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Current Drug Targets

Volume 22, 17 Issues, 2021
ISSN: 1873-5592 (Online)
ISSN: 1389-4501 (Print)
This journal supports open access

Aims & Scope

Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes.

Current Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of drug targets. The journal also accepts for publication full-length/mini review articles and drug clinical trial studies.

As the discovery, identification, characterization and validation of novel human drug targets for drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.

Current Drug Targets

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Volume 22

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Number 3





Review Article (Mini-Review)





Review Article

Application of Poloxamers for the Development of Drug Delivery System to Treat Leishmaniasis: A Review

, 22(3): 296 - 309

Audrey Silva, Amanda Costa, Sona Jain, Eduardo Coelho, Ricardo Fujiwara, Ricardo Scher, Rogéria Nunes and Silvio Dolabella*


DOI: 10.2174/1389450121666201106145022


Review Article







Review Article

Application of Ultrasound Elastography for Assessing Intestinal Fibrosis in Inflammatory Bowel Disease: Fiction or Reality?

, 22(3): 347 - 355

Roberto Gabbiadini, Eirini Zacharopoulou, Federica Furfaro, Vincenzo Craviotto, Alessandra Zilli, Daniela Gilardi, Giulia Roda, Laura Loy, Gionata Fiorino, Laurent Peyrin-Biroulet, Silvio Danese and Mariangela Allocca*


DOI: 10.2174/1389450121666201119142919


Current Drug Targets, Volume 22 (2021) - Number 5


This issue is in progress but contains articles that are final and fully citable.

Current Drug Targets, Volume 22 (2021) - Number 4


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

The Emergence of Immune-checkpoint Inhibitors in Colorectal Cancer Therapy


Michele Ghidini*, Nicola Fusco, Massimiliano Salati, Shelize Khakoo, Gianluca Tomasello, Fausto Petrelli, Dario Trapani and Angelica Petrillo


DOI: 10.2174/1389450122666210204204415
View Abstract View on PubMed




Implications of microRNAs in the Pathogenesis of Atherosclerosis and Prospects for Therapy


Armita Mahdavi Gorabi, Mohsen Ghanbari, Thozhukat Sathyapalan, Tannaz Jamialahmadi and Amirhossein Sahebkar*


DOI: 10.2174/1389450122666210120143450
View Abstract View on PubMed




Anti-VEGF Therapy in Myopic CNV


Lisa Toto*, Luca Di Antonio, Olivia Costantino and Rodolfo Mastropasqua


DOI: 10.2174/1389450122999210128180725
View Abstract View on PubMed



Inflammatory Bowel Disease in Migrant Populations: Should we Look Even Further Back?


Gionata Fiorino, Maria Manuela Estevinho, Diogo José M. Lopes, Filippo Chersi, Mariangela Allocca, Miguel Torre Souto, Silvio Danese and Fernando Magro*


DOI: 10.2174/1389450122666210203193817
View Abstract View on PubMed



Abstracts Ahead of Print




Current Perspectives of Healthy Mitochondrial Function for Healthy Neurons


Arunachalam Muthuraman*, Muthusamy Ramesh*, Venkataratinakumar Thiagarajan, Sumeet Kumar Singla, Seema Mudhol and Serva Peddha Muthukumar


DOI: 10.2174/1389450122666210222163528
View Abstract




The role of Non-coding Genome in Cancer-associated Fibroblasts; state-of-the-art and perspectives in cancer targeted therapy


Arezoo Gowhari Shabgah, Hamed Mohammadi, Pouya Goleij, Mahdiyeh Hedayati-Moghadam, Arash Salmaninejad and Jamshid Gholizadeh Navashenaq*


DOI: 10.2174/1389450122666210216091953
View Abstract


Small-molecule antiviral agents in ongoing clinical trials for COVID-19


Çağla Begüm Apaydın, Gözde Çınar and Gökçe Cihan-Üstündağ*


DOI: 10.2174/1389450122666210215112150
View Abstract


New framework for the discovery of PRC2 inhibitors: Epigenetic Drugs


Danishuddin Danish, Naidu Subbarao*, Mohd Khan, Sultan Alouffi and Shahper Khan*


DOI: 10.2174/1389450122666210215111744
View Abstract



Published Contents

Editor's Choice

Downregulation of Membrane-bound Angiotensin Converting Enzyme 2 (ACE2) Receptor has a Pivotal Role in COVID-19 Immunopathology

, 2021; 22(3): 254 - 281

Cristina Vieira, Lucas Nery, Ludimila Martins, Luiz Jabour, Raphael Dias and Ana Cristina Simões e Silva*


DOI: 10.2174/1389450121666201020154033



Fibrotic Strictures in Crohn’s Disease: Mechanisms and Predictive Factors

, 2021; 22(2): 241 - 251

Riccardo Mager, Giulia Roda, Mohammad Khaled Shalaby and Stefania Vetrano*


DOI: 10.2174/1389450121666201020160803



Neoadjuvant Chemotherapy Before Radical Cystectomy: Why We Must Adhere?

, 2021; 22(1): 14 - 21

Beppe Calò*, Michele Marchioni, Francesca Sanguedolce, Ugo Giovanni Falagario, Marco Chirico, Giuseppe Carrieri and Luigi Cormio


DOI: 10.2174/1389450121666200802022150



The Activating Receptors of Natural Killer Cells and Their Inter-Switching Potentials

, 2020; 21(16): 1733 - 1751

Adekunle Babajide Rowaiye, Titilayo Asala, Angus Nnamdi Oli*, Ikemefuna Chijioke Uzochukwu, Alex Akpa and Charles Okechukwu Esimone


DOI: 10.2174/1389450121666200910160929




Exosomes in Inflammatory Bowel Disease: What Have We Learned So Far?

, 2020; 21(14): 1448 - 1455

Haichao Wang, Chen Ye, Yaling Wu, Pengyu Yang, Chunqiu Chen, Zhanju Liu and Xiaolei Wang*


DOI: 10.2174/1389450121666200428102330



PD1/PD-L1 Axis in Uro-oncology

, 2020; 21(13): 1293 - 1300

Kerstin Junker*, Markus Eckstein, Michelangelo Fiorentino and Rodolfo Montironi


DOI: 10.2174/1389450121666200326123700



Anti-VEGF Treatment in Corneal Diseases

, 2020; 21(12): 1159 - 1180

Giuseppe Giannaccare, Marco Pellegrini, Cristina Bovone, Rossella Spena, Carlotta Senni, Vincenzo Scorcia and Massimo Busin*


DOI: 10.2174/1389450121666200319111710





Open Access Articles

Recognition of Plasminogen Activator Inhibitor Type 1 as the Primary Regulator of Fibrinolysis

, 2019; 20(16): 1695 - 1701

Tetsumei Urano*, Yuko Suzuki, Takayuki Iwaki, Hideto Sano, Naoki Honkura and Francis J. Castellino




Current Understanding of Group A Streptococcal Biofilms

, 2019; 20(9): 982 - 993

Heema K.N. Vyas, Emma-Jayne Proctor, Jason McArthur, Jody Gorman and Martina Sanderson-Smith*








Opportunities of Bacterial Cellulose to Treat Epithelial Tissues

, 2019; 20(8): 808 - 822

Irene Anton-Sales, Uwe Beekmann, Anna Laromaine*, Anna Roig* and Dana Kralisch





Blood Eosinophils as Biomarkers to Drive Treatment Choices in Asthma and COPD

, 2018; 19(16): 1882 - 1896

Konstantinos Kostikas, Caterina Brindicci and Francesco Patalano*




Current Status and Perspectives on Pharmacologic Therapy for Abdominal Aortic Aneurysm

, 2018; 19(11): 1265 - 1275

Koichi Yoshimura*, Noriyasu Morikage, Shizuka Nishino-Fujimoto, Akira Furutani, Bungo Shirasawa and Kimikazu Hamano





TXNIP in Metabolic Regulation: Physiological Role and Therapeutic Outlook

, 2017; 18(9): 1095 - 1103

Naif Mohammad Alhawiti, Saeed Al Mahri, Mohammad Azhar Aziz, Shuja Shafi Malik and Sameer Mohammad*






Structural and Functional Aspects of Class A Carbapenemases

, 2016; 17(9): 1006 - 1028

Thierry Naas, Laurent Dortet and Bogdan I. Iorga





Most Cited Articles


Review Article

Bioinformatics approaches for anti-cancer drug discovery

, 2020; 21(1): 3-17.

Kening Li, Yuxin Du, Lu Li and Dong-Qing Wei*


DOI: 10.2174/1389450120666190923162203


Review Article

Targeting cancer stem cells pathways for the effective treatment of cancer

, 2020; 21(3): 258-278.

Ashish Ranjan Dwivedi, Amandeep Thakur, Vijay Kumar, Ira Skvortsova and Vinod Kumar*


DOI: 10.2174/1389450120666190821160730


Review Article (Mini-Review)

The therapeutic potential of chemokines in the treatment of chemotherapy-induced peripheral neuropathy

, 2020; 21(3): 288-301.

Lin Zhou, Luyao Ao, Yunyi Yan, Wanting Li, Anqi Ye, Yahui Hu*, Weirong Fang* and Yunman Li*


DOI: 10.2174/1389450120666190906153652



Review Article (Mini-Review)

Antiviral drug targets of single-stranded rna viruses causing chronic human diseases

, 2020; 21(2): 105-124.

Dhurvas Chandrasekaran Dinesh*, Selvaraj Tamilarasan, Kaushik Rajaram and Evžen Bouřa*


DOI: 10.2174/1389450119666190920153247



Review Article

The potential of pi3k/akt/mtor signaling as a druggable target for endometrial and ovarian carcinomas

, 2020; 21(10): 946-961.

Csongor György Lengyel*, Sara Cecilia Altuna, Baker Shalal Habeeb, Dario Trapani and Shah Zeb Khan


DOI: 10.2174/1389450120666191120123612


Review Article

ACE2/angiotensin-(1-7)/mas receptor axis in human cancer: Potential role for pediatric tumors

, 2020; 21(9): 892-901.

Ana Luiza Ataide Carneiro de Paula Gonzaga , Vitória Andrade Palmeira , Thomas Felipe Silva Ribeiro , Larissa Braga Costa , Karla Emília de Sá Rodrigues and Ana Cristina Simões-e-Silva *


DOI: 10.2174/1389450121666200210124217


Review Article

Medicinal perspective of indole derivatives: Recent developments and structure-activity relationship studies

, 2020; 21(9): 864-891.

Devendra Kumar, Sahil Sharma, Sourav Kalra, Gurpreet Singh, Vikramdeep Monga and Bhupinder Kumar*


DOI: 10.2174/1389450121666200310115327


Review Article

Nanosized modification strategies for improving the antitumor efficacy of MEK inhibitors

, 2020; 21(3): 228-251.

Yanan Li, Qingrong Dong, Ting Mei, Meichen Zheng, Ramasamy Raj Kumar, Bin Yu, Chunsheng Wu, Hui Zhang* and Feifei An*


DOI: 10.2174/1389450120666190807143245


General Review Article

Advances in the treatment of ovarian cancer using PARP inhibitors and the underlying mechanism of resistance

, 2020; 21(2): 167-178.

Ling Wang, Qi Wang, Yangchun Xu, Manhua Cui and Liying Han*


DOI: 10.2174/1389450120666190925123507


Editorial

Computational advances in chronic diseases diagnostics and therapy-i

, 2020; 21(1): 1-2.

Gurudeeban Selvaraj, Chandrabose Selvaraj and Dong-Qing Wei


DOI: 10.2174/138945012101191206142040


Review Article (Mini-Review)

Novel treatment for the most resistant schizophrenia: Dual activation of NMDA receptor and antioxidant

, 2020; 21(6): 610-615.

Chieh-Hsin Lin, Yu-Ming Chen and Hsien-Yuan Lane*


DOI: 10.2174/1389450120666191011163539


Review Article

IL-37 as a potential biotherapeutics of inflammatory diseases

, 2020; 21(9): 855-863.

Junhui Bai, Yukun Li, Meixiang Li, Sijie Tan* and Daichao Wu*


DOI: 10.2174/1389450121666200429114926



Most Accessed Articles


Targeting Cancer Stem Cells Pathways for the Effective Treatment of Cancer

, 2020; 21(3): 258-278.

Ashish Ranjan Dwivedi, Amandeep Thakur, Vijay Kumar, Ira Skvortsova and Vinod Kumar*


DOI: 10.2174/1389450120666190821160730




The Epigenetic Modification of Epigallocatechin Gallate (EGCG) on Cancer

, 2020; 21(11): 1099-1104.

Linqi Yang, Wenqi Zhang, Saiyam Chopra, Deeepjyot Kaur, Huibing Wang, Meng Li, Pingping Chen* and Wei Zhang*


DOI: 10.2174/1389450121666200504080112


Targeting Host Cell Proteases to Prevent SARS-CoV-2 Invasion

, 2021; 22(2): 192-201.

Upinder Kaur, Sankha Shubhra Chakrabarti*, Bisweswar Ojha, Bhairav Kumar Pathak, Amit Singh, Luciano Saso and Sasanka Chakrabarti


DOI: 10.2174/1389450121666200924113243


COVID-19 and Renal Diseases: An Update

, 2021; 22(1): 52-67.

Letícia Bitencourt, Ana Luisa Pedrosa, Stephanie Bruna Camilo Soares de Brito, Ana Cláudia Fontoura Fróes, Sarah Tayná de Carvalho, Giulio Gori Fonseca, Guilherme Costa Ferreira, Pollyanna Faria Fradico and Ana Cristina Simões e Silva*


DOI: 10.2174/1389450121999201013151300


Edaravone May Prevent Ferroptosis in ALS

, 2020; 21(8): 776-780.

Snežana Spasić*, Aleksandra Nikolić-Kokić, Srđan Miletić, Zorana Oreščanin-Dušić, Mihajlo B. Spasić, Duško Blagojević and Zorica Stević


DOI: 10.2174/1389450121666200220123305



Application of Artificial Intelligence in Targeting Retinal Diseases

, 2020; 21(12): 1208-1215.

Francesco Saverio Sorrentino, Giuseppe Jurman, Katia De Nadai, Claudio Campa, Cesare Furlanello and Francesco Parmeggiani*


DOI: 10.2174/1389450121666200708120646


Anti-VEGF and Retinal Dystrophies

, 2020; 21(12): 1201-1207.

Maurizio Battaglia Parodi, Pierluigi Iacono* and Stefano Da Pozzo


DOI: 10.2174/1389450121666200428103334




Targeting Drugs Against Fibroblast Growth Factor(s)-Induced Cell Signaling

, 2021; 22(2): 214-240.

Shilpi Agrawal, Sanhita Maity, Zeina AlRaawi, Musaab Al-Ameer and Thallapuranam Krishnaswamy Suresh Kumar*


DOI: 10.2174/1389450121999201012201926





Editor-in-Chief

graphic
Francis J. Castellino
(14643 citations)
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
(USA)
View Full Editorial Board

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Journal History

Current Drug Targets Journal was launched in 2000. Dr. Francis J. Castellino serves as the Editor-in-Chief of the journal.

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