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Current Drug Metabolism

Volume 21, 14 Issues, 2020
ISSN: 1875-5453 (Online)
ISSN: 1389-2002 (Print)
This journal supports open access
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Ranking and Category

  • 200th of 298 in

    Biochemistry & Molecular Biology

  • 158th of 267 in

    Pharmacology & Pharmacy

In the current Pandemic scenario, all articles related to Coronavirus will be processed on a free, quick track basis, to ensure timely review and publication of much needed research

Aims & Scope

Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism, pharmacokinetics, and drug disposition. The journal serves as an international forum for the publication of full-length/mini review, research articles and guest edited issues in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the most important developments. The journal covers the following general topic areas: pharmaceutics, pharmacokinetics, toxicology, and most importantly drug metabolism.

More specifically, in vitro and in vivo drug metabolism of phase I and phase II enzymes or metabolic pathways; drug-drug interactions and enzyme kinetics; pharmacokinetics, pharmacokinetic-pharmacodynamic modeling, and toxicokinetics; interspecies differences in metabolism or pharmacokinetics, species scaling and extrapolations; drug transporters; target organ toxicity and interindividual variability in drug exposure-response; extrahepatic metabolism; bioactivation, reactive metabolites, and developments for the identification of drug metabolites. Preclinical and clinical reviews describing the drug metabolism and pharmacokinetics of marketed drugs or drug classes.

Current Drug Metabolism

,

Volume 21

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Number 1



Biography   Open Access



Preface   Open Access



Editorial   Open Access



Review Article



Review Article



Review Article



Review Article

Prognostic Role of Hedgehog-GLI1 Signaling Pathway in Aggressive and Metastatic Breast Cancers

, 21(1): 33 - 43

Prasuja Rokkam, Shailender Gugalavath, Deepak Kakara Gift Kumar, Rahul Kumar Vempati and Rama Rao Malla*


DOI: 10.2174/1389200221666200122120625


Review Article



Current Drug Metabolism, Volume 21 (2020) - Number 2


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print



The Potential Role of Serum Exosomes in Preeclampsia


Xuelin Gao, Lulu Shao, Xinying Ge, Long Zhang , Dexin Chen and Rongxia He*


DOI: 10.2174/1389200221666200525152441
View Abstract


Nano phytomedicine based delivery system for CNS disease


Mohammed Asadullah Jahangir, Chettupalli Anand, Abdul Muheem, Sadaf Jamal Gilani*, Md. Taleuzzaman, Ameeduz Zafar, Mohammad Jaffer, Surajpal Verma and Mohammad Abul Barkat


DOI: 10.2174/1389200221666200523161003
View Abstract


Modulation of the drug resistance by Platonia insignis Mart. extract, ethyl acetate fraction and Morelloflavone/Volkensiflavone (biflavonoids) in Staphylococcus aureus strains overexpressing efflux pump genes


Andressa Kelly Ferreira e Silva, Antonielly Campinho dos Reis, Emanuelly Elanny Andrade Pinheiroc, Jonas Nascimento de Sousa, Felipe Araújo de Alcântara Oliveira, Arkellau Kenned Silva Moura, José de Souza Lima Neto, Antonia Maria das Graças Lopes Citó, José Pinto de Siqueira-Júnior, Glenn William Kaatz and Humberto Medeiros Barreto*


DOI: 10.2174/1389200221666200523155617
View Abstract


Tumor-targeted drug delivery by nanocomposites


Abu Baker*, Mohd Salman Khan, Muhammad Zafar Iqbal and Mohd Sajid Khan


DOI: 10.2174/1389200221666200520092333
View Abstract



Using reduced amino acid alphabet and biological properties to analyze and predict animal neurotoxin protein


Yao Yu, Shiyuan Wang, Yakun Wang, Yiyin Cao, Chunlu Yu, Yi Pan, Dongqing Su, Qianzi Lu, Yongchun Zuo and Lei Yang*


DOI: 10.2174/1389200221666200520090555
View Abstract



Evaluation of the Effects of Maytenus ilicifolia on the Activities of Cytochrome P450 3A and P-Glycoprotein


Sara Batista do Nascimento, Mariana de Lima Nascimento, Laís Lobato de Araújo, Flávio Martins de Oliveira, Maria do Carmo Vieira, Joaquim Maurício Duarte-Almeida, João Máximo Siqueira, Isabela da Costa César, Hartmut Derendorf and Whocely Victor de Castro*


DOI: 10.2174/1389200221666200512112718
View Abstract View on PubMed


Abstracts Ahead of Print

There are currently no Abstracts Ahead of Print available for this journal.

Published Contents

Editor's Choice


Effect of Environmental Exposure and Pharmacogenomics on Drug Metabolism

, 2019; 20(14): 1103 - 1113

Basu Dev Banerjee*, Ranjeet Kumar, Krishna Latha Thamineni, Harendra Shah, Gaurav Kumar Thakur and Tusha Sharma


DOI: 10.2174/1389200221666200110153304



Therapeutic Study of Phytochemicals Against Cancer and Alzheimer’s Disease Management

, 2019; 20(13): 1006 - 1013

Syed Sayeed Ahmad, Tayyaba Waheed, Sayed Rozeen, Sufia Mahmood and Mohammad Amjad Kamal*


DOI: 10.2174/1389200221666200103092719



A Retrospective Look at Anti-EGFR Agents in Pancreatic Cancer Therapy

, 2019; 20(12): 958 - 966

Henu K. Verma, Praveen K. Kampalli, Saikrishna Lakkakula, Gayathri Chalikonda, Lakkakula V.K.S. Bhaskar* and Smaranika Pattnaik*


DOI: 10.2174/1389200220666191122104955




Assessment of miR-212 and Other Biomarkers in the Diagnosis and Treatment of HBV-infection-related Liver Diseases

, 2019; 20(10): 785 - 798

Yigan Zhang, Huaze Xi, Xin Nie, Peng Zhang, Ning Lan, Ying Lu, Jinrong Liu and Wenzhen Yuan*


DOI: 10.2174/1389200220666191011120434




Influence of the OATP Polymorphism on the Population Pharmacokinetics of Methotrexate in Chinese Patients

, 2019; 20(7): 592 - 600

Zhiqi Wang, Nan Zhang, Chaoyang Chen, Shuqing Chen, Junyu Xu, Ying Zhou, Xia Zhao* and Yimin Cui*


DOI: 10.2174/1389200220666190701094756



Interethnic Variations of UGT1A1 and UGT1A7 Polymorphisms in the Jordanian Population

, 2019; 20(5): 399 - 410

Sara Abudahab*, Nancy Hakooz, Yazun Jarrar, Mohammad Al Shahhab, Ahmad Saleh, Malek Zihlif and Rana Dajani


DOI: 10.2174/1389200220666190528085151



Effects of CYP2C8 and SLCO1B1 Genetic Polymorphisms on Repaglinide Pharmacokinetics: A Systematic Review and Meta-Analysis

, 2019; 20(4): 266 - 274

Shuang Zhou, Qian Xiang, Guangyan Mu, Lingyue Ma, Shuqing Chen, Qiufen Xie, Zhuo Zhang and Yimin Cui*


DOI: 10.2174/1389200220666190111114146



Open Access Articles

Dysregulation of lncRNA and circRNA Expression in Mouse Testes after Exposure to Triptolide

, 2019; 20(8): 665 - 673

Suping Xiong, Yanting Li, Yang Xiang, Na Peng, Chunmiao Shen, Yanqiu Cai, Dandan Song, Peng Zhang, Xiaolong Wang, Xuihui Zeng and Xiaoning Zhang*




Influence of the OATP Polymorphism on the Population Pharmacokinetics of Methotrexate in Chinese Patients

, 2019; 20(7): 592 - 600

Zhiqi Wang, Nan Zhang, Chaoyang Chen, Shuqing Chen, Junyu Xu, Ying Zhou, Xia Zhao* and Yimin Cui*




Decreased Disposition of Anticancer Drugs Predominantly Eliminated via the Liver in Patients with Renal Failure

, 2019; 20(5): 361 - 376

Ken-ichi Fujita *, Natsumi Matsumoto, Hiroo Ishida, Yutaro Kubota, Shinichi Iwai, Motoko Shibanuma and Yukio Kato




Effects of CYP2C8 and SLCO1B1 Genetic Polymorphisms on Repaglinide Pharmacokinetics: A Systematic Review and Meta-Analysis

, 2019; 20(4): 266 - 274

Shuang Zhou, Qian Xiang, Guangyan Mu, Lingyue Ma, Shuqing Chen, Qiufen Xie, Zhuo Zhang and Yimin Cui*






Survey of Drug Oxidation Activities in Hepatic and Intestinal Microsomes of Individual Common Marmosets, a New Nonhuman Primate Animal Model

, 2019; 20(2): 103 - 113

Shotaro Uehara, Toru Oshio, Kazuyuki Nakanishi, Etsuko Tomioka, Miyu Suzuki, Takashi Inoue, Yasuhiro Uno, Erika Sasaki and Hiroshi Yamazaki*





Thiazide Therapy in Chronic Kidney Disease: Renal and Extra Renal Targets

, 2018; 19(12): 1012 - 1020

Negiin Pourafshar*, Saeed Alshahrani, Ashkan Karimi and Manoocher Soleimani*




Models of Drug Induced Liver Injury (DILI) – Current Issues and Future Perspectives

, 2018; 19(10): 830 - 838

Lucija Kuna, Ivana Bozic, Tomislav Kizivat, Kristina Bojanic, Margareta Mrso, Edgar Kralj, Robert Smolic, George Y. Wu and Martina Smolic*






Digestive Enzyme Supplementation in Gastrointestinal Diseases

, 2016; 17(2): 187 - 193

Gianluca Ianiro, Silvia Pecere, Valentina Giorgio, Antonio Gasbarrini and Giovanni Cammarota




Role of Drug Metabolism in the Cytotoxicity and Clinical Efficacy of Anthracyclines

, 2015; 16(6): 412 - 426

Derek W. Edwardson, Rashmi Narendrula, Simon Chewchuk, Kyle Mispel-Beyer, Jonathan P.J. Mapletoft and Amadeo M. Parissenti




Preclinical Pharmacokinetics, Pharmacodynamics and Safety of Sucroferric Oxyhydroxide

, 2014; 15(10): 953 - 965

Mario Cozzolino, Felix Funk, Viatcheslav Rakov, Olivier Phan and Isaac Teitelbaum





Most Cited Articles


Review Article

Survey of machine learning techniques in drug discovery

, 2019; 20(3): 185-193.

Natalie Stephenson, Emily Shane, Jessica Chase, Jason Rowland, David Ries, Nicola Justice, Jie Zhang, Leong Chan and Renzhi Cao*


DOI: 10.2174/1389200219666180820112457


Review Article

Recent advances in machine learning methods for predicting heat shock proteins

, 2019; 20(3): 224-228.

Wei Chen*, Pengmian Feng, Tao Liu and Dianchuan Jin


DOI: 10.2174/1389200219666181031105916



Review Article

Magnetic nanoparticles: Current trends and future aspects in diagnostics and nanomedicine

, 2019; 20(6): 457-472.

Naga Veera Srikanth Vallabani, Sanjay Singh* and Ajay Singh Karakoti*


DOI: 10.2174/1389200220666181122124458



Review Article

Survey of machine learning techniques for prediction of the isoform specificity of cytochrome P450 substrates

, 2019; 20(3): 229-235.

Yi Xiong, Yanhua Qiao, Daisuke Kihara, Hui-Yuan Zhang, Xiaolei Zhu* and Dong-Qing Wei*


DOI: 10.2174/1389200219666181019094526


Review Article

Iron oxide nanoparticles for breast cancer theranostics

, 2019; 20(6): 446-456.

Md. Salman Shakil, Md. Ashraful Hasan* and Satya Ranjan Sarker*


DOI: 10.2174/1389200220666181122105043




Review Article

Curcumin-a novel therapeutic agent in the prevention of colorectal cancer

, 2019; 20(12): 977-987.

Manoj K. Gupta, Ramakrishna Vadde and Vemula Sarojamma*


DOI: 10.2174/1389200220666191007153238


Review Article

Herb-drug interactions and hepatotoxicity

, 2019; 20(4): 275-282.

Mohammad K. Parvez* and Vikas Rishi


DOI: 10.2174/1389200220666190325141422


Review Article

Recent advances in the machine learning-based drug-target interaction prediction

, 2019; 20(3): 194-202.

Wen Zhang*, Weiran Lin, Ding Zhang, Siman Wang, Jingwen Shi and Yanqing Niu


DOI: 10.2174/1389200219666180821094047


Review Article

A review of theranostics applications and toxicities of carbon nanomaterials

, 2019; 20(6): 506-532.

Nitin Gupta, Divya Bharti Rai, Ashok Kumar Jangid and Hitesh Kulhari*


DOI: 10.2174/1389200219666180925094515


Review Article

Mitochondrial metabolism in cancer cachexia: Novel drug target

, 2019; 20(14): 1141-1153.

Dhwani T. Dave and Bhoomika M. Patel*


DOI: 10.2174/1389200220666190816162658



Most Accessed Articles

Exosomes and Female Infertility

, 2019; 20(10): 773-780.

Xiaoyan Sun, Xiaoling Ma, Xia Yang and Xuehong Zhang*


DOI: 10.2174/1389200220666191015155910



Serial Quantification of Urinary Protein Biomarkers to Predict Drug-induced Acute Kidney Injury

, 2019; 20(8): 656-664.

Yi Da, K. Akalya, Tanusya Murali, Anantharaman Vathsala, Chuen-Seng Tan, Sanmay Low, Hui-Ning Lim, Boon-Wee Teo, Titus Lau, Lizhen Ong and Horng-Ruey Chua*


DOI: 10.2174/1389200220666190711114504



Possible Pathways of Hepatotoxicity Caused by Chemical Agents

, 2019; 20(11): 867-879.

Roohi Mohi-ud-din, Reyaz Hassan Mir, Gifty Sawhney, Mohd Akbar Dar and Zulfiqar Ali Bhat*


DOI: 10.2174/1389200220666191105121653


Tyrosine Kinase Inhibitors – A Review on Pharmacology, Metabolism and Side Effects

, 2009; 10(5): 470-481.

Jorg Thomas Hartmann, Michael Haap, Hans-Georg Kopp and Hans-Peter Lipp


DOI: 10.2174/138920009788897975



Use of Non-steroidal Anti-inflammatory Drugs in Pregnancy: Impact on the Fetus and Newborn

, 2012; 13(4): 474-490.

Roberto Antonucci, Marco Zaffanello, Elisabetta Puxeddu, Annalisa Porcella, Laura Cuzzolin, Maria Dolores Pilloni and Vassilios Fanos


DOI: 10.2174/138920012800166607




Editor-in-Chief

Ming Hu
University of Houston College of Pharmacy
Houston, TX
(USA)
Biography View Full Editorial Board

Journal History

Current Drug Metabolism was launched in 2000. Dr. Michael Sinz serves as the Editor-in-Chief of the journal.
Scopus CiteScore Metrics: 2.75

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