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CNS & Neurological Disorders - Drug Targets

Formerly: Current Drug Targets - CNS & Neurological Disorders

Volume 21, 10 Issues, 2022
ISSN: 1996-3181 (Online)
ISSN: 1871-5273 (Print)
This journal supports open access

Aims & Scope

CNS & Neurological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in neurological and central nervous system (CNS) disorders e.g. disease specific proteins, receptors, enzymes, genes.

CNS & Neurological Disorders - Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of CNS & neurological drug targets. The journal also accepts for publication original research articles, letters, reviews and drug clinical trial studies.

As the discovery, identification, characterization and validation of novel human drug targets for neurological and CNS drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.

CNS & Neurological Disorders - Drug Targets

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Volume 21

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Number 4





Review Article

Epigenetic Basis of Psychiatric Disorders: A Narrative Review

, 21(4): 302 - 315

Fabio Panariello, Giuseppe Fanelli, Chiara Fabbri, Anna Rita Atti, Diana De Ronchi and Alessandro Serretti*


DOI: 10.2174/1871527320666210825101915


Systematic Review Article

Hematological Consequences of Valproic Acid in Pediatric Patients: A Systematic Review with a Mechanistic Approach

, 21(4): 316 - 325

Bamdad Riahi-Zanjani, Mohammad Delirrad, Rana Fazeli-Bakhtiyari, Mahood Sadeghi, Hadi Zare-Zardini, Abbas Jafari* and Adel Ghorani-Azam*


DOI: 10.2174/1871527320666210811162345


Research Article

Real-World Data Regarding Long-Term Administration of Natalizumab Derived from a Neurology Department along with Literature Review

, 21(4): 326 - 334

Eugenia Irene Davidescu, Irina Odajiu, Constantin-Dragoș Sandu, Amalia Ghergu, Dimela Luca, Dafin Fior Mureșanu and Bogdan Ovidiu Popescu*


DOI: 10.2174/1871527320666210827113733





Articles Ahead of Print

Markers of Neuroinflammation in the Serum of Prepubertal Children with Fetal Alcohol Spectrum Disorders


Marco Fiore*, Carla Petrella, Giovanna Coriale, Pamela Rosso, Elena Fico, Massimo Ralli, Antonio Greco, Marco De Vincentiis, Antonio Minni, Antonella Polimeni, Mario Vitali, Marisa Patrizia Messina, Giampiero Ferraguti, Francesca Tarani, Simone de Persis, Mauro Ceccanti and Luigi Tarani


DOI: 10.2174/1871527320666211201154839
View Abstract View on PubMed







Lactose and Casein Cause Changes on Biomarkers of Oxidative Damage and Dysbiosis in an Experimental Model of Multiple Sclerosis


Begoña M. Escribano*, Ana Muñoz-Jurado*, Evelio Luque, Cristina Conde*, Montse Feijóo, Manuel LaTorre, Manuel E. Valdelvira, Paula Buendía, Ana I. Giraldo, Javier Caballero-Villarraso, Abel Santamaría, Eduardo Agüera and Isaac Túnez


DOI: 10.2174/1871527320666211207101113
View Abstract View on PubMed


Role of Vitamins in Neurodegenerative Diseases: A Review


Ravi Ranjan Kumar, Lovekesh Singh, Amandeep Thakur, Shamsher Singh and Bhupinder Kumar*


DOI: 10.2174/1871527320666211119122150
View Abstract View on PubMed



Comparing the Efficacy and Safety of Dexmedetomidine/Ketamine with Propofol/Fentanyl for Sedation in Colonoscopy Patients: A Doubleblinded Randomized Clinical Trial


Reza Aminnejad, Ahmad Hormati*, Hamed Shafiee, Faezeh Alemi, Maryam Hormati, Mohammad Saeidi, Sajjad Ahmadpour, Seyed Mahdi Sabouri and Mohammad Aghaali


DOI: 10.2174/1871527320666211006141406
View Abstract View on PubMed


Abstracts Ahead of Print


Structural Activity Relationship based Medicinal Perspectives of Pyrimidine Derivatives as Anti-Alzheimer’s Agents: A Comprehensive Review


Subham Das, Saleem Akbar, Bahar Ahmed, Rikeshwar Prasad Dewangan, Ashif Iqubal, Faheem Hyder Pottoo and Alex Joseph*


DOI: 10.2174/1871527321666220107154617
View Abstract


Neuroprotective Potential of Bacopa monnieri: Modulation of Inflammatory Signals


Erica Costantini, Srinivas Jarlapoodi, Federica Serra, Lisa Aielli, Haroon Khan, Tarun Belwal, Katia Falasca and Marcella Reale*


DOI: 10.2174/1871527321666220111124047
View Abstract


Impact of the COVID-19 Pandemic on Chronic Neurological Disorders: Focus on Patients with Dementia


Maria Antonietta Barbieri, Gianluca Bagnato, Carmelo Ioppolo, Antonio Giovanni Versace and Natasha Irrera*


DOI: 10.2174/1871527321666220111124928
View Abstract




An Updated Review of Epigenetic-Related Mechanisms and Their Contribution to Multiple Sclerosis Disease


Maedeh Eslahi, Negin Nematbakhsh, Narges Dastmalchi, Shahram Teimourian and Reza Safaralizadeh*


DOI: 10.2174/1871527321666220119104649
View Abstract




Transdermal Nutraceuticals Delivery System for CNS Disease


Mohammed Asadullah Jahangir, Pooja Jain, Rishabh Verma, Mohamad Taleuzzaman*, Mohamed Jawed Ahsan, Anand Kumar Chettupalli, Abdul Muheem and Mohd. Aamir Mirza


DOI: 10.2174/1871527321666220112154051
View Abstract


Published Contents

Editor's Choice


Cellular Senescence and ApoE4: Their Repercussions in Alzheimer’s Disease

, 2021; 20(9): 778 - 785

Angeles C. Tecalco-Cruz*, Jesús Zepeda-Cervantes, Lilia López-Canovas, Josué Oriando Ramírez-Jarquín, José Pedraza-Chaverrí and Alfredo Briones-Herrera


DOI: 10.2174/1871527320666210628102721




Cellular and Molecular Mechanisms of Dementia: Decoding the Causal link of Diabetes Mellitus in Alzheimer’s Disease

, 2021; 20(7): 602 - 612

Mahmood Rasool*, Arif Malik, Sulayman Waquar, Ahmad Zaheer, Muhammad Asif, Zafar Iqbal, Kalamegam Gauthaman*, Mohammad Amjad Kamal and Peter Natesan Pushparaj*


DOI: 10.2174/1871527320666210212114116




Neurological Manifestations of COVID-19 and the Importance of Magnetic Resonance Imaging

, 2021; 20(5): 390 - 391

Rubens J. Gagliardi*, Renan Domingues, Cristine Cukier, Maria F. Mendes, Vivian D.B. Gagliardi and Francisco T.M. de Oliveira


DOI: 10.2174/1871527320666210122093458




The Role of Statins in the Management of Delirium: Recent Advances

, 2021; 20(3): 203 - 215

Junhui Chen, Yuhai Wang, Ximin Hu, Mingchang Li, Kun Xiong, Zhaocai Zhang* and Qianxue Chen*


DOI: 10.2174/1871527319666200720111318




Nanoparticles Based Intranasal Delivery of Drug to Treat Alzheimer’s Disease: A Recent Update

, 2020; 19(9): 648 - 662

Manisha Pandey*, Hira Choudhury*, Rohit Kumar Verma, Viney Chawla, Subrat Kumar Bhattamisra, Bapi Gorain, Maria Abdul Ghafoor Raja and Muhammad Wahab Amjad


DOI: 10.2174/1871527319999200819095620



Open Access Articles

Effectiveness and Safety Profile of <i>Ginkgo biloba</i> Standardized Extract (EGb761®) in Patients with Amnestic Mild Cognitive Impairment

, 2021; 20(4): 378 - 384

Ovidiu Băjenaru, Gabriel Prada, Florina Antochi, Cătălin Jianu, Cătălina Tudose, Adina Cuciureanu, Any A. Docu, Valérie Perrot, Madalina Avram and Cristina Tiu*




Molecular and Biochemical Pathways Encompassing Diabetes Mellitus and Dementia

, 2021; 20: 1 - 15 (E-Pub Ahead of Print)

Tapan Behl*, Arpita Arora, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Saurabh Bhatia, Ahmed Al-Harrasi, Simona Bungau and Ebrahim Mostafavi*




Management of Impulse Control Disorders with Subthalamic Nucleus Deep Brain Stimulation in Parkinson’s Disease

, 2020; 19(8): 611 - 617

Deborah Amstutz, Steffen Paschen, Martin Lenard Lachenmayer, Marie Elise Maradan-Gachet, Günther Deuschl, Paul Krack and Ines Debove*




When Sick Brain and Hopelessness Meet: Some Aspects of Suicidality in the Neurological Patient

, 2020; 19(4): 257 - 263

Alessandra Costanza*, Andrea Amerio, Andrea Aguglia, Andrea Escelsior, Gianluca Serafini, Isabella Berardelli, Maurizio Pompili and Mario Amore





Fire Needle Acupuncture Regulates Wnt/ERK Multiple Pathways to Promote Neural Stem Cells to Differentiate into Neurons in Rats with Spinal Cord Injury

, 2019; 18(3): 245 - 255

Jiachun Xu, Suli Cheng, Zhaohua Jiao, Zhiheng Zhao, Zhimin Cai, Nan Su, Baohong Liu, Zhen Zhou* and Yan Li*




Oleanolic Acid Ameliorates A&#946;25-35 Injection-induced Memory Deficit in Alzheimer’s Disease Model Rats by Maintaining Synaptic Plasticity

, 2018; 17(5): 389 - 399

Kai Wang, Weiming Sun, Linlin Zhang, Wei Guo, Jiachun Xu, Shuang Liu, Zhen Zhou and Yulian Zhang*




Physiological and Morphological Principles Underpinning Recruitment of the Cerebellar Reserve

, 2018; 17(3): 184 - 192

Shinji Kakei*, Takahiro Ishikawa, Jongho Lee, Takeru Honda and Donna S. Hoffman




Demonstration of Biological and Immunological Equivalence of a Generic Glatiramer Acetate

, 2017; 16(6): 714 - 723

Josephine D`Alessandro, Kevin Garofalo, Ganlin Zhao, Christopher Honan, Jay Duffner, Ishan Capila, Ian Fier, Ganesh Kaundinya, Daniel Kantor and Tanmoy Ganguly*




Nanomaterials for Neurology: State-of-the-Art

, 2016; 15(10): 1306 - 1324

María Fernanda Veloz-Castillo, Rachel M. West, Jessica Cordero-Arreola, Oscar Arias-Carrión and Miguel A. Méndez-Rojas




The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders

, 2016; 15(5): 564 - 577

Yuko Okamoto, Makoto Ishitobi, Yuji Wada and Hirotaka Kosaka





The Effects of Testosterone Supplementation on Cognitive Functioning in Older Men.

, 2016; 15(3): 337 - 343

Eka J. Wahjoepramono, Prita R. Asih, Vilia Aniwiyanti, Kevin Taddei, Satvinder S. Dhaliwal, Stephanie J. Fuller, Jonathan Foster, Malcolm Carruthers, Giuseppe Verdile, Hamid R Sohrabi and Ralph N. Martins





Most Cited Articles

Review Article

Nf-κb as a key mediator of brain inflammation in Alzheimer’s disease

, 2019; 18(1): 3-10.

Chul Ju Hwang, Dong-Young Choi, Mi Hee Park and Jin Tae Hong*


DOI: 10.2174/1871527316666170807130011


Research Article

Ethyl acetohydroxamate incorporated chalcones: Unveiling a novel class of chalcones for multitarget monoamine oxidase-b inhibitors against alzheimer’s disease

, 2019; 18(8): 643-654.

Reeta, Seung Cheol Baek, Jae Pil Lee, T.M. Rangarajan*, Ayushee, Rishi Pal Singh, Manjula Singh, Giuseppe Felice Mangiatordi, Orazio Nicolotti, Hoon Kim* and Bijo Mathew*


DOI: 10.2174/1871527318666190906101326



Review Article

Epigenetics in neurodegenerative diseases: The role of histone deacetylases

, 2019; 18(1): 11-18.

Sorabh Sharma, K.C. Sarathlal and Rajeev Taliyan*


DOI: 10.2174/1871527317666181004155136


Letter Article

When sick brain and hopelessness meet: Some aspects of suicidality in the neurological patient

, 2020; 19(4): 257-263.

Alessandra Costanza*, Andrea Amerio, Andrea Aguglia, Andrea Escelsior, Gianluca Serafini, Isabella Berardelli, Maurizio Pompili and Mario Amore


DOI: 10.2174/1871527319666200611130804


Review Article

Perspective design of chalcones for the management of cns disorders: A mini-review

, 2019; 18(6): 432-445.

Bijo Mathew*, Della Grace Thomas Parambi, Vishnu Sankar Sivasankarapillai, Md. Sahab Uddin, Jerad Suresh, Githa Elizabeth Mathew, Monu Joy, Akash Marathakam and Sheeba Varghese Gupta


DOI: 10.2174/1871527318666190610111246



Research Article

The role of annexin A1 and formyl peptide receptor 2/3 signaling in chronic corticosterone-induced depression-like behaviors and impairment in hippocampal-dependent memory

, 2020; 19(1): 27-43.

Alessio Filippo Peritore, Rosalia Crupi, Maria Scuto, Enrico Gugliandolo, Rosalba Siracusa, Daniela Impellizzeri, Marika Cordaro, Ramona D’amico, Roberta Fusco, Rosanna Di Paola and Salvatore Cuzzocrea*


DOI: 10.2174/1871527319666200107094732


Research Article

Xuesaitong may protect against ischemic stroke by modulating microglial phenotypes and inhibiting neuronal cell apoptosis via the STAT3 signaling pathway

, 2019; 18(2): 115-123.

Fangfang Li , Haiping Zhao, Ziping Han, Rongliang Wang, Zhen Tao, Zhibin Fan, Sijia Zhang, Guangwen Li, Zhigang Chen* and Yumin Luo*


DOI: 10.2174/1871527317666181114140340


Review Article

Neuro-psychiatric alterations in patients with diabetic foot syndrome

, 2019; 18(8): 598-608.

Emmanuel Navarro-Flores, Pilar Pérez-Ros, Francisco Miguel Martínez-Arnau, Iván Julían-Rochina and Omar Cauli*


DOI: 10.2174/1871527318666191002094406


Research Article

Cordycepin exerts neuroprotective effects via an anti-apoptotic mechanism based on the mitochondrial pathway in a rotenone-induced parkinsonism rat model

, 2019; 18(8): 609-620.

Xin Jiang, Pei-Chen Tang, Qin Chen, Xin Zhang, Yi-Yun Fan, Bo-Cheng Yu, Xin-Xia Gu, Ying Sun, Xiao-Qun Ge* and Xiao-Ling Zhang*


DOI: 10.2174/1871527318666190905152138


General Research Article

Neuroprotection of rotenone-induced parkinsonism by ursolic acid in pd mouse model

, 2020; 19(7): 527-540.

Walia Zahra, Sachchida Nand Rai, Hareram Birla, Saumitra Sen Singh, Aaina Singh Rathore, Hagera Dilnashin, Richa Singh, Chetan Keswani, Rakesh K. Singh and Surya Pratap Singh*


DOI: 10.2174/1871527319666200812224457



Clinical Trial

Ultramicronized palmitoylethanolamide (Um-PEA) as add-on treatment in fibromyalgia syndrome (FMS): Retrospective observational study on 407 patients

, 2019; 18(4): 326-333.

Vittorio Schweiger*, Alvise Martini, Paola Bellamoli, Katia Donadello, Carlo Schievano, Giovanna D. Balzo, Piercarlo Sarzi-Puttini, Massimo Parolini and Enrico Polati


DOI: 10.2174/1871527318666190227205359




Most Accessed Articles



Herbal Drug Interaction: Mechanistic Details through Pharmacokinetic Portfolio

, 2021; 20(8): 677-686.

Salman Ahmed, Haroon Khan*, Hamed Mirzaei, Muhammad Mohtasheemul Hasan, Mohamed Eddouks and Maria Daglia*


DOI: 10.2174/1871527319666201008151710




Autophagic Dysfunction in Dementia: Scope for Development of Potential Remedies

, 2021; 20(8): 704-722.

Bhumika Kumar, Mukesh Pandey, Ashwini Kumar Mishra, Anjali Sharma, Faizana Fayaz and Faheem Hyder Pottoo*


DOI: 10.2174/1871527319666201209112256



Neuroregenerative Activity of the Dipeptide Mimetic of Brain-derived Neurotrophic Factor GSB-106 Under Experimental Ischemic Stroke

, 2021; 20(10): 954-962.

Tatiana A. Gudasheva*, Polina Y. Povarnina, Tatiana A. Antipova, Sergey V. Kruglov, Ilya O. Logvinov, Dmitry M. Nikiforov and Sergey B. Seredenin


DOI: 10.2174/1871527320666210525090904


Beta-Caryophyllene, a CB2R Selective Agonist, Protects Against Cognitive Impairment Caused by Neuro-inflammation and Not in Dementia Due to Ageing Induced by Mitochondrial Dysfunction

, 2021; 20(10): 963-974.

Urja Kanojia, Shrikant Gyaneshwar Chaturbhuj, Runali Sankhe, Maushami Das, Raviteja Surubhotla, Nandakumar Krishnadas, Karthik Gourishetti, Pawan Ganesh Nayak and Anoop Kishore*


DOI: 10.2174/1871527320666210202121103



Carvacrol as a Potential Neuroprotective Agent for Neurological Diseases: A Systematic Review Article

, 2021; 20(10): 942-953.

Mohammad Yassin Zamanian, Małgorzata Kujawska, Marjan Nikbakhtzadeh, Amin Hassanshahi, Soudeh Ramezanpour , Zahra Kamiab and Gholamreza Bazmandegan*


DOI: 10.2174/1871527320666210506185042



Immunotherapies for Parkinson’s Disease: Progression of Clinical Development

, 2021; 20(9): 802-813.

Jet Shee Teng, Yin Yin Ooi, Soi Moi Chye, Anna Pick Kiong Ling and Rhun Yian Koh*


DOI: 10.2174/1871527320666210526160926






Editor-in-Chief

graphic
Edoardo Spina
Department of Clinical and Experimental Medicine
University of Messina
Policlinico Universitario
Via Consolare Valeria
Messina
(Italy)
Biography
View Full Editorial Board

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Journal History

Current Drug Targets - CNS & Neurological Disorders was launched in 2002 and later renamed in 2006 as CNS & Neurological Disorders - Drug Targets.

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