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Current Gene Therapy

Volume 22, 5 Issues, 2022
ISSN: 1566-5232 (Print)
ISSN: 1875-5631 (Online)
This journal supports open access

Aims & Scope

Current Gene Therapy is a bi-monthly peer-reviewed journal aimed at academic and industrial scientists with an interest in major topics concerning basic research and clinical applications of gene and cell therapy of diseases. Cell therapy manuscripts can also include application in diseases when cells have been genetically modified. Current Gene Therapy publishes full-length/mini reviews and original research on the latest developments in gene transfer and gene expression analysis, vector development, cellular genetic engineering, animal models and human clinical applications of gene and cell therapy for the treatment of diseases.

Current Gene Therapy publishes reviews and original research containing experimental data on gene and cell therapy. The journal also includes manuscripts on technological advances, ethical and regulatory considerations of gene and cell therapy. Reviews should provide the reader with a comprehensive assessment of any area of experimental biology applied to molecular medicine that is not only of significance within a particular field of gene therapy and cell therapy but also of interest to investigators in other fields. Authors are encouraged to provide their own assessment and vision for future advances. Reviews are also welcome on late breaking discoveries on which substantial literature has not yet been amassed. Such reviews provide a forum for sharply focused topics of recent experimental investigations in gene therapy primarily to make these results accessible to both clinical and basic researchers. Manuscripts containing experimental data should be original data, not previously published.

Current Gene Therapy


Volume 22


Number 4

Review Article

New Hope for Intervertebral Disc Degeneration: Bone Marrow Mesenchymal Stem Cells and Exosomes Derived from Bone Marrow Mesenchymal Stem Cell Transplantation

, 22(4): 291 - 302

Xiao-bo Zhang*, Xiang-yi Chen, Jin Qi, Hai-yu Zhou, Xiao-bing Zhao, Yi-cun Hu, Rui-hao Zhang, De-chen Yu, Xi-dan Gao, Ke-ping Wang and Lin Ma

DOI: 10.2174/1566523221666211012092855

Review Article

Research Article

Exosomal MiR-29a in Cardiomyocytes Induced by Angiotensin II Regulates Cardiac Microvascular Endothelial Cell Proliferation, Migration and Angiogenesis by Targeting VEGFA

, 22(4): 331 - 341

Guangzhao Li, Zhimei Qiu, Chaofu Li, Ranzun Zhao, Yu Zhang, Changyin Shen, Weiwei Liu, Xianping Long, Shaowei Zhuang, Yan Wang* and Bei Shi*

DOI: 10.2174/1566523222666220303102951

Research Article

AAV9-coGLB1 Improves Lysosomal Storage and Rescues Central Nervous System Inflammation in a Mutant Mouse Model of GM1 Gangliosidosis

, 22(4): 352 - 365

Sichi Liu, Wenhao Ma, Yuyu Feng, Yan Zhang, Xuefang Jia, Chengfang Tang, Fang Tang, Xiaobing Wu* and Yonglan Huang*

DOI: 10.2174/1566523222666220304092732

Articles Ahead of Print

Therapeutic Effects of Mesenchymal Stem Cells Expressing Erythropoietin on Cancer-Related Anemia in Mice Model

Mohammad Estiri, Bahareh Estiri, Asghar Fallah, Marziyeh Aghazadeh, Amir Sedaqati, Abbas Abdollahi, Mahsa Rabienia, Nahid Mortazavidehkordi and Akbar Farjadfar*

DOI: 10.2174/1566523222666220405134136
View Abstract View on PubMed

Abstracts Ahead of Print

Published Contents

Editor's Choice

Recent Advances in CRISPR/Cas9 Directed Base Editing

, 2021; 21(4): 327 - 337

Nan Liu, Lifang Zhou, Junyan Qu and Shaohua Yao*

DOI: 10.2174/1566523221666210322090638

Potential Non-coding RNAs from Microorganisms and their Therapeutic Use in the Treatment of Different Human Cancers

, 2021; 21(3): 207 - 215

Raju Biswas, Dipanjana Ghosh, Bhramar Dutta, Urmi Halder, Prittam Goswami and Rajib Bandopadhyay*

DOI: 10.2174/1566523220999201230204814

Challenges of Gene Therapy for Neurodegenerative Disorders

, 2021; 21(1): 3 - 10

Md. Sahab Uddin*, Zeeshan Ahmad Khan, Dewan Md. Sumsuzzman, Asma Perveen and Ghulam Md. Ashraf*

DOI: 10.2174/1566523220999201105150442

Gene Therapy for Hemophilia A: Where We Stand

, 2020; 20(2): 142 - 151

Miaojin Zhou, Zhiqing Hu, Chunhua Zhang, Lingqian Wu, Zhuo Li* and Desheng Liang*

DOI: 10.2174/1566523220666200806110849

Open Access Articles

Gene Therapy in the Anterior Eye Segment

, 2022; 22(2): 104 - 131

Cynthia Amador, Ruchi Shah, Sean Ghiam, Andrei A. Kramerov and Alexander V. Ljubimov*

Feasibility of Mesenchymal Stem Cell Therapy for COVID-19: A Mini Review

, 2020; 20(4): 285 - 288

Jingwen Li, Xinyi Wang, Na Li , Ying Jiang, Heqing Huang*, Tao Wang, Zhicheng Lin and Nian Xiong*

A Recurrent Rare SOX9 Variant (M469V) is Associated with Congenital Vertebral Malformations

, 2019; 19(4): 242 - 247

Nan Wu, Lianlei Wang, Jianhua Hu*, Sen Zhao, Bowen Liu, Yaqi Li, Huakang Du, Yuanqiang Zhang, Xiaoxin Li, Zihui Yan, Shengru Wang, Yipeng Wang, Jianguo Zhang, Zhihong Wu, DISCO (Deciphering Disorders Involving Scoliosis & Comorbidities) study group and Guixing Qiu

Three Cases of Leber’s Hereditary Optic Neuropathy with Rapid Increase in Visual Acuity After Gene Therapy

, 2019; 19(2): 134 - 138

Yong Zhang, Jia-jia Yuan, Hong-li Liu, Zhen Tian, Si-wei Liu and Bin Li*

Clinical Observation of Patients with Leber’s Hereditary Optic Neuropathy Before Gene Therapy

, 2018; 18(6): 386 - 392

Jiajia Yuan, Yong Zhang, Hongli Liu, Zhen Tian, Xin Li, Yichen Zheng, Qin Gao, Lin Song, Xiao Xiao, Jian Sun, Zhitao Wang and Bin Li*

Clinical-Grade Oncolytic Adenovirus Purification Using Polysorbate 20 as an Alternative for Cell Lysis

, 2018; 18(6): 366 - 374

Mafalda G. Moleirinho, Sara Rosa, Manuel J.T. Carrondo*, Ricardo J.S. Silva, Åsa Hagner-McWhirter, Gustaf Ahlén, Mats Lundgren, Paula M. Alves and Cristina Peixoto

Emerging Therapeutic Approaches for Diamond Blackfan Anemia

, 2018; 18(6): 327 - 335

Anna Aspesi*, Chiara Borsotti and Antonia Follenzi*

EZH2 RIP-seq Identifies Tissue-specific Long Non-coding RNAs

, 2018; 18(5): 275 - 285

Yan Wang, Yinping Xie, Lili Li, Yuan He, Di Zheng, Pengcheng Yu, Ling Yu, Lixu Tang, Yibin Wang* and Zhihua Wang*

Genetics and Therapies for GM2 Gangliosidosis

, 2018; 18(2): 68 - 89

Maria Begona Cachon-Gonzalez*, Eva Zaccariotto and Timothy Martin Cox

Molecular Adjuvants Based on Plasmids Encoding Protein Aggregation Domains Affect Bone Marrow Niche Homeostasis

, 2017; 17(5): 391 - 397

Maria Giovanna Sabbieti, Giovanna Lacava, Andrea Amaroli, Luigi Marchetti, Roberta Censi, Piera Di Martino and Dimitrios Agas*

The Progress of Gene Therapy for Leber's Optic Hereditary Neuropathy

, 2017; 17(4): 320 - 326

Yong Zhang, Zhen Tian, Jiajia Yuan, Chang Liu, Hong li Liu, Si Qi Ma and Bin Li*

Most Cited Articles

General Review Article

The therapeutic potential and role of miRNA, IncRNA, and circRNA in osteoarthritis

, 2019; 19(4): 255-263.

Yuangang Wu, Xiaoxi Lu, Bin Shen and Yi Zeng*

DOI: 10.2174/1566523219666190716092203

Review Article

The emerging role of stem cells in regenerative dentistry

, 2020; 20(4): 259-268.

Paolo Capparè*, Giulia Tetè, Maria Teresa Sberna and Paola Panina-Bordignon*

DOI: 10.2174/1566523220999200818115803

Review Article

Current rna-based therapeutics in clinical trials

, 2019; 19(3): 172-196.

Ling-Yan Zhou, Zhou Qin, Yang-Hui Zhu, Zhi-Yao He* and Ting Xu*

DOI: 10.2174/1566523219666190719100526

Review Article

The relationship between ferroptosis and tumors: A novel landscape for therapeutic approach

, 2019; 19(2): 117-124.

Xiaojun Xia, Xiaoping Fan*, Mingyi Zhao* and Ping Zhu*

DOI: 10.2174/1566523219666190628152137

Research Article

Functional improvement of chimeric antigen receptor through intrinsic interleukin-15Rα signaling

, 2019; 19(1): 40-53.

Sushmita Nair, Jing-Bo Wang, Shih-Ting Tsao, Yuchen Liu, Wei Zhu, William B. Slayton, Jan S. Moreb, Lujia Dong and Lung-Ji Chang*

DOI: 10.2174/1566523218666181116093857

General Review Article

Circular RNAs serve as novel biomarkers and therapeutic targets in cancers

, 2019; 19(2): 125-133.

Shuai Fang, Jinchang Pan, Chengwei Zhou, Hui Tian, Jinxian He, Weiyu Shen, Xiaofeng Jin, Xiaodan Meng, Nan Jiang and Zhaohui Gong*

DOI: 10.2174/1566523218666181109142756

Research Article

Mirna-146a improves immunomodulatory effects of msc-derived exosomes in rheumatoid arthritis

, 2020; 20(4): 297-312.

Fataneh Tavasolian, Ahmad Zavaran Hosseini*, Sara Soudi and Mahmood Naderi

DOI: 10.2174/1566523220666200916120708

Research Article

Effect of tumor suppressor miR-34a loaded on ZSM-5 nanozeolite in hepatocellular carcinoma: In vitro and in vivo approach

, 2019; 19(5): 342-354.

Zeinab Salah*, Eman M. Abd El Azeem, Hanan F. Youssef , Amira M. Gamal-Eldeen*, Abdel R. Farrag, Emad El-Meliegy, Bangly Soliman and Mahmoud Elhefnawi*

DOI: 10.2174/1566523219666191108103739

Research Article

A mendelian randomization study on infant length and type 2 diabetes mellitus risk

, 2019; 19(4): 224-231.

He Zhuang, Ying Zhang, Shuo Yang, Liang Cheng* and Shu-Lin Liu*

DOI: 10.2174/1566523219666190925115535

Review Article

Exosomes: Structure, biogenesis, types and application in diagnosis and gene and drug delivery

, 2020; 20(3): 195-206.

Shriya Agarwal, Vinayak Agarwal, Mugdha Agarwal and Manisha Singh*

DOI: 10.2174/1566523220999200731011702

Most Accessed Articles

Molecular Genetics of Early- and Late-Onset Alzheimer's Disease

, 2021; 21(1): 43-52.

Uddin, Md Sahab; Hasana, Sharifa; Hossain, Md Farhad; Islam, Md Siddiqul; Behl, Tapan; Perveen, Asma; Hafeez, Abdul; Ashraf, Ghulam Md

DOI: 10.2174/1566523220666201123112822

Standardizing the Effective Correlated Dosage of Olanzapine and Empagliflozin in Female Wistar Rats

, 2021; 21(1): 53-59.

Ashraf, Ghulam Md; Alghamdi, Badrah S.; Alshehri, Fahad S.; Alam, Mohammad Z.; Tayeb, Haythum O.; Tarazi, Frank, I

DOI: 10.2174/1566523220999201111195047

The Dramatic Role of IFN Family in Aberrant Inflammatory Osteolysis

, 2021; 21(2): 112-129.

Deng, Zihan; Hu, Wenhui; Ai, Hongbo; Chen, Yueqi; Dong, Shiwu

DOI: 10.2174/1566523220666201127114845

Exploring the Role of Gene Therapy for Neurological Disorders

, 2021; 21(1): 11-22.

Puranik, Nidhi; Yadav, Dhananjay; Chauhan, Pallavi Singh; Kwak, Minseok; Jin, Jun-O

DOI: 10.2174/1566523220999200917114101

CRISPR/Cas9 Technology as a Modern Genetic Manipulation Tool for Recapitulating of Neurodegenerative Disorders in Large Animal Models

, 2021; 21(2): 130-148.

Barazesh, Mahdi; Mohammadi, Shiva; Bahrami, Yadollah; Mokarram, Pooneh; Morowvat, Mohammad Hossein; Saidijam, Massoud; Karimipoor, Morteza; Kavousipour, Soudabe; Vosoughi, Amir Reza; Khanaki, Korosh

DOI: 10.2174/1566523220666201214115024


, 2021; 21(1): 1-1.

Cheng, Liang; Lewin, Alfred

DOI: 10.2174/156652322101210112155555

A Five-gene Signature for Predicting the Prognosis of Colorectal Cancer

, 2021; 21(4): 280-289.

Hong, Junfeng; Lin, Xiangwu; Hu, Xinyu; Wu, Xiaolong; Fang, Wenzheng

DOI: 10.2174/1566523220666201012151803

Gene Therapy Strategies for Glaucomatous Neurodegeneration

, 2021; 21(5): 362-381.

Lani-Louzada, Rafael; Dias, Mariana Santana; Linden, Rafael; Ribas, Vinicius Toledo; Petrs-Silva, Hilda

DOI: 10.2174/1566523221666210126152000


Liang Cheng
College of Bioinformatics, Science and Technology
Harbin Medical University
Harbin, Heilongjiang
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