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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

Volume 22, 20 Issues, 2022
ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)
This journal supports open access

Aims & Scope

Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents.

Each issue contains a series of timely in-depth/mini reviews and guest edited issues written by leaders in the field covering a range of current topics in cancer medicinal chemistry. The journal only considers high quality research papers for publication.

Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery.

Anti-Cancer Agents in Medicinal Chemistry

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Volume 22

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Number 3




Review Article (Mini-Review)

PROTACs: A Hope for Breast Cancer Patients?

, 22(3): 406 - 417

Rajwinder Kaur, Gaurav Chaudhary, Amritpal Kaur, Pargat Singh, Gagan Deep Longowal, Gayatri P. Sapkale and Sandeep Arora*


DOI: 10.2174/1871520621666210308100327


Review Article

Xanthohumol: A Metabolite with Promising Anti-Neoplastic Potential

, 22(3): 418 - 432

Hardeep S. Tuli*, Vaishali Aggarwal, Gaurav Parashar, Diwakar Aggarwal, Nidarshana C. Parashar, Muobarak J. Tuorkey, Mehmet Varol, Katrin Sak, Manoj Kumar and Harpal S. Buttar


DOI: 10.2174/1871520621666210223095021


Review Article

Precision Oncology, Signaling, and Anticancer Agents in Cancer Therapeutics

, 22(3): 433 - 468

Dia Advani, Sudhanshu Sharma, Smita Kumari, Rashmi K. Ambasta and Pravir Kumar*


DOI: 10.2174/1871520621666210308101029




Review Article

Gallic Acid: A Dietary Polyphenol that Exhibits Anti-neoplastic Activities by Modulating Multiple Oncogenic Targets

, 22(3): 499 - 514

Hardeep Singh Tuli*, Hiral Mistry, Ginpreet Kaur, Diwakar Aggarwal, Vivek Kumar Garg, Sonam Mittal, Mükerrem Betül Yerer, Katrin Sak and Md Asaduzzaman Khan


DOI: 10.2174/1871520621666211119085834


Review Article

Repurposing Drugs as Novel Triple-negative Breast Cancer Therapeutics

, 22(3): 515 - 550

Amiya Das, Pallavi Agarwal, Gaurav Kumar Jain, Geeta Aggarwal, Viney Lather* and Deepti Pandita*


DOI: 10.2174/1871520621666211021143255


Articles Ahead of Print

Eryngium billardieri Extract and Fractions Induce Apoptosis in Cancerous Cells


Samira Hasanbeiglu, Kamran Hosseini, Ommoleila Molavi, Parina Asgharian* and Vahideh Tarhriz*


DOI: 10.2174/1871520621666211201151736
View Abstract View on PubMed


Molecular Docking and In Vitro Anticancer Screening of Synthesized Arylthiazole linked 2H-indol-2-one Derivatives as VEGFR-2 Kinase Inhibitors


Nishtha Shalmali, Sandhya Bawa*, Md Rahmat Ali, Sourav Kalra, Raj Kumar, Bushra Zeya, Moshahid Alam Rizvi, Sangh Partap and Asif Husain


DOI: 10.2174/1871520621666211118102139
View Abstract View on PubMed


Is It Time to Consider the Androgen Receptor as a Therapeutic Target in Breast Cancer?


Melika Kooshki Forooshani, Rosa Scarpitta, Giuseppe Nicolò Fanelli, Mario Miccoli, Antonio Giuseppe Naccarato and Cristian Scatena*


DOI: 10.2174/1871520621666211201150818
View Abstract View on PubMed


Current Developments in the Pyran-based Analogues as Anticancer Agents


Parul Grover , Monika Bhardwaj , Lovekesh Mehta, Garima Kapoor and Pooja A. Chawla *


DOI: 10.2174/1871520621666211119090302
View Abstract View on PubMed






Rational Design of Anti-Angiogenic Peptides to Inhibit VEGF/VEGFR2 Interactions for Cancer Therapeutics


Samaneh Ghasemali, Safar Farajnia*, Abolfazl Barzegar*, Mohammad Rahmati, Babak Negahdari, Leila Rahbarnia and Hamidreza Yousefi-nodeh


DOI: 10.2174/1871520621666211118104051
View Abstract View on PubMed



Abstracts Ahead of Print







Design, Synthesis and Evaluation of Novel (E)-N'-((1-(4-chlorobenzyl)-1H-indol-3-yl)methylene)-2-(4-oxoquinazolin-3(4H)-yl)acetohydrazides as Antitumor Agents


Do Thi Mai Dung, Eun Jae Park, Duong Tien Anh, Pham-The Hai, Le Quang Bao, A Young Ji, Jong Soon Kang, Truong Thanh Tung, Sang-Bae Han* and Nguyen-Hai Nam*


DOI: 10.2174/1871520622666220118154914
View Abstract





Published Contents

Editor's Choice


Design, Synthesis and Biological Evaluation of 4, 6-Coumarin Derivatives as Anti- Cancer and Apoptosis-Inducing Agents

, 2021; 21(17): 2351 - 2367

Guoyi Yan, Jiang Luo , Xuan Han, Wenjuan Zhang , Chunlan Pu, Meng Zhou, Xinxin Zhong, Xueyan Hou, Man Zhou Hou and Rui Li *


DOI: 10.2174/1871520621666210129093857




Design, Synthesis and Biological Evaluation of a Novel Series of Thiadiazole- Based Anticancer Agents as Potent Angiogenesis Inhibitors

, 2021; 21(15): 2041 - 2049

Burcugül Altuğ-Tasa, Betül Kaya-Çavuşoğlu*, Ayşe T. Koparal, Gülhan Turan, Ali S. Koparal and Zafer A. Kaplancıklı


DOI: 10.2174/1871520621666201231143535



Synthetic Spirocyclohexadienones as New Anti-Migratory Compounds in Triple- Negative Breast Cancer Cell Migration

, 2021; 21(14): 1901 - 1910

Wanessa F. Altei, Bianca C. Pachane, Lucimara J. Martins, Ralph C. Gomes, Ricardo N. Santos, Daniara C. Fernandes, Heloisa S. Selistre-de-Araújo, Fernando Coelho * and Adriano D. Andricopulo*


DOI: 10.2174/1871520621666201207092836






Synthesis of 1H-1,2,3-Triazole-Linked Quinoline-Isatin Molecular Hybrids as Anti-Breast Cancer and Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Agents

, 2021; 21(10): 1228 - 1239

Paul Awolade, Nosipho Cele, Oluwakemi Ebenezer, Nagaraju Kerru, Lalitha Gummidi, Liang Gu, Gabriella Palma, Mandeep Kaur and Parvesh Singh*


DOI: 10.2174/1871520620666200929153138



On the Cytotoxicity of Chiral Ruthenium Complexes Containing Sulfur Amino Acids against Breast Tumor Cells (MDA-231 and MCF-7)

, 2021; 21(9): 1172 - 1182

Celisnolia M. Leite*, João Honorato de Araujo-Neto, Rodrigo S. Corrêa, Legna Colina-Vegas, Diego Martínez-Otero, Paulo R. Martins, Cristiane G. Silva and Alzir A. Batista*


DOI: 10.2174/1871520620666200824114816



Open Access Articles




The Killing of Human Neuroblastoma Cells by the Small Molecule JQ1 Occurs in a p53-Dependent Manner

, 2020; 20(13): 1613 - 1625

Joseph Mazar*, Caleb Gordon, Varun Naga and Tamarah J. Westmoreland




Cytotoxic Sesquiterpenes from Sonchus oleraceus

, 2020; 20(6): 709 - 714

Hongying Zhang, Yiding Wang, Shaojiu Wang, Qian Wang, Tianjing Wang, Jie Zhu* and Bing Liu




Proteomic Level Changes on Treatment in MCF-7/DDP Breast Cancer Drug- Resistant Cells

, 2020; 20(6): 687 - 699

Gongshen Jin*, Kangwei Wang, Yonghong Liu, Xianhu Liu, Xiaojing Zhang and Hao Zhang





Triphenylethylene-Coumarin Hybrid TCH-5c Suppresses Tumorigenic Progression in Breast Cancer Mainly Through the Inhibition of Angiogenesis

, 2019; 19(10): 1253 - 1261

Naipeng Cui, Dan-Dan Lin, Yang Shen, Jian-Guo Shi, Bing Wang, Ming-Zhi Zhao, Lishuang Zheng, Hua Chen* and Jian-Hong Shi*




Nicotinamide Overcomes Doxorubicin Resistance of Breast Cancer Cells through Deregulating SIRT1/Akt Pathway

, 2019; 19(5): 687 - 696

Yingze Wei, Yan Guo, Jianyun Zhou, Kui Dai, Qiang Xu and Xiaoxia Jin*




New Strategies for Therapeutic Cancer Vaccines

, 2019; 19(2): 213 - 221

Hanjiao Qin, Jiyao Sheng, Dan Zhang, Xuewen Zhang, Linlin Liu*, Bingjin Li*, Guangquan Li* and Zhuo Zhang




Astragalin Attenuates UVB Radiation-induced Actinic Keratosis Formation

, 2018; 18(7): 1001 - 1008

Na Li, Kun Zhang, Xin Mu, Qiong Tian, Wenli Liu, Tianyuan Gao, Xiaona Ma* and Jian Zhang*





Epigenetic and miRNAs Dysregulation in Prostate Cancer: The role of Nutraceuticals

, 2016; 16(11): 1385 - 1402

Alessandra Bosutti, Fabrizio Zanconati, Gabriele Grassi, Barbara Dapas, Sabina Passamonti and Bruna Scaggiante




Blood-Brain Barrier and Breast Cancer Resistance Protein: A Limit to the Therapy of CNS Tumors and Neurodegenerative Diseases

, 2016; 16(7): 810 - 815

Anna Lisa Iorio, Martina da Ros, Ornella Fantappiè, Maurizio Lucchesi, Ludovica Facchini, Alessia Stival, Sabrina Becciani, Milena Guidi, Claudio Favre, Maurizio de Martino, Lorenzo Genitori and Iacopo Sardi





Most Cited Articles



Review Article

Crocetin and crocin from saffron in cancer chemotherapy and chemoprevention

, 2019; 19(1): 38-47.

Alessandro Colapietro, Andrea Mancini, Anna Maria D'Alessandro and Claudio Festuccia*


DOI: 10.2174/1871520619666181231112453


Review Article

Phytochemicals in anticancer drug development

, 2019; 19(2): 172-183.

Rohit Dutt, Vandana Garg, Naveen Khatri and Anil K. Madan*


DOI: 10.2174/1871520618666181106115802




Review Article

Nitrogen-containing heterocycles as anticancer agents: An overview

, 2020; 20(18): 2150-2168.

Damanpreet K. Lang, Rajwinder Kaur*, Rashmi Arora, Balraj Saini and Sandeep Arora


DOI: 10.2174/1871520620666200705214917


Research Article

Synthesis and biological evaluation of novel heterocyclic imines linked coumarin- thiazole hybrids as anticancer agents

, 2019; 19(4): 557-566.

Nerella S. Goud, Mahammad S. Ghouse, Jatoth Vishnu, Jakkula Pranay, Ravi Alvala, Venu Talla, Insaf A. Qureshi and Mallika Alvala*


DOI: 10.2174/1871520619666190207140120


Research Article

Molecular docking study, cytotoxicity, cell cycle arrest and apoptotic induction of novel chalcones incorporating thiadiazolyl isoquinoline in cervical cancer

, 2020; 20(1): 70-83.

Mohamed A. Tantawy, Farid M. Sroor*, Magda F. Mohamed*, Mostafa E. El-Naggar, Fatma M. Saleh, Hamdi M. Hassaneen and Ismail A. Abdelhamid*


DOI: 10.2174/1871520619666191024121116


Research Article

Hybridized quinoline derivatives as anticancer agents: Design, synthesis, biological evaluation and molecular docking

, 2019; 19(4): 439-452.

Mohamed R. Selim, Medhat A. Zahran, Amany Belal*, Moustafa S. Abusaif*, Said A. Shedid, Ahmed B.M. Mehany, Gameel A.M. Elhagali and Yousry A. Ammar*


DOI: 10.2174/1871520618666181112121058


Review Article

Recent advances of silver nanoparticles in cancer diagnosis and treatment

, 2020; 20(11): 1276-1287.

Tran Q. Huy*, Pham T.M. Huyen, Anh-Tuan Le and Matteo Tonezzer*


DOI: 10.2174/1871520619666190710121727


Review Article

Quercetin loaded nanoparticles in targeting cancer: Recent development

, 2019; 19(13): 1560-1576.

Manjula Vinayak* and Akhilendra K. Maurya


DOI: 10.2174/1871520619666190705150214


Review Article

Garlic and its active compounds: A potential candidate in the prevention of cancer by modulating various cell signalling pathways

, 2019; 19(11): 1314-1324.

Saleh A. Almatroodi, Mohammed A. Alsahli, Ahmad Almatroudi and Arshad H. Rahmani*


DOI: 10.2174/1871520619666190409100955


Research Article

Let-7a could serve as a biomarker for chemo-responsiveness to docetaxel in gastric cancer

, 2019; 19(3): 304-309.

Najibeh Shekari, Faezeh Asghari, Navideh Haghnavaz, Dariush Shanehbandi, Vahid Khaze, Behzad Baradaran and Tohid Kazemi*


DOI: 10.2174/1871520619666181213110258


Research Article

Antitumor potential of berberine and cinnamic acid against solid ehrlich carcinoma in mice

, 2019; 19(3): 356-364.

Rafa S. Almeer, Ahmed M. Aref, Romisa A. Hussein, Mohamed S. Othman and Ahmed E. Abdel Moneim*


DOI: 10.2174/1871520618666181116162441



Most Accessed Articles

Potential Interactions between miRNAs and Hypoxia: A New Layer in Cancer Hypoxia

, 2021; 21(17): 2315-2326.

Behnam Emamgolizadeh-Gurt Tapeh, Mohammad R. Alivand and Saeed Solalii*


DOI: 10.2174/1871520621666210201100326


Resveratrol as an Enhancer of Apoptosis in Cancer: A Mechanistic Review

, 2021; 21(17): 2327-2336.

Milad Ashrafizadeh, Shahram Taeb, Hamed Haghi-Aminjan, Shima Afrashi, Kave Moloudi, Ahmed E. Musa, Masoud Najafi* and Bagher Farhood*


DOI: 10.2174/1871520620666201020160348


Lemongrass (Cymbopogon citratus (D.C.) Stapf) Presents Antitumoral Effect and Improves Chemotherapy Activity in Prostate Cancer Cells

, 2021; 21(17): 2337-2350.

Lucas F. Gomes, Pâmela J.H. Longhi, Larissa Machado, Ivana B. Mânica da Cruz, Marco A.E. Montano, Mathias Martins, Sérgio A. Machado, Jovani A. Steffani and Francine C. Cadoná*


DOI: 10.2174/1871520621666210112111711


Emerging Molecular Functions of MicroRNA-9: Cancer Pathology and Therapeutic Implications

, 2021; 21(17): 2304-2314.

Behnam Emamgolizadeh Gurt Tapeh , Bashir Mosayyebi, Behzad Mansoori , Zahra Alipoor Gravand, Hamzeh Sarvnaz and Ali Mohammadi *


DOI: 10.2174/1871520621666210217094839








Design, Synthesis and Biological Evaluation of 4, 6-Coumarin Derivatives as Anti- Cancer and Apoptosis-Inducing Agents

, 2021; 21(17): 2351-2367.

Guoyi Yan, Jiang Luo , Xuan Han, Wenjuan Zhang , Chunlan Pu, Meng Zhou, Xinxin Zhong, Xueyan Hou, Man Zhou Hou and Rui Li *


DOI: 10.2174/1871520621666210129093857



γ-Synuclein is Closely Involved in Autophagy that Protects Colon Cancer Cell from Endoplasmic Reticulum Stress

, 2021; 21(17): 2385-2396.

Qing Ye, Yuanfei Peng, Feng Huang*, Jinhu Chen, Yangmei Xu, Yangming Li, Shengyuan Liu and Lijie Huang


DOI: 10.2174/1871520621666210119093327


Anti-Tumor Efficacy of Pyrvinium Pamoate Nanoliposomes in an Experimental Model of Melanoma

, 2021; 21(17): 2379-2384.

Mahdi Hatamipour, Mahmoud R. Jaafari, Mahtab Zangui, Neda Shakour and Amirhossein Sahebkar*


DOI: 10.2174/1871520621666210217095627





Editor-in-Chief

graphic
Simone Carradori
Department of Pharmacy
“G. d’Annunzio” University of Chieti-Pescara
Chieti
(Italy)
Biography
View Full Editorial Board

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Journal History

Current Medicinal Chemistry - Anti-Cancer Agents was launched in 2001 and later renamed in 2006 as Anti-Cancer Agents in Medicinal Chemistry.

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