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Combinatorial Chemistry & High Throughput Screening

Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 25, 14 Issues, 2022
ISSN: 1875-5402 (Online)
ISSN: 1386-2073 (Print)
This journal supports open access

Aims & Scope

Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal:

  • Target identification and validation
  • Assay design, development, miniaturization and comparison
  • High throughput/high content/in silico screening and associated technologies
  • Label-free detection technologies and applications
  • Stem cell technologies
  • Biomarkers
  • ADMET/PK/PD methodologies and screening
  • Probe discovery and development, hit to lead optimization
  • Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries)
  • Chemical library design and chemical diversity
  • Chemo/bio-informatics, data mining
  • Compound management
  • Pharmacognosy
  • Natural Products Research (Chemistry, Biology and Pharmacology of Natural Products)
  • Natural Product Analytical Studies
  • Bipharmaceutical studies of Natural products
  • Drug repurposing
  • Data management and statistical analysis
  • Laboratory automation, robotics, microfluidics, signal detection technologies
  • Current & Future Institutional Research Profile
  • Technology transfer, legal and licensing issues
  • Patents

In these respective subject areas, Combinatorial Chemistry & High Throughput Screening is intended to function as the most comprehensive and up-to-date medium available. The journal should be of value to individuals engaged in the process of drug discovery and development, in the settings of industry, academia or government.

Combinatorial Chemistry & High Throughput Screening

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Volume 25

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Number 4



Review Article



Review Article

Novel Drug Delivery System for Curcumin: Implementation to Improve Therapeutic Efficacy against Neurological Disorders

, 25(4): 607 - 615

Roohi Mohi-ud-din*, Reyaz Hassan Mir, Taha Umair Wani, Abdul Jalil Shah, Ishtiyaq Mohi-Ud-Din, Mudasir Ahmad Dar and Faheem Hyder Pottoo*


DOI: 10.2174/1386207324666210705114058


Review Article

Berberine in the Treatment of Neurodegenerative Diseases and Nanotechnology Enabled Targeted Delivery

, 25(4): 616 - 633

Roohi Mohi-ud-din*, Reyaz Hassan Mir, Taha Umair Wani, Abdul Jalil Shah, Nazia Banday and Faheem Hyder Pottoo*


DOI: 10.2174/1386207324666210804122539


Research Article

Predicting Drug-Target Affinity Based on Recurrent Neural Networks and Graph Convolutional Neural Networks

, 25(4): 634 - 641

Qingyu Tian*, Mao Ding*, Hui Yang, Caibin Yue, Yue Zhong, Zhenzhen Du, Dayan Liu, Jiali Liu and Yufeng Deng


DOI: 10.2174/1386207324666210215101825


Research Article





Research Article

Water Mapping and Scoring Approaches to Predict the Role of Hydration Sites in the Binding Affinity of PAK1 Inhibitors

, 25(4): 660 - 676

Jayashree Biswal, Prajisha Jayaprakash, Suresh Kumar Rayala, Ganesh Venkatraman, Raghu Rangasamy, Saritha Poopandi and Jeyaraman Jeyakanthan*


DOI: 10.2174/1386207324666210308110646


Articles Ahead of Print





Can We Use mTOR Inhibitors for COVID-19 Therapy?


Ina Y. Aneva *, Solomon Habtemariam, Maciej Banach, Parames C. Sil , Kasturi Sarkar, Adeleh Sahebnasagh , Mohammad Amjad Kamal, Maryam Khayatkashani and Hamid Reza Khayat Kashani*


DOI: 10.2174/1386207325666211130140923
View Abstract View on PubMed


miR-4295 Promotes the Malignant Progression of Gastric Cancer via Targeting PTEN


Xiaoyan Yang, Jing Yang, Yunlian Tang, Zhizhong Xie, Yang Zhang, Xiaoyong Lei* and Runliang Gan*


DOI: 10.2174/1386207325666211110095307
View Abstract View on PubMed




Amalgamation and Scrutinizing of Leucine Derivatives Schiff Bases Complexes as Antimicrobial Agent


Muhammad Pervaiz*, Ikram Ahmad, Zohaib Saeed, Muhammad Sagir, Umer Younas, Muhammad Bilal Tahir*, Awais Ahmad, Ayoub Rashid, Quratulain Syed and Ahmad Adnan


DOI: 10.2174/1386207325666210927092623
View Abstract View on PubMed



Abstracts Ahead of Print


In-silico validation of the proposed treatment strategy of periodontitis


Pooja Jain, Uzma Farooq, Lalit Mohan Nainwal, Mumtaz Alam, Naseef PP, Mohamed Saheer Kuruniyan, Mohd. Aamir Mirza and Zeenat Iqbal*


DOI: 10.2174/1386207325666220126102235
View Abstract









Anti-Proliferative Activity of Piper trioicum Leaf Essential Oil Based on Phytoconstituent Analysis, Molecular Docking and In Silico ADMET Approaches


Sudipta Jena, Asit Ray, Ambika Sahoo, Prabhat Kumar Das, Pradeep Kumar Kamila, Subrat Kumar Kar, Sanghamitra Nayak and Pratap Chandra Panda


DOI: 10.2174/1386207325666211222113239
View Abstract


Published Contents

Editor's Choice


A Potential MRI Agent and an Anticancer Drug Encapsulated within CPMV Virus-Like Particles

, 2021; 24(10): 1557 - 1571

Alaa A.A. Aljabali*, Lorca Alzoubi, Yassmen Hamzat, Alaa Alqudah, Mohammad A. Obeid, Mazhar S. Al Zoubi, Raed M. Ennab, Walhan Alshaer, Khaled Albatayneh, Bahaa Al-Trad, Dana A. Alqudah, Dinesh Kumar Chellappan, Gaurav Gupta, Murtaza M. Tambuwala, Dua Kamal and David J. Evans


DOI: 10.2174/1386207323666200914110012








Cervical Cancer Diagnosis: Insights into Biochemical Biomarkers and Imaging Techniques

, 2021; 24(5): 605 - 623

Fatemeh Tavakoli, Sara Sadat Khatami, Fatemeh Momeni, Javid Azadbakht* and Faezeh Ghasemi*


DOI: 10.2174/1386207323666200901101955





Open Access Articles


Elucidation of the Mechanisms and Molecular Targets of Qishen Yiqi Formula for the Treatment of Pulmonary Arterial Hypertension using a Bioinformatics/Network Topology-based Strategy

, 2021; 24(5): 701 - 715

Peiliang Wu, Xiaona Xie, Mayun Chen, Junwei Sun, Luqiong Cai, Jinqiu Wei, Lin Yang, Xiaoying Huang* and Liangxing Wang*





Network Pharmacology-based Investigation of the Underlying Mechanism of Panax notoginseng Treatment of Diabetic Retinopathy

, 2020; 23(4): 334 - 344

Chunli Piao*, Zheyu Sun, De Jin, Han Wang, Xuemin Wu, Naiwen Zhang, Fengmei Lian* and Xiaolin Tong*





Transcriptome Analysis of FEN1 Knockdown HEK293T Cell Strain Reveals Alteration in Nucleic Acid Metabolism, Virus Infection, Cell Morphogenesis and Cancer Development

, 2019; 22(6): 379 - 386

Song-Bai Liu*, Xiu-Qin Qiu, Wei-Qiang Guo, Jin-Li Li, Qian Su, Jia-Hui Du, He-Juan Hu, Xiao-Xiao Wang, Yao-Hua Song, Xiao Lou* and Xiang-Bin Xu*




Effect of the Phragmitis Rhizoma Aqueous Extract on the Pharmacokinetics of Docetaxel in Rats

, 2019; 22(5): 326 - 332

Sarah Shin, No Soo Kim, Young Ah Kim, Hea Ry Oh and Ok-Sun Bang*







High Throughput Screening of Esterases, Lipases and Phospholipases in Mutant and Metagenomic Libraries: A Review

, 2016; 19(8): 605 - 615

Carlina Peña-García, Mónica Martínez-Martínez, Dolores Reyes-Duarte* and Manuel Ferrer*





Identification of Protein Palmitoylation Inhibitors from a Scaffold Ranking Library

, 2016; 19(4): 262 - 274

Laura D. Hamel, Brian J. Lenhart, David A. Mitchell, Radleigh G. Santos, Marc A. Giulianotti and Robert J. Deschenes*





Most Cited Articles


Research Article

Drug target group prediction with multiple drug networks

, 2020; 23(4): 274-284.

Jingang Che, Lei Chen*, Zi-Han Guo, Shuaiqun Wang and Aorigele


DOI: 10.2174/1386207322666190702103927



Review Article

Progress in molecularly imprinted polymers for biomedical applications

, 2019; 22(2): 78-88.

Jane Ru Choi*, Kar Wey Yong*, Jean Yu Choi and Alistair C. Cowie


DOI: 10.2174/1386207322666190325115526


Research Article

Identification of the active constituents and significant pathways of guizhi-shaoyao-zhimu decoction for the treatment of diabetes mellitus based on molecular docking and network pharmacology

, 2019; 22(9): 584-598.

Qing Zhang, Ruolan Li, Wei Peng, Mengmeng Zhang, Jia Liu, Shujun Wei, Jiaolong Wang, Chunjie Wu, Yongxiang Gao* and Xufeng Pu*


DOI: 10.2174/1386207322666191022101613




General Research Article

Lead finding from selected flavonoids with antiviral (Sars-cov-2) potentials against covid-19: An in-silico evaluation

, 2021; 24(6): 879-890.

Uma Sankar Gorla*, Koteswara Rao, Uma Sankar Kulandaivelu, Rajasekhar Reddy Alavala and Siva Prasad Panda


DOI: 10.2174/1386207323999200818162706


General Research Article

Discovery of potent sars-cov-2 inhibitors from approved antiviral drugs via docking and virtual screening

, 2021; 24(3): 441-454.

Samir Chtita *, Assia Belhassan, Adnane Aouidate, Salah Belaidi, Mohammed Bouachrine and Tahar Lakhlifi


DOI: 10.2174/1386207323999200730205447






Research Article

Green route for the removal of pb from aquatic environment

, 2020; 23(7): 587-598.

Ahmed Refaat*, Hanan Elhaes, Nabila S. Ammar, Hanan S. Ibrahim and Medhat Ibrahim


DOI: 10.2174/1386207323666200127123349




Most Accessed Articles




Risk of Drug Resistance and Repeated Infection with Klebsiella pneumoniae and Escherichia coli in Intensive Care Unit Cancer Patients

, 2022; 25(2): 324-334.

Samah M. Refay, Eman H. Ahmed, Ahmed R. Abd ELzaher, Ahmed M. Morsy, Manal M. Yasser* and Ayman M. Mahmoud*


DOI: 10.2174/1386207324666210121104724


MicroRNA and Exosome in Retinal-related Diseases: Their Roles in the Pathogenesis and Diagnosis

, 2022; 25(2): 211-228.

Arash Salmaninejad*, Ghazaleh Pourali, Ali Shahini, Hassan Darabi and Sara Azhdari


DOI: 10.2174/1386207323999201230205435








Synthesis of Novel Hydrazones of Levofloxacin Related Molecule and their In Vitro evaluation as antioxidant, and Molecular Docking Studies

, 2022; 25(2): 274-283.

Bharat B. Kashid*, Jaydeo T. Kilbile, Kishor D. Wani, Suhas. M. Pawar, Vijay M. Khedkar and Anil A. Ghanwat*


DOI: 10.2174/1386207323666201229150734



Identification of an MiRNA-mRNA Regulatory Network in Colorectal Cancer

, 2021; 24(10): 1736-1745.

Ming-fu Cui, Yuan-yu Wu, Ming-yan Chen, Yang Zhao, Song-yun Han, Rui-jie Wang, Haiyan Zhang* and Xue-dong Fang*


DOI: 10.2174/1386207323666201110154142


Nutraceuticals for Sleep Disorders

, 2021; 24(10): 1583-1592.

Ruhi Ali*, Sana Tariq, Ozaifa Kareem, Faizana Fayaz, Tahira Aziz, Meenu, Faheem Hyder Pottoo and Nadeem Siddiqui


DOI: 10.2174/1386207324666210121111446




Editor-in-Chief

graphic
Gerald H. Lushington
LiS Consulting
Lawrence, KS
(USA)
Biography
View Full Editorial Board

COPE Compliant

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Journal History

Combinatorial Chemistry & High Throughput Screening Journal was launched in 1998. Dr. Gerald H. Lushington serves as the Editor-in-Chief of the journal.

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