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Current Drug Targets

Volume 23, 17 Issues, 2022
ISSN: 1873-5592 (Online)
ISSN: 1389-4501 (Print)
This journal supports open access

Aims & Scope

Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes.

Current Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of drug targets. The journal also accepts for publication full-length/mini review articles and drug clinical trial studies.

As the discovery, identification, characterization and validation of novel human drug targets for drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.

Current Drug Targets

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Volume 23

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Number 1





Review Article

Role of ATP-binding Cassette Transporters in Sorafenib Therapy for Hepatocellular Carcinoma: An Overview

, 23(1): 21 - 32

Maria Manuela Estevinho*, Carlos Fernandes, João Carlos Silva, Ana Catarina Gomes, Edgar Afecto, João Correia and João Carvalho


DOI: 10.2174/1389450122666210412125018


Review Article

Triazole-containing Heterocycles: Privileged Scaffolds in Anti-<i>Trypanosoma Cruzi</i> Drug Development

, 23(1): 33 - 59

Kamdem Boniface Pone*, Sadou Dalhatou , Hugues Kamdem Paumo, Lebogang Maureen Katata-Seru and Elizabeth Igne Ferreira


DOI: 10.2174/1389450122666210412125643


Review Article



Review Article

Endemic and Indigenous Plants from Mascarene Islands with Antiviral Propensities

, 23(1): 72 - 86

Mahomoodally Mohamad Fawzi*, Jugreet Bibi Sharmeen, Haddad Juliano and El Kalamouni Chaker


DOI: 10.2174/1389450122666210824143910


Review Article




Articles Ahead of Print

HPV-mediated Cervical Cancer: A Systematic Review on Immunological Basis, Molecular Biology, and Immune Evasion Mechanisms


Ramar Vanajothi, Natarajan Srikanth, Rajendran Vijayakumar, Manikandan Palanisamy, Sundaresan Bhavaniramya and Kumpati Premkumar*


DOI: 10.2174/1389450123666211221160632
View Abstract View on PubMed





Promising Protective Effects of Chrysin in Cardiometabolic Diseases


Marjan Talebi, Mohsen Talebi, Tahereh Farkhondeh, Jesus Simal-Gandara, Dalia M. Kopustinskiene, Jurga Bernatoniene, Ali Mohammad Pourbagher-Shahri and Saeed Samarghandian*


DOI: 10.2174/1389450122666211005113234
View Abstract View on PubMed



Oral Semaglutide in the Management of Type 2 DM: Clinical Status and Comparative Analysis


Ilora Bandyopadhyay, Sunny Dave, Amita Rai, Madhavan Nampoothiri, Mallikarjuna Rao Chamallamudi and Nitesh Kumar*


DOI: 10.2174/1389450122666210901125420
View Abstract View on PubMed



A Mechanistic Review on Plant-derived Natural Inhibitors of Human Coronaviruses with Emphasis on SARS-COV-1 and SARS-COV-2


Sai Krishna Guguloth, A.R. Lakshmi, Radhika Rajendran, Kaushik Rajaram, Thirunavukkarasu Chinnasamy, Jian-Dong Huang, Hongjie Zhang, Sanjib Senapati and Siva Sundara Kumar Durairajan*


DOI: 10.2174/1389450122666211005115313
View Abstract View on PubMed



Abstracts Ahead of Print




A Review on CRISPR-Mediated Epigenome Editing: A Future Directive for Therapeutic Management of Cancer


Rudra Chakravarti, Swadhin Kumar Lenka, Anupam Gautam, Rajveer Singh, Velayutham Ravichandiran, Syamal Roy and Dipanjan Ghosh*


DOI: 10.2174/1389450123666220117105531
View Abstract



New Trends On Biological Activities And Clinical Studies Of Quinolinic Analogues: A Review


Sandra Elizabeth Barbosa da Silva, José Arion da Silva Moura , Tiago Rafael de Sousa Nunes , Ivan da Rocha Pitta and Marina Galdino da Rocha Pitta*


DOI: 10.2174/1389450122666210415100151
View Abstract


Published Contents

Editor's Choice

Small-molecule Antiviral Agents in Ongoing Clinical Trials for COVID-19

, 2021; 22(17): 1986 - 2005

Çağla Begüm Apaydın, Gözde Çınar and Gökçe Cihan-Üstündağ*


DOI: 10.2174/1389450122666210215112150




GSK-3 Inhibitors: A New Class of Drugs for Alzheimer’s Disease Treatment

, 2021; 22(15): 1725 - 1737

Dilipkumar Pal, Souvik Mukherjee, In-Ho Song and Satish B. Nimse*


DOI: 10.2174/1389450122666210114095307



Role of Mitochondrial Heat-shock Proteins and Immunophilins in Neuro Degenerative Diseases

, 2021; 22(14): 1596 - 1617

Cristina Daneri-Becerra, Sol M. Ciucci, Gisela Mazaira and Mario D. Galigniana*


DOI: 10.2174/1389450121999201230204320





New Framework for the Discovery of PRC2 Inhibitors: Epigenetic Drugs

, 2021; 22(11): 1198 - 1206

Danishuddin, Naidu Subbarao*, Mohd Khan, Sultan Alouffi and Shahper Khan*


DOI: 10.2174/1389450122666210215111744




The Emergence of Immune-checkpoint Inhibitors in Colorectal Cancer Therapy

, 2021; 22(9): 1021 - 1033

Michele Ghidini*, Nicola Fusco, Massimiliano Salati, Shelize Khakoo, Gianluca Tomasello, Fausto Petrelli, Dario Trapani and Angelica Petrillo


DOI: 10.2174/1389450122666210204204415




Open Access Articles

Characteristic of Cyclodextrins: Their Role and Use in the Pharmaceutical Technology

, 2020; 21(14): 1495 - 1510

Malwina Lachowicz*, Andrzej Stańczak and Michał Kołodziejczyk




Opportunities of Bacterial Cellulose to Treat Epithelial Tissues

, 2019; 20(8): 808 - 822

Irene Anton-Sales, Uwe Beekmann, Anna Laromaine*, Anna Roig* and Dana Kralisch




Blood Eosinophils as Biomarkers to Drive Treatment Choices in Asthma and COPD

, 2018; 19(16): 1882 - 1896

Konstantinos Kostikas, Caterina Brindicci and Francesco Patalano*




Current Status and Perspectives on Pharmacologic Therapy for Abdominal Aortic Aneurysm

, 2018; 19(11): 1265 - 1275

Koichi Yoshimura*, Noriyasu Morikage, Shizuka Nishino-Fujimoto, Akira Furutani, Bungo Shirasawa and Kimikazu Hamano





TXNIP in Metabolic Regulation: Physiological Role and Therapeutic Outlook

, 2017; 18(9): 1095 - 1103

Naif Mohammad Alhawiti, Saeed Al Mahri, Mohammad Azhar Aziz, Shuja Shafi Malik and Sameer Mohammad*






Structural and Functional Aspects of Class A Carbapenemases

, 2016; 17(9): 1006 - 1028

Thierry Naas, Laurent Dortet and Bogdan I. Iorga




Targeted Thromboelastographic (TEG) Blood Component and Pharmacologic Hemostatic Therapy in Traumatic and Acquired Coagulopathy

, 2016; 17(8): 954 - 970

Mary K Bader, Francis J. Castellino, Victoria Ploplis, Faisal Shariff, Anton Crepinsek, Scott Thomas, Alyson Liew-Spilger, Sophia Binz, Jonathon McCollester, Mark Walsh, Adam Miller, Braxton Fritz, Swetha Chitta, Manar Jbara, Sarah Greve, Michael Son, Daniel Hake and Stephanie Fritz




Insights into a Critical Role of the FOXO3a-FOXM1 Axis in DNA Damage Response and Genotoxic Drug Resistance

, 2016; 17(2): 164 - 177

Gabriela Nestal de Moraes, Laura Bella, Stefania Zona, Matthew J. Burton and Eric W.-F. Lam





Most Cited Articles



Review Article

Celecoxib in cancer therapy and prevention - review

, 2019; 20(3): 302-315.

Natalia Tołoczko-Iwaniuk , Dorota Dziemiańczyk-Pakieła, Beata Klaudia Nowaszewska, Katarzyna Celińska-Janowicz and Wojciech Miltyk*


DOI: 10.2174/1389450119666180803121737


Review Article

Cyclin-dependent kinase 2 in cellular senescence and cancer. A structural and functional review

, 2019; 20(7): 716-726.

Priscylla Andrade Volkart, Gabriela Bitencourt-Ferreira, André Arigony Souto* and Walter Filgueira de Azevedo *


DOI: 10.2174/1389450120666181204165344




Review Article

High mobility group box-1 (HMGB1): A potential target in therapeutics

, 2019; 20(14): 1474-1485.

Eyaldeva C. Vijayakumar, Lokesh Kumar Bhatt* and Kedar S. Prabhavalkar


DOI: 10.2174/1389450120666190618125100


Review Article

A survey for predicting enzyme family classes using machine learning methods

, 2019; 20(5): 540-550.

Jiu-Xin Tan, Hao Lv, Fang Wang, Fu-Ying Dao, Wei Chen* and Hui Ding*


DOI: 10.2174/1389450119666181002143355



Review Article

Opportunities of bacterial cellulose to treat epithelial tissues

, 2019; 20(8): 808-822.

Irene Anton-Sales, Uwe Beekmann, Anna Laromaine*, Anna Roig* and Dana Kralisch


DOI: 10.2174/1389450120666181129092144


Review Article

Bioinformatics approaches for anti-cancer drug discovery

, 2020; 21(1): 3-17.

Kening Li, Yuxin Du, Lu Li and Dong-Qing Wei*


DOI: 10.2174/1389450120666190923162203


Review Article

CDK9 as an appealing target for therapeutic interventions

, 2019; 20(4): 453-464.

Shirin Eyvazi, Mohammad Saeid Hejazi, Homan Kahroba, Mozghan Abasi, Reza Eghdam Zamiri and Vahideh Tarhriz*


DOI: 10.2174/1389450119666181026152221


Review Article

Exosomes in therapy: Engineering, pharmacokinetics and future applications

, 2019; 20(1): 87-95.

Claudia Arenaccio, Chiara Chiozzini, Flavia Ferrantelli, Patrizia Leone, Eleonora Olivetta and Maurizio Federico*


DOI: 10.2174/1389450119666180521100409



Review Article

Inhibition of RAGE axis signaling: A pharmacological challenge

, 2019; 20(3): 340-346.

Armando Rojas*, Miguel Morales, Ileana Gonzalez and Paulina Araya


DOI: 10.2174/1389450119666180820105956



Most Accessed Articles

Small-molecule Antiviral Agents in Ongoing Clinical Trials for COVID-19

, 2021; 22(17): 1986-2005.

Çağla Begüm Apaydın, Gözde Çınar and Gökçe Cihan-Üstündağ*


DOI: 10.2174/1389450122666210215112150



A Review on Anti-urease Potential of Coumarins

, 2021; 22(17): 1926-1943.

Humna Asghar*, Hafsa Asghar and Tanzeela Asghar


DOI: 10.2174/1389450122666210222091412


Revealing Insights into Natural Products Against mcr-1-Producing Bacteria

, 2021; 22(17): 1964-1985.

Ana Beatriz Souza Flor dos Santos, Manuele Figueiredo da Silva, João Xavier de Araújo-Júnior and Edeildo Ferreira da Silva-Júnior *


DOI: 10.2174/1389450122666210415102413





3D Printing Technology in Pharmaceutical Dosage Forms: Advantages and Challenges

, 2021; 22(16): 1901-1914.

Prasanna Kumar Desu, Balaji Maddiboyina, Kondi Vanitha, Shiva Naga Koteswara Rao Gudhanti, Rapuri Anusha and Vikas Jhawat*


DOI: 10.2174/1389450122666210120142416




Dysregulation of Lysyl Oxidases Expression in Diabetic Nephropathy and Renal Cell Carcinoma

, 2021; 22(17): 1916-1925.

Carolina Añazco*, Sebastián Cerro, Nicolás Pereira, Camila Rojas, Álvaro Torres and Isabel Vidal-Beltrán


DOI: 10.2174/1389450122666210712163702




CD47 Functionalization of Nanoparticles as a Poly(ethylene glycol) Alternative: A Novel Approach to Improve Drug Delivery

, 2021; 22(15): 1750-1759.

Noushin R. Vandchali, Fatemeh Moadab, Eskandar Taghizadeh, Amir Tajbakhsh and Seyed M. Gheibihayat*


DOI: 10.2174/1389450122666210204203514


Inflammatory Bowel Disease in Migrant Populations: Should we Look Even Further Back?

, 2021; 22(15): 1706-1715.

Gionata Fiorino, Maria M. Estevinho, Diogo J.M. Lopes, Filippo Chersi, Mariangela Allocca, Miguel T. Souto, Silvio Danese and Fernando Magro*


DOI: 10.2174/1389450122666210203193817




Editor-in-Chief

graphic
Francis J. Castellino
(14643 citations)
Dean Emeritus, College of Science,
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
(USA)
View Full Editorial Board

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Journal History

Current Drug Targets Journal was launched in 2000. Dr. Francis J. Castellino serves as the Editor-in-Chief of the journal.

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