036



Review Article

Pharmacokinetic and pharmacodynamic aspects of peyote and mescaline: Clinical and forensic repercussions

, 2019; 12(3): 184-194.

Ricardo Jorge Dinis-Oliveira*, Carolina Lança Pereira and Diana Dias da Silva


DOI: 10.2174/1874467211666181010154139



Research Article

Effects of myo-inositol alone and in combination with seleno-l-methionine on cadmium-induced testicular damage in mice

, 2019; 12(4): 311-323.

Salvatore Benvenga, Antonio Micali*, Giovanni Pallio, Roberto Vita, Consuelo Malta, Domenico Puzzolo, Natasha Irrera, Francesco Squadrito, Domenica Altavilla and Letteria Minutoli


DOI: 10.2174/1874467212666190620143303


Review Article

A contemporary overview of PPARα/γ dual agonists for the management of diabetic dyslipidemia

, 2019; 12(3): 195-201.

Pitchai Balakumar*, Nanjaian Mahadevan and Ramanathan Sambathkumar


DOI: 10.2174/1874467212666190111165015


Review Article

Mechanisms for radioprotection by melatonin; can it be used as a radiation countermeasure?

, 2019; 12(1): 2-11.

Peyman Amini, Hanifeh Mirtavoos-Mahyari, Elahe Motevaseli, Dheyauldeen Shabeeb, Ahmed Eleojo Musa, Mohsen Cheki, Bagher Farhood, Rasoul Yahyapour, Alireza Shirazi, Nouraddin Abdi Goushbolagh and Masoud Najafi*


DOI: 10.2174/1874467211666180802164449


Review Article

Therapeutic promises of chlorogenic acid with special emphasis on its anti-obesity property

, 2020; 13(1): 7-16.

Rajnish Kumar, Anju Sharma, Mohammed Shariq Iqbal and Janmejai K. Srivastava*


DOI: 10.2174/1874467212666190716145210


Review Article

Targeting chromatin remodeling for cancer therapy

, 2019; 12(3): 215-229.

Jasmine Kaur, Abdelkader Daoud and Scott T. Eblen*


DOI: 10.2174/1874467212666190215112915


Research Article

In-vitro pre-treatment of cancer cells with TGF-β1: A novel approach of tail vein lung cancer metastasis mouse model for anti-metastatic studies

, 2019; 12(4): 249-260.

Ghulam Jilany Khan*, Li Sun, Muhammad Abbas, Muhammad Naveed, Talha Jamshaid, Mirza Muhammad Faran Ashraf Baig and Shengtao Yuan*


DOI: 10.2174/1874467212666190306165703


Research Article

Synergistic effect of epigenetic inhibitors decitabine and suberoylanilide hydroxamic acid on colorectal cancer in vitro

, 2019; 12(4): 281-300.

Sonia Abou Najem, Ghada Khawaja, Mohammad Hassan Hodroj and Sandra Rizk*


DOI: 10.2174/1874467212666190313154531



Review Article

Kinase targets for mycolic acid biosynthesis in mycobacterium tuberculosis

, 2019; 12(1): 27-49.

Shahinda S.R. Alsayed, Chau C. Beh, Neil R. Foster, Alan D. Payne, Yu Yu and Hendra Gunosewoyo*


DOI: 10.2174/1874467211666181025141114



Most Accessed Articles


Polyphenols as Potential Therapeutics for Pain and Inflammation in Spinal Cord Injury

, 2021; 14(5): 714-730.

Ashif Iqubal, Musheer Ahmed, Mohammad K. Iqubal, Faheem H. Pottoo* and Syed E. Haque*


DOI: 10.2174/1874467213666201223111743





Ginkgolic Acids Confer Potential Anticancer Effects by Targeting Pro- Inflammatory and Oncogenic Signaling Molecules

, 2021; 14(5): 806-822.

Muthu K. Shanmugam*, Manoj Garg , Pooja Makhija, Alan P. Kumar , Javad Sharifi-Rad , Wissam Zam and Anupam Bishayee*


DOI: 10.2174/1874467214666210126112413


TRIM65 in White Matter Lesions, Innate Immunity, and Tumor

, 2021; 14(5): 798-805.

Bingxue Liu, Yunlian Tang*, Ping Yang, Chu Wu and Yue Huang


DOI: 10.2174/1874467214666210203211603


Pain Perception and Management: Where do We Stand?

, 2021; 14(5): 678-688.

Bilal Afridi, Haroon Khan*, Esra K. Akkol* and Michael Aschner


DOI: 10.2174/1874467213666200611142438



Statins Attenuate Fibrotic Manifestations of Cardiac Tissue Damage

, 2021; 14(5): 782-797.

Armita M. Gorabi, Nasim Kiaie, Vanessa Bianconi, Matteo Pirro, Tannaz Jamialahmadi and Amirhossein Sahebkar*


DOI: 10.2174/1874467214666210210123206





Chlorpyrifos with Age-Dependent Effects in Cardiac Tissue of Male Rats

, 2021; 14(5): 894-899.

Behzad Mesbahzadeh, Hossein Salarjavan, Saeed Samarghandian* and Tahereh Farkhondeh*


DOI: 10.2174/1874467214666210111105321





Editor-in-Chief

graphic
Michael Kahn
(19369 citations)
Beckman Research Institute
City of Hope
Duarte, CA 91010-3000
(USA)
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