Bentham Science Logo
Journal Cover

Track Your Manuscript:


Current Drug Metabolism

Volume 23, 14 Issues, 2022
ISSN: 1875-5453 (Online)
ISSN: 1389-2002 (Print)
This journal supports open access

Aims & Scope

Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism, pharmacokinetics, and drug disposition. The journal serves as an international forum for the publication of full-length/mini review, research articles and guest edited issues in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the most important developments. The journal covers the following general topic areas: pharmaceutics, pharmacokinetics, toxicology, and most importantly drug metabolism.

More specifically, in vitro and in vivo drug metabolism of phase I and phase II enzymes or metabolic pathways; drug-drug interactions and enzyme kinetics; pharmacokinetics, pharmacokinetic-pharmacodynamic modeling, and toxicokinetics; interspecies differences in metabolism or pharmacokinetics, species scaling and extrapolations; drug transporters; target organ toxicity and interindividual variability in drug exposure-response; extrahepatic metabolism; bioactivation, reactive metabolites, and developments for the identification of drug metabolites. Preclinical and clinical reviews describing the drug metabolism and pharmacokinetics of marketed drugs or drug classes.

Current Drug Metabolism

,

Volume 22

-

Number 14






Research Article



Research Article

Identification and Quantification of MIDD0301 Metabolites

, 22(14): 1114 - 1123

M.S. Rashid Roni, Nicolas M. Zahn, Brandon N. Mikulsky, Daniel A. Webb, Md Yeunus Mian, Daniel E. Knutson, Margaret L. Guthrie, James M. Cook, Douglas C. Stafford and Leggy A. Arnold*


DOI: 10.2174/1389200222666211202093841


Research Article

Higher Teicoplanin Blood Level Needed in Elderly Critically Ill Patients

, 22(14): 1124 - 1131

Ling Wang, Mingguang Chen, Hong Ye, Xiaolan Lin, Yixuan Li, Junshan Ruan*, Fenghui Lin* and Yuxing Lin


DOI: 10.2174/1389200222666211122124420


Research Article



Clinical Trial

A Randomized Trial of Short-term Treatment with Folic Acid to Reduce the Oxidative Stress of Patients with Chronic Kidney Disease

, 22(14): 1139 - 1150

Andressa Keiko Matsumoto*, Ana Paula Michelin, Laura de Oliveira Semeão, Walter Sepúlveda-Loyola, João Victor de Lima Pedrão, Guilherme Martins Porto, Beatriz Suellen Arceni, Estefânia Gastaldello Moreira, Vinicius Daher Alvares Delfino and Décio Sabbatini Barbosa


DOI: 10.2174/1389200222666211210153145


Articles Ahead of Print





Withdrawal Notice: The Recent Advancement in the Field of Super Paramagnetic Iron Oxide Nanoparticles (SPIONs) for Aiming Breast Cancer


Debalina Maity, Sankha Bhattacharya*, Yudhishtir Singh Baghel, Sushilkumar Singh, Shweta Rai, Ritika S., Shubham Shrestha, Neeraj Singh and Akhil Kumar


DOI: 10.2174/1573399816666200627213646
View Abstract



Published Contents

Editor's Choice

Metabolite Identification in the Preclinical and Clinical Phase of Drug Development

, 2021; 22(11): 838 - 857

Yali Wu, Lulu Pan, Zhendong Chen, Yuandong Zheng, Xingxing Diao* and Dafang Zhong*


DOI: 10.2174/1389200222666211006104502



In vitro Measurement and In vivo Prediction of Time-Dependent Inhibitory Effects of Three Tyrosine Kinase Inhibitors on CYP3A Activity

, 2021; 22(10): 802 - 810

Liyan Wang, Tingting Zhao, Yunxiang Wang, Banglian Hu, Jianfei Tao, Jinshan Ke, Tingfei Wei, Guangbo Ge, Qiang Meng, Changyuan Wang, Qi Liu, Huijun Sun, Jingjing Wu* and Yanwei Chen*


DOI: 10.2174/1389200222666210902130319






An Overview of Dietary Supplements on Obesity and Type 2 Diabetes: Efficacy and Mechanisms

, 2021; 22(6): 415 - 440

Xiaohong Liu, Xin Zeng, Wen Liu, Yanrong Lu, Jingqiu Cheng and Younan Chen*


DOI: 10.2174/1389200222666210406110450





Topical Capsaicin for the Treatment of Neuropathic Pain

, 2021; 22(3): 198 - 207

Adiba Sultana, Rajeev K. Singla, Xuefei He, Yan Sun, Md. Shahin Alam and Bairong Shen*


DOI: 10.2174/1389200221999201116143701




Open Access Articles

Glutamine Antagonist GA-607 Causes a Dramatic Accumulation of FGAR which can be used to Monitor Target Engagement

, 2021; 22(9): 735 - 745

Jesse Alt , Sadakatali S. Gori, Kathryn M. Lemberg, Arindom Pal , Vijayabhaskar Veeravalli, Ying Wu, Joanna M.H. Aguilar , Ranjeet P. Dash, Lukáš Tenora , Pavel Majer, Qi Sun, Barbara S. Slusher* and Rana Rais*






Dysregulation of lncRNA and circRNA Expression in Mouse Testes after Exposure to Triptolide

, 2019; 20(8): 665 - 673

Suping Xiong, Yanting Li, Yang Xiang, Na Peng, Chunmiao Shen, Yanqiu Cai, Dandan Song, Peng Zhang, Xiaolong Wang, Xuihui Zeng and Xiaoning Zhang*




Influence of the OATP Polymorphism on the Population Pharmacokinetics of Methotrexate in Chinese Patients

, 2019; 20(7): 592 - 600

Zhiqi Wang, Nan Zhang, Chaoyang Chen, Shuqing Chen, Junyu Xu, Ying Zhou, Xia Zhao* and Yimin Cui*




Effects of CYP2C8 and SLCO1B1 Genetic Polymorphisms on Repaglinide Pharmacokinetics: A Systematic Review and Meta-Analysis

, 2019; 20(4): 266 - 274

Shuang Zhou, Qian Xiang, Guangyan Mu, Lingyue Ma, Shuqing Chen, Qiufen Xie, Zhuo Zhang and Yimin Cui*






Thiazide Therapy in Chronic Kidney Disease: Renal and Extra Renal Targets

, 2018; 19(12): 1012 - 1020

Negiin Pourafshar*, Saeed Alshahrani, Ashkan Karimi and Manoocher Soleimani*




Models of Drug Induced Liver Injury (DILI) – Current Issues and Future Perspectives

, 2018; 19(10): 830 - 838

Lucija Kuna, Ivana Bozic, Tomislav Kizivat, Kristina Bojanic, Margareta Mrso, Edgar Kralj, Robert Smolic, George Y. Wu and Martina Smolic*






Digestive Enzyme Supplementation in Gastrointestinal Diseases

, 2016; 17(2): 187 - 193

Gianluca Ianiro, Silvia Pecere, Valentina Giorgio, Antonio Gasbarrini and Giovanni Cammarota




Role of Drug Metabolism in the Cytotoxicity and Clinical Efficacy of Anthracyclines

, 2015; 16(6): 412 - 426

Derek W. Edwardson, Rashmi Narendrula, Simon Chewchuk, Kyle Mispel-Beyer, Jonathan P.J. Mapletoft and Amadeo M. Parissenti





Most Cited Articles

Review Article

Survey of machine learning techniques in drug discovery

, 2019; 20(3): 185-193.

Natalie Stephenson, Emily Shane, Jessica Chase, Jason Rowland, David Ries, Nicola Justice, Jie Zhang, Leong Chan and Renzhi Cao*


DOI: 10.2174/1389200219666180820112457


Review Article

Recent advances in machine learning methods for predicting heat shock proteins

, 2019; 20(3): 224-228.

Wei Chen*, Pengmian Feng, Tao Liu and Dianchuan Jin


DOI: 10.2174/1389200219666181031105916



Review Article

Cancer nanotechnology: A new revolution for cancer diagnosis and therapy

, 2019; 20(6): 416-429.

Vivek K Chaturvedi, Anshuman Singh, Vinay K. Singh and Mohan P. Singh*


DOI: 10.2174/1389200219666180918111528



Review Article

Magnetic nanoparticles: Current trends and future aspects in diagnostics and nanomedicine

, 2019; 20(6): 457-472.

Naga Veera Srikanth Vallabani, Sanjay Singh* and Ajay Singh Karakoti*


DOI: 10.2174/1389200220666181122124458


Review Article

Herb-drug interactions and hepatotoxicity

, 2019; 20(4): 275-282.

Mohammad K. Parvez* and Vikas Rishi


DOI: 10.2174/1389200220666190325141422




Review Article

Recent advances in the machine learning-based drug-target interaction prediction

, 2019; 20(3): 194-202.

Wen Zhang*, Weiran Lin, Ding Zhang, Siman Wang, Jingwen Shi and Yanqing Niu


DOI: 10.2174/1389200219666180821094047





Review Article

Survey of machine learning techniques for prediction of the isoform specificity of cytochrome P450 substrates

, 2019; 20(3): 229-235.

Yi Xiong, Yanhua Qiao, Daisuke Kihara, Hui-Yuan Zhang, Xiaolei Zhu* and Dong-Qing Wei*


DOI: 10.2174/1389200219666181019094526


General Review Article

Advanced glycation end products (AGEs), glutathione and breast cancer: Factors, mechanism and therapeutic interventions

, 2019; 20(1): 65-71.

Anil K. Sharma, Var R. Sharma, Girish K. Gupta, Ghulam Md. Ashraf and Mohammad A. Kamal*


DOI: 10.2174/1389200219666180912104342



Most Accessed Articles






A Review on Pharmacokinetic and Pharmacodynamic Drug Interactions of Adrenergic β-blockers with Clinically Relevant Drugs-An Overview

, 2021; 22(9): 672-682.

Naina Mohamed Pakkir Maideen*, Balasubramanian Rajkapoor, Sudha Muthusamy, Sambathkumar Ramanathan, Subramaniam Ananda Thangadurai and Abdussalam A. Sughir


DOI: 10.2174/1389200222666210614112529


Oxypeucedanin is a Mechanism-based Inactivator of CYP2B6 and CYP2D6

, 2021; 22(11): 882-892.

Kehan Zhang, Yilin Li, Yao Fu, Tiantian Cui, Qian Wang, Xu Mao, Ying Peng* and Jiang Zheng*


DOI: 10.2174/1389200222666210629114830



Glutamine Antagonist GA-607 Causes a Dramatic Accumulation of FGAR which can be used to Monitor Target Engagement

, 2021; 22(9): 735-745.

Jesse Alt , Sadakatali S. Gori, Kathryn M. Lemberg, Arindom Pal , Vijayabhaskar Veeravalli, Ying Wu, Joanna M.H. Aguilar , Ranjeet P. Dash, Lukáš Tenora , Pavel Majer, Qi Sun, Barbara S. Slusher* and Rana Rais*


DOI: 10.2174/1389200222666210831125041


Evaluation and Clinical Implication of Zhenwu Decoction on Seven Cytochrome P450 Enzyme in Chronic Heart Failure Rats

, 2021; 22(9): 746-755.

Li-Li Hong, Hong-Song Wang*, Xiao-Yu Cheng*, Sheng Zhang, Yan Zhao, Qian Wang, Ya-TIng Zhao, Lei Wang, Lan Ge, Jun Su and Wei-Dong Chen


DOI: 10.2174/1389200222666210701171047


Absorption, Metabolism, Distribution, and Excretion of Letermovir

, 2021; 22(10): 784-794.

Karsten Menzel*, Prajakti Kothare, Jacqueline B. McCrea, Xiaoyan Chu and Dirk Kropeit


DOI: 10.2174/1389200222666210223112826



The Role of Biotransformation in the Activity of Endocrine Disruptors

, 2021; 22(8): 628-644.

Elif I. Erguc, Alev Tascioglu-Aliyev, Bita Entezari and Hande Gurer-Orhan *


DOI: 10.2174/1389200222666210603114617



Comprehensive Identification of Astilbin Metabolites in Rats Based on Multiple Metabolite Templates Combined with UHPLC-Q-Exactive Mass Spectrometry

, 2021; 22(10): 811-823.

Shan Jiang, Haoran Li, Ailin Yang, Hongbing Zhang, Pingping Dong, Fan Dong, Long Dai, Shaoping Wang* and Jiayu Zhang*


DOI: 10.2174/1389200222666210811110619




Editor-in-Chief

graphic
Ming Hu
College of Pharmacy
University of Houston
Houston, TX
(United States)
Biography
View Full Editorial Board

COPE Compliant

Cope Logo

Journal History

Current Drug Metabolism was launched in 2000. Dr. Ming Hu serves as the Editor-in-Chief of the journal.

Related Journals

Related eBooks

eBooks Catalog