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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

Volume 22, 20 Issues, 2022
ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)
This journal supports open access

Aims & Scope

Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents. Each issue contains a series of timely in-depth/mini-reviews and guest-edited issues written by leaders in the field covering a range of current topics in oncology and medicinal chemistry. The journal considers high-quality reviews and research papers for publication. Scientific areas within the scope of the journal include:

  • Medicinal chemistry, prevention, diagnosis, and treatment of malignant diseases
  • In silico studies of drug-target interaction in anti-cancer drug assessment
  • Underlying biology and medicinal chemistry strategies for anti-cancer drug synthesis and development
  • New drugs related to a specific target or target class for anticancer drugs
  • Drug repositioning in cancer
  • Clinical cancer research
  • Radiotherapy and systemic treatment of cancer
  • Other related areas

Special Issues devoted to crucial topics, providing the latest comprehensive information on cutting-edge areas of research and technological advances, are welcome.

Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery.

Anti-Cancer Agents in Medicinal Chemistry


Volume 22


Number 16

Review Article

Azole-Pyrimidine Hybrid Anticancer Agents: A Review of Molecular Structure, Structure Activity Relationship, and Molecular Docking

, 22(16): 2822 - 2851

Chinweike Cosmas Eze*, Amarachukwu Mercy Ezeokonkwo, Izuchukwu David Ugwu, Uchenna Florence Eze, Ebuka Leonard Onyeyilim, Izuchi Solomon Attah and Ifeoma Vivian Okonkwo

DOI: 10.2174/1871520622666220318090147

Review Article

Recent Advances in Synthesis and Anticancer Potential of Triazole-Containing Scaffolds

, 22(16): 2852 - 2875

Devidas S. Bhagat*, Gurvinder S. Bumbrah, Pooja A. Chawla*, Wasudeo B. Gurnule and Sampada K. Shejul

DOI: 10.2174/1871520622666220217161346

Review Article

Site-Specific Binding of Anti-Cancer Drugs to Human Serum Albumin

, 22(16): 2876 - 2884

Mrinalini Bhosale, Ishtiaq Jeelani*, Allah Nawaz, Hitoshi Abe and Subhash Padhye

DOI: 10.2174/1871520622666220324094033

Research Article

Antitumor Effects of Turmeric on OVCAR-3 Ovarian Cancer Cell Lines

, 22(16): 2896 - 2901

Hulusi Goktug Gurer*, Ozlem Ozgur Gursoy, Ceren Yildiz Eren and Canan Vejselova Sezer

DOI: 10.2174/1871520622666220426103332

Anti-Cancer Agents in Medicinal Chemistry, Volume 22 (2022) - Number 17

This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Antiproliferative Effects of Artabotrys odoratissimus Fruit Extract and its Bioactive Fraction through Upregulation of p53/γH2AX Signals and G2/M Phase Arrest in MIA PaCa-2 Cells

Meghana Pargi, Sandeep Kumar Jain Raviraj, Prashanth Narayanappa, Santhosh Kumar J Urumarudappa, Pallavi Malleshappa and Kumaraswamy Halleshappa Monnenahally

DOI: 10.2174/1871520622666220201103431
View Abstract View on PubMed

Anti-Tumor and Anti-Metastasis Effects of Berbamine-Loaded Lipid Nanoparticles on Pancreatic Cancer

Zhiyi Tang, Yichun Niu, Zhiyuan Xu, Yanmei Shi, Yaqiong Liu, Wen Fu, Mengyao Zheng, Haiyu He* and Tao Wu*

DOI: 10.2174/1871520622666220501161636
View Abstract View on PubMed

Role of Collagen Regulators in Cancer Treatment: A Comprehensive Review

Tanuja Angre, Adarsh Kumar, Ankit Kumar Singh, Suresh Thareja and Pradeep Kumar*

DOI: 10.2174/1871520622666220501162351
View Abstract View on PubMed

CDC25B Inhibition by Menadione: A Potential New Therapeutical Approach

Helem Ferreira Ribeiro, Carla de Castro Sant’ Anna*, Valdenira de Jesus Oliveira Kato, Rafael Maia de Sousa Brasil, Amanda Braga Bona, Danielle Feio da Costa, Isamu Komatsu Lima, Paulo Cardoso Soares, Ana Paula Araújo Guimarães, Paulo Pimentel de Assumpção and Rommel Rodriguez Burbano

DOI: 10.2174/1871520622666220418131935
View Abstract View on PubMed

Abstracts Ahead of Print

Galbanic acid improves accumulation and toxicity of arsenic trioxide in MT-2 cells

Maryam Mahdifar, Fatemeh B. Rassouli*, Mehrdad Iranshahi, Sajad Goudarzi, Marzieh Golizadeh and Houshang Rafatpanah

DOI: 10.2174/1871520622666220722105802
View Abstract

In Silico and In Vitro Determination of Antiproliferative Activity of Series N-Pyrrolyl Hydrazide-Hydrazones and Evaluation of Their Effects on Isolated Rat Mycrosomes and Hepatocytes

Maya Georgieva*, Diana Tzankova, Emilio Mateev, Borislav Angelov, Magdalena Kondeva-Burdina, Georgi Momekov, Virginia Tzankova and Alexander Zlatkov

DOI: 10.2174/1871520622666220701114306
View Abstract

Tivozanib: A new hope of treating renal cell carcinoma

Indu Passi, Koushal Billowria, Bhupinder Kumar and Pooja A. Chawla*

DOI: 10.2174/1871520622666220617103126
View Abstract

Characterization of functionalized PLGA nanoparticles loaded with mangiferin and lupeol, and their effect on BEAS-2B and HepG2 cell lines

Razura-Carmona Francisco Fabián, Herrera-Martínez Mayra, Zamora-Gasga Víctor Manuel, Sáyago-Ayerdi Sonia Guadalupe, Pérez-Larios Alejandro* and Sánchez-Burgos Jorge Alberto

DOI: 10.2174/1871520622666220617101515
View Abstract

Published Contents

Editor's Choice

Design, Synthesis and Biological Evaluation of 4, 6-Coumarin Derivatives as Anti- Cancer and Apoptosis-Inducing Agents

, 2021; 21(17): 2351 - 2367

Guoyi Yan, Jiang Luo , Xuan Han, Wenjuan Zhang , Chunlan Pu, Meng Zhou, Xinxin Zhong, Xueyan Hou, Man Zhou Hou and Rui Li *

DOI: 10.2174/1871520621666210129093857

Design, Synthesis and Biological Evaluation of a Novel Series of Thiadiazole- Based Anticancer Agents as Potent Angiogenesis Inhibitors

, 2021; 21(15): 2041 - 2049

Burcugül Altuğ-Tasa, Betül Kaya-Çavuşoğlu*, Ayşe T. Koparal, Gülhan Turan, Ali S. Koparal and Zafer A. Kaplancıklı

DOI: 10.2174/1871520621666201231143535

Synthetic Spirocyclohexadienones as New Anti-Migratory Compounds in Triple- Negative Breast Cancer Cell Migration

, 2021; 21(14): 1901 - 1910

Wanessa F. Altei, Bianca C. Pachane, Lucimara J. Martins, Ralph C. Gomes, Ricardo N. Santos, Daniara C. Fernandes, Heloisa S. Selistre-de-Araújo, Fernando Coelho * and Adriano D. Andricopulo*

DOI: 10.2174/1871520621666201207092836

Synthesis of 1H-1,2,3-Triazole-Linked Quinoline-Isatin Molecular Hybrids as Anti-Breast Cancer and Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Agents

, 2021; 21(10): 1228 - 1239

Paul Awolade, Nosipho Cele, Oluwakemi Ebenezer, Nagaraju Kerru, Lalitha Gummidi, Liang Gu, Gabriella Palma, Mandeep Kaur and Parvesh Singh*

DOI: 10.2174/1871520620666200929153138

On the Cytotoxicity of Chiral Ruthenium Complexes Containing Sulfur Amino Acids against Breast Tumor Cells (MDA-231 and MCF-7)

, 2021; 21(9): 1172 - 1182

Celisnolia M. Leite*, João Honorato de Araujo-Neto, Rodrigo S. Corrêa, Legna Colina-Vegas, Diego Martínez-Otero, Paulo R. Martins, Cristiane G. Silva and Alzir A. Batista*

DOI: 10.2174/1871520620666200824114816

Open Access Articles

Antitumor Effects of Turmeric on OVCAR-3 Ovarian Cancer Cell Lines

, 2022; 22(16): 2896 - 2901

Hulusi Goktug Gurer*, Ozlem Ozgur Gursoy, Ceren Yildiz Eren and Canan Vejselova Sezer

Chemical Constituents and Antitumor Mechanisms of Artemisia

, 2022; 22(10): 1838 - 1844

Yasin Kamarya, Xia Lijie* and Li Jinyao*

New C2- and N3-Modified Thieno[2,3-d]Pyrimidine Conjugates with Cytotoxicity in the Nanomolar Range

, 2022; 22(6): 1201 - 1212

Anelia Ts. Mavrova*, Stefan Dimov, Denitsa Yancheva*, Miroslav Rangelov, Diana Wesselinova and Emilia Naydenova

The Killing of Human Neuroblastoma Cells by the Small Molecule JQ1 Occurs in a p53-Dependent Manner

, 2020; 20(13): 1613 - 1625

Joseph Mazar*, Caleb Gordon, Varun Naga and Tamarah J. Westmoreland

Cytotoxic Sesquiterpenes from Sonchus oleraceus

, 2020; 20(6): 709 - 714

Hongying Zhang, Yiding Wang, Shaojiu Wang, Qian Wang, Tianjing Wang, Jie Zhu* and Bing Liu

Proteomic Level Changes on Treatment in MCF-7/DDP Breast Cancer Drug- Resistant Cells

, 2020; 20(6): 687 - 699

Gongshen Jin*, Kangwei Wang, Yonghong Liu, Xianhu Liu, Xiaojing Zhang and Hao Zhang

Triphenylethylene-Coumarin Hybrid TCH-5c Suppresses Tumorigenic Progression in Breast Cancer Mainly Through the Inhibition of Angiogenesis

, 2019; 19(10): 1253 - 1261

Naipeng Cui, Dan-Dan Lin, Yang Shen, Jian-Guo Shi, Bing Wang, Ming-Zhi Zhao, Lishuang Zheng, Hua Chen* and Jian-Hong Shi*

Nicotinamide Overcomes Doxorubicin Resistance of Breast Cancer Cells through Deregulating SIRT1/Akt Pathway

, 2019; 19(5): 687 - 696

Yingze Wei, Yan Guo, Jianyun Zhou, Kui Dai, Qiang Xu and Xiaoxia Jin*

New Strategies for Therapeutic Cancer Vaccines

, 2019; 19(2): 213 - 221

Hanjiao Qin, Jiyao Sheng, Dan Zhang, Xuewen Zhang, Linlin Liu*, Bingjin Li*, Guangquan Li* and Zhuo Zhang

Astragalin Attenuates UVB Radiation-induced Actinic Keratosis Formation

, 2018; 18(7): 1001 - 1008

Na Li, Kun Zhang, Xin Mu, Qiong Tian, Wenli Liu, Tianyuan Gao, Xiaona Ma* and Jian Zhang*

Most Cited Articles

Review Article

Crocetin and crocin from saffron in cancer chemotherapy and chemoprevention

, 2019; 19(1): 38-47.

Alessandro Colapietro, Andrea Mancini, Anna Maria D'Alessandro and Claudio Festuccia*

DOI: 10.2174/1871520619666181231112453

Review Article

Phytochemicals in anticancer drug development

, 2019; 19(2): 172-183.

Rohit Dutt, Vandana Garg, Naveen Khatri and Anil K. Madan*

DOI: 10.2174/1871520618666181106115802

Review Article

Nitrogen-containing heterocycles as anticancer agents: An overview

, 2020; 20(18): 2150-2168.

Damanpreet K. Lang, Rajwinder Kaur*, Rashmi Arora, Balraj Saini and Sandeep Arora

DOI: 10.2174/1871520620666200705214917

Research Article

Synthesis and biological evaluation of novel heterocyclic imines linked coumarin- thiazole hybrids as anticancer agents

, 2019; 19(4): 557-566.

Nerella S. Goud, Mahammad S. Ghouse, Jatoth Vishnu, Jakkula Pranay, Ravi Alvala, Venu Talla, Insaf A. Qureshi and Mallika Alvala*

DOI: 10.2174/1871520619666190207140120

Research Article

Molecular docking study, cytotoxicity, cell cycle arrest and apoptotic induction of novel chalcones incorporating thiadiazolyl isoquinoline in cervical cancer

, 2020; 20(1): 70-83.

Mohamed A. Tantawy, Farid M. Sroor*, Magda F. Mohamed*, Mostafa E. El-Naggar, Fatma M. Saleh, Hamdi M. Hassaneen and Ismail A. Abdelhamid*

DOI: 10.2174/1871520619666191024121116

Research Article

Hybridized quinoline derivatives as anticancer agents: Design, synthesis, biological evaluation and molecular docking

, 2019; 19(4): 439-452.

Mohamed R. Selim, Medhat A. Zahran, Amany Belal*, Moustafa S. Abusaif*, Said A. Shedid, Ahmed B.M. Mehany, Gameel A.M. Elhagali and Yousry A. Ammar*

DOI: 10.2174/1871520618666181112121058

Review Article

Recent advances of silver nanoparticles in cancer diagnosis and treatment

, 2020; 20(11): 1276-1287.

Tran Q. Huy*, Pham T.M. Huyen, Anh-Tuan Le and Matteo Tonezzer*

DOI: 10.2174/1871520619666190710121727

Review Article

Quercetin loaded nanoparticles in targeting cancer: Recent development

, 2019; 19(13): 1560-1576.

Manjula Vinayak* and Akhilendra K. Maurya

DOI: 10.2174/1871520619666190705150214

Review Article

Garlic and its active compounds: A potential candidate in the prevention of cancer by modulating various cell signalling pathways

, 2019; 19(11): 1314-1324.

Saleh A. Almatroodi, Mohammed A. Alsahli, Ahmad Almatroudi and Arshad H. Rahmani*

DOI: 10.2174/1871520619666190409100955

Research Article

Let-7a could serve as a biomarker for chemo-responsiveness to docetaxel in gastric cancer

, 2019; 19(3): 304-309.

Najibeh Shekari, Faezeh Asghari, Navideh Haghnavaz, Dariush Shanehbandi, Vahid Khaze, Behzad Baradaran and Tohid Kazemi*

DOI: 10.2174/1871520619666181213110258

Research Article

Antitumor potential of berberine and cinnamic acid against solid ehrlich carcinoma in mice

, 2019; 19(3): 356-364.

Rafa S. Almeer, Ahmed M. Aref, Romisa A. Hussein, Mohamed S. Othman and Ahmed E. Abdel Moneim*

DOI: 10.2174/1871520618666181116162441

Most Accessed Articles

A Review of Chemotherapy and Photodynamic Therapy for Lung Cancer Treatment

, 2021; 21(2): 149-161.

El-Hussein, Ahmed; Manoto, Sello L.; Ombinda-Lemboumba, Saturnin; Alrowaili, Ziya A.; Mthunzi-Kufa, Patience

DOI: 10.2174/1871520620666200403144945

The Engaged Role of Tumor Microenvironment in Cancer Metabolism: Focusing on Cancer-Associated Fibroblast and Exosome Mediators

, 2021; 21(2): 254-266.

Ilkhani, Khandan; Bastami, Milad; Delgir, Soheila; Safi, Asma; Talebian, Shahrzad; Alivand, Mohammad-Reza

DOI: 10.2174/1871520620666200910123428

Elucidation of S-Allylcysteine Role in Inducing Apoptosis by Inhibiting PD-L1 Expression in Human Lung Cancer Cells

, 2021; 21(4): 532-541.

Khan, Fahad; Pandey, Pratibha; Mishra, Rashmi; Arif, Mohd.; Kumar, Ambuj; Jafri, Asif; Mazumder, Rupa

DOI: 10.2174/1871520620666200728121929

Fused and Substituted Pyrimidine Derivatives as Profound Anti-Cancer Agents

, 2021; 21(7): 861-893.

Abbas, Nahid; Matada, Gurubasavaraja S. P.; Dhiwar, Prasad S.; Patel, Shilpa; Devasahayam, Giles

DOI: 10.2174/1871520620666200721104431

Fluorinated-NHC Transition Metal Complexes: Leading Characters as Potential Anticancer Metallodrugs

, 2021; 21(8): 938-948.

Rufino-Felipe, Ernesto; Colorado-Peralta, Raul; Reyes-Marquez, Viviana; Valdes, Hugo; Morales-Morales, David

DOI: 10.2174/1871520620666200908103452

Thymoquinone Inhibits Proliferation and Migration of MDA-MB-231 Triple Negative Breast Cancer Cells by Suppressing Autophagy, Beclin-1 and LC3

, 2021; 21(3): 355-364.

Unal, Tuba D.; Hamurcu, Zuhal; Delibasi, Nesrin; Cinar, Venhar; Guler, Ahsen; Gokce, Sevda; Nurdinov, Nursultan; Ozpolat, Bulent

DOI: 10.2174/1871520620666200807221047


Simone Carradori
Department of Pharmacy
“G. d’Annunzio” University of Chieti-Pescara
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