E-Pub Articles Ahead of Print ::: Current Pharmaceutical Design

ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)


Volume 23, 46 Issues, 2017


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Current Pharmaceutical Design

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Articles Ahead of Print

Intraoperative Seizures: Anesthetic Drugs and Antiepileptic Drugs


Alberto Uribe*, Alix Zuleta-Alarcon, Mahmoud Kassem, Gurneet S. Sandhu and Sergio D. Bergese


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New Strategies for the Prevention and Treatment of Bone Loss - From Mechanical Loading Point of View


Ce Shi , Bai Yang* and Hongchen Sun*


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AED Strategy after Refractory Epilepsy Surgery


Andreas Zigouris, George A Alexiou*, Marios S. Themistocleous and Spyridon Voulgaris


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Anti-epileptic Drug (AED) Use in Subarachnoid Hemorrhage (SAH) and Intracranial Hemorrhage (ICH)


Rui Feng*, Justin Mascitelli, Alexander G. Chartrain, Konstantinos Margetis and J Mocco


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Epilepsy and Neurosurgery: Historical Highlights


Marianna Karamanou*, Gregory Tsoucalas, Marios Themistocleous, Dimitrios Giakoumettis, George Stranjalis and George Androutsos


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Statins and Vulnerable Plaque


Maria Drakopoulou, Konstantinos Toutouzas*, Archontoula Michelongona and Dimitrios Tousoulis


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Overview on Inhalable Nanocarriers for Respiratory Immunization


Rui C. Ferreira, Hermenegildo Neves, João F. Pinto and Carla M. Lopes*


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Statins in Peripheral Arterial Disease


Scott T. Chiesa, Nikos Papageorgiou and Marietta Charakida*


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Statins in Stable Angina Pectoris


Adam Ioannou, Nikolaos Papageorgiou *, Vincent McVaughan , Marietta Charakida , Dimitris Bertsias , Fay Zacharia, Gerasimos Siasos, George Latsios, Spyridon Papaioannou, Evangelos Oikonomou and Dimitris Tousoulis


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Graphene-Based Nanomaterials: Potential Tools for Neurorepair


Qing Wang , Yan-Hua Li, Wei-Jia Jiang, Jian-Guo Zhao, Bao-Guo Xiao , Guang-Xian Zhang* and Cun-Gen Ma


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Specific Patient Features Affect Antiepileptic Drug Therapy Decisions: Focus on Gender, Age, and Psychiatric Comorbidities


Pisani Laura Rosa, Nikanorova Marina, Johannessen Landmark Cecilie, Johannessen Svein Ivar and Pisani Francesco*


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Statins and Left Ventricular Function


Agamemnon Bakakos, Evangelos Oikonomou*, Georgia Vogiatzi , Gerasimos Siasos, Sotiris Tsalamandris , Alexios Antonopoulos , Costas Mourouzis, Petros Fountoulakis, Manolis Vavuranakis and Dimitris Tousoulis


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Perivascular Adipose Tissue as an Endocrine Organ: The Role of Statins


Fabio Sanna*, Marios Margaritis and Charalambos Antoniades


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Statins and Oxidative Stress in the Cardiovascular System


Marios Margaritis, Fabio Sanna and Charalambos Antoniades*


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Novel Treatment and New Drugs in Epilepsy Treatment


Elissavet. Eskioglou, M. P. Perrenoud, Phiilippe. Ryvlin and Jan. Novy*


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Optimising β-lactam Dosing in Neonates: A Review of Pharmacokinetics, Drug Exposure and Pathogens


Aline Fuchs*, Grace Li, Johannes Van Den Anker and Julia Bielicki


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Editorial: Polymeric Nanocarriers as Robust Platforms for Cancer Therapy


Ahmed O. Elzoghby *





Collaboration in Regulatory Science to Facilitate Therapeutic Development for Neonates


Susan K. McCune*, Yeruk Ager Mulugeta and Gerri R. Baer


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Developmental Pharmacokinetics in Neonates: Maturational Changes and Beyond


Karel Allegaert *, Paola Mian and John van den Anker


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Pharmacological Aspects of Neuro-Immune Interactions


Vadim V. Tarasov, Nikita V. Kudryashov, Vladimir N. Chubarev, Tatiana S. Kalinina, George E. Barreto, Ghulam Md Ashraf and Gjumrakch Aliev*


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Nasal Delivery of Antioxidants by Cholesterol-incorporated Liposomes Extends the Neuroprotective Time Window in Cerebral Ischemia


Seul Ki Min, Yeo Seon Kwon, Myung Kwon Cho and Hwa Sung Shin*


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The Food and Drug Addiction Epidemic: Targeting Dopamine Homeostasis


Kenneth Blum, Panayotis K Thanos, Gene-Jack Wang, Marcelo Febo, Zsolt Demetrovics, Edward Justin Modestino*, Eric R. Braverman, David Baron, Rajendra D. Badgaiyan and Mark S. Gold


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Effects of Excitotoxic Lesion with Inhaled Anesthetics on Nervous System Cells of Rodents


Maria Fernanda Quiroz-Padilla*, Gemma Guillazo-Blanch, Magdy Y Sanchez, Maria Andrea Dominguez-Sanchez and Rosa Margaria Gomez


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Genetic Variants of PEAR1 are Associated with Platelet Function and Antiplatelet Drug Efficacy: A Systematic Review and Meta-Analysis


Qian Xiang, Shuang Zhou, Joshua P. Lewis, Alan R. Shuldiner, Guanhua Ren and Yimin Cui


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A Novel Danshensu-Tetramethylpyrazine Conjugate DT-018 Provides Cardioprotection by Preserving Mitochondrial Function Through the MEF2D/PGC-1α Pathway


Xiaojing Zhang, Jingxiong Luo, Yali Huang, Huixing Deng, Huihui Hu, Pei Yu, Yewei Sun*, Luchen Shan* and Yuqiang Wang


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Statins in Aortic Stenosis


Karl Norrington, Emmanuel Androulakis*, Evangelos Oikonomou, Georgia Vogiatzi and Dimitris Tousoulis


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Biomarkers of Cardiovascular Risk in Haemodialysis Patients


Beata Franczyk, Anna Gluba-Brzózka* and Jacek Rysz


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Statins in Acute Coronary Syndromes


Manolis Vavuranakis*, Maria Kariori, Gerasimos Siasos, Konstantinos Kalogeras and Dimitris Tousoulis


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Intravenous Paracetamol Dosing Guidelines for Pain Management in (pre)term Neonates Using the Paediatric Study Decision Tree


P. Mian*, C.A.J. Knibbe, E.A.M. Calvier, D. Tibboel and K. Allegaert


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Seizures and Anticonvulsants in Brain Tumours: Frequency, Mechanisms and Anti-Epileptic Management


Charles Vecht*, Louis Royer-Perron, Caroline Houillier and Gilles Huberfeld


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Ion Channel and Neurotransmitter Modulators as Electroceutical Approaches to the Control of Cancer


Jack Tuszynski, Tatiana M. Tilli and Michael Levin*


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2-Hydroxypropyl-β-cyclodextrins and the Blood-Brain Barrier: Considerations for Niemann-Pick Disease Type C1


Pericles Calias*


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Purine and Pyrimidine Phosphoribosytransferases: A Versatile Tool for Enzymatic Synthesis of Nucleoside-5′-monophosphates


J. Del Arco and J. Fernández-Lucas*


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Whole Cell Biocatalysts for the Preparation of Nucleosides and their Derivatives


Elizabeth S. Lewkowicz and Adolfo M. Iribarren*


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Cellulose-based Nanocarriers as Platforms for Cancer Therapy


Ling-Yan Meng, Bin Wang, Ming-Guo Ma* and Jie-Fang Zhu*


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Current Delivery Strategies to Improve the Target of Cell Penetrating Peptides Used for Tumor-Related Therapeutics


Fang Zhang, Dandan Yang, Shanshan Jiang, Lei Wu, Li Qin, Huiyang He and Peng Zhang*


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Current Methods of the Circulating Tumor Cells (CTC) Analysis: A Brief Overview


Natalia Dementeva, Daria Kokova and Oleg A. Mayboroda*


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Neonatal Pain, Still Searching for the Optimal Approach


Elizabeth Walter-Nicolet*, Laurent Calvel*, Geraldine Gazzo, Pierrick Poisbeau and Pierre Kuhn


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PBPK in Preterm and Term Neonates: A Review


Robin Michelet*, Jan Van Bocxlaer and An Vermeulen


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A Human Proximal Tubular Epithelial Cell Model to Explore a Knowledge Gap on Neonatal Drug Disposition


Ahmed Reda, Anke Raaijmakers, Saskia van Dorst, Charlotte G.G.M. Pauwels, Karel Allegaert, Mohamed A Elmonem, Rosalinde Masereeuw, Lambertus van den Heuvel, Elena Levtchenko and Fanny Oliveira Arcolino*


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How to Treat Patients with Essential Hypertension and Peripheral Arterial Disease


Salvatore Santo Signorelli*


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Tumor Targeting of Polymeric Nanoparticles Conjugated with Peptides, Saccharides, and Small Molecules for Anticancer Drugs


Banu Bayram, Aykut Özgür, Lütfi Tutar and Yusuf Tutar*


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Virtual Screening and Statistical Analysis in the Design of New Caffeine Analogues Molecules with Potential Epithelial Anticancer Activity


Josivan da Silva Costa*, Karina da Silva Lopes Costa, Josiane Viana Cruz, Ryan da Silva Ramos, Luciane Barros Silva, Davi Do Socorro Barros Brasil, Carlos Henrique Tomich de Paula da Silva, Cleydson Breno Rodrigues dos Santos and Williams Jorge da Cruz Macêdo


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Icariin Attenuates Interleukin-1β-Induced Inflammatory Response in Human Nucleus Pulposus Cells


Wen-bin Hua, Yu-kun Zhang, Xing-huo Wu, Liang Kang, Ji Tu, Kang-cheng Zhao, Shuai Li, Kun Wang, Yu Song, Rong-jin Luo, Zeng-wu Shao and Cao Yang*


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Neonatal Plasticity of the Nociceptive System: Mechanisms, Effects, and Treatment of Repetitive Painful Procedures During NICU Admittance


N J Van den Hoogen*, J Patijn , D Tibboel and E A Joosten


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Aerosol: A Novel Vehicle in Pharmacotherapy in Neonates


Ronan MacLoughlin*, Colin Telfer, Andy Clark and James Fink


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Editorial: Novel Perspectives in the Treatment of Epilepsy


Umberto Aguglia* and Ettore Beghi





Experimental Treatment Options in Absence Epilepsy


Gilles van Luijtelaar*, Mehrnoush Zobeiri, Annika Lüttjohann and Antoine Depaulis


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The Roles of microRNAs in Regulating Chemotherapy Resistance of Non-Small Cell Lung Cancer


Xiaoxuan Wei, Xiaoyan Shen, Yanchen Ren and Weidong Hu*


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Discrepancies in Animal Models of Preterm Birth


Clarence R. Manuel, Charles R. Ashby and Sandra E. Reznik*


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Maternal Immunomodulation Therapy for Prevention of Preterm Birth and Prematurity-Related Morbidity: The New Era of Immuno-Perinatology


Shriddha Nayak, Jared Welling and Irina Burd*


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Preterm Birth and Neonatal Injuries: Importance of Interleukin-1 and Potential of Interleukin-1 Receptor Antagonists


Mathieu Nadeau-Vallée, Dima Obari, Alexandra Beaudry-Richard, Estefania Marin Sierra, Alexandre Beaulac, Noémie Maurice, David M. Olson* and Sylvain Chemtob*


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Instrumenting a Fetal Membrane on a Chip as Emerging Technology for Preterm Birth Research


Juan S. Gnecco, Anjali P. Anders, David Cliffel, Virginia Pensabene, Lisa M. Rogers, Kevin Osteen and David M. Aronoff*


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Pharmacology and Literature Review Based on Related Death and Non-Fatal Case Reports of the Benzofurans and Benzodifurans Designer Drugs


Bernardino Barceló Martín* and Isabel Gomila


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Update of Standard Practices for New Method Validation in Forensic Toxicology


Sarah M.R. Wille*, Wim Coucke, Thierry De Baere and Frank T. Peters


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Interest of Single Hair Analysis to Document Drug Exposure: Literature Review and a Case Report Involving Zuclopenthixol


Nathalie Allibe*, Pascal Kintz, Amandine Faure, François Paysant, Anne-Pascale Michard-Lenoir, Françoise Stanke-Labesque, Virginie Scolan and Hélène Eysseric-Guerin


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Mephedrone Concentrations in Cases of Clinical Intoxication


Esther Papaseit, Eulàlia Olesti, Rafael de la Torre, Marta Torrens and Magí Farré*


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Nanovesicular Formulations for Cancer Gene Therapy


Lorena Tavano, Elisabetta Mazzotta and Rita Muzzalupo*


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Long-lasting Insulin Treatment Via a Single Subcutaneous Administration of Liposomes in Thermoreversible Pluronic® F127 Based Hydrogel


Xiaoyu Chen, Blenda Chi Kwan Wong, Hubiao Chen, Shiping Zhang, Zhaoxiang Bian, Ge Zhang, Congcong Lin, Muhammad Kashif Riaz, Deependra Tyagi, Aiping Lu* and Zhijun Yang*


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Anti-Cancer Drug Delivery Using Carbohydrate-Based Polymers


Javad Ranjbari, Ahad Mokhtarzadeh, Abbas Alibakhshi, Maryam Tabarzad, Maryam Hejazi and Mohammad Ramezani*


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Synthesis and Characterization of a New Benzoindole Derivative with Apoptotic Activity Against Colon Cancer Cells


Fatemeh Hajiaghaalipou*, Fadhil Lafta Faraj, Elham Bagheri, Hamid Khaledi, Hapipah Mohd Ali, Nazia Abdul Majid and Mahmood Ameen Abdulla


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Statins and Contrast-Induced Nephropathy: A Systematic Review and Meta-Analysis


Alexandros Briasoulis*, Mohan Pala , Tesfaye Telila , Obsinet Merid, Emmanuel Akintoye, Georgia Vogiatzi , Evangelos Oikonomou and Dimitris Tousoulis


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Beneficial Effects of Corn Silk on Metabolic Syndrome


Bing Wang, Tiegang Xiao, Jun Ruan and Wensheng Liu*


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A Review of Chinese Herbal Medicine for the Treatment of Chronic Heart Failure


Yong Wang*, Qiyan Wang, Chun Li, Linghui Lu, Qian Zhang, Ruixin Zhu and Wei Wang


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Natural Active Compounds from Plant Food and Chinese Herbal Medicine for Nonalcoholic Fatty Liver Disease


Qian Liu, Lixin Zhu, Chen Cheng, Yiyang Hu* and Qin Feng*


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Chinese Herbal Medicine for the Treatment of Depression: Applications, Efficacies and Mechanisms


Yuanyuan Wang, Menglin Li, Yan Liang, Yiting Yang, Zhe Liu, Keyu Yao, Zijie Chen and Shuangqing Zhai


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An Overview of Cardenolides in Digitalis - More Than a Cardiotonic Compound


Ekrem Gurel*, Serhan Karvar, Buhara Yucesan, Ismail Eker and Muhammad Sameeullah


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The Therapeutical Effect of Chinese Medicine for the Treatment of Atherosclerotic Coronary Heart Disease


Jian Zhang , Hui Meng, Yi Zhang , Xuefeng Zhang , MingYan Shao, Chun Li * and Pengfei Tu*


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Big Data Analyses for Continuous Evaluation of Pharmacotherapy: A Proof of Principle with Doxapram in Preterm Infants


Robert B. Flint*, Willem van Weteringen, Swantje Völler, Jarinda A Poppe, Birgit CP Koch, Ronald de Groot, Dick Tibboel, Catherijne AJ Knibbe, Irwin KM Reiss, Sinno HP Simons and DINO Research group


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A Special Focus on Selexipag - Treatment of Pulmonary Arterial Hypertension


Louise Marqvard Sørensen, Markus Wehland, Marcus Krüger, Ulf Simonsen, Mohamed Zakaria Nassef, Manfred Infanger and Daniela Grimm*


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Why Not All Hypertensive Patients Are Tachycardic at Rest?


Maciej Siński*, Piotr Jędrusik and Jacek Lewandowski


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PD-1/PD-L1 Inhibitors for Immuno-oncology: From Antibodies to Small Molecules


Qiaohong Geng, Peifu Jiao*, Peng Jin, Gaoxing Su, Jinlong Dong and Bing Yan*


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Statins in Diabetes Mellitus


Charalambos Vlachopoulos*, Nikolaos Ioakeimidis, Konstantinos Aznaouridis, George Lazaros and Dimtris Tousoulis


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Editorial: Astrocyte-Targeted Therapeutic Strategies for Neurological Disorders


Ikuko Miyazaki *





IGF-1 as a Drug for Preterm Infants: A Step-Wise Clinical Development


Ann Hellstrom*, David Ley, Boubou Hallberg, Chatarina Lofqvist, Ingrid Hansen-Pupp, Luca A. Ramenghi, Jan Borg, Lois E. H. Smith and Anna-Lena Hard


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Astroglial Connexins as a Therapeutic Target for Alzheimer's Disease


Chenju Yi*, Annette Koulakoff and Christian Giaume


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Sexual Dysfunction in Epilepsy and the Role of Anti-Epileptic Drugs


Mahinda Yogarajah and Marco Mula *


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Hair Analysis in Forensic Toxicology: An Updated Review with a Special Focus on Pitfalls


Pascal Kintz *


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Prevalence and Surveillance of Synthetic Cathinones Use by Hair Analysis: An Update Review


JC. Alvarez*, N. Fabresse and IA. Larabi


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Nails in Forensic Toxicology: An Update


Renata Solimini*, Adele Minutillo, Chrystalla Kyriakou , Simona Pichini, Roberta Pacifici and Francesco Paolo Busardò


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Therapeutic Drug Monitoring in Neonates: What Makes them Unique?


P. Mian*, R. B. Flint, D. Tibboel, J. N. van den Anker, K. Allegaert and B. C.P. Koch


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Age-Appropriate Formulations Including Pharmaceutical Excipients in Neonatal Medicines


Karin Kogermann*, Jana Lass, Georgi Nellisd, Tuuli Metsvaht and Irja Lutsar


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Analgesics in Pregnancy: An Update on Use, Safety and Pharmacokinetic Changes in Drug Disposition


Hayley R Price and Abby C Collier*


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Modelling Bronchopulmonary Dysplasia in Animals: Arguments for the Preterm Rabbit Model


Thomas Salaets, Andre Gie, Bieke Tack, Jan Deprest and Jaan Toelen*


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Inflammation and Epilepsy: Preclinical Findings and Potential Clinical Translation


Gaetano Terrone, Alessia Salamone and Annamaria Vezzani*


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The Use of Hemodynamic and Cerebral Monitoring to Study Pharmacodynamics in Neonates


A. Smits, L. Thewissen, A. Dereymaeker, E. Dempsey, A. Caicedo and Gunnar Naulaers*


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Long-term Effects of Early Exposure to Stress, Pain, Opioids and Anaesthetics on Pain Sensitivity and Neurocognition


Gerbrich E. van den Bosch, Monique van Dijk, Dick Tibboel and Jurgen C. de Graaff*


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Diabetes-Related Neurological Implications and Pharmacogenomics


Rojas Carranza Camilo Andrés, Bustos Cruz Rosa Helena*, Pino Pinzón Carmen Juliana , Ariza Marquez Yeimy Viviana, Gómez Bello Rosa Margarita and Cañadas Garre Marisa


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Modulation of both Insulin Resistance and Cancer Growth by Inositol


Mariano Bizzarri*, Simona Dinicola and Alessandra Cucina


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Anthocyanins: Multi-Target Agents for Prevention and Therapy of Chronic Diseases


Swathi Putta, Nagendra Sastry Yarla, Ilaria Peluso, Dinesh Kumar Tiwari, Gorla V.Reddy, Priyanka Voori Giri, Naresh Kumar, Ramarao Malla, Veera Brahma Chari, Rama Sekhara Reddy D, Ramesh Bade, Mastan Mannarapu, George Barretto, Da-Yong Lu, Vadim V. Tarasov, Vladimir N. Chubarev, Frederico Fávaro Ribeiro, Luciana Scotti, Marcus T. Scotti, M. A.Kamal, Gjumrakch Aliev, Chinthalapally V. Rao, George Perry and Anupam Bishayee


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Role of Bradykinin in the Regulation of Endothelial Nitric Oxide Synthase Expression by Cardiovascular Drugs


Jin Bo Su*


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Role of Pharmacogenomics in Antiepileptic Drug Therapy: Current Status and Future Perspectives


Antonio Gambardella*, Angelo Labate, Laura Mumoli, Iscia Lopes-Cendes and Fernando Cendes*


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Danshen (Salvia miltiorrhiza Bunge): A Prospective Healing Sage for Cardiovascular Diseases


Wei Chen* and Guoxun Chen


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The Efficacy and Potential Mechanisms of Chinese Herbal Medicine on Irritable Bowel Syndrome


Zijuan Bi, Yu Zheng, Jianye Yuan* and Zhaoxiang Bian*


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Imaging Biomarkers of Anti-Epileptic Drug Action: Insights from Magnetic Resonance Imaging


Lorenzo Caciagli, Fenglai Xiao, Britta Wandschneider and Matthias J. Koepp*


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MiRNA-based Therapeutic Strategy in Lung Cancer


Guang Li, Jing Fang, Ying Wang, Hu Wang* and Cheng-Cao Sun*


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Role of miRNA in Lung Cancer-Potential Biomarkers and Therapies


Xiaohong Du, Jitai Zhang, Juping Wang*, Xiaoming Lin* and Feng Ding*


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MiRNA-based Therapeutics for Lung Cancer


Miaowei Wu, Guosheng Wang, Wei Tian, Yongchuan Deng* and Yibing Xu*


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Regulation Mechanism of MicroRNAs in Non-Small Cell Lung Cancer


Feng-Yun Gong, Tao Bai, Ding-Yu Zhang*, Chao-lin Huang, Jing Lv, Jing-Li Wang, Xu-Dong Hu, Juan Wang and Wei Liu


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Good Practices in Forensic Toxicology


Olaf H. Drummer*


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LSD Detection and Interpretation in Hair


Camille Richeval, Delphine Allorge, X. Vanhoye and Jean-michel Gaulier*


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Overview of Forensic Toxicology, Yesterday, Today and in the Future


Heesun Chung* and Sanggil Choe


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Method Development in Forensic Toxicology


Frank T. Peters*, Dirk K. Wissenbach, Francesco Paolo Busardò, Emilia Marchei and Simona Pichini


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The Transport Mechanism of Extracellular Vesicles at the Blood-Brain Barrier


Junichi Matsumoto, Tessandra Stewart, William A. Banks and Jing Zhang*


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Allopurinol: Old Drug, New Indication in Neonates?


Kim V Annink, Axel R Franz, Jan B Derks, Mario Rüdiger, Frank van Bel and Manon J.N.L. Benders*


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Sialidases: Therapeutic and Antiatherogenic Potential


Vasily Nikolaevich Sukhorukov *, Vasily Petrovich Karagodin , Emile Rustemovich Zakiev , Andrey Vyacheslavovich Grechko and Alexandr Nikolaevich Orekhov


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Cardiovascular Drug Therapy for Human Newborn: Review of Pharmacodynamic Data


Ebru Ergenekon, Héctor Rojas-Anaya, María Carmen Bravo, Charalampos Kotidis, Liam Mahoney and Heike Rabe*


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Alzheimer’s Disease and Parkinson’s Disease: A Review of Current Treatment Adopting a Nanotechnology Approach


Adriana Trompetero, Aldemar Gordillo, Carolina del Pilar Mora, María Cristina Velasquillo and Rosa Helena Bustos*


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Synthesis and Biological Evaluation of New Tyrosol-Salicylate Derivatives as Potential Anti-Inflammatory Agents


Rafael P. Aguiar*, Fahad S. Aldawsari, Luiz A. M. Wiirzler, Saulo E. Silva- Filho, Francielli M. S. Silva-Comar, Ciomar A. Bersani-Amado, Carlos A. Velázquez-Martínez and Roberto K. N. Cuman


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Percutaneous Treatment of Aortic Valve Disease: Contemporary Overview and Future Trends


Marko Banovic*, Jozef Bartunek, Serge D. Nikolic, Vladan Vukcevic, Srdjan Aleksandric and Bernard Iung


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Effect of Magnesium Supplementation on Plasma C-reactive Protein Concentrations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials


Luis E. Simental-Mendía, Amirhossein Sahebkar, Martha Rodríguez-Morán, Graciela Zambrano-Galván and Fernando Guerrero-Romero*


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Formulation, Quality Control and Safety Issues of Nanocarriers Used for Cancer Treatment


Ismael D. Bianco*, Marcelo R. Ceballos, Cristian Casado, Viviana G. Dabbene, Carolina Rizzi and R. Kiyomi Mizutamari


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Management of Blood Pressure and Heart Rate in Patients with Diabetes Mellitus


Ioanna Gouni-Berthold*, Ruth Hanssen, Lisa Ravarani and Heiner K. Berthold


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What is the Real Efficacy of Beta-Blockers for the Treatment of Essential Hypertension?


Christian Höcht*, Facundo M Bertera, Julieta S Del Mauro, Yanina Santander Plantamura, Carlos A Taira and Ariel H Polizio


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The “Neurocentric” Approach to Essential Hypertension: How Reliable is the Paradigm of Hyperkinetic Hypertension? A Focus on the Sympathetic Nervous System Dysregulation in Essential Hypertensive Patients with Elevated Resting Heart Rate


Domenico Di Raimondo*, Gaia Musiari, Mauro Grova, Giuseppe Miceli, Antonino Tuttolomondo and Antonio Pinto


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Polymeric Nanocarriers: A New Horizon for the Effective Management of Breast Cancer


Iliyas Khan, Hitesh Kumar, Gaurav Mishra, Avinash Gothwal, Prashant Kesharwani and Umesh Gupta*


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Management of Blood Pressure and Heart Rate in Chronic Kidney Disease


Antonia Kaltsatou*


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Hybrid Polymeric-Magnetic Nanoparticles in Cancer Treatments


Alexandra Muñoz Bonilla and Pilar Herrasti González *


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Supramolecular Self-Assembled Nanogels a New Platform for Anticancer Drug Delivery


Jaleh Varshosaz*, Somayeh Taymouri and Erfaneh Ghassami


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Modulation of Heart Rate by Acute or Chronic Aerobic Exercise. Potential Effects on Blood Pressure Control


Carme Perez-Quilis, J. Derek Kingsley, Kabir Malkani, Gianfranco Cervellin, Giuseppe Lippi and Fabian Sanchis-Gomar*


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Zein-based Nanocarriers as Potential Natural Alternatives for Drug and Gene Delivery: Focus on Cancer Therapy


Ahmed Elzoghby*, May Freag*, Hadeer Mamdouh and Kadria Elkhodairy


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Albumin Nanocarriers, γ - Irradiated Crosslinked, Combined with Therapeutic Drugs for Cancer Therapy


Macarena Siri, Estefanía Achilli, Mariano Grasselli and Silvia del V. Alonso*


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Using Properties of Tumor Microenvironments for Controlling Local, On-Demand Delivery from Biopolymer-Based Nanocarriers


Abdullah K. Alshememry, Suleiman S. El-Tokhy and Larry D. Unsworth*


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Diabetes Mellitus and Male Aging: Pharmacotherapeutics and Clinical Implications


Swathi Putta, Ilaria Peluso, Nagendra Sastry Yarla, Eswar Kumar Kilari, Anupam Bishayee, Da-Yong Lu, George E. Barreto, Ghulam Md Ashraf, Luciana Scotti, Marcus T. Scotti, Rajeev K. Singla, Thonos Alexiou, Atanas G. Atanasov, Vadim V. Tarasov, P. Veera Bramhachari, Sarat Babu Imandi, Madhuri Chintala, Bechan Sharma, Marcella Reale, Rosanna Filosa, Gjumrakch Aliev and Mohammad Amjad Kamal*


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Editorial: Recent Advances in the Field of Kinases and Kinase Inhibitors


Zunnan Huang and Mee-Hyun Lee





Ketogenic Diets in the Treatment of Epilepsy


Maurizio Elia*, Joerg Klepper, Baerbel Leiendecker and Hans Hartmann


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Management of Antiepileptic Treatment After Epilepsy Surgery - Practices and Problems


Guido Rubboli*, Anne Sabers, Peter Uldall and Kristina Malmgren


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Antiepileptic Treatments in Developing Countries


Jeremy Jost*, Athanase Millogo and Pierre-Marie Preux


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Treatment of Epileptic Encephalopathies


Simona Balestrini* and Sanjay M Sisodiya


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The Role of Exosomes and Exosome-derived microRNAs in Atherosclerosis


Xinjie Lu*


View Abstract View on PubMed


Implications of Photophysical and Physicochemical Factors on Successful Application of Photodynamic Therapy


Shubhajit Paul, Paul Wan Sia Heng and Lai Wah Chan*


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Pivotal Roles of Interleukin-17 as the Epicenter of Bone Loss Diseases


Chongshan Liao, Chengfei Zhang and Yanqi Yang*


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Epigenetics of Virus-Induced Tumors: Perspectives for Therapeutic Targeting


Svetlana Vinokurova*


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Role of the Immune Component of Tumor Microenvironment in the Efficiency of Cancer Treatment: Perspectives for the Personalized Therapy


Marina Stakheyeva, Vladimir Riabov, Irina Mitrofanova, Nikolai Litviakov, Evgeny Choynzonov, Nadezhda Cherdyntseva and Julia Kzhyshkowska*


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DNA Base Excision Repair: The Achilles’ Heel of Tumour Cells and their Microenvironment


M Poletto *, A J Legrand * and G L Dianov


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Identification of Antineoplastic Targets with Systems Approaches, Using Resveratrol as an In-Depth Case Study


Nivedita Singh, Sherry Freiesleben, Shailendra K. Gupta*, Yogeshwer Shukla and Olaf Wolkenhauer


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Always Look On the Bright Side: Anti-Tumor Functions of Neutrophils


Sandra Völs, Ronit Vogt Sionov and Zvi Granot*


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Modulation of GABAA Receptors in the Treatment of Epilepsy


Eleonora Palma*, Gabriele Ruffolo, Pierangelo Cifelli, Cristina Roseti, Erwin A. van Vliet and Eleonora Aronica


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Update on Pharmacological Treatment of Progressive Myoclonus Epilepsies.


Edoardo Ferlazzo*, Dorothee Kasteleijn-Nolst Trenite, Gerrit-Jan de Haan, Felix Felix Nitschke, Saija Ahonen, Sara Gasparini and Berge A. Minassian


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Antiepileptic Drugs in Clinical Development: Differentiate or Die?


Gaetano Zaccara * and D. Schmidt


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Safety Profile of the Newest Antiepileptic Drugs: A Curated Literature Review


Caterina Palleria, Giuseppe Cozza, Rajeshree Khengar, Vincenzo Libri and Giovambattista De Sarro*


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Nano-sized Ultrasound Contrast Agents for Cancer Therapy and Theranostics


Hao Li, Shenglong Gan, Shi-Ting Feng, Guofu Zhou, Zhi Dong, Rongqin Zheng* and Zi-Ping Li*


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Potentially Clinically Relevant Pharmacodynamic Interactions Between Antiepileptic Drugs and Psychotropic Drugs: An Update


Edoardo Spina* and Jose de Leon


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Management of Blood Pressure and Heart Rate in Patients with Acute Stroke


Carlo Maida, Antonino Tuttolomondo*, Domenico Di Raimondo and Antonio Pinto


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The Lipid-Lowering Effects and Associated Mechanisms of Dietary Phytosterol Supplementation


Jerad H Dumolt and Todd C Rideout*


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Current and Emerging Strategies in Osteoporosis Management


Stefka Ivanova and Liliya Vasileva*


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Molecular Tests for the Choice of Cancer Therapy


Anna P. Sokolenko and Evgeny N. Imyanitov*


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Recent Advances in the Function of the 67 kDa Laminin Receptor and its Targeting for Personalized Therapy in Cancer


Ada Pesapane, Pia Ragno, Carmine Selleri and Nunzia Montuori*


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Bioinformatics Approaches to Profile the Tumor Microenvironment for Immunotherapeutic Discovery


Trevor Clancy, Ruth Dannenfelser, Olga Troyanskaya, Karl Johan Malmberg, Eivind Hovig and Vessela Kristensen*


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Aquaporin 4 in Astrocytes is a Target for Therapy in Alzheimer's Disease


Yu-Long Lan, Jian-Jiao Chen, Gang Hu, Jun Xu, Ming Xiao and Shao Li*


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New Strategies for the Prevention and Treatment of Systemic and Local Bone Loss; from Pathophysiology to Clinical Application


A. Fassio, Maurizio Rossini , Ombretta Viapiana, Luca Idolazzi, Camilla Benini, Elisabetta Vantaggiato and Davide Gatti


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Altered Homeostatic Functions in Reactive Astrocytes and Their Potential as a Therapeutic Target After Brain Ischemic Injury


Helena Pivonkova and Miroslava Anderova*


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Targeting Human Astrocytes’ Calcium-sensing Receptors for Treatment of Alzheimer’s Disease


Anna Chiarini, Ubaldo Armato*, James F. Whitfield and Ilaria Dal Pra


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Astrocyte: An Innovative Approach for Alzheimer's Disease Therapy


Maria Rosanna Bronzuoli, Roberta Facchinetti, Luca Steardo and Caterina Scuderi*


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Therapeutic Strategy of Targeting Astrocytes for Neuroprotection in Parkinson's Disease


Ikuko Miyazaki* and Masato Asanuma


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Plasmodial Hsp40s: New Avenues for Antimalarial Drug Discovery


Michael O Daniyan and Gregory L Blatch


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Recent Advances in Polymeric Nanosystems for Treating Cutaneous Melanoma and Its Metastasis


Yi-Ping Chou, Yin-Ku Lin, Chun-Han Chen and Jia-You Fang*


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Potential Application of 5-Aryl-Substituted 2-Amino-benzamide Type of HDAC1/2- Selective Inhibitors to Pharmaceuticals


Shinichi Uesato, Yoshiyuki Hirata and Tsutomu Sasaki


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Antidiabetic Drugs and the Kidney


Moses Elisaf, Eleftheria Tzavela, Nikolaos Karanatsis and Vasilis Tsimihodimos


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Targeting Astrocytes for Treating Neurological Disorders: Carbon Monoxide and Noradrenaline-Induced Increase in Lactate


Anemari Horvat, Nina Vardjan* and Robert Zorec*


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Post Mortem Redistribution of Drugs: Current State of Knowledge


Caroline Sastre, Christophe Bartoli, Valerie Baillif-Couniou, Georges Leonetti and Anne-Laure Pelissier-Alicot*


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Metallothionein is a Potential Therapeutic Strategy for Amyotrophic Lateral Sclerosis


Shin-ichi Ono*


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GLT-1 Upregulation as a Potential Therapeutic Target for Ischemic Brain Injury


Yu-Yan Hu, Li Li, Xiao-Hui Xian, Min Zhang, Xiao-Cai Sun, Shu-Qin Li, Xin Cui, Jie Qi and Wen-Bin Li*


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Role and Therapeutic Potential of Astrocytes in Amyotrophic Lateral Sclerosis


Mariana Pehar, Benjamin A. Harlan, Kelby M. Killoy and Marcelo R. Vargas*


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Application of Alphaviral Vectors for Immunomodulation in Cancer Therapy


Anna Zajakina, Karina Spunde and Kenneth Lundstrom*


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Astrocytes Pathology in ALS: A Potential Therapeutic Target?


Sonja Johann*


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Targeting Astrocytes for Treatment in Amyotrophic Lateral Sclerosis


Mina Perić, Dinko Mitrečić and Pavle R. Andjus*


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Targeting the Tumor Microenvironment by Intervention in Interleukin-1 Biology


Elena Voronov and Ron N Apte *


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Tumor Reversion: Mesenchymal-Epithelial Transition as a Critical Step in Managing the Tumor-Microenvironment Cross-Talk


Mariano Bizzarri*, Alessandra Cucina and Sara Proietti*


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Obesity-Induced Hypertension: New Insights


Christina Antza, Stella Stabouli, Michalis Natsis, Ioannis Doundoulakis and Vasilios Kotsis*


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The Second-generation of Highly Potent Hepatitis C Virus (HCV) NS3/4A Protease Inhibitors: Evolutionary Design Based on Tailor-made Amino Acids, Synthesis and Major Features of Bio-activity


Shuni Wang, Yibing Wang, Jiang Wang, Tatsunori Sato, Kunisuke Izawa*, Vadim A. Soloshonok* and Hong Liu*


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Hormones and Sarcopenia


John E. Morley*


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Micro-RNA Profiling as a Predictor of Clinical Outcomes for Head and Neck Cancer Patients


Tatyana Isayeva*, Margaret Brandwein-Gensler , Maheshika Somarathna , Lakisha D Moore-Smith and Timmy Lee


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Effect and Mechanism of Curcumin on EZH2 – miR-101 Regulatory Feedback Loop in Multiple Myeloma


Chuanqing Wu, Tuo Ruan, Weizhen Liu, Xiaojie Zhu, Juan Pan, Wen Lu, Chen Yan, Kaixiong Tao , Weikang Zhang* and Chun Zhang*


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Application of Bone Marrow Stem Cell Based Therapy in Bone Loss Diseases


Nan Xiao*


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Self-Assembled Nanocarriers Based on Amphiphilic Natural Polymers for Anti- Cancer Drug Delivery Applications


Sally Sabra, Mona Abdelmoneem, Mahmoud Abdelwakil, Moustafa Taha Mabrouk, Doaa Anwar, Rania Mohamed, Sherine Khattab, Adnan Bekhit, Kadria Elkhodairy, May Freag and Ahmed Elzoghby*


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Bone-Muscle Crosstalk: Unraveling New Therapeutic Targets for Osteoporosis


Anna Picca, Riccardo Calvani*, Ester Manes-Gravina, Leonardo Spaziani, Francesco Landi, Roberto Bernabei and Emanuele Marzetti


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Hyaluronate-Lipid Nanohybrids: Fruitful Harmony in Cancer Targeting


May S Freag*


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Micelles As Delivery System for Cancer Treatment


Dilek Keskin and Ayşen Tezcaner*


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Management of Blood Pressure and Heart Rate in Acute Decompensated Heart Failure with Volume Overload


Duygu Kocyigit*, Kadri Murat Gurses, Muhammed Ulvi Yalcin and Lale Tokgozoglu


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Ligand-modified Biopolymeric Nanoparticles as Efficient Tools for Targeted Cancer Therapy


Hasan Kouchakzadeh*, Tooba Soudi, Niloofar Heshmati Aghda and Seyed Abbas Shojaosadati


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Modulation of Inflammatory Response to Implanted Biomaterials Using Natural Compounds


Maria Yanez, James Blanchette and Ehsan Jabbarzadeh*


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Pharmacological Treatment of Bone Loss


Rui Pang and Weibo Xia*


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‘Osteoimmunology’ Offers New Perspectives for the Treatment of Pathological Bone Loss


Hongrui Liu, Tingting Luo, Jiali Tan, Minqi Li and Jie Guo*


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Prospect of Combination and Sequential Therapies for Postmenopausal Osteoporosis


Hao Liu and Binbin Li*


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Low Testosterone Levels and Metabolic Syndrome in Aging Male


Rodrigo Blaya*, Patrícia Blaya, Luiza Rhoden and Ernani Luis Rhoden


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Fertility and Sperm Quality in the Aging Male


Susana Almeida, Luís Rato, Mário Sousa, Marco G. Alves and Pedro F. Oliveira*


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Redox Regulation of Fertility in Aging Male and the Role of Antioxidants: A Savior or Stressor


Kristian Leisegang, Ralf Henkel* and Ashok Agarwal


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Unravelling the Power of Omics for the Infertile Ageing Male


Paulo Bastos, Maria João Freitas, André Gomes, Rui Vitorino and Margarida Fardilha*


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Global Effects Of Early Life Stress On Neurons And Glial Cells


Dueñas Zulma, Caicedo-Mera Juan Carlos and Torner Luz


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Editorial: Pharmaceutical Applications of Dendrimers


Jose Correa-Basurto*





Natural Approaches in Diabetes Management: A Review of Diet, Exercise, and Natural Products


William M. Schultz, Tina Varghese, Robert E. Hein, Devinder S. Dhindsa, Elliot N. Mahlof, Hannah C. Cai, Geoffrey Southmayd, Pratik B. Sandesaraa, Danny J. Eapen and Laurence S. Sperling


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