The Role of Nutraceuticals in Degenerative Diseases provides a comprehensive overview of the growing role of nutraceuticals in preventing and managing degenerative disorders. As awareness of dietary supplements as supportive therapy increases, this book examines how nutraceuticals can complement conventional treatments in slowing cellular degeneration and improving quality of life. The book systematically explains the causes, mechanisms, and therapeutic approaches of major degenerative diseases, including respiratory, neurodegenerative, cardiovascular, musculoskeletal, renal, hepatic, ophthalmic, and metabolic disorders. It covers both foundational concepts of nutraceuticals and disease pathology, along with disease-specific applications supported by mechanistic insights and emerging research. Topics such as in silico identification of nutraceuticals, biomarkers, and prevention strategies are also discussed, offering a balanced view of theory and practice. Key Features; -Explains fundamentals, scope, and identification of nutraceuticals -Describes mechanisms and progression of major degenerative diseases -Examines disease-specific nutraceutical interventions across organ systems -Integrates conventional therapy with dietary and preventive strategies -Highlights emerging research, biomarkers, and preventive approaches

Frontiers in Computational Chemistry (Volume 8) offers a comprehensive overview of new advances in computational modeling techniques for drug discovery and development. This volume focuses on an overview of computer-aided drug design and therapy, molecular dynamics simulations and quantum mechanical calculations, while presenting some applications in computational chemistry. The edited chapters cover applications in the computational design of therapeutic peptides, protein-ligand interactions, anti-inflammatory drug design targeting the NLRP3 complex, and the study of photophysical processes. Each chapter provides theoretical explanations followed by experimental methods and current research updates.

With the global rise in use of herbal medicine alongside conventional drugs, understanding the interactions between them has become critical to ensuring therapeutic effectiveness and patient safety. Herb-Drug Interactions: A Medicinal Approach integrates traditional knowledge, modern pharmacology, and computational tools to provide a holistic perspective on herb-drug interactions. The book covers the historical evolution of herbal medicine, chemistry and mechanisms of herb-drug interactions, pharmacodynamics in metabolic diseases, and clinical implications. It also explores transport mechanisms, healthcare applications, and advanced computational approaches, including databases and bioinformatics tools. Special attention is given to vulnerable populations such as children, the elderly, and pregnant women, offering practical clinical insights. By combining mechanistic understanding with real-world applications, the book serves as both a reference and a guide for advancing safe, evidence-based integrative healthcare. Key Features - Integrates traditional herbal knowledge with modern pharmacology and computational approaches. - Explains mechanisms, pharmacodynamics, and clinical implications of herb-drug interactions. - Highlights therapeutic potential, drug-herb synergy, and safety considerations. - Focuses on vulnerable populations: paediatrics, geriatrics, and pregnancy. - Provides practical guidance for evidence-based integrative healthcare.

The Role of Nutraceuticals in Degenerative Diseases provides a comprehensive overview of the growing role of nutraceuticals in preventing and managing degenerative disorders. As awareness increases around dietary supplements as supportive therapy, this book examines how nutraceuticals can complement conventional treatments in slowing cellular degeneration and improving quality of life. The book systematically explains the causes, mechanisms, and therapeutic approaches of major degenerative diseases, including respiratory, neurodegenerative, cardiovascular, musculoskeletal, renal, hepatic, ophthalmic, and metabolic disorders. It covers both foundational concepts of nutraceuticals and disease pathology, along with disease-specific applications supported by mechanistic insights and emerging research. Topics such as in silico identification of nutraceuticals, biomarkers, and prevention strategies are also discussed, offering a balanced view of theory and practice. Key Features Explains fundamentals, scope, and identification of nutraceuticals Describes mechanisms and progression of major degenerative diseases Examines disease-specific nutraceutical interventions across organ systems Integrates conventional therapy with dietary and preventive strategies Highlights emerging research, biomarkers, and preventive approaches.

Brain Tumor Drug Development provides a clear, multidisciplinary update on modern therapies for glioblastoma and other aggressive brain tumors. The book focuses on improving drug precision, crossing the blood-brain barrier, identifying biomarkers, designing effective trials, and accelerating translation from research to real patient care. Key Features Discusses how to overcome the blood-brain barrier using advanced delivery methods Explains how to improve drug penetration and specificity with nano and polymer-based systems Explores new therapies through immunotherapy, gene therapy, and personalised medicine Outlines preclinical models and identifies biomarkers to support clinical success Details regulatory-aligned clinical trial strategies for faster translation

The Role of Asymmetric Synthesis in Drug Discovery presents a comprehensive overview of how enantioselective synthesis drives the development of safer, more effective therapeutics. Because the 3D arrangement of atoms profoundly affects a drug's activity, efficacy, and safety, asymmetric synthesis enables the precise production of single enantiomers-minimizing side effects and maximizing therapeutic performance. In the era of precision medicine, this selective control is indispensable for designing molecules that interact optimally with biological targets. Spanning ten chapters, the book highlights cutting-edge experimental research on the asymmetric synthesis of diverse bioactive heterocycles. Topics include foundational principles of enantioselective synthesis, chiral heterocycles, alkaloids, terpenoids, spirooxindoles, dihydropyrimidinones, piperazine derivatives, and asymmetric oxazines. Additional chapters explore chiral triazoles, benzimidazoles, and broader classes of chiral pharmaceuticals synthesized through asymmetric strategies. Together, these chapters illustrate both the scientific depth and therapeutic potential of modern asymmetric methodologies. The book serves as a forward-looking resource designed to inspire new research on chiral heterocycles and to support ongoing efforts in medicinal chemistry and drug design. Key Features: Explores core principles of enantioselective and asymmetric synthesis in drug discovery. Highlights synthetic strategies for diverse bioactive chiral heterocycles and natural products. Showcases experimental advancements in the synthesis of alkaloids, terpenoids, spirooxindoles, and more. Examines green, modern, and emerging approaches to asymmetric synthesis. Demonstrates therapeutic relevance through biological evaluations and pharmaceutical applications. Inspires future research on novel chiral scaffolds for drug development.

Solid Base Catalysis: A New Frontier in Industrial Sustainability showcases the efficiency, reusability, and environmental benefits of solid based catalysts in modern green chemistry. Across ten chapters, the book presents advanced catalyst fabrication techniques, including sol-gel, hydrothermal, vapor deposition, and innovative waste-derived approaches paired with cutting-edge structural and spectroscopic characterization tools. The text highlights catalyst-enabled organic synthesis, biomass conversion, pharmaceutical intermediate production, heterocycle generation, and renewable energy applications, bridging foundational principles with industrial relevance. Detailed case studies on hydrogenation, multicomponent reactions, transesterification, depolymerization, bond-forming reactions, and CO₂ conversion to methanol connect academic research with industrial practice, positioning solid base catalysts as a cornerstone technology for sustainable chemistry, circular bioeconomy, and clean-energy innovation. Key Features Examines cutting-edge synthesis methods for solid base catalysts Analyzes material structure and functionality via advanced characterization techniques Demonstrates catalytic pathways for organic synthesis and fine chemicals manufacturing Enables biomass valorization and renewable feedstock conversion Facilitates hydrogenation, multicomponent, and C-C/C-N/C-S bond-forming reactions Advances CO₂ utilization, bio-oil upgrading, and sustainable fuel production Bridges fundamental catalysis principles with industrial case studies and real-world applications

Brain Tumour Drug Development provides a clear, multidisciplinary update on modern therapies for glioblastoma and other aggressive brain tumours. The book focuses on improving drug precision, crossing the blood-brain barrier, identifying biomarkers, designing effective trials, and accelerating translation from research to real patient care. Key Features Overcomes the blood-brain barrier using advanced delivery methods Improves drug penetration & specificity with nano and polymer-based systems Explores new therapies through immunotherapy, gene therapy, and personalised medicine Builds preclinical models & identifies biomarkers to support clinical success Designs regulatory-aligned clinical trial strategies for faster translation

Handbook of Practical Pharmacology – I serves as a vital bridge between theoretical pharmacology and laboratory application, equipping learners with the experimental skills essential to understanding drug actions through hands-on animal studies. A comprehensive, curriculum-based guide designed for second-year B. Pharm. students, fully aligned with the Pharmacy Council of India’s 2014 regulations. The book introduces students to fundamental laboratory concepts, animal handling as per CCSEA guidelines, drug administration routes, and experimental models like Rotarod, Actophotometer, and rabbit eye studies. It explores pharmacodynamic responses to various classes of drugs, including hepatic enzyme inducers, skeletal muscle relaxants, anticonvulsants, and anxiolytics. Each chapter combines clarity, precision, and ethical awareness, ensuring reproducibility and adherence to professional standards. Serving both as a laboratory manual and a learning companion, this handbook enhances analytical thinking and experimental competence, helping students gain a deeper, practice-based understanding of pharmacology. Key Features · Aligns with the PCI 2014 syllabus for second-year B. Pharm. students. · Explains fundamental experimental pharmacology concepts and instrumentation. · Demonstrates animal handling and drug administration techniques per CCSEA guidelines. · Guides pharmacodynamic testing using established models like Rotarod, Actophotometer, and MES. · Promotes laboratory competence, ethical compliance, and analytical reasoning in pharmacology

Drug Repurposing for Antivirals is a timely volume bridging pharmacology, virology, and computational science to present a cohesive understanding of the scientific and translational potential of drug repurposing in antiviral therapy with innovative strategies of finding new antiviral applications for existing drugs, an approach that shortens development timelines, reduces costs, and accelerates clinical deployment The book covers core concepts, from historical successes to modern applications in combating viral diseases. It explores computational screening, molecular docking, and AI-driven tools for identifying candidate molecules; experimental validation methods; and real-world case studies involving influenza, SARS-CoV-2, HIV, and hepatitis viruses. Special focus is given to host-targeted antivirals, broad-spectrum agents, and strategies to counter viral resistance. Regulatory aspects, challenges, and future directions for integrating repurposed antivirals into clinical practice are also discussed. Key Features: Integrates theory, methodology, and real-world case studies. Covers both computational and experimental approaches. Highlights implications for pandemic preparedness and rapid-response drug discovery. Includes contributions from leading experts in virology, medicinal chemistry, and pharmacology.