Clinical Cancer Drugs
Volume 7, 2 Issues, 2020
ISSN: 2212-6988 (Online)
ISSN: 2212-697X (Print)
This journal supports open access
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ISSN: 2212-6988 (Online)
ISSN: 2212-697X (Print)
This journal supports open access
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In the current Pandemic scenario, all articles related to Coronavirus will be processed on a quick track basis, to ensure timely review and publication of much needed research
Aims & Scope
Clinical Cancer Drugs publishes original research, full-length reviews/ mini reviews, and thematic issues in all core areas of translational and clinical cancer drug research.
The journal publishes pre-clinical and clinical studies on the development of new anti-cancer agents. Clinical studies of new reported anti-cancer drugs include Phase 1–IV clinical trial studies, their designs, research methodologies, and analyses. The journal is essential reading for clinical oncologists, toxicologists, medicinal chemists, and pharmacologists.
Clinical Cancer Drugs
,Volume 7
-Number 1
Preface Open Access
Preface
Biography Open Access
Meet Our Editorial Board Member
Review Article Open Access
Complexity in Clinical Trials: Blind Spots, Misleading Criteria, Winners and Losers
, 7(1): 3 - 15Gang Yuan, Lishi Wang, Jing Li, Helin Feng, Jiafu Ji, Weikuan Gu* and Baoen Shan*
DOI: 10.2174/2212697X06666191021125423
Complexity in Clinical Trials: Blind Spots, Misleading Criteria, Winners and Losers
Research Article Open Access
Metformin Treatment Sensitizes Human Laryngeal Cancer Cell Line Hep- 2 to 5-Fluorouracil
, 7(1): 16 - 24Neslisah Barlak, Fatma Sanli, Ozel Capik, Elanur Tuysuz, Elanur Aydın Karatas, Hasan Turkez and Omer Faruk Karatas*
DOI: 10.2174/2212697X06666190906165309
Metformin Treatment Sensitizes Human Laryngeal Cancer Cell Line Hep- 2 to 5-Fluorouracil
Research Article Open Access
The Potential Role of Claudins in Regulation of Metastasis and Development of Drug Resistance in Breast Cancer
, 7(1): 25 - 43Hemantkumar Patadia, Ankita Priyadarshini, Jay Ranade and Ajit Gangawane*
DOI: 10.2174/2212697X06666191021121022
The Potential Role of Claudins in Regulation of Metastasis and Development of Drug Resistance in Breast Cancer
Research Article Open Access
Melatonin Induces Apoptosis and Inhibits the Proliferation of Cancer Cells via Reactive Oxygen Species-mediated MAPK and mTOR Pathways
, 7(1): 44 - 56Reena Kasi, Pei Ling Yeo, Ng. Khuen Yen, Rhun Yian Koh, Gnanajothy Ponnudurai, Yee Lian Tiong and Soi Moi Chye*
DOI: 10.2174/2212697X06666191116151114
Melatonin Induces Apoptosis and Inhibits the Proliferation of Cancer Cells via Reactive Oxygen Species-mediated MAPK and mTOR Pathways
Clinical Trial Open Access
Clinical Impact of Gastric Acid Suppressants Use on the Efficacy of Gefitinib in Patients with Advanced Adenocarcinoma of the Lung Harboring Common EGFR Mutations
, 7(1): 57 - 61Wang Chun Kwok, James Chung Man Ho, David Chi Leung Lam, Macy Mei Sze Lui, Mary Sau Man Ip and Terence Chi Chun Tam*
DOI: 10.2174/2212697X06666191021155535
Clinical Impact of Gastric Acid Suppressants Use on the Efficacy of Gefitinib in Patients with Advanced Adenocarcinoma of the Lung Harboring Common EGFR Mutations
Articles Ahead of Print
1+1 > 2: Integration of the host-directed Traditional Chinese Medicine and the virus-targeted Modern Medicine in control of COVID-19
Jianjun Sun*
DOI: 10.2174/2212697X07999200623130743
View Abstract
A Phase I Study of OMN54 (Aneustat™) in Patients with Advanced Malignancies
Karen A Gelmon*, Christian Kollmannsberger, Stephen Chia, Anna V. Tinker, Teresa Mitchell, Stephen Lam, Teresa Joshi, David Kwok, John Ostrem, Simon Sutcliffe and Daniel J Renouf
DOI: 10.2174/1574893615999200601130946
View Abstract
Sphingosine Analogs and Protein Phosphatase 2A as a Molecular Targeted Cancer Therapy: A Mini Systematic Review
Thomas Mayerhofer and Rajesh Kumar Jha*
DOI: 10.2174/2212697X07999200504110631
View Abstract
Alsevirone-NF Reduces Serum Testosterone and Inhibits Prostate Cancer Xenograft Growth in Balb/c Nude Mice
Pokrovsky V.S.*, Zolottsev V.A., Latysheva A.S., Kudinov V.A., Anisimova N.Yu., Almanza R.L.M., Alekseeva O.Yu., Baskaev K.K., Smirnova G.B., Borisova Yu.A. and Ipatova O.M.
DOI: 10.2174/2212697X07999200511082225
View Abstract
A Maximum Entropy Estimator for the Average Survival Time Differences between Two Groups
Marian Manciu*, Sorour Hosseini and Joscelyne Guzman-Gonzalez
DOI: 10.2174/2212697X07999200331120654
View Abstract
MiRNAs: A New Approach to Predict and Overcome Resistance to Anticancer Drugs
Noor Altaleb*
DOI: 10.2174/2212697X07666200130092419
View Abstract
Withdrawn: Intraoperative Sono-photodynamic Therapy for Anaplastic Astrocytoma Grade III With Transformation in Glioblastoma Grade IV
Dmitry Tzerkovsky*, Fedor Borichevsky, Yuri Grachev and Yuri Istomin
DOI: 10.2174/2212697X04666170727151321
View Abstract
Abstracts Ahead of Print
There are currently no Abstracts Ahead of Print available for this journal.
Published Contents
Editor's Choice
Clinical Impact of Gastric Acid Suppressants Use on the Efficacy of Gefitinib in Patients with Advanced Adenocarcinoma of the Lung Harboring Common EGFR Mutations
, 2020; 7(1): 57 - 61Wang Chun Kwok, James Chung Man Ho, David Chi Leung Lam, Macy Mei Sze Lui, Mary Sau Man Ip and Terence Chi Chun Tam*
DOI: 10.2174/2212697X06666191021155535
A Marine-based Meriolin (3-Pyrimidinylazaindole) Derivative (4ab) Targets PI3K/AKT /mTOR Pathway Inducing Cell Cycle Arrest and Apoptosis in Molt-4 Cells
, 2019; 6(1): 33 - 40Gousia Chashoo*, Umed Singh, Parvinder P. Singh, Dilip M. Mondhe and Ram A. Vishwakarma
DOI: 10.2174/2212697X06666190509094514
Effects of Lysozyme on Ehrlich Ascites Carcinoma Cells: The Possible Physiological Role of Lysozyme in the Prevention of Carcinogenesis
, 2018; 5(2): 113 - 118Vardan K. Gasparyan*, Hayk A. Harutyunyan, Mariam V. Mikaelyan and Gayane G. Poghosyan
DOI: 10.2174/2212697X06666190110120026
Arachidonic Acid Induces the Migration of MDA-MB-231 Cells by Activating Raft-associated Leukotriene B4 Receptors
, 2018; 5(1): 28 - 41Atasi De Chatterjee, Debarshi Roy, Priscilla Guevara, Rituraj Pal, Mahesh Narayan, Sukla Roychowdhury and Siddhartha Das*
DOI: 10.2174/2212697X05666180418145601
Prevalence of Neuropathy Associated With Bortezomib: A Retrospective Study
, 2017; 4(1): 69 - 72Pulivarthi Swaroopa, Mathew Josy, Ehresmann Kirsten and Gurram Murali Krishna*
DOI: 10.2174/2212697X03666161128102453
Transforming Mutations of Jak3 (A573V and M511I) Show Differential Sensitivity to Selective Jak3 Inhibitors
, 2016; 3(2): 131 - 137G. Steven Martinez, Jeremy A. Ross and Robert A. Kirken
DOI: 10.2174/2212697X03666160610085943
A Single Center Phase II Study of Continuous Infusion of Low-dose 5- fluorouracil for Heavily Pretreated Patients With Metastatic Colorectal Cancer
, 2015; 2(2): 87 - 90Hong-tao Chen, Yi-feng Liao, Mei Xiao, Lin Ma and Hong-Yu Zhang
DOI: 10.2174/2212697X02666151026215656
Inhibition of Autophagy by Targeting ATG4B: Promises and Challenges of An Emerging Anti-cancer Strategy
, 2015; 2(1): 61 - 70Kelly Lien, Michelle Rocha, Elisa Tran, Van C. Hoang, Annabelle Chow and Urban Emmenegger
DOI: 10.2174/2212697X02666150331202809
Impaired Autophagy Mediates Resistance to Low-Dose Metronomic Cyclophosphamide Chemotherapy
, 2014; 1(2): 116 - 126Annabelle Chow, Giulio Francia, Andrew Kouri, Christina Lee, John M. Ebos, Robert S. Kerbel and Urban Emmenegger
DOI: 10.2174/2212697X01666131218235200
The Epithelial-Stromal Interaction as a Potential Target for Breast Cancer Treatment
, 2014; 1(1): 65 - 71Bianca Maria Veneziani, Micaela Montanari, Maria Letizia Cataldo, Luigi Coppola, Agostina Nardone, Sara Corvigno, Carmine De Angelis, Grazia Arpino, Mario Giuliano, Chiara Carlomagno, Roberto Bianco and Sabino De Placido
DOI: 10.2174/2212697X113016660008
Open Access Articles
Clinical Impact of Gastric Acid Suppressants Use on the Efficacy of Gefitinib in Patients with Advanced Adenocarcinoma of the Lung Harboring Common EGFR Mutations
, 2020; 7(1): 57 - 61Wang Chun Kwok, James Chung Man Ho, David Chi Leung Lam, Macy Mei Sze Lui, Mary Sau Man Ip and Terence Chi Chun Tam*
Melatonin Induces Apoptosis and Inhibits the Proliferation of Cancer Cells via Reactive Oxygen Species-mediated MAPK and mTOR Pathways
, 2020; 7(1): 44 - 56Reena Kasi, Pei Ling Yeo, Ng. Khuen Yen, Rhun Yian Koh, Gnanajothy Ponnudurai, Yee Lian Tiong and Soi Moi Chye*
Complexity in Clinical Trials: Blind Spots, Misleading Criteria, Winners and Losers
, 2020; 7(1): 3 - 15Gang Yuan, Lishi Wang, Jing Li, Helin Feng, Jiafu Ji, Weikuan Gu* and Baoen Shan*
The Potential Role of Claudins in Regulation of Metastasis and Development of Drug Resistance in Breast Cancer
, 2020; 7(1): 25 - 43Hemantkumar Patadia, Ankita Priyadarshini, Jay Ranade and Ajit Gangawane*
Metformin Treatment Sensitizes Human Laryngeal Cancer Cell Line Hep- 2 to 5-Fluorouracil
, 2020; 7(1): 16 - 24Neslisah Barlak, Fatma Sanli, Ozel Capik, Elanur Tuysuz, Elanur Aydın Karatas, Hasan Turkez and Omer Faruk Karatas*
Novel Molecular Targets and Mechanisms Involved in the Invasion and Metastasis of Pancreatic Cancer
, 2019; 6(1): 8 - 20Ziyi Li, Weidong Li, Yuqi Dong and Xueying Sun*
Head and Neck Cancer with Lung Metastases: Treatment Challenges
, 2019; 6(1): 48 - 53Selvamalar Vengathajalam* and Norhafiza Mat Lazim
Coenzyme Q10 Attenuates Cisplatin-induced Nephrotoxicity Through Counteracting Oxidative Stress and Inflammation
, 2019; 6(1): 41 - 47Hala S. Bash and Ihsan S. Rabeea*
A Marine-based Meriolin (3-Pyrimidinylazaindole) Derivative (4ab) Targets PI3K/AKT /mTOR Pathway Inducing Cell Cycle Arrest and Apoptosis in Molt-4 Cells
, 2019; 6(1): 33 - 40Gousia Chashoo*, Umed Singh, Parvinder P. Singh, Dilip M. Mondhe and Ram A. Vishwakarma
Targeting Breast Cancer Stem Cells (BCSCs) with Liposomal Formulations
, 2019; 6(1): 3 - 7Sumayah Al-Mahmood*
Evaluation of Fibrolytic Effect of Bauhinia purpurea L.
, 2019; 6(1): 21 - 32Jeevan R. Dash, Tapas K. Sar*, Rinku Buragohain, Indranil Samanta and Rahul Nanotkar
Computational Analysis of the Binding Site(s) of TNF β-TNFR1 Complex: Implications for Designing Novel Anticancer Agents
, 2018; 5(2): 94 - 104Trupti Kashinath Khatal and Ganesh Ulhasrao Chaturbhuj*
Erlotinib in Non-Small Cell Lung Cancer: From a thought to Necessity
, 2018; 5(2): 87 - 93Parijat Pandey and Harish Dureja*
May Endocrine Therapy be Associated with Cognitive Impairment in Breast Cancer Patients?
, 2018; 5(2): 75 - 86Riccardo Presciuttini, Romano Danesi and Guido Bocci*
New Robotic Technologies in Cancer Colon Screening
, 2018; 5(2): 68 - 74Luigi Manfredi* and Gianfranco Natale
Most Cited Articles
Upfront DPD Deficiency Detection to Secure 5-FU Administration: Part 1 – Where Do We Stand?
, 2017; 4(2): 74-81.Manon Launay, Joseph Ciccolini*, Anne Rodallec, Claire Fournel, Florence Duffaud, Sebastien Salas and Bruno Lacarelle
DOI: 10.2174/2212697X04666170531080625
The PI3K/AKT/mTOR-Signal Transduction Pathway as Drug Target in Triple-Negative Breast Cancer
, 2017; 4(1): 47-58.Jens C. Hahne*, Jorg B. Engel, Arnd Honig, Susanne R. Meyer, Domenico Zito, Andrea Lampis and Nicola Valeri
DOI: 10.2174/2212697X04666170321112629
Intra-arterial Temozolomide, Osmotic Blood-brain Barrier Disruption and Radiotherapy in a Rat F98-Glioma Model
, 2017; 4(2): 135-144.Annie I. Drapeau, Marie-Belle Poirier, Guru-Swamy Madugundu, J. Richard Wagner and David Fortin*
DOI: 10.2174/2212697X04666170727152212
Pharmacokinetic Markers of 5-Fluorouracil Toxicity in Clinical Trials and Real World
, 2017; 4(2): 82-92.Antonello Di Paolo*, Marzia Del Re, Elena Arrigoni, Teresa Di Desidero, Eleonora Rofi, Romano Danesi and Guido Bocci
DOI: 10.2174/2212697X04666170817124625
Most Accessed Articles
Metformin Treatment Sensitizes Human Laryngeal Cancer Cell Line Hep- 2 to 5-Fluorouracil
, 2020; 7(1): 16-24.Neslisah Barlak, Fatma Sanli, Ozel Capik, Elanur Tuysuz, Elanur Aydın Karatas, Hasan Turkez and Omer Faruk Karatas*
DOI: 10.2174/2212697X06666190906165309
The Potential Role of Claudins in Regulation of Metastasis and Development of Drug Resistance in Breast Cancer
, 2020; 7(1): 25-43.Hemantkumar Patadia, Ankita Priyadarshini, Jay Ranade and Ajit Gangawane*
DOI: 10.2174/2212697X06666191021121022
Clinical Impact of Gastric Acid Suppressants Use on the Efficacy of Gefitinib in Patients with Advanced Adenocarcinoma of the Lung Harboring Common EGFR Mutations
, 2020; 7(1): 57-61.Wang Chun Kwok, James Chung Man Ho, David Chi Leung Lam, Macy Mei Sze Lui, Mary Sau Man Ip and Terence Chi Chun Tam*
DOI: 10.2174/2212697X06666191021155535
Melatonin Induces Apoptosis and Inhibits the Proliferation of Cancer Cells via Reactive Oxygen Species-mediated MAPK and mTOR Pathways
, 2020; 7(1): 44-56.Reena Kasi, Pei Ling Yeo, Ng. Khuen Yen, Rhun Yian Koh, Gnanajothy Ponnudurai, Yee Lian Tiong and Soi Moi Chye*
DOI: 10.2174/2212697X06666191116151114
Complexity in Clinical Trials: Blind Spots, Misleading Criteria, Winners and Losers
, 2020; 7(1): 3-15.Gang Yuan, Lishi Wang, Jing Li, Helin Feng, Jiafu Ji, Weikuan Gu* and Baoen Shan*
DOI: 10.2174/2212697X06666191021125423
Targeting Breast Cancer Stem Cells (BCSCs) with Liposomal Formulations
, 2019; 6(1): 3-7.Sumayah Al-Mahmood*
DOI: 10.2174/2212697X06666190318150757
Novel Molecular Targets and Mechanisms Involved in the Invasion and Metastasis of Pancreatic Cancer
, 2019; 6(1): 8-20.Ziyi Li, Weidong Li, Yuqi Dong and Xueying Sun*
DOI: 10.2174/2212697X06666190328180331
Efficacy of Therapy with c-Met/HGF Inhibitors in Solid Tumors: A Systematic Review Based on 24 Clinical Trials
, 2016; 3(2): 87-99.Yin Yin, He Wang, Mingjie Lu and Wei Zhu
DOI: 10.2174/2212697X03666160805114707
Editor-in-Chief
Giulio Francia
The University of Texas
El Paso, TX
(USA)
Biography
View Full Editorial Board
The University of Texas
El Paso, TX
Biography
Biography of Giulio Francia
Dr. Francia began his career by undertaking a PhD with Dr. Ian Hart at the Imperial Cancer Research Fund in London, UK, which has since evolved into Cancer UK. After his PhD, he trained with Dr. Robert Kerbel in Toronto, Canada, on aspects of metastasis, therapies for metastatic disease, and tumor resistance to therapy. He is now Assistant Professor at The University of Texas at El Paso, where he is attempting to set up a research program that is internationally recognized for pioneering new cancer therapeutic ideas, and for generating in vivo models to help translate laboratory findings into the clinic - by developing new metastatic tumor models, and by refining those he has already established.
About the Journal
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Journal History
Clinical Cancer Drugs was introduced in 2014 with the assistance of Dr. Giulio Francia, who is the current Editor-in-Chief serving since 2014.
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