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Current Drug Metabolism

Volume 23, 14 Issues, 2022
ISSN: 1875-5453 (Online)
ISSN: 1389-2002 (Print)
This journal supports open access

Aims & Scope

Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism, pharmacokinetics, and drug disposition. The journal serves as an international forum for the publication of full-length/mini review, research articles and guest edited issues in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the most important developments. The journal covers the following general topic areas: pharmaceutics, pharmacokinetics, toxicology, and most importantly drug metabolism.

More specifically, in vitro and in vivo drug metabolism of phase I and phase II enzymes or metabolic pathways; drug-drug interactions and enzyme kinetics; pharmacokinetics, pharmacokinetic-pharmacodynamic modeling, and toxicokinetics; interspecies differences in metabolism or pharmacokinetics, species scaling and extrapolations; drug transporters; target organ toxicity and interindividual variability in drug exposure-response; extrahepatic metabolism; bioactivation, reactive metabolites, and developments for the identification of drug metabolites. Preclinical and clinical reviews describing the drug metabolism and pharmacokinetics of marketed drugs or drug classes.

Current Drug Metabolism

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Volume 23

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Number 5




Mini-Review Article

Dermatokinetics: Advances and Experimental Models, Focus on Skin Metabolism

, 23(5): 340 - 354

Paul Quantin, Mathilde Stricher, Sophie Catoire, Hervé Ficheux and Christophe Egles*


DOI: 10.2174/1389200223666220517114004


Review Article

Cytochromes P450: Role in Carcinogenesis and Relevance to Cancers

, 23(5): 355 - 373

A’edah Abu-Bakar, Boon Hooi Tan, Hasseri Halim, Salfarina Ramli, Yan Pan and Chin Eng Ong*


DOI: 10.2174/1389200223666220328143828




Research Article

Urine Metabolites as a Predictor of Warfarin Response Based on INR in Atrial Fibrillation

, 23(5): 415 - 422

Abdulkader Ahmad Bawadikji, Chin-Hoe Teh, Muhamad Ali Bin Sheikh Abdul Kader, Syed Azhar Syed Sulaiman and Baharudin Ibrahim*


DOI: 10.2174/1389200223666220413112649


Research Article

Interactions Between Meropenem and Renal Drug Transporters

, 23(5): 423 - 431

Jing Dong, Yanhui Liu, Longxuan Li*, Yunhe Ding, Jun Qian and Zheng Jiao*


DOI: 10.2174/1389200223666220428081109


Articles Ahead of Print

Unraveling the Structure-Dependent Inhibitory Effects of Ginsenoside Series Compounds on Human Cytochrome P450 1B1


Tingting Zhao, Xiaodong Chen, Hong Yu, Jie Du, Dalong Wang, Changyuan Wang, Qiang Meng, Huijun Sun, Kexin Liu and Jingjing Wu*


DOI: 10.2174/1389200223666220601102629
View Abstract View on PubMed










An Overview of the Neuropharmacological Potential of Thymoquinone and its Targeted Delivery Prospects for CNS Disorder


Rishabh Verma, Ali Sartaj, Farheen Fatima Qizilbash, Mohammed M Ghoneim, Sultan Alshehri, Syed Sarim Imam, Chandra Kala, Md. Shamsher Alam, Sadaf Jamal Gilani and Mohamad Taleuzzaman*


DOI: 10.2174/1389200223666220608142506
View Abstract View on PubMed


Abstracts Ahead of Print


Pharmaceutical Nanoemulsion System: A Strategy to Enhance the Bioavailability of Drugs


Shobhit Kumar*, Parul Waliyan, Rakesh Pahwa, Javed Ali, Sanjula Baboota, Shrestha Sharma and Faheem Hyder Pottoo


DOI: 10.2174/1389200223666220630161615
View Abstract


Pharmacokinetics and Metabolism of Traditional Chinese Medicine in the Treatment of COVID-19


Xiaofang Xu, Qian Shen, Hui Wang, Zian Zeng, Meng Liu, Guang Wu, Yusheng Zhou* and Rong Li*


DOI: 10.2174/1389200223666220630124403
View Abstract





Promising Role of Natural Exosomal Nanoparticles in Cancer Chemoimmunotherapy


Archana Premnath, Sonu Benny, Aneesh Thankappan Presanna* and Sabitha Mangalathillam*


DOI: 10.2174/1389200223666220627103213
View Abstract


Effect of C. cyminum and L. sativum on Pharmacokinetics and Pharmacodynamics of Antidiabetic Drug Gliclazide


Abdulelah I. Al-Suwaydani, Mohd Aftab Alam*, Mohammed Raish, Yousef A. Bin Jardan, Abdul Ahad and Fahad I. Al-Jenoobi


DOI: 10.2174/1389200223666220623155939
View Abstract



Additive Manufacturing and Printing Approaches for the Development of Pharmaceutical Dosage Forms with Improved Biopharmaceutical Attributes


S.M. Kawish, Shwetakshi Sharma, Waleed H Almalki, Saad Alghamdi, Obaid Afzal, Imran Kazmi, Abdulmalik Saleh Alfawaz Altamimi, Fahad A. Al-Abbasi, Sarwar Beg and Farhan J Ahmad*


DOI: 10.2174/1389200223666220616123842
View Abstract


Published Contents

Editor's Choice

Metabolite Identification in the Preclinical and Clinical Phase of Drug Development

, 2021; 22(11): 838 - 857

Yali Wu, Lulu Pan, Zhendong Chen, Yuandong Zheng, Xingxing Diao* and Dafang Zhong*


DOI: 10.2174/1389200222666211006104502



In vitro Measurement and In vivo Prediction of Time-Dependent Inhibitory Effects of Three Tyrosine Kinase Inhibitors on CYP3A Activity

, 2021; 22(10): 802 - 810

Liyan Wang, Tingting Zhao, Yunxiang Wang, Banglian Hu, Jianfei Tao, Jinshan Ke, Tingfei Wei, Guangbo Ge, Qiang Meng, Changyuan Wang, Qi Liu, Huijun Sun, Jingjing Wu* and Yanwei Chen*


DOI: 10.2174/1389200222666210902130319






An Overview of Dietary Supplements on Obesity and Type 2 Diabetes: Efficacy and Mechanisms

, 2021; 22(6): 415 - 440

Xiaohong Liu, Xin Zeng, Wen Liu, Yanrong Lu, Jingqiu Cheng and Younan Chen*


DOI: 10.2174/1389200222666210406110450





Topical Capsaicin for the Treatment of Neuropathic Pain

, 2021; 22(3): 198 - 207

Adiba Sultana, Rajeev K. Singla, Xuefei He, Yan Sun, Md. Shahin Alam and Bairong Shen*


DOI: 10.2174/1389200221999201116143701




Open Access Articles

Glutamine Antagonist GA-607 Causes a Dramatic Accumulation of FGAR which can be used to Monitor Target Engagement

, 2021; 22(9): 735 - 745

Jesse Alt , Sadakatali S. Gori, Kathryn M. Lemberg, Arindom Pal , Vijayabhaskar Veeravalli, Ying Wu, Joanna M.H. Aguilar , Ranjeet P. Dash, Lukáš Tenora , Pavel Majer, Qi Sun, Barbara S. Slusher* and Rana Rais*






Dysregulation of lncRNA and circRNA Expression in Mouse Testes after Exposure to Triptolide

, 2019; 20(8): 665 - 673

Suping Xiong, Yanting Li, Yang Xiang, Na Peng, Chunmiao Shen, Yanqiu Cai, Dandan Song, Peng Zhang, Xiaolong Wang, Xuihui Zeng and Xiaoning Zhang*




Influence of the OATP Polymorphism on the Population Pharmacokinetics of Methotrexate in Chinese Patients

, 2019; 20(7): 592 - 600

Zhiqi Wang, Nan Zhang, Chaoyang Chen, Shuqing Chen, Junyu Xu, Ying Zhou, Xia Zhao* and Yimin Cui*




Effects of CYP2C8 and SLCO1B1 Genetic Polymorphisms on Repaglinide Pharmacokinetics: A Systematic Review and Meta-Analysis

, 2019; 20(4): 266 - 274

Shuang Zhou, Qian Xiang, Guangyan Mu, Lingyue Ma, Shuqing Chen, Qiufen Xie, Zhuo Zhang and Yimin Cui*






Thiazide Therapy in Chronic Kidney Disease: Renal and Extra Renal Targets

, 2018; 19(12): 1012 - 1020

Negiin Pourafshar*, Saeed Alshahrani, Ashkan Karimi and Manoocher Soleimani*




Models of Drug Induced Liver Injury (DILI) – Current Issues and Future Perspectives

, 2018; 19(10): 830 - 838

Lucija Kuna, Ivana Bozic, Tomislav Kizivat, Kristina Bojanic, Margareta Mrso, Edgar Kralj, Robert Smolic, George Y. Wu and Martina Smolic*






Digestive Enzyme Supplementation in Gastrointestinal Diseases

, 2016; 17(2): 187 - 193

Gianluca Ianiro, Silvia Pecere, Valentina Giorgio, Antonio Gasbarrini and Giovanni Cammarota




Role of Drug Metabolism in the Cytotoxicity and Clinical Efficacy of Anthracyclines

, 2015; 16(6): 412 - 426

Derek W. Edwardson, Rashmi Narendrula, Simon Chewchuk, Kyle Mispel-Beyer, Jonathan P.J. Mapletoft and Amadeo M. Parissenti





Most Cited Articles

Review Article

Survey of machine learning techniques in drug discovery

, 2019; 20(3): 185-193.

Natalie Stephenson, Emily Shane, Jessica Chase, Jason Rowland, David Ries, Nicola Justice, Jie Zhang, Leong Chan and Renzhi Cao*


DOI: 10.2174/1389200219666180820112457


Review Article

Recent advances in machine learning methods for predicting heat shock proteins

, 2019; 20(3): 224-228.

Wei Chen*, Pengmian Feng, Tao Liu and Dianchuan Jin


DOI: 10.2174/1389200219666181031105916



Review Article

Cancer nanotechnology: A new revolution for cancer diagnosis and therapy

, 2019; 20(6): 416-429.

Vivek K Chaturvedi, Anshuman Singh, Vinay K. Singh and Mohan P. Singh*


DOI: 10.2174/1389200219666180918111528



Review Article

Magnetic nanoparticles: Current trends and future aspects in diagnostics and nanomedicine

, 2019; 20(6): 457-472.

Naga Veera Srikanth Vallabani, Sanjay Singh* and Ajay Singh Karakoti*


DOI: 10.2174/1389200220666181122124458


Review Article

Herb-drug interactions and hepatotoxicity

, 2019; 20(4): 275-282.

Mohammad K. Parvez* and Vikas Rishi


DOI: 10.2174/1389200220666190325141422




Review Article

Recent advances in the machine learning-based drug-target interaction prediction

, 2019; 20(3): 194-202.

Wen Zhang*, Weiran Lin, Ding Zhang, Siman Wang, Jingwen Shi and Yanqing Niu


DOI: 10.2174/1389200219666180821094047





Review Article

Survey of machine learning techniques for prediction of the isoform specificity of cytochrome P450 substrates

, 2019; 20(3): 229-235.

Yi Xiong, Yanhua Qiao, Daisuke Kihara, Hui-Yuan Zhang, Xiaolei Zhu* and Dong-Qing Wei*


DOI: 10.2174/1389200219666181019094526


General Review Article

Advanced glycation end products (AGEs), glutathione and breast cancer: Factors, mechanism and therapeutic interventions

, 2019; 20(1): 65-71.

Anil K. Sharma, Var R. Sharma, Girish K. Gupta, Ghulam Md. Ashraf and Mohammad A. Kamal*


DOI: 10.2174/1389200219666180912104342



Most Accessed Articles


Modulation of Drug Resistance by Limonene: Inhibition of Efflux Pumps in Staphylococcus aureus Strains RN-4220 and IS-58

, 2021; 22(2): 110-113.

de Araujo, Ana C. J.; Freitas, Priscilla R.; dos Santos Barbosa, Cristina R.; Muniz, Debora F.; Ribeiro-Filho, Jaime; Tintino, Saulo R.; Junior, Jose P. S.; Filho, Jose M. B.; de Sousa, Gabriela R.; Coutinho, Henrique D. M.


DOI: 10.2174/1389200221999210104204718


Modulation of the Drug Resistance by Platonia insignis Mart. Extract, Ethyl Acetate Fraction and Morelloflavone/Volkensiflavone (Biflavonoids) in Staphylococcus aureus Strains Overexpressing Efflux Pump Genes

, 2021; 22(2): 114-122.

Silva, Andressa K. F. E.; dos Reis, Antonielly C.; Pinheiro, Emanuelly E. A.; de Sousa, Jonas N.; de Alcantara Oliveira, Felipe A.; Moura, Arkellau K. S.; Neto, Jose de Souza L.; Cito, Antonia M. das Gracas L.; Siqueira-Junior, Jose P.; Kaatz, Glenn W.; Barreto, Humberto M.


DOI: 10.2174/1389200221666200523155617


Metabolism and Mechanism of Human Cytochrome P450 Enzyme 1A2

, 2021; 22(1): 40-49.

Guo, Jingchao; Zhu, Xiaohui; Badawy, Sara; Ihsan, Awais; Liu, Zhenli; Xie, Changqing; Wang, Xu


DOI: 10.2174/1389200221999210101233135


Topical Capsaicin for the Treatment of Neuropathic Pain

, 2021; 22(3): 198-207.

Sultana, Adiba; Singla, Rajeev K.; He, Xuefei; Sun, Yan; Alam, Md Shahin; Shen, Bairong


DOI: 10.2174/1389200221999201116143701


A Novel Nanoformulation of Ellagic Acid is Promising in Restoring Oxidative Homeostasis in Rat Brains with Alzheimer's Disease

, 2021; 22(4): 299-307.

Harakeh, Steve; Qari, Mohamad H.; Ramadan, Wafaa S.; Al Jaouni, Soad K.; Almuhayawi, Mohammed S.; Al Amri, Turki; Ashraf, Ghulam Md; Bharali, Dhruba J.; Mousa, Shaker A.


DOI: 10.2174/1389200221666201216170851





Effectiveness and Tolerability of Very-low Volume Preparation for Colonoscopy: A Narrative Review

, 2021; 22(2): 85-88.

Sinagra, Emanuele; Sferrazza, Sandro; Vitello, Alessandro; Morreale, Gaetano; Rossi, Francesca; Conoscenti, Giuseppe; Pallio, Socrate; Raimondo, Dario; Maida, Marcello


DOI: 10.2174/1389200221999201208212007





The Emerging Roles of Extracellular Vesicles in Ovarian Cancer

, 2021; 22(2): 139-149.

Wang, Yin-Xue; Wang, Yi-Xiang; Li, Yi-Ke; Tu, Shi-Yan; Wang, Yi-Qing


DOI: 10.2174/1389200221666201110155721


Advances in Understanding the Metabolites and Metabolomics of Polygonum multiflorum Thunb: A Mini-review

, 2021; 22(3): 165-172.

Yang, Jian-Bo; Gao, Hui-Yu; Song, Yun-Fei; Liu, Yue; Wang, Qi; Wang, Ying; Ma, Shuang-Cheng; Cheng, Xian-Long; Wei, Feng


DOI: 10.2174/1389200221666201201091345




Editor-in-Chief

graphic
Ming Hu
College of Pharmacy
University of Houston
Houston, TX
(United States)
Biography
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